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Showing 1 to 12 of 53 entries
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Intra-testicular signals regulate germ cell progression and production of qualitatively mature spermatozoa in vertebrates.

Frontiers in endocrinology

Meccariello R, Chianese R, Chioccarelli T, Ciaramella V, Fasano S, Pierantoni R, Cobellis G.
PMID: 24847312
Front Endocrinol (Lausanne). 2014 May 08;5:69. doi: 10.3389/fendo.2014.00069. eCollection 2014.

Spermatogenesis, a highly conserved process in vertebrates, is mainly under the hypothalamic-pituitary control, being regulated by the secretion of pituitary gonadotropins, follicle stimulating hormone, and luteinizing hormone, in response to stimulation exerted by gonadotropin releasing hormone from hypothalamic neurons....

Does Kisspeptin Signaling have a Role in the Testes?.

Frontiers in endocrinology

Mei H, Doran J, Kyle V, Yeo SH, Colledge WH.
PMID: 24416028
Front Endocrinol (Lausanne). 2013 Dec 30;4:198. doi: 10.3389/fendo.2013.00198. eCollection 2013.

Kisspeptins are a family of overlapping neuropeptides encoded by the Kiss1 gene that regulate the mammalian reproductive axis by a central action in the hypothalamus to stimulate GnRH release. Kisspeptins and their receptor (GPR54 also called KISS1R) are also...

New insights into the control of pulsatile GnRH release: the role of Kiss1/neurokinin B neurons.

Frontiers in endocrinology

Navarro VM.
PMID: 22649420
Front Endocrinol (Lausanne). 2012 Apr 02;3:48. doi: 10.3389/fendo.2012.00048. eCollection 2012.

Gonadotropin-releasing hormone (GnRH) is the ultimate output signal of an intricate network of neuroendocrine factors that, acting on the pituitary, trigger gonadotropin release. In turn, gonadotropins exert their trophic action on the gonads to stimulate the synthesis of sex...

Afferent neuronal control of type-I gonadotropin releasing hormone neurons in the human.

Frontiers in endocrinology

Hrabovszky E, Liposits Z.
PMID: 24062728
Front Endocrinol (Lausanne). 2013 Sep 20;4:130. doi: 10.3389/fendo.2013.00130.

Understanding the regulation of the human menstrual cycle represents an important ultimate challenge of reproductive neuroendocrine research. However, direct translation of information from laboratory animal experiments to the human is often complicated by strikingly different and unique reproductive strategies...

Arg-Phe-amide-related peptides influence gonadotropin-releasing hormone neurons.

Neural regeneration research

Kelestimur H, Kacar E, Uzun A, Ozcan M, Kutlu S.
PMID: 25206468
Neural Regen Res. 2013 Jun 25;8(18):1714-20. doi: 10.3969/j.issn.1673-5374.2013.18.009.

The hypothalamic Arg-Phe-amide-related peptides, gonadotropin-inhibitory hormone and orthologous mammalian peptides of Arg-Phe-amide, may be important regulators of the hypothalamus-pituitary-gonadal reproductive axis. These peptides may modulate the effects of kisspeptins because they are presently recognized as the most potent activators...

Facing the Challenges of Neuropeptide Gene Knockouts: Why Do They Not Inhibit Reproduction in Adult Teleost Fish?.

Frontiers in neuroscience

Trudeau VL.
PMID: 29773976
Front Neurosci. 2018 May 03;12:302. doi: 10.3389/fnins.2018.00302. eCollection 2018.

Genetic manipulation of teleost endocrine systems started with transgenic overexpression of pituitary growth hormone. Such strategies enhance growth and reduce fertility, but the fish still breed. Genome editing using transcription activator-like effector nuclease in zebrafish and medaka has established...

Kisspeptin/Kisspeptin Receptor System in the Ovary.

Frontiers in endocrinology

Hu KL, Zhao H, Chang HM, Yu Y, Qiao J.
PMID: 29354093
Front Endocrinol (Lausanne). 2018 Jan 04;8:365. doi: 10.3389/fendo.2017.00365. eCollection 2017.

Kisspeptins are a family of neuropeptides that are critical for initiating puberty and regulating ovulation in sexually mature females

Thyroid hormone and seasonal rhythmicity.

Frontiers in endocrinology

Dardente H, Hazlerigg DG, Ebling FJ.
PMID: 24616714
Front Endocrinol (Lausanne). 2014 Feb 26;5:19. doi: 10.3389/fendo.2014.00019. eCollection 2014.

Living organisms show seasonality in a wide array of functions such as reproduction, fattening, hibernation, and migration. At temperate latitudes, changes in photoperiod maintain the alignment of annual rhythms with predictable changes in the environment. The appropriate physiological response...

Mechanisms of obesity-induced male infertility.

Expert review of endocrinology & metabolism

Phillips KP, Tanphaichitr N.
PMID: 30764048
Expert Rev Endocrinol Metab. 2010 Mar;5(2):229-251. doi: 10.1586/eem.09.65.

Male infertility, characterized by hypogonadism, decreased semen quality or ejaculatory dysfunction, accounts for approximately 20% of infertility cases. Obesity and metabolic dysfunction have been identified, among other causal factors, to contribute to male infertility. In the context of the...

Kisspeptin-8 Induces Anxiety-Like Behavior and Hypolocomotion by Activating the HPA Axis and Increasing GABA Release in the Nucleus Accumbens in Rats.

Biomedicines

Ibos KE, Bodnár É, Bagosi Z, Bozsó Z, Tóth G, Szabó G, Csabafi K.
PMID: 33503835
Biomedicines. 2021 Jan 25;9(2). doi: 10.3390/biomedicines9020112.

Kisspeptins (Kp) are RF-amide neuropeptide regulators of the reproductive axis that also influence anxiety, locomotion, and metabolism. We aimed to investigate the effects of intracerebroventricular Kp-8 (an N-terminally truncated octapeptide) treatment in Wistar rats. Elevated plus maze (EPM), computerized...

Role of Kisspeptin on Hypothalamic-Pituitary-Gonadal Pathology and Its Effect on Reproduction.

Cureus

Padda J, Khalid K, Moosa A, Syam M, Kakani V, Imdad U, Ismail D, Cooper AC, Jean-Charles G.
PMID: 34646652
Cureus. 2021 Aug 31;13(8):e17600. doi: 10.7759/cureus.17600. eCollection 2021 Aug.

Kisspeptin is a neuropeptide that plays a significant role in human reproduction by its action on the hypothalamic-pituitary-gonadal (HPG) axis and functions through a G-protein-coupled receptor called G-protein-coupled receptor 54/kisspeptin 1 receptor (GPR54/KISS1R). It is encoded by the kisspeptin...

Precocious sexual maturation: Unravelling the mechanisms of pubertal onset through clinical observations.

Journal of neuroendocrinology

Soriano-Guillén L, Tena-Sempere M, Seraphim CE, Latronico AC, Argente J.
PMID: 33904190
J Neuroendocrinol. 2021 Apr 26;e12979. doi: 10.1111/jne.12979. Epub 2021 Apr 26.

Puberty is a crucial biological process normally occurring at a specific time during the lifespan, during which sexual and somatic maturation are completed, and reproductive capacity is reached. Pubertal timing is not only determined by genetics, but also by...

Showing 1 to 12 of 53 entries