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Lentivirus-induced knockdown of LRP1 induces osteoarthritic-like effects and increases susceptibility to apoptosis in chondrocytes via the nuclear factor-κB pathway.

Experimental and therapeutic medicine

Yang E, Zheng H, Peng H, Ding Y.
PMID: 26170918
Exp Ther Med. 2015 Jul;10(1):97-105. doi: 10.3892/etm.2015.2471. Epub 2015 May 05.

Low-density lipoprotein receptor-related protein 1 (LRP1) is known to regulate cell survival and inflammation. The present study investigated the involvement of LRP1 in the regulation of tumor necrosis factor (TNF)-α-induced expression of matrix metalloproteinase (MMP)-13. Furthermore, the study aimed...

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Yang E, Zheng H, Peng H, et al. Lentivirus-induced knockdown of LRP1 induces osteoarthritic-like effects and increases susceptibility to apoptosis in chondrocytes via the nuclear factor-κB pathway. Exp Ther Med. 2015;10(1):97-105doi: 10.3892/etm.2015.2471.
Yang, E., Zheng, H., Peng, H., & Ding, Y. (2015). Lentivirus-induced knockdown of LRP1 induces osteoarthritic-like effects and increases susceptibility to apoptosis in chondrocytes via the nuclear factor-κB pathway. Experimental and therapeutic medicine, 10(1), 97-105. https://doi.org/10.3892/etm.2015.2471
Yang, Erping, et al. "Lentivirus-induced knockdown of LRP1 induces osteoarthritic-like effects and increases susceptibility to apoptosis in chondrocytes via the nuclear factor-κB pathway." Experimental and therapeutic medicine vol. 10,1 (2015): 97-105. doi: https://doi.org/10.3892/etm.2015.2471
Yang E, Zheng H, Peng H, Ding Y. Lentivirus-induced knockdown of LRP1 induces osteoarthritic-like effects and increases susceptibility to apoptosis in chondrocytes via the nuclear factor-κB pathway. Exp Ther Med. 2015 Jul;10(1):97-105. doi: 10.3892/etm.2015.2471. Epub 2015 May 05. PMID: 26170918; PMCID: PMC4486959.
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Suppression of Alzheimer's disease-related phenotypes by the heat shock protein 70 inducer, geranylgeranylacetone, in APP/PS1 transgenic mice via the ERK/p38 MAPK signaling pathway.

Experimental and therapeutic medicine

Sun Y, Zhang JR, Chen S.
PMID: 29285052
Exp Ther Med. 2017 Dec;14(6):5267-5274. doi: 10.3892/etm.2017.5253. Epub 2017 Oct 03.

HSP70 overexpression has a remedying effect in neurodegenerative diseases. In Alzheimer's disease (AD), the suppressive effects of HSP70 overexpression on AD-related phenotypes and the underlying mechanisms are unknown. In the current study, the effect of geranylgeranylacetone (GGA), a non-toxic...

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Sun Y, Zhang JR, Chen S. Suppression of Alzheimer's disease-related phenotypes by the heat shock protein 70 inducer, geranylgeranylacetone, in APP/PS1 transgenic mice via the ERK/p38 MAPK signaling pathway. Exp Ther Med. 2017;14(6):5267-5274doi: 10.3892/etm.2017.5253.
Sun, Y., Zhang, J. R., & Chen, S. (2017). Suppression of Alzheimer's disease-related phenotypes by the heat shock protein 70 inducer, geranylgeranylacetone, in APP/PS1 transgenic mice via the ERK/p38 MAPK signaling pathway. Experimental and therapeutic medicine, 14(6), 5267-5274. https://doi.org/10.3892/etm.2017.5253
Sun, Yuan, et al. "Suppression of Alzheimer's disease-related phenotypes by the heat shock protein 70 inducer, geranylgeranylacetone, in APP/PS1 transgenic mice via the ERK/p38 MAPK signaling pathway." Experimental and therapeutic medicine vol. 14,6 (2017): 5267-5274. doi: https://doi.org/10.3892/etm.2017.5253
Sun Y, Zhang JR, Chen S. Suppression of Alzheimer's disease-related phenotypes by the heat shock protein 70 inducer, geranylgeranylacetone, in APP/PS1 transgenic mice via the ERK/p38 MAPK signaling pathway. Exp Ther Med. 2017 Dec;14(6):5267-5274. doi: 10.3892/etm.2017.5253. Epub 2017 Oct 03. PMID: 29285052; PMCID: PMC5740803.
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LRP1 Modulates APP Intraneuronal Transport and Processing in Its Monomeric and Dimeric State.

