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Liver fat accumulation is associated with reduced hepatic insulin extraction and beta cell dysfunction in healthy older individuals.

Diabetology & metabolic syndrome

Finucane FM, Sharp SJ, Hatunic M, Sleigh A, De Lucia Rolfe E, Aihie Sayer A, Cooper C, Griffin SJ, Wareham NJ.
PMID: 24669786
Diabetol Metab Syndr. 2014 Mar 26;6(1):43. doi: 10.1186/1758-5996-6-43.

BACKGROUND: There is a well-established association between type 2 diabetes and non-alcoholic fatty liver disease (NAFLD) secondary to excess accumulation of intrahepatic lipid (IHL), but the mechanistic basis for this association is unclear. Emerging evidence suggests that in addition...

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Finucane FM, Sharp SJ, Hatunic M, et al. Liver fat accumulation is associated with reduced hepatic insulin extraction and beta cell dysfunction in healthy older individuals. Diabetol Metab Syndr. 2014;6(1):43doi: 10.1186/1758-5996-6-43.
Finucane, F. M., Sharp, S. J., Hatunic, M., Sleigh, A., De Lucia Rolfe, E., Aihie Sayer, A., Cooper, C., Griffin, S. J., & Wareham, N. J. (2014). Liver fat accumulation is associated with reduced hepatic insulin extraction and beta cell dysfunction in healthy older individuals. Diabetology & metabolic syndrome, 6(1), 43. https://doi.org/10.1186/1758-5996-6-43
Finucane, Francis M, et al. "Liver fat accumulation is associated with reduced hepatic insulin extraction and beta cell dysfunction in healthy older individuals." Diabetology & metabolic syndrome vol. 6,1 (2014): 43. doi: https://doi.org/10.1186/1758-5996-6-43
Finucane FM, Sharp SJ, Hatunic M, Sleigh A, De Lucia Rolfe E, Aihie Sayer A, Cooper C, Griffin SJ, Wareham NJ. Liver fat accumulation is associated with reduced hepatic insulin extraction and beta cell dysfunction in healthy older individuals. Diabetol Metab Syndr. 2014 Mar 26;6(1):43. doi: 10.1186/1758-5996-6-43. PMID: 24669786; PMCID: PMC3974597.
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Replication and characterization of .

Heliyon

Boutwell B, Hinds D, Tielbeek J, Ong KK, Day FR, Perry JRB.
PMID: 28795158
Heliyon. 2017 Jul 26;3(7):e00349. doi: 10.1016/j.heliyon.2017.e00349. eCollection 2017 Jul.

Progress identifying the genetic determinants of personality has historically been slow, with candidate gene studies and small-scale genome-wide association studies yielding few reproducible results. In the UK Biobank study, genetic variants in

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Boutwell B, Hinds D, et al. Replication and characterization of . Heliyon. 2017;3(7):e00349doi: 10.1016/j.heliyon.2017.e00349.
Boutwell, B., Hinds, D., Tielbeek, J., Ong, K. K., Day, F. R., & Perry, J. R. B. (2017). Replication and characterization of . Heliyon, 3(7), e00349. https://doi.org/10.1016/j.heliyon.2017.e00349
Boutwell, Brian, et al. "Replication and characterization of ." Heliyon vol. 3,7 (2017): e00349. doi: https://doi.org/10.1016/j.heliyon.2017.e00349
Boutwell B, Hinds D, Tielbeek J, Ong KK, Day FR, Perry JRB. Replication and characterization of . Heliyon. 2017 Jul 26;3(7):e00349. doi: 10.1016/j.heliyon.2017.e00349. eCollection 2017 Jul. PMID: 28795158; PMCID: PMC5537199.
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Genetic risk score for adult body mass index associations with childhood and adolescent weight gain in an African population.

Genes & nutrition

Munthali RJ, Sahibdeen V, Kagura J, Hendry LM, Norris SA, Ong KK, Day FR, Lombard Z.
PMID: 30123368
Genes Nutr. 2018 Aug 01;13:24. doi: 10.1186/s12263-018-0613-7. eCollection 2018.

BACKGROUND: Ninety-seven independent single nucleotide polymorphisms (SNPs) are robustly associated with adult body mass index (BMI kg/mRESULTS: The cross-sectional association between the wGRS and BMI strengthened with age from 5 to 18 years. The significant associations were observed from...

