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Showing 1 to 5 of 5 entries
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Induction of apoptosis by IFNγ in human neuroblastoma cell lines through the CD95/CD95L autocrine circuit.

Cell death and differentiation

Bernassola F, Scheuerpflug C, Herr I, Krammer PH, Debatin KM, Melino G.
PMID: 26256517
Cell Death Differ. 2015 Sep;22(9):1562. doi: 10.1038/cdd.2015.89.

No abstract available.

ΔNp63α modulates histone methyl transferase SETDB1 to transcriptionally repress target genes in cancers.

Cell death discovery

Regina C, Compagnone M, Peschiaroli A, Lena AM, Melino G, Candi E.
PMID: 27551509
Cell Death Discov. 2016 Feb 29;2:16015. doi: 10.1038/cddiscovery.2016.15. eCollection 2016.

No abstract available.

Stearoyl-CoA-desaturase 1 regulates lung cancer stemness via stabilization and nuclear localization of YAP/TAZ.

Oncogene

Noto A, De Vitis C, Pisanu ME, Roscilli G, Ricci G, Catizone A, Sorrentino G, Chianese G, Taglialatela-Scafati O, Trisciuoglio D, Del Bufalo D, Di Martile M, Di Napoli A, Ruco L, Costantini S, Jakopin Z, Budillon A, Melino G, Del Sal G, Ciliberto G, Mancini R.
PMID: 28628115
Oncogene. 2017 Aug 10;36(32):4671-4672. doi: 10.1038/onc.2017.212. Epub 2017 Jun 19.

This corrects the article DOI: 10.1038/onc.2017.75.

Discovery of Novel Isatin-Based p53 Inducers.

ACS medicinal chemistry letters

Davidovich P, Aksenova V, Petrova V, Tentler D, Orlova D, Smirnov S, Gurzhiy V, Okorokov AL, Garabadzhiu A, Melino G, Barlev N, Tribulovich V.
PMID: 26288684
ACS Med Chem Lett. 2015 Jul 06;6(8):856-60. doi: 10.1021/acsmedchemlett.5b00011. eCollection 2015 Aug 13.

A series of isatin Schiff base derivatives were identified during in silico screening of the small molecule library for novel activators of p53. The compounds selected based on molecular docking results were further validated by a high-content screening assay...

The hypoxic tumour microenvironment.

Oncogenesis

Petrova V, Annicchiarico-Petruzzelli M, Melino G, Amelio I.
PMID: 29362402
Oncogenesis. 2018 Jan 24;7(1):10. doi: 10.1038/s41389-017-0011-9.

Cancer progression often benefits from the selective conditions present in the tumour microenvironment, such as the presence of cancer-associated fibroblasts (CAFs), deregulated ECM deposition, expanded vascularisation and repression of the immune response. Generation of a hypoxic environment and activation...

Showing 1 to 5 of 5 entries