Frontiers in molecular neuroscience

Herr UM, Strecker P, Storck SE, Thomas C, Rabiej V, Junker A, Schilling S, Schmidt N, Dowds CM, Eggert S, Pietrzik CU, Kins S.
PMID: 28496400
Front Mol Neurosci. 2017 Apr 27;10:118. doi: 10.3389/fnmol.2017.00118. eCollection 2017.

The low-density lipoprotein receptor-related protein 1, LRP1, interacts with APP and affects its processing. This is assumed to be mostly caused by the impact of LRP1 on APP endocytosis. More recently, also an interaction of APP and LRP1 early...

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Herr UM, Strecker P, Storck SE, et al. LRP1 Modulates APP Intraneuronal Transport and Processing in Its Monomeric and Dimeric State. Front Mol Neurosci. 2017;10:118doi: 10.3389/fnmol.2017.00118.
Herr, U. M., Strecker, P., Storck, S. E., Thomas, C., Rabiej, V., Junker, A., Schilling, S., Schmidt, N., Dowds, C. M., Eggert, S., Pietrzik, C. U., & Kins, S. (2017). LRP1 Modulates APP Intraneuronal Transport and Processing in Its Monomeric and Dimeric State. Frontiers in molecular neuroscience, 10118. https://doi.org/10.3389/fnmol.2017.00118
Herr, Uta-Mareike, et al. "LRP1 Modulates APP Intraneuronal Transport and Processing in Its Monomeric and Dimeric State." Frontiers in molecular neuroscience vol. 10 (2017): 118. doi: https://doi.org/10.3389/fnmol.2017.00118
Herr UM, Strecker P, Storck SE, Thomas C, Rabiej V, Junker A, Schilling S, Schmidt N, Dowds CM, Eggert S, Pietrzik CU, Kins S. LRP1 Modulates APP Intraneuronal Transport and Processing in Its Monomeric and Dimeric State. Front Mol Neurosci. 2017 Apr 27;10:118. doi: 10.3389/fnmol.2017.00118. eCollection 2017. PMID: 28496400; PMCID: PMC5406469.
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The Blood-Brain Barrier in Alzheimer's Disease.

Handbook of experimental pharmacology

Storck SE, Hartz AMS, Pietrzik CU.
PMID: 33580390
Handb Exp Pharmacol. 2021 Feb 13; doi: 10.1007/164_2020_418. Epub 2021 Feb 13.

The accumulation of neurotoxic amyloid-beta (Aβ) in the brain is one of the characteristic hallmarks of Alzheimer's disease (AD). Aβ-peptide brain homeostasis is governed by its production and various clearance mechanisms. The blood-brain barrier provides a large surface area...

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Storck SE, Hartz AMS, Pietrzik CU. The Blood-Brain Barrier in Alzheimer's Disease. Handb Exp Pharmacol. 2021;doi: 10.1007/164_2020_418.
Storck, S. E., Hartz, A. M. S., & Pietrzik, C. U. (2021). The Blood-Brain Barrier in Alzheimer's Disease. Handbook of experimental pharmacology, . https://doi.org/10.1007/164_2020_418
Storck, Steffen E, et al. "The Blood-Brain Barrier in Alzheimer's Disease." Handbook of experimental pharmacology vol. (2021). doi: https://doi.org/10.1007/164_2020_418
Storck SE, Hartz AMS, Pietrzik CU. The Blood-Brain Barrier in Alzheimer's Disease. Handb Exp Pharmacol. 2021 Feb 13; doi: 10.1007/164_2020_418. Epub 2021 Feb 13. PMID: 33580390.
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APOE genotype moderates the relationship between LRP1 polymorphism and cognition across the Alzheimer's disease spectrum via disturbing default mode network.