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Munthali RJ, Sahibdeen V, Kagura J, et al. Genetic risk score for adult body mass index associations with childhood and adolescent weight gain in an African population. Genes Nutr. 2018;13:24doi: 10.1186/s12263-018-0613-7.
Munthali, R. J., Sahibdeen, V., Kagura, J., Hendry, L. M., Norris, S. A., Ong, K. K., Day, F. R., & Lombard, Z. (2018). Genetic risk score for adult body mass index associations with childhood and adolescent weight gain in an African population. Genes & nutrition, 1324. https://doi.org/10.1186/s12263-018-0613-7
Munthali, Richard J, et al. "Genetic risk score for adult body mass index associations with childhood and adolescent weight gain in an African population." Genes & nutrition vol. 13 (2018): 24. doi: https://doi.org/10.1186/s12263-018-0613-7
Munthali RJ, Sahibdeen V, Kagura J, Hendry LM, Norris SA, Ong KK, Day FR, Lombard Z. Genetic risk score for adult body mass index associations with childhood and adolescent weight gain in an African population. Genes Nutr. 2018 Aug 01;13:24. doi: 10.1186/s12263-018-0613-7. eCollection 2018. PMID: 30123368; PMCID: PMC6090951.
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Season of birth is associated with birth weight, pubertal timing, adult body size and educational attainment: a UK Biobank study.

Heliyon

Day FR, Forouhi NG, Ong KK, Perry JR.
PMID: 27123493
Heliyon. 2015 Oct 12;1(2):e00031. doi: 10.1016/j.heliyon.2015.e00031. eCollection 2015 Oct.

Season of birth, a marker of

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Day FR, Forouhi NG, Ong KK, et al. Season of birth is associated with birth weight, pubertal timing, adult body size and educational attainment: a UK Biobank study. Heliyon. 2015;1(2):e00031doi: 10.1016/j.heliyon.2015.e00031.
Day, F. R., Forouhi, N. G., Ong, K. K., & Perry, J. R. (2015). Season of birth is associated with birth weight, pubertal timing, adult body size and educational attainment: a UK Biobank study. Heliyon, 1(2), e00031. https://doi.org/10.1016/j.heliyon.2015.e00031
Day, Felix R, et al. "Season of birth is associated with birth weight, pubertal timing, adult body size and educational attainment: a UK Biobank study." Heliyon vol. 1,2 (2015): e00031. doi: https://doi.org/10.1016/j.heliyon.2015.e00031
Day FR, Forouhi NG, Ong KK, Perry JR. Season of birth is associated with birth weight, pubertal timing, adult body size and educational attainment: a UK Biobank study. Heliyon. 2015 Oct 12;1(2):e00031. doi: 10.1016/j.heliyon.2015.e00031. eCollection 2015 Oct. PMID: 27123493; PMCID: PMC4832516.
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Modification of genetic influences on adiposity between 36 and 63 years of age by physical activity and smoking in the 1946 British Birth Cohort Study.

Nutrition & diabetes

Johnson W, Ong KK, Elks CE, Wareham NJ, Wong A, Muniz-Terrera G, Hardy R.
PMID: 25198238
Nutr Diabetes. 2014 Sep 08;4:e136. doi: 10.1038/nutd.2014.33.

BACKGROUND: Previous studies reporting on the interaction between physical activity and genetic susceptibility on obesity have been cross-sectional and have not considered the potential influences of other lifestyle behaviours. The aim of this study was to examine modification of...

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Johnson W, Ong KK, Elks CE, et al. Modification of genetic influences on adiposity between 36 and 63 years of age by physical activity and smoking in the 1946 British Birth Cohort Study. Nutr Diabetes. 2014;4:e136doi: 10.1038/nutd.2014.33.
Johnson, W., Ong, K. K., Elks, C. E., Wareham, N. J., Wong, A., Muniz-Terrera, G., Hardy, R. (2014). Modification of genetic influences on adiposity between 36 and 63 years of age by physical activity and smoking in the 1946 British Birth Cohort Study. Nutrition & diabetes, 4e136. https://doi.org/10.1038/nutd.2014.33
Johnson, W, et al. "Modification of genetic influences on adiposity between 36 and 63 years of age by physical activity and smoking in the 1946 British Birth Cohort Study." Nutrition & diabetes vol. 4 (2014): e136. doi: https://doi.org/10.1038/nutd.2014.33
Johnson W, Ong KK, Elks CE, Wareham NJ, Wong A, Muniz-Terrera G, Hardy R. Modification of genetic influences on adiposity between 36 and 63 years of age by physical activity and smoking in the 1946 British Birth Cohort Study. Nutr Diabetes. 2014 Sep 08;4:e136. doi: 10.1038/nutd.2014.33. PMID: 25198238; PMCID: PMC4183974.
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Corrigendum: Rare coding variants and X-linked loci associated with age at menarche.

