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Genetic and environmental determinants of stressful life events and their overlap with depression and neuroticism.

Wellcome open research

Clarke TK, Zeng Y, Navrady L, Xia C, Haley C, Campbell A, Navarro P, Amador C, Adams MJ, Howard DM, Soler A, Hayward C, Thomson PA, Smith BH, Padmanabhan S, Hocking LJ, Hall LS, Porteous DJ, Deary IJ, McIntosh AM.
PMID: 30756089
Wellcome Open Res. 2019 Jan 14;3:11. doi: 10.12688/wellcomeopenres.13893.2. eCollection 2018.

No abstract available.

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Clarke TK, Zeng Y, Navrady L, et al. Genetic and environmental determinants of stressful life events and their overlap with depression and neuroticism. Wellcome Open Res. 2019;3:11doi: 10.12688/wellcomeopenres.13893.2.
Clarke, T. K., Zeng, Y., Navrady, L., Xia, C., Haley, C., Campbell, A., Navarro, P., Amador, C., Adams, M. J., Howard, D. M., Soler, A., Hayward, C., Thomson, P. A., Smith, B. H., Padmanabhan, S., Hocking, L. J., Hall, L. S., Porteous, D. J., Deary, I. J., & McIntosh, A. M. (2018). Genetic and environmental determinants of stressful life events and their overlap with depression and neuroticism. Wellcome open research, 311. https://doi.org/10.12688/wellcomeopenres.13893.2
Clarke, Toni-Kim, et al. "Genetic and environmental determinants of stressful life events and their overlap with depression and neuroticism." Wellcome open research vol. 3 (2018): 11. doi: https://doi.org/10.12688/wellcomeopenres.13893.2
Clarke TK, Zeng Y, Navrady L, Xia C, Haley C, Campbell A, Navarro P, Amador C, Adams MJ, Howard DM, Soler A, Hayward C, Thomson PA, Smith BH, Padmanabhan S, Hocking LJ, Hall LS, Porteous DJ, Deary IJ, McIntosh AM. Genetic and environmental determinants of stressful life events and their overlap with depression and neuroticism. Wellcome Open Res. 2019 Jan 14;3:11. doi: 10.12688/wellcomeopenres.13893.2. eCollection 2018. PMID: 30756089; PMCID: PMC6352921.
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Correction: Pedigree- and SNP-Associated Genetics and Recent Environment are the Major Contributors to Anthropometric and Cardiometabolic Trait Variation.

PLoS genetics

Xia C, Amador C, Huffman J, Trochet H, Campbell A, Porteous D, Scotland G, Hastie ND, Hayward C, Vitart V, Navarro P, Haley CS.
PMID: 28196069
PLoS Genet. 2017 Feb 14;13(2):e1006608. doi: 10.1371/journal.pgen.1006608. eCollection 2017 Feb.

[This corrects the article DOI: 10.1371/journal.pgen.1005804.].

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Xia C, Amador C, Huffman J, et al. Correction: Pedigree- and SNP-Associated Genetics and Recent Environment are the Major Contributors to Anthropometric and Cardiometabolic Trait Variation. PLoS Genet. 2017;13(2):e1006608doi: 10.1371/journal.pgen.1006608.
Xia, C., Amador, C., Huffman, J., Trochet, H., Campbell, A., Porteous, D., Scotland, G., Hastie, N. D., Hayward, C., Vitart, V., Navarro, P., & Haley, C. S. (2017). Correction: Pedigree- and SNP-Associated Genetics and Recent Environment are the Major Contributors to Anthropometric and Cardiometabolic Trait Variation. PLoS genetics, 13(2), e1006608. https://doi.org/10.1371/journal.pgen.1006608
Xia, Charley, et al. "Correction: Pedigree- and SNP-Associated Genetics and Recent Environment are the Major Contributors to Anthropometric and Cardiometabolic Trait Variation." PLoS genetics vol. 13,2 (2017): e1006608. doi: https://doi.org/10.1371/journal.pgen.1006608
Xia C, Amador C, Huffman J, Trochet H, Campbell A, Porteous D, Scotland G, Hastie ND, Hayward C, Vitart V, Navarro P, Haley CS. Correction: Pedigree- and SNP-Associated Genetics and Recent Environment are the Major Contributors to Anthropometric and Cardiometabolic Trait Variation. PLoS Genet. 2017 Feb 14;13(2):e1006608. doi: 10.1371/journal.pgen.1006608. eCollection 2017 Feb. PMID: 28196069; PMCID: PMC5308822.
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Identification of epigenome-wide DNA methylation differences between carriers of APOE ε4 and APOE ε2 alleles.

