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Showing 1 to 12 of 12 entries
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Genetic architecture of host proteins interacting with SARS-CoV-2.

bioRxiv : the preprint server for biology

Pietzner M, Wheeler E, Carrasco-Zanini J, Raffler J, Kerrison ND, Oerton E, Auyeung VPW, Luan J, Finan C, Casas JP, Ostroff R, Williams SA, Kastenmüller G, Ralser M, Gamazon ER, Wareham NJ, Hingorani AD, Langenberg C.
PMID: 32637948
bioRxiv. 2020 Jul 01; doi: 10.1101/2020.07.01.182709.

Strategies to develop therapeutics for SARS-CoV-2 infection may be informed by experimental identification of viral-host protein interactions in cellular assays and measurement of host response proteins in COVID-19 patients. Identification of genetic variants that influence the level or activity...

Longitudinal Trends in Childhood Insulin Levels and Body Mass Index and Associations With Risks of Psychosis and Depression in Young Adults.

JAMA psychiatry

Perry BI, Stochl J, Upthegrove R, Zammit S, Wareham N, Langenberg C, Winpenny E, Dunger D, Jones PB, Khandaker GM.
PMID: 33439216
JAMA Psychiatry. 2021 Apr 01;78(4):416-425. doi: 10.1001/jamapsychiatry.2020.4180.

IMPORTANCE: Cardiometabolic disorders often occur concomitantly with psychosis and depression, contribute to high mortality rates, and are detectable from the onset of the psychiatric disorders. However, it is unclear whether longitudinal trends in cardiometabolic traits from childhood are associated...

3,5-T2-A Janus-Faced Thyroid Hormone Metabolite Exerts Both Canonical T3-Mimetic Endocrine and Intracrine Hepatic Action.

Frontiers in endocrinology

Köhrle J, Lehmphul I, Pietzner M, Renko K, Rijntjes E, Richards K, Anselmo J, Danielsen M, Jonklaas J.
PMID: 31969860
Front Endocrinol (Lausanne). 2020 Jan 08;10:787. doi: 10.3389/fendo.2019.00787. eCollection 2019.

Over the last decades, thyroid hormone metabolites (THMs) received marked attention as it has been demonstrated that they are bioactive compounds. Their concentrations were determined by immunoassay or mass-spectrometry methods. Among those metabolites, 3,5-diiodothyronine (3,5-T2), occurs at low nanomolar...

Genome-wide association analysis of type 2 diabetes in the EPIC-InterAct study.

Scientific data

Cai L, Wheeler E, Kerrison ND, Luan J, Deloukas P, Franks PW, Amiano P, Ardanaz E, Bonet C, Fagherazzi G, Groop LC, Kaaks R, Huerta JM, Masala G, Nilsson PM, Overvad K, Pala V, Panico S, Rodriguez-Barranco M, Rolandsson O, Sacerdote C, Schulze MB, Spijkerman AMW, Tjonneland A, Tumino R, van der Schouw YT, Sharp SJ, Forouhi NG, Riboli E, McCarthy MI, Barroso I, Langenberg C, Wareham NJ.
PMID: 33188205
Sci Data. 2020 Nov 13;7(1):393. doi: 10.1038/s41597-020-00716-7.

Type 2 diabetes (T2D) is a global public health challenge. Whilst the advent of genome-wide association studies has identified >400 genetic variants associated with T2D, our understanding of its biological mechanisms and translational insights is still limited. The EPIC-InterAct...

Dietary Fatty Acids, Macronutrient Substitutions, Food Sources and Incidence of Coronary Heart Disease: Findings From the EPIC-CVD Case-Cohort Study Across Nine European Countries.

Journal of the American Heart Association

Steur M, Johnson L, Sharp SJ, Imamura F, Sluijs I, Key TJ, Wood A, Chowdhury R, Guevara M, Jakobsen MU, Johansson I, Koulman A, Overvad K, Sánchez MJ, van der Schouw YT, Trichopoulou A, Weiderpass E, Wennberg M, Zheng JS, Boeing H, Boer JMA, Boutron-Ruault MC, Ericson U, Heath AK, Huybrechts I, Imaz L, Kaaks R, Krogh V, Kühn T, Kyrø C, Masala G, Melander O, Moreno-Iribas C, Panico S, Quirós JR, Rodríguez-Barranco M, Sacerdote C, Santiuste C, Skeie G, Tjønneland A, Tumino R, Verschuren WMM, Zamora-Ros R, Dahm CC, Perez-Cornago A, Schulze MB, Tong TYN, Riboli E, Wareham NJ, Danesh J, Butterworth AS, Forouhi NG.
PMID: 34796724
J Am Heart Assoc. 2021 Dec 07;10(23):e019814. doi: 10.1161/JAHA.120.019814. Epub 2021 Nov 19.

Background There is controversy about associations between total dietary fatty acids, their classes (saturated fatty acids [SFAs], monounsaturated fatty acids, and polyunsaturated fatty acids), and risk of coronary heart disease (CHD). Specifically, the relevance of food sources of SFAs...

Genetic and In Vitro Inhibition of .

JACC. Basic to translational science

Perrot N, Valerio V, Moschetta D, Boekholdt SM, Dina C, Chen HY, Abner E, Martinsson A, Manikpurage HD, Rigade S, Capoulade R, Mass E, Clavel MA, Le Tourneau T, Messika-Zeitoun D, Wareham NJ, Engert JC, Polvani G, Pibarot P, Esko T, Smith JG, Mathieu P, Thanassoulis G, Schott JJ, Bossé Y, Camera M, Thériault S, Poggio P, Arsenault BJ.
PMID: 32760854
JACC Basic Transl Sci. 2020 Jul 01;5(7):649-661. doi: 10.1016/j.jacbts.2020.05.004. eCollection 2020 Jul.