Nature communications

Lunetta KL, Day FR, Sulem P, Ruth KS, Tung JY, Hinds DA, Esko T, Elks CE, Altmaier E, He C, Huffman JE, Mihailov E, Porcu E, Robino A, Rose LM, Schick UM, Stolk L, Teumer A, Thompson DJ, Traglia M, Wang CA, Yerges-Armstrong LM, Antoniou AC, Barbieri C, Coviello AD, Cucca F, Demerath EW, Dunning AM, Gandin I, Grove ML, Gudbjartsson DF, Hocking LJ, Hofman A, Huang J, Jackson RD, Karasik D, Kriebel J, Lange EM, Lange LA, Langenberg C, Li X, Luan J, Mägi R, Morrison AC, Padmanabhan S, Pirie A, Polasek O, Porteous D, Reiner AP, Rivadeneira F, Rudan I, Sala CF, Schlessinger D, Scott RA, Stöckl D, Visser JA, Völker U, Vozzi D, Wilson JG, Zygmunt M, Boerwinkle E, Buring JE, Crisponi L, Easton DF, Hayward C, Hu FB, Liu S, Metspalu A, Pennell CE, Ridker PM, Strauch K, Streeten EA, Toniolo D, Uitterlinden AG, Ulivi S, Völzke H, Wareham NJ, Wellons M, Franceschini N, Chasman DI, Thorsteinsdottir U, Murray A, Stefansson K, Murabito JM, Ong KK, Perry JR.
PMID: 26674845
Nat Commun. 2015 Dec 17;6:10257. doi: 10.1038/ncomms10257.

No abstract available.

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Lunetta KL, Day FR, Sulem P, et al. Corrigendum: Rare coding variants and X-linked loci associated with age at menarche. Nat Commun. 2015;6:10257doi: 10.1038/ncomms10257.
Lunetta, K. L., Day, F. R., Sulem, P., Ruth, K. S., Tung, J. Y., Hinds, D. A., Esko, T., Elks, C. E., Altmaier, E., He, C., Huffman, J. E., Mihailov, E., Porcu, E., Robino, A., Rose, L. M., Schick, U. M., Stolk, L., Teumer, A., Thompson, D. J., Traglia, M., Wang, C. A., Yerges-Armstrong, L. M., Antoniou, A. C., Barbieri, C., Coviello, A. D., Cucca, F., Demerath, E. W., Dunning, A. M., Gandin, I., Grove, M. L., Gudbjartsson, D. F., Hocking, L. J., Hofman, A., Huang, J., Jackson, R. D., Karasik, D., Kriebel, J., Lange, E. M., Lange, L. A., Langenberg, C., Li, X., Luan, J., Mägi, R., Morrison, A. C., Padmanabhan, S., Pirie, A., Polasek, O., Porteous, D., Reiner, A. P., Rivadeneira, F., Rudan, I., Sala, C. F., Schlessinger, D., Scott, R. A., Stöckl, D., Visser, J. A., Völker, U., Vozzi, D., Wilson, J. G., Zygmunt, M., Boerwinkle, E., Buring, J. E., Crisponi, L., Easton, D. F., Hayward, C., Hu, F. B., Liu, S., Metspalu, A., Pennell, C. E., Ridker, P. M., Strauch, K., Streeten, E. A., Toniolo, D., Uitterlinden, A. G., Ulivi, S., Völzke, H., Wareham, N. J., Wellons, M., Franceschini, N., Chasman, D. I., Thorsteinsdottir, U., Murray, A., Stefansson, K., Murabito, J. M., Ong, K. K., & Perry, J. R. (2015). Corrigendum: Rare coding variants and X-linked loci associated with age at menarche. Nature communications, 610257. https://doi.org/10.1038/ncomms10257
Lunetta, Kathryn L, et al. "Corrigendum: Rare coding variants and X-linked loci associated with age at menarche." Nature communications vol. 6 (2015): 10257. doi: https://doi.org/10.1038/ncomms10257
Lunetta KL, Day FR, Sulem P, Ruth KS, Tung JY, Hinds DA, Esko T, Elks CE, Altmaier E, He C, Huffman JE, Mihailov E, Porcu E, Robino A, Rose LM, Schick UM, Stolk L, Teumer A, Thompson DJ, Traglia M, Wang CA, Yerges-Armstrong LM, Antoniou AC, Barbieri C, Coviello AD, Cucca F, Demerath EW, Dunning AM, Gandin I, Grove ML, Gudbjartsson DF, Hocking LJ, Hofman A, Huang J, Jackson RD, Karasik D, Kriebel J, Lange EM, Lange LA, Langenberg C, Li X, Luan J, Mägi R, Morrison AC, Padmanabhan S, Pirie A, Polasek O, Porteous D, Reiner AP, Rivadeneira F, Rudan I, Sala CF, Schlessinger D, Scott RA, Stöckl D, Visser JA, Völker U, Vozzi D, Wilson JG, Zygmunt M, Boerwinkle E, Buring JE, Crisponi L, Easton DF, Hayward C, Hu FB, Liu S, Metspalu A, Pennell CE, Ridker PM, Strauch K, Streeten EA, Toniolo D, Uitterlinden AG, Ulivi S, Völzke H, Wareham NJ, Wellons M, Franceschini N, Chasman DI, Thorsteinsdottir U, Murray A, Stefansson K, Murabito JM, Ong KK, Perry JR. Corrigendum: Rare coding variants and X-linked loci associated with age at menarche. Nat Commun. 2015 Dec 17;6:10257. doi: 10.1038/ncomms10257. PMID: 26674845; PMCID: PMC4703878.
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Genetic Regulation of Puberty Timing in Humans.