Genome medicine

Walker RM, Vaher K, Bermingham ML, Morris SW, Bretherick AD, Zeng Y, Rawlik K, Amador C, Campbell A, Haley CS, Hayward C, Porteous DJ, McIntosh AM, Marioni RE, Evans KL.
PMID: 33397400
Genome Med. 2021 Jan 04;13(1):1. doi: 10.1186/s13073-020-00808-4.

BACKGROUND: The apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for late onset Alzheimer's disease, whilst the ε2 allele confers protection. Previous studies report differential DNA methylation of APOE between ε4 and ε2 carriers, but associations...

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Walker RM, Vaher K, Bermingham ML, et al. Identification of epigenome-wide DNA methylation differences between carriers of APOE ε4 and APOE ε2 alleles. Genome Med. 2021;13(1):1doi: 10.1186/s13073-020-00808-4.
Walker, R. M., Vaher, K., Bermingham, M. L., Morris, S. W., Bretherick, A. D., Zeng, Y., Rawlik, K., Amador, C., Campbell, A., Haley, C. S., Hayward, C., Porteous, D. J., McIntosh, A. M., Marioni, R. E., & Evans, K. L. (2021). Identification of epigenome-wide DNA methylation differences between carriers of APOE ε4 and APOE ε2 alleles. Genome medicine, 13(1), 1. https://doi.org/10.1186/s13073-020-00808-4
Walker, Rosie M, et al. "Identification of epigenome-wide DNA methylation differences between carriers of APOE ε4 and APOE ε2 alleles." Genome medicine vol. 13,1 (2021): 1. doi: https://doi.org/10.1186/s13073-020-00808-4
Walker RM, Vaher K, Bermingham ML, Morris SW, Bretherick AD, Zeng Y, Rawlik K, Amador C, Campbell A, Haley CS, Hayward C, Porteous DJ, McIntosh AM, Marioni RE, Evans KL. Identification of epigenome-wide DNA methylation differences between carriers of APOE ε4 and APOE ε2 alleles. Genome Med. 2021 Jan 04;13(1):1. doi: 10.1186/s13073-020-00808-4. PMID: 33397400; PMCID: PMC7784364.
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Publisher Correction: Parent of origin genetic effects on methylation in humans are common and influence complex trait variation.

Nature communications

Zeng Y, Amador C, Xia C, Marioni R, Sproul D, Walker RM, Morris SW, Bretherick A, Canela-Xandri O, Boutin TS, Clark DW, Campbell A, Rawlik K, Hayward C, Nagy R, Tenesa A, Porteous DJ, Wilson JF, Deary IJ, Evans KL, McIntosh AM, Navarro P, Haley CS.
PMID: 31043600
Nat Commun. 2019 May 01;10(1):2069. doi: 10.1038/s41467-019-10155-7.

In the original version of this Article, the legend in the upper panel of Figure 2 incorrectly read 'paternal imprinting' and should have read 'maternal imprinting'. This has been corrected in both the PDF and HTML versions of the...