CNS neuroscience & therapeutics

Zang F, Zhu Y, Zhang Q, Tan C, Wang Q, Xie C.
PMID: 34387022
CNS Neurosci Ther. 2021 Nov;27(11):1385-1395. doi: 10.1111/cns.13716. Epub 2021 Aug 12.

AIMS: This study aims to investigate the mechanisms by which apolipoprotein E (APOE) genotype modulates the relationship between low-density lipoprotein receptor-related protein 1 (LRP1) rs1799986 variant on the default mode network (DMN) and cognition in Alzheimer's disease (AD) spectrum...

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Zang F, Zhu Y, Zhang Q, et al. APOE genotype moderates the relationship between LRP1 polymorphism and cognition across the Alzheimer's disease spectrum via disturbing default mode network. CNS Neurosci Ther. 2021;27(11):1385-1395doi: 10.1111/cns.13716.
Zang, F., Zhu, Y., Zhang, Q., Tan, C., Wang, Q., Xie, C. (2021). APOE genotype moderates the relationship between LRP1 polymorphism and cognition across the Alzheimer's disease spectrum via disturbing default mode network. CNS neuroscience & therapeutics, 27(11), 1385-1395. https://doi.org/10.1111/cns.13716
Zang, Feifei, et al. "APOE genotype moderates the relationship between LRP1 polymorphism and cognition across the Alzheimer's disease spectrum via disturbing default mode network." CNS neuroscience & therapeutics vol. 27,11 (2021): 1385-1395. doi: https://doi.org/10.1111/cns.13716
Zang F, Zhu Y, Zhang Q, Tan C, Wang Q, Xie C. APOE genotype moderates the relationship between LRP1 polymorphism and cognition across the Alzheimer's disease spectrum via disturbing default mode network. CNS Neurosci Ther. 2021 Nov;27(11):1385-1395. doi: 10.1111/cns.13716. Epub 2021 Aug 12. PMID: 34387022; PMCID: PMC8504518.
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Low-density lipoprotein receptor-related protein 1 is a CROPs-associated receptor for Clostridioides infection toxin B.

Science China. Life sciences

Guo S, Chen Y, Liu J, Zhang X, Liu Z, Zhou Z, Wei W.
PMID: 34279819
Sci China Life Sci. 2022 Jan;65(1):107-118. doi: 10.1007/s11427-021-1943-9. Epub 2021 Jul 15.

As the leading cause of worldwide hospital-acquired infection, Clostridioides difficile (C. difficile) infection has caused heavy economic and hospitalized burden, while its pathogenesis is not fully understood. Toxin B (TcdB) is one of the major virulent factors of C....

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Guo S, Chen Y, Liu J, et al. Low-density lipoprotein receptor-related protein 1 is a CROPs-associated receptor for Clostridioides infection toxin B. Sci China Life Sci. 2021;65(1):107-118doi: 10.1007/s11427-021-1943-9.
Guo, S., Chen, Y., Liu, J., Zhang, X., Liu, Z., Zhou, Z., & Wei, W. (2022). Low-density lipoprotein receptor-related protein 1 is a CROPs-associated receptor for Clostridioides infection toxin B. Science China. Life sciences, 65(1), 107-118. https://doi.org/10.1007/s11427-021-1943-9
Guo, Shengjie, et al. "Low-density lipoprotein receptor-related protein 1 is a CROPs-associated receptor for Clostridioides infection toxin B." Science China. Life sciences vol. 65,1 (2022): 107-118. doi: https://doi.org/10.1007/s11427-021-1943-9
Guo S, Chen Y, Liu J, Zhang X, Liu Z, Zhou Z, Wei W. Low-density lipoprotein receptor-related protein 1 is a CROPs-associated receptor for Clostridioides infection toxin B. Sci China Life Sci. 2022 Jan;65(1):107-118. doi: 10.1007/s11427-021-1943-9. Epub 2021 Jul 15. PMID: 34279819.
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Escape from abluminal LRP1-mediated clearance for boosted nanoparticle brain delivery and brain metastasis treatment.

