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Utility of Genetically Predicted Lp(a) (Lipoprotein [a]) and ApoB Levels for Cardiovascular Risk Assessment.

Circulation. Genomic and precision medicine

Wu H, Luan J, Forgetta V, Engert JC, Thanassoulis G, Mooser V, Wareham NJ, Langenberg C, Richards JB.
PMID: 34461734
Circ Genom Precis Med. 2021 Oct;14(5):e003312. doi: 10.1161/CIRCGEN.121.003312. Epub 2021 Aug 31.

BACKGROUND: Current lipid guidelines suggest measurement of Lp(a) (lipoprotein[a]) and ApoB (apolipoprotein B) for atherosclerotic cardiovascular disease risk assessment. Polygenic risk scores (PRSs) for Lp(a) and ApoB may identify individuals unlikely to have elevated Lp(a) or ApoB and thus...

Cite
Wu H, Luan J, Forgetta V, et al. Utility of Genetically Predicted Lp(a) (Lipoprotein [a]) and ApoB Levels for Cardiovascular Risk Assessment. Circ Genom Precis Med. 2021;14(5):e003312doi: 10.1161/CIRCGEN.121.003312.
Wu, H., Luan, J., Forgetta, V., Engert, J. C., Thanassoulis, G., Mooser, V., Wareham, N. J., Langenberg, C., & Richards, J. B. (2021). Utility of Genetically Predicted Lp(a) (Lipoprotein [a]) and ApoB Levels for Cardiovascular Risk Assessment. Circulation. Genomic and precision medicine, 14(5), e003312. https://doi.org/10.1161/CIRCGEN.121.003312
Wu, Haoyu, et al. "Utility of Genetically Predicted Lp(a) (Lipoprotein [a]) and ApoB Levels for Cardiovascular Risk Assessment." Circulation. Genomic and precision medicine vol. 14,5 (2021): e003312. doi: https://doi.org/10.1161/CIRCGEN.121.003312
Wu H, Luan J, Forgetta V, Engert JC, Thanassoulis G, Mooser V, Wareham NJ, Langenberg C, Richards JB. Utility of Genetically Predicted Lp(a) (Lipoprotein [a]) and ApoB Levels for Cardiovascular Risk Assessment. Circ Genom Precis Med. 2021 Oct;14(5):e003312. doi: 10.1161/CIRCGEN.121.003312. Epub 2021 Aug 31. PMID: 34461734.
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Genetically Predicted Glucose-Dependent Insulinotropic Polypeptide (GIP) Levels and Cardiovascular Disease Risk Are Driven by Distinct Causal Variants in the .

Diabetes

Bowker N, Hansford R, Burgess S, Foley CN, Auyeung VPW, Erzurumluoglu AM, Stewart ID, Wheeler E, Pietzner M, Gribble F, Reimann F, Bhatnagar P, Coghlan MP, Wareham NJ, Langenberg C.
PMID: 34426508
Diabetes. 2021 Nov;70(11):2706-2719. doi: 10.2337/db21-0103. Epub 2021 Aug 23.

There is considerable interest in GIPR agonism to enhance the insulinotropic and extrapancreatic effects of GIP, thereby improving glycemic and weight control in type 2 diabetes (T2D) and obesity. Recent genetic epidemiological evidence has implicated higher GIPR-mediated GIP levels...

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Bowker N, Hansford R, Burgess S, et al. Genetically Predicted Glucose-Dependent Insulinotropic Polypeptide (GIP) Levels and Cardiovascular Disease Risk Are Driven by Distinct Causal Variants in the . Diabetes. 2021;70(11):2706-2719doi: 10.2337/db21-0103.
Bowker, N., Hansford, R., Burgess, S., Foley, C. N., Auyeung, V. P. W., Erzurumluoglu, A. M., Stewart, I. D., Wheeler, E., Pietzner, M., Gribble, F., Reimann, F., Bhatnagar, P., Coghlan, M. P., Wareham, N. J., & Langenberg, C. (2021). Genetically Predicted Glucose-Dependent Insulinotropic Polypeptide (GIP) Levels and Cardiovascular Disease Risk Are Driven by Distinct Causal Variants in the . Diabetes, 70(11), 2706-2719. https://doi.org/10.2337/db21-0103
Bowker, Nicholas, et al. "Genetically Predicted Glucose-Dependent Insulinotropic Polypeptide (GIP) Levels and Cardiovascular Disease Risk Are Driven by Distinct Causal Variants in the ." Diabetes vol. 70,11 (2021): 2706-2719. doi: https://doi.org/10.2337/db21-0103
Bowker N, Hansford R, Burgess S, Foley CN, Auyeung VPW, Erzurumluoglu AM, Stewart ID, Wheeler E, Pietzner M, Gribble F, Reimann F, Bhatnagar P, Coghlan MP, Wareham NJ, Langenberg C. Genetically Predicted Glucose-Dependent Insulinotropic Polypeptide (GIP) Levels and Cardiovascular Disease Risk Are Driven by Distinct Causal Variants in the . Diabetes. 2021 Nov;70(11):2706-2719. doi: 10.2337/db21-0103. Epub 2021 Aug 23. PMID: 34426508; PMCID: PMC8564402.
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