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Zeng Y, Amador C, Xia C, et al. Publisher Correction: Parent of origin genetic effects on methylation in humans are common and influence complex trait variation. Nat Commun. 2019;10(1):2069doi: 10.1038/s41467-019-10155-7.
Zeng, Y., Amador, C., Xia, C., Marioni, R., Sproul, D., Walker, R. M., Morris, S. W., Bretherick, A., Canela-Xandri, O., Boutin, T. S., Clark, D. W., Campbell, A., Rawlik, K., Hayward, C., Nagy, R., Tenesa, A., Porteous, D. J., Wilson, J. F., Deary, I. J., Evans, K. L., McIntosh, A. M., Navarro, P., & Haley, C. S. (2019). Publisher Correction: Parent of origin genetic effects on methylation in humans are common and influence complex trait variation. Nature communications, 10(1), 2069. https://doi.org/10.1038/s41467-019-10155-7
Zeng, Yanni, et al. "Publisher Correction: Parent of origin genetic effects on methylation in humans are common and influence complex trait variation." Nature communications vol. 10,1 (2019): 2069. doi: https://doi.org/10.1038/s41467-019-10155-7
Zeng Y, Amador C, Xia C, Marioni R, Sproul D, Walker RM, Morris SW, Bretherick A, Canela-Xandri O, Boutin TS, Clark DW, Campbell A, Rawlik K, Hayward C, Nagy R, Tenesa A, Porteous DJ, Wilson JF, Deary IJ, Evans KL, McIntosh AM, Navarro P, Haley CS. Publisher Correction: Parent of origin genetic effects on methylation in humans are common and influence complex trait variation. Nat Commun. 2019 May 01;10(1):2069. doi: 10.1038/s41467-019-10155-7. PMID: 31043600; PMCID: PMC6494888.
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Variants associated with .

Wellcome open research

Fawcett KA, Obeidat M, Melbourne C, Shrine N, Guyatt AL, John C, Luan J, Richmond A, Moksnes MR, Granell R, Weiss S, Imboden M, May-Wilson S, Hysi P, Boutin TS, Portas L, Flexeder C, Harris SE, Wang CA, Lyytikäinen LP, Palviainen T, Foong RE, Keidel D, Minelli C, Langenberg C, Bossé Y, Van den Berge M, Sin DD, Hao K, Campbell A, Porteous D, Padmanabhan S, Smith BH, Evans DM, Ring S, Langhammer A, Hveem K, Willer C, Ewert R, Stubbe B, Pirastu N, Klaric L, Joshi PK, Patasova K, Massimo M, Polasek O, Starr JM, Karrasch S, Strauch K, Meitinger T, Rudan I, Rantanen T, Pietiläinen K, Kähönen M, Raitakari OT, Hall GL, Sly PD, Pennell CE, Kaprio J, Lehtimäki T, Vitart V, Deary IJ, Jarvis D, Wilson JF, Spector T, Probst-Hensch N, Wareham NJ, Völzke H, Henderson J, Strachan DP, Brumpton BM, Hayward C, Hall IP, Tobin MD, Wain LV.
PMID: 33728380
Wellcome Open Res. 2020 Jun 01;5:111. doi: 10.12688/wellcomeopenres.15846.1. eCollection 2020.

No abstract available.