Acta pharmaceutica Sinica. B

Khan NU, Ni J, Ju X, Miao T, Chen H, Han L.
PMID: 34094838
Acta Pharm Sin B. 2021 May;11(5):1341-1354. doi: 10.1016/j.apsb.2020.10.015. Epub 2020 Oct 21.

Breast cancer brain metastases (BCBMs) are one of the most difficult malignancies to treat due to the intracranial location and multifocal growth. Chemotherapy and molecular targeted therapy are extremely ineffective for BCBMs due to the inept brain accumulation because...

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Khan NU, Ni J, Ju X, et al. Escape from abluminal LRP1-mediated clearance for boosted nanoparticle brain delivery and brain metastasis treatment. Acta Pharm Sin B. 2020;11(5):1341-1354doi: 10.1016/j.apsb.2020.10.015.
Khan, N. U., Ni, J., Ju, X., Miao, T., Chen, H., & Han, L. (2021). Escape from abluminal LRP1-mediated clearance for boosted nanoparticle brain delivery and brain metastasis treatment. Acta pharmaceutica Sinica. B, 11(5), 1341-1354. https://doi.org/10.1016/j.apsb.2020.10.015
Khan, Naveed Ullah, et al. "Escape from abluminal LRP1-mediated clearance for boosted nanoparticle brain delivery and brain metastasis treatment." Acta pharmaceutica Sinica. B vol. 11,5 (2021): 1341-1354. doi: https://doi.org/10.1016/j.apsb.2020.10.015
Khan NU, Ni J, Ju X, Miao T, Chen H, Han L. Escape from abluminal LRP1-mediated clearance for boosted nanoparticle brain delivery and brain metastasis treatment. Acta Pharm Sin B. 2021 May;11(5):1341-1354. doi: 10.1016/j.apsb.2020.10.015. Epub 2020 Oct 21. PMID: 34094838; PMCID: PMC8148067.
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The Dual Role of Low-Density Lipoprotein Receptor-Related Protein 1 in Atherosclerosis.

Frontiers in cardiovascular medicine

Chen J, Su Y, Pi S, Hu B, Mao L.
PMID: 34124208
Front Cardiovasc Med. 2021 May 28;8:682389. doi: 10.3389/fcvm.2021.682389. eCollection 2021.

Low-density lipoprotein receptor-related protein-1 (LRP1) is a large endocytic and signaling receptor belonging to the LDL receptor (LDLR) gene family and that is widely expressed in several tissues. LRP1 comprises a large extracellular domain (ECD; 515 kDa, α chain)...

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Chen J, Su Y, Pi S, et al. The Dual Role of Low-Density Lipoprotein Receptor-Related Protein 1 in Atherosclerosis. Front Cardiovasc Med. 2021;8:682389doi: 10.3389/fcvm.2021.682389.
Chen, J., Su, Y., Pi, S., Hu, B., & Mao, L. (2021). The Dual Role of Low-Density Lipoprotein Receptor-Related Protein 1 in Atherosclerosis. Frontiers in cardiovascular medicine, 8682389. https://doi.org/10.3389/fcvm.2021.682389
Chen, Jiefang, et al. "The Dual Role of Low-Density Lipoprotein Receptor-Related Protein 1 in Atherosclerosis." Frontiers in cardiovascular medicine vol. 8 (2021): 682389. doi: https://doi.org/10.3389/fcvm.2021.682389
Chen J, Su Y, Pi S, Hu B, Mao L. The Dual Role of Low-Density Lipoprotein Receptor-Related Protein 1 in Atherosclerosis. Front Cardiovasc Med. 2021 May 28;8:682389. doi: 10.3389/fcvm.2021.682389. eCollection 2021. PMID: 34124208; PMCID: PMC8192809.
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Prominent Receptors of Liver Sinusoidal Endothelial Cells in Liver Homeostasis and Disease.

Frontiers in physiology

Pandey E, Nour AS, Harris EN.
PMID: 32848838
Front Physiol. 2020 Jul 21;11:873. doi: 10.3389/fphys.2020.00873. eCollection 2020.