Neuroendocrinology

Day FR, Perry JR, Ong KK.
PMID: 25968239
Neuroendocrinology. 2015;102(4):247-255. doi: 10.1159/000431023. Epub 2015 May 07.

Understanding the regulation of puberty timing has relevance to developmental and human biology and to the pathogenesis of various diseases. Recent large-scale genome-wide association studies on puberty timing and adult height, body mass index (BMI) and central body shape...

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Day FR, Perry JR, Ong KK. Genetic Regulation of Puberty Timing in Humans. Neuroendocrinology. 2015;102(4):247-255doi: 10.1159/000431023.
Day, F. R., Perry, J. R., & Ong, K. K. (2015). Genetic Regulation of Puberty Timing in Humans. Neuroendocrinology, 102(4), 247-255. https://doi.org/10.1159/000431023
Day, Felix R, et al. "Genetic Regulation of Puberty Timing in Humans." Neuroendocrinology vol. 102,4 (2015): 247-255. doi: https://doi.org/10.1159/000431023
Day FR, Perry JR, Ong KK. Genetic Regulation of Puberty Timing in Humans. Neuroendocrinology. 2015;102(4):247-255. doi: 10.1159/000431023. Epub 2015 May 07. PMID: 25968239; PMCID: PMC6309186.
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Intrahepatic Lipid Content and Insulin Resistance Are More Strongly Associated with Impaired NEFA Suppression after Oral Glucose Loading Than with Fasting NEFA Levels in Healthy Older Individuals.

International journal of endocrinology

Finucane FM, Sharp SJ, Hatunic M, Sleigh A, De Lucia Rolfe E, Sayer AA, Cooper C, Griffin SJ, Savage DB, Wareham NJ.
PMID: 23737780
Int J Endocrinol. 2013;2013:870487. doi: 10.1155/2013/870487. Epub 2013 May 02.

Introduction. The mechanisms underlying the association between insulin resistance and intrahepatic lipid (IHL) accumulation are not completely understood. We sought to determine whether this association was explained by differences in fasting non-esterified fatty acid (NEFA) levels and/or NEFA suppression...

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Finucane FM, Sharp SJ, Hatunic M, et al. Intrahepatic Lipid Content and Insulin Resistance Are More Strongly Associated with Impaired NEFA Suppression after Oral Glucose Loading Than with Fasting NEFA Levels in Healthy Older Individuals. Int J Endocrinol. 2013;2013:870487doi: 10.1155/2013/870487.
Finucane, F. M., Sharp, S. J., Hatunic, M., Sleigh, A., De Lucia Rolfe, E., Sayer, A. A., Cooper, C., Griffin, S. J., Savage, D. B., & Wareham, N. J. (2013). Intrahepatic Lipid Content and Insulin Resistance Are More Strongly Associated with Impaired NEFA Suppression after Oral Glucose Loading Than with Fasting NEFA Levels in Healthy Older Individuals. International journal of endocrinology, 2013870487. https://doi.org/10.1155/2013/870487
Finucane, Francis M, et al. "Intrahepatic Lipid Content and Insulin Resistance Are More Strongly Associated with Impaired NEFA Suppression after Oral Glucose Loading Than with Fasting NEFA Levels in Healthy Older Individuals." International journal of endocrinology vol. 2013 (2013): 870487. doi: https://doi.org/10.1155/2013/870487
Finucane FM, Sharp SJ, Hatunic M, Sleigh A, De Lucia Rolfe E, Sayer AA, Cooper C, Griffin SJ, Savage DB, Wareham NJ. Intrahepatic Lipid Content and Insulin Resistance Are More Strongly Associated with Impaired NEFA Suppression after Oral Glucose Loading Than with Fasting NEFA Levels in Healthy Older Individuals. Int J Endocrinol. 2013;2013:870487. doi: 10.1155/2013/870487. Epub 2013 May 02. PMID: 23737780; PMCID: PMC3659510.
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Secular Trends on Birth Parameters, Growth, and Pubertal Timing in Girls with Turner Syndrome.