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Fawcett KA, Obeidat M, Melbourne C, et al. Variants associated with . Wellcome Open Res. 2020;5:111doi: 10.12688/wellcomeopenres.15846.1.
Fawcett, K. A., Obeidat, M., Melbourne, C., Shrine, N., Guyatt, A. L., John, C., Luan, J., Richmond, A., Moksnes, M. R., Granell, R., Weiss, S., Imboden, M., May-Wilson, S., Hysi, P., Boutin, T. S., Portas, L., Flexeder, C., Harris, S. E., Wang, C. A., Lyytikäinen, L. P., Palviainen, T., Foong, R. E., Keidel, D., Minelli, C., Langenberg, C., Bossé, Y., Van den Berge, M., Sin, D. D., Hao, K., Campbell, A., Porteous, D., Padmanabhan, S., Smith, B. H., Evans, D. M., Ring, S., Langhammer, A., Hveem, K., Willer, C., Ewert, R., Stubbe, B., Pirastu, N., Klaric, L., Joshi, P. K., Patasova, K., Massimo, M., Polasek, O., Starr, J. M., Karrasch, S., Strauch, K., Meitinger, T., Rudan, I., Rantanen, T., Pietiläinen, K., Kähönen, M., Raitakari, O. T., Hall, G. L., Sly, P. D., Pennell, C. E., Kaprio, J., Lehtimäki, T., Vitart, V., Deary, I. J., Jarvis, D., Wilson, J. F., Spector, T., Probst-Hensch, N., Wareham, N. J., Völzke, H., Henderson, J., Strachan, D. P., Brumpton, B. M., Hayward, C., Hall, I. P., Tobin, M. D., & Wain, L. V. (2020). Variants associated with . Wellcome open research, 5111. https://doi.org/10.12688/wellcomeopenres.15846.1
Fawcett, Katherine A, et al. "Variants associated with ." Wellcome open research vol. 5 (2020): 111. doi: https://doi.org/10.12688/wellcomeopenres.15846.1
Fawcett KA, Obeidat M, Melbourne C, Shrine N, Guyatt AL, John C, Luan J, Richmond A, Moksnes MR, Granell R, Weiss S, Imboden M, May-Wilson S, Hysi P, Boutin TS, Portas L, Flexeder C, Harris SE, Wang CA, Lyytikäinen LP, Palviainen T, Foong RE, Keidel D, Minelli C, Langenberg C, Bossé Y, Van den Berge M, Sin DD, Hao K, Campbell A, Porteous D, Padmanabhan S, Smith BH, Evans DM, Ring S, Langhammer A, Hveem K, Willer C, Ewert R, Stubbe B, Pirastu N, Klaric L, Joshi PK, Patasova K, Massimo M, Polasek O, Starr JM, Karrasch S, Strauch K, Meitinger T, Rudan I, Rantanen T, Pietiläinen K, Kähönen M, Raitakari OT, Hall GL, Sly PD, Pennell CE, Kaprio J, Lehtimäki T, Vitart V, Deary IJ, Jarvis D, Wilson JF, Spector T, Probst-Hensch N, Wareham NJ, Völzke H, Henderson J, Strachan DP, Brumpton BM, Hayward C, Hall IP, Tobin MD, Wain LV. Variants associated with . Wellcome Open Res. 2020 Jun 01;5:111. doi: 10.12688/wellcomeopenres.15846.1. eCollection 2020. PMID: 33728380; PMCID: PMC7938335.
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Nontrivial Replication of Loci Detected by Multi-Trait Methods.

Frontiers in genetics

Ning Z, Tsepilov YA, Sharapov SZ, Wang Z, Grishenko AK, Feng X, Shirali M, Joshi PK, Wilson JF, Pawitan Y, Haley CS, Aulchenko YS, Shen X.
PMID: 33613642
Front Genet. 2021 Feb 03;12:627989. doi: 10.3389/fgene.2021.627989. eCollection 2021.

The ever-growing genome-wide association studies (GWAS) have revealed widespread pleiotropy. To exploit this, various methods that jointly consider associations of a genetic variant with multiple traits have been developed. Most efforts have been made concerning improving GWAS discovery power....