Liver sinusoidal endothelial cells (LSECs) are the most abundant non-parenchymal cells lining the sinusoidal capillaries of the hepatic system. LSECs are characterized with numerous fenestrae and lack basement membrane as well as a diaphragm. These unique morphological characteristics of...

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Pandey E, Nour AS, Harris EN. Prominent Receptors of Liver Sinusoidal Endothelial Cells in Liver Homeostasis and Disease. Front Physiol. 2020;11:873doi: 10.3389/fphys.2020.00873.
Pandey, E., Nour, A. S., & Harris, E. N. (2020). Prominent Receptors of Liver Sinusoidal Endothelial Cells in Liver Homeostasis and Disease. Frontiers in physiology, 11873. https://doi.org/10.3389/fphys.2020.00873
Pandey, Ekta, et al. "Prominent Receptors of Liver Sinusoidal Endothelial Cells in Liver Homeostasis and Disease." Frontiers in physiology vol. 11 (2020): 873. doi: https://doi.org/10.3389/fphys.2020.00873
Pandey E, Nour AS, Harris EN. Prominent Receptors of Liver Sinusoidal Endothelial Cells in Liver Homeostasis and Disease. Front Physiol. 2020 Jul 21;11:873. doi: 10.3389/fphys.2020.00873. eCollection 2020. PMID: 32848838; PMCID: PMC7396565.
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On the shuttling across the blood-brain barrier via tubule formation: Mechanism and cargo avidity bias.

Science advances

Tian X, Leite DM, Scarpa E, Nyberg S, Fullstone G, Forth J, Matias D, Apriceno A, Poma A, Duro-Castano A, Vuyyuru M, Harker-Kirschneck L, Šarić A, Zhang Z, Xiang P, Fang B, Tian Y, Luo L, Rizzello L, Battaglia G.
PMID: 33246953
Sci Adv. 2020 Nov 27;6(48). doi: 10.1126/sciadv.abc4397. Print 2020 Nov.

The blood-brain barrier is made of polarized brain endothelial cells (BECs) phenotypically conditioned by the central nervous system (CNS). Although transport across BECs is of paramount importance for nutrient uptake as well as ridding the brain of waste products,...

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Tian X, Leite DM, Scarpa E, et al. On the shuttling across the blood-brain barrier via tubule formation: Mechanism and cargo avidity bias. Sci Adv. 2020;6(48)doi: 10.1126/sciadv.abc4397.
Tian, X., Leite, D. M., Scarpa, E., Nyberg, S., Fullstone, G., Forth, J., Matias, D., Apriceno, A., Poma, A., Duro-Castano, A., Vuyyuru, M., Harker-Kirschneck, L., Šarić, A., Zhang, Z., Xiang, P., Fang, B., Tian, Y., Luo, L., Rizzello, L., & Battaglia, G. (2020). On the shuttling across the blood-brain barrier via tubule formation: Mechanism and cargo avidity bias. Science advances, 6(48), . https://doi.org/10.1126/sciadv.abc4397
Tian, Xiaohe, et al. "On the shuttling across the blood-brain barrier via tubule formation: Mechanism and cargo avidity bias." Science advances vol. 6,48 (2020). doi: https://doi.org/10.1126/sciadv.abc4397
Tian X, Leite DM, Scarpa E, Nyberg S, Fullstone G, Forth J, Matias D, Apriceno A, Poma A, Duro-Castano A, Vuyyuru M, Harker-Kirschneck L, Šarić A, Zhang Z, Xiang P, Fang B, Tian Y, Luo L, Rizzello L, Battaglia G. On the shuttling across the blood-brain barrier via tubule formation: Mechanism and cargo avidity bias. Sci Adv. 2020 Nov 27;6(48). doi: 10.1126/sciadv.abc4397. Print 2020 Nov. PMID: 33246953; PMCID: PMC7695481.
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Glypican 4 Regulates Aβ Internalization in Neural Stem Cells Partly .