The authors investigated whether PCSK9 inhibition could represent a therapeutic strategy in calcific aortic valve stenosis (CAVS). A meta-analysis of 10 studies was performed to determine the impact of the

Hypertensive Disorders of Pregnancy (HDP) and the Risk of Common Cancers in Women: Evidence from the European Prospective Investigation into Cancer (EPIC)-Norfolk Prospective Population-Based Study.

Cancers

Pasdar Z, Gamble DT, Myint PK, Luben RN, Wareham NJ, Khaw KT, Bhattacharya S.
PMID: 33114193
Cancers (Basel). 2020 Oct 23;12(11). doi: 10.3390/cancers12113100.

PURPOSE: The purpose was to determine the association between HDP and cancer in a UK cohort.METHODS: Between 1993 and 1997, participants from the EPIC-Norfolk cohort attended baseline health-checks and completed questionnaires, where a history of HDP was collected. Incident...

Social inequality and the syndemic of chronic disease and COVID-19: county-level analysis in the USA.

Journal of epidemiology and community health

Islam N, Lacey B, Shabnam S, Erzurumluoglu AM, Dambha-Miller H, Chowell G, Kawachi I, Marmot M.
PMID: 33402397
J Epidemiol Community Health. 2021 Jan 05; doi: 10.1136/jech-2020-215626. Epub 2021 Jan 05.

BACKGROUND: Given the effect of chronic diseases on risk of severe COVID-19 infection, the present pandemic may have a particularly profound impact on socially disadvantaged counties.METHODS: Counties in the USA were categorised into five groups by level of social...

Longitudinal Trends in Childhood Insulin Levels and Body Mass Index and Associations With Risks of Psychosis and Depression in Young Adults.

JAMA psychiatry

Perry BI, Stochl J, Upthegrove R, Zammit S, Wareham N, Langenberg C, Winpenny E, Dunger D, Jones PB, Khandaker GM.
PMID: 33439216
JAMA Psychiatry. 2021 Apr 01;78(4):416-425. doi: 10.1001/jamapsychiatry.2020.4180.

IMPORTANCE: Cardiometabolic disorders often occur concomitantly with psychosis and depression, contribute to high mortality rates, and are detectable from the onset of the psychiatric disorders. However, it is unclear whether longitudinal trends in cardiometabolic traits from childhood are associated...

Blood polyphenol concentrations and differentiated thyroid carcinoma in women from the European Prospective Investigation into Cancer and Nutrition (EPIC) study.

The American journal of clinical nutrition

Zamora-Ros R, Lujan-Barroso L, Achaintre D, Franceschi S, Kyrø C, Overvad K, Tjønneland A, Truong T, Lecuyer L, Boutron-Ruault MC, Katzke V, Johnson TS, Schulze MB, Trichopoulou A, Peppa E, La Vechia C, Masala G, Pala V, Panico S, Tumino R, Ricceri F, Skeie G, Quirós JR, Rodriguez-Barranco M, Amiano P, Chirlaque MD, Ardanaz E, Almquist M, Hennings J, Vermeulen R, Wareham NJ, Tong TYN, Aune D, Byrnes G, Weiderpass E, Scalbert A, Rinaldi S, Agudo A.
PMID: 33021645
Am J Clin Nutr. 2020 Oct 06; doi: 10.1093/ajcn/nqaa277. Epub 2020 Oct 06.

BACKGROUND: Polyphenols are natural compounds with anticarcinogenic properties in cellular and animal models, but epidemiological evidence determining the associations of these compounds with thyroid cancer (TC) is lacking.OBJECTIVES: The aim of this study was to evaluate the relations between...

Appetite disinhibition rather than hunger explains genetic effects on adult BMI trajectory.

International journal of obesity (2005)

Brunner EJ, Maruyama K, Shipley M, Cable N, Iso H, Hiyoshi A, Stallone D, Kumari M, Tabak A, Singh-Manoux A, Wilson J, Langenberg C, Wareham N, Boniface D, Hingorani A, Kivimäki M, Llewellyn C.
PMID: 33446837
Int J Obes (Lond). 2021 Apr;45(4):758-765. doi: 10.1038/s41366-020-00735-9. Epub 2021 Jan 14.

BACKGROUND/OBJECTIVES: The mediating role of eating behaviors in genetic susceptibility to weight gain during mid-adult life is not fully understood. This longitudinal study aims to help us understand contributions of genetic susceptibility and appetite to weight gain.SUBJECTS/METHODS: We followed...

Longitudinal Trends in Childhood Insulin Levels and Body Mass Index and Associations With Risks of Psychosis and Depression in Young Adults.

JAMA psychiatry

Perry BI, Stochl J, Upthegrove R, Zammit S, Wareham N, Langenberg C, Winpenny E, Dunger D, Jones PB, Khandaker GM.
PMID: 33439216
JAMA Psychiatry. 2021 Apr 01;78(4):416-425. doi: 10.1001/jamapsychiatry.2020.4180.

IMPORTANCE: Cardiometabolic disorders often occur concomitantly with psychosis and depression, contribute to high mortality rates, and are detectable from the onset of the psychiatric disorders. However, it is unclear whether longitudinal trends in cardiometabolic traits from childhood are associated...

Showing 1 to 12 of 12 entries