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Ning Z, Tsepilov YA, Sharapov SZ, et al. Nontrivial Replication of Loci Detected by Multi-Trait Methods. Front Genet. 2021;12:627989doi: 10.3389/fgene.2021.627989.
Ning, Z., Tsepilov, Y. A., Sharapov, S. Z., Wang, Z., Grishenko, A. K., Feng, X., Shirali, M., Joshi, P. K., Wilson, J. F., Pawitan, Y., Haley, C. S., Aulchenko, Y. S., & Shen, X. (2021). Nontrivial Replication of Loci Detected by Multi-Trait Methods. Frontiers in genetics, 12627989. https://doi.org/10.3389/fgene.2021.627989
Ning, Zheng, et al. "Nontrivial Replication of Loci Detected by Multi-Trait Methods." Frontiers in genetics vol. 12 (2021): 627989. doi: https://doi.org/10.3389/fgene.2021.627989
Ning Z, Tsepilov YA, Sharapov SZ, Wang Z, Grishenko AK, Feng X, Shirali M, Joshi PK, Wilson JF, Pawitan Y, Haley CS, Aulchenko YS, Shen X. Nontrivial Replication of Loci Detected by Multi-Trait Methods. Front Genet. 2021 Feb 03;12:627989. doi: 10.3389/fgene.2021.627989. eCollection 2021. PMID: 33613642; PMCID: PMC7886991.
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Methylome-wide association study of early life stressors and adult mental health.

Human molecular genetics

Howard DM, Pain O, Arathimos R, Barbu MC, Amador C, Walker RM, Jermy B, Adams MJ, Deary IJ, Porteous D, Campbell A, Sullivan PF, Evans KL, Arseneault L, Wray NR, Meaney M, McIntosh AM, Lewis CM.
PMID: 34523677
Hum Mol Genet. 2021 Sep 15; doi: 10.1093/hmg/ddab274. Epub 2021 Sep 15.

The environment and events that we are exposed to in utero, during birth and in early childhood influence our future physical and mental health. The underlying mechanisms that lead to these outcomes are unclear, but long-term changes in epigenetic...

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Howard DM, Pain O, Arathimos R, et al. Methylome-wide association study of early life stressors and adult mental health. Hum Mol Genet. 2021;doi: 10.1093/hmg/ddab274.
Howard, D. M., Pain, O., Arathimos, R., Barbu, M. C., Amador, C., Walker, R. M., Jermy, B., Adams, M. J., Deary, I. J., Porteous, D., Campbell, A., Sullivan, P. F., Evans, K. L., Arseneault, L., Wray, N. R., Meaney, M., McIntosh, A. M., & Lewis, C. M. (2021). Methylome-wide association study of early life stressors and adult mental health. Human molecular genetics, . https://doi.org/10.1093/hmg/ddab274
Howard, David M, et al. "Methylome-wide association study of early life stressors and adult mental health." Human molecular genetics vol. (2021). doi: https://doi.org/10.1093/hmg/ddab274
Howard DM, Pain O, Arathimos R, Barbu MC, Amador C, Walker RM, Jermy B, Adams MJ, Deary IJ, Porteous D, Campbell A, Sullivan PF, Evans KL, Arseneault L, Wray NR, Meaney M, McIntosh AM, Lewis CM. Methylome-wide association study of early life stressors and adult mental health. Hum Mol Genet. 2021 Sep 15; doi: 10.1093/hmg/ddab274. Epub 2021 Sep 15. PMID: 34523677.
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Haplotype-based association analysis of general cognitive ability in Generation Scotland, the English Longitudinal Study of Ageing, and UK Biobank.

Wellcome open research

Howard DM, Adams MJ, Clarke TK, Wigmore EM, Zeng Y, Hagenaars SP, Lyall DM, Thomson PA, Evans KL, Porteous DJ, Nagy R, Hayward C, Haley CS, Smith BH, Murray AD, Batty GD, Deary IJ, McIntosh AM.
PMID: 28989979
Wellcome Open Res. 2017 Aug 10;2:61. doi: 10.12688/wellcomeopenres.12171.1. eCollection 2017.

BACKGROUND: Cognitive ability is a heritable trait with a polygenic architecture, for which several associated variants have been identified using genotype-based and candidate gene approaches. Haplotype-based analyses are a complementary technique that take phased genotype data into account, and...