Frontiers in cellular neuroscience

Ma K, Xing S, Luan Y, Zhang C, Liu Y, Fei Y, Zhang Z, Liu Y, Chen X.
PMID: 34552470
Front Cell Neurosci. 2021 Sep 06;15:732429. doi: 10.3389/fncel.2021.732429. eCollection 2021.

Neural stem cell (NSC) damage has been reported in patients with Alzheimer's disease. Intracellular Aβ plays a vital role in NSC damage. Heparan sulfate proteoglycans are potent mediators of Aβ enrichment in the brain. We hypothesized the heparan sulfate...

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Ma K, Xing S, Luan Y, et al. Glypican 4 Regulates Aβ Internalization in Neural Stem Cells Partly . Front Cell Neurosci. 2021;15:732429doi: 10.3389/fncel.2021.732429.
Ma, K., Xing, S., Luan, Y., Zhang, C., Liu, Y., Fei, Y., Zhang, Z., Liu, Y., & Chen, X. (2021). Glypican 4 Regulates Aβ Internalization in Neural Stem Cells Partly . Frontiers in cellular neuroscience, 15732429. https://doi.org/10.3389/fncel.2021.732429
Ma, Kaige, et al. "Glypican 4 Regulates Aβ Internalization in Neural Stem Cells Partly ." Frontiers in cellular neuroscience vol. 15 (2021): 732429. doi: https://doi.org/10.3389/fncel.2021.732429
Ma K, Xing S, Luan Y, Zhang C, Liu Y, Fei Y, Zhang Z, Liu Y, Chen X. Glypican 4 Regulates Aβ Internalization in Neural Stem Cells Partly . Front Cell Neurosci. 2021 Sep 06;15:732429. doi: 10.3389/fncel.2021.732429. eCollection 2021. PMID: 34552470; PMCID: PMC8450433.
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Low-density-lipoprotein-receptor-related protein 1 mediates Notch pathway activation.

Developmental cell

Bian W, Tang M, Jiang H, Xu W, Hao W, Sui Y, Hou Y, Nie L, Zhang H, Wang C, Li N, Wang J, Qin J, Wu L, Ma X, Chen J, Wang W, Li X.
PMID: 34626540
Dev Cell. 2021 Oct 25;56(20):2902-2919.e8. doi: 10.1016/j.devcel.2021.09.015. Epub 2021 Oct 08.

The Notch signaling pathway controls cell growth, differentiation, and fate decisions, and its dysregulation has been linked to various human genetic disorders and cancers. To comprehensively understand the global organization of the Notch pathway and identify potential drug targets...

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Bian W, Tang M, Jiang H, et al. Low-density-lipoprotein-receptor-related protein 1 mediates Notch pathway activation. Dev Cell. 2021;56(20):2902-2919.e8doi: 10.1016/j.devcel.2021.09.015.
Bian, W., Tang, M., Jiang, H., Xu, W., Hao, W., Sui, Y., Hou, Y., Nie, L., Zhang, H., Wang, C., Li, N., Wang, J., Qin, J., Wu, L., Ma, X., Chen, J., Wang, W., & Li, X. (2021). Low-density-lipoprotein-receptor-related protein 1 mediates Notch pathway activation. Developmental cell, 56(20), 2902-2919.e8. https://doi.org/10.1016/j.devcel.2021.09.015
Bian, Weixiang, et al. "Low-density-lipoprotein-receptor-related protein 1 mediates Notch pathway activation." Developmental cell vol. 56,20 (2021): 2902-2919.e8. doi: https://doi.org/10.1016/j.devcel.2021.09.015
Bian W, Tang M, Jiang H, Xu W, Hao W, Sui Y, Hou Y, Nie L, Zhang H, Wang C, Li N, Wang J, Qin J, Wu L, Ma X, Chen J, Wang W, Li X. Low-density-lipoprotein-receptor-related protein 1 mediates Notch pathway activation. Dev Cell. 2021 Oct 25;56(20):2902-2919.e8. doi: 10.1016/j.devcel.2021.09.015. Epub 2021 Oct 08. PMID: 34626540.
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Showing 1 to 12 of 90 entries