Frontiers in endocrinology

Woelfle J, Lindberg A, Aydin F, Ong KK, Camacho-Hubner C, Gohlke B.
PMID: 29541059
Front Endocrinol (Lausanne). 2018 Feb 28;9:54. doi: 10.3389/fendo.2018.00054. eCollection 2018.

BACKGROUND: Whether children with chromosomal disorders of growth and puberty are affected by secular trends (STs) as observed in the general population remains unanswered, but this question has relevance for expectations of spontaneous development and treatment responses.OBJECTIVES: The aim...

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Woelfle J, Lindberg A, Aydin F, et al. Secular Trends on Birth Parameters, Growth, and Pubertal Timing in Girls with Turner Syndrome. Front Endocrinol (Lausanne). 2018;9:54doi: 10.3389/fendo.2018.00054.
Woelfle, J., Lindberg, A., Aydin, F., Ong, K. K., Camacho-Hubner, C., & Gohlke, B. (2018). Secular Trends on Birth Parameters, Growth, and Pubertal Timing in Girls with Turner Syndrome. Frontiers in endocrinology, 954. https://doi.org/10.3389/fendo.2018.00054
Woelfle, Joachim, et al. "Secular Trends on Birth Parameters, Growth, and Pubertal Timing in Girls with Turner Syndrome." Frontiers in endocrinology vol. 9 (2018): 54. doi: https://doi.org/10.3389/fendo.2018.00054
Woelfle J, Lindberg A, Aydin F, Ong KK, Camacho-Hubner C, Gohlke B. Secular Trends on Birth Parameters, Growth, and Pubertal Timing in Girls with Turner Syndrome. Front Endocrinol (Lausanne). 2018 Feb 28;9:54. doi: 10.3389/fendo.2018.00054. eCollection 2018. PMID: 29541059; PMCID: PMC5836145.
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Exploring the genetic correlations of antisocial behaviour and life history traits.

BJPsych open

Tielbeek JJ, Barnes JC, Popma A, Polderman TJC, Lee JJ, Perry JRB, Posthuma D, Boutwell BB.
PMID: 30450226
BJPsych Open. 2018 Nov 05;4(6):467-470. doi: 10.1192/bjo.2018.63. eCollection 2018 Nov.

Prior evolutionary theory provided reason to suspect that measures of development and reproduction would be correlated with antisocial behaviours in human and non-human species. Behavioural genetics has revealed that most quantitative traits are heritable, suggesting that these phenotypic correlations...

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Tielbeek JJ, Barnes JC, Popma A, et al. Exploring the genetic correlations of antisocial behaviour and life history traits. BJPsych Open. 2018;4(6):467-470doi: 10.1192/bjo.2018.63.
Tielbeek, J. J., Barnes, J. C., Popma, A., Polderman, T. J. C., Lee, J. J., Perry, J. R. B., Posthuma, D., & Boutwell, B. B. (2018). Exploring the genetic correlations of antisocial behaviour and life history traits. BJPsych open, 4(6), 467-470. https://doi.org/10.1192/bjo.2018.63
Tielbeek, Jorim J, et al. "Exploring the genetic correlations of antisocial behaviour and life history traits." BJPsych open vol. 4,6 (2018): 467-470. doi: https://doi.org/10.1192/bjo.2018.63
Tielbeek JJ, Barnes JC, Popma A, Polderman TJC, Lee JJ, Perry JRB, Posthuma D, Boutwell BB. Exploring the genetic correlations of antisocial behaviour and life history traits. BJPsych Open. 2018 Nov 05;4(6):467-470. doi: 10.1192/bjo.2018.63. eCollection 2018 Nov. PMID: 30450226; PMCID: PMC6235975.
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Showing 1 to 10 of 10 entries