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Howard DM, Adams MJ, Clarke TK, et al. Haplotype-based association analysis of general cognitive ability in Generation Scotland, the English Longitudinal Study of Ageing, and UK Biobank. Wellcome Open Res. 2017;2:61doi: 10.12688/wellcomeopenres.12171.1.
Howard, D. M., Adams, M. J., Clarke, T. K., Wigmore, E. M., Zeng, Y., Hagenaars, S. P., Lyall, D. M., Thomson, P. A., Evans, K. L., Porteous, D. J., Nagy, R., Hayward, C., Haley, C. S., Smith, B. H., Murray, A. D., Batty, G. D., Deary, I. J., & McIntosh, A. M. (2017). Haplotype-based association analysis of general cognitive ability in Generation Scotland, the English Longitudinal Study of Ageing, and UK Biobank. Wellcome open research, 261. https://doi.org/10.12688/wellcomeopenres.12171.1
Howard, David M, et al. "Haplotype-based association analysis of general cognitive ability in Generation Scotland, the English Longitudinal Study of Ageing, and UK Biobank." Wellcome open research vol. 2 (2017): 61. doi: https://doi.org/10.12688/wellcomeopenres.12171.1
Howard DM, Adams MJ, Clarke TK, Wigmore EM, Zeng Y, Hagenaars SP, Lyall DM, Thomson PA, Evans KL, Porteous DJ, Nagy R, Hayward C, Haley CS, Smith BH, Murray AD, Batty GD, Deary IJ, McIntosh AM. Haplotype-based association analysis of general cognitive ability in Generation Scotland, the English Longitudinal Study of Ageing, and UK Biobank. Wellcome Open Res. 2017 Aug 10;2:61. doi: 10.12688/wellcomeopenres.12171.1. eCollection 2017. PMID: 28989979; PMCID: PMC5605947.
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Genome-wide methylation data improves dissection of the effect of smoking on body mass index.

PLoS genetics

Amador C, Zeng Y, Barber M, Walker RM, Campbell A, McIntosh AM, Evans KL, Porteous DJ, Hayward C, Wilson JF, Navarro P, Haley CS.
PMID: 34499657
PLoS Genet. 2021 Sep 09;17(9):e1009750. doi: 10.1371/journal.pgen.1009750. eCollection 2021 Sep.

Variation in obesity-related traits has a genetic basis with heritabilities between 40 and 70%. While the global obesity pandemic is usually associated with environmental changes related to lifestyle and socioeconomic changes, most genetic studies do not include all relevant...

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Amador C, Zeng Y, Barber M, et al. Genome-wide methylation data improves dissection of the effect of smoking on body mass index. PLoS Genet. 2021;17(9):e1009750doi: 10.1371/journal.pgen.1009750.
Amador, C., Zeng, Y., Barber, M., Walker, R. M., Campbell, A., McIntosh, A. M., Evans, K. L., Porteous, D. J., Hayward, C., Wilson, J. F., Navarro, P., & Haley, C. S. (2021). Genome-wide methylation data improves dissection of the effect of smoking on body mass index. PLoS genetics, 17(9), e1009750. https://doi.org/10.1371/journal.pgen.1009750
Amador, Carmen, et al. "Genome-wide methylation data improves dissection of the effect of smoking on body mass index." PLoS genetics vol. 17,9 (2021): e1009750. doi: https://doi.org/10.1371/journal.pgen.1009750
Amador C, Zeng Y, Barber M, Walker RM, Campbell A, McIntosh AM, Evans KL, Porteous DJ, Hayward C, Wilson JF, Navarro P, Haley CS. Genome-wide methylation data improves dissection of the effect of smoking on body mass index. PLoS Genet. 2021 Sep 09;17(9):e1009750. doi: 10.1371/journal.pgen.1009750. eCollection 2021 Sep. PMID: 34499657; PMCID: PMC8428545.
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