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Showing 1 to 12 of 19 entries
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The effect of oral essential amino acids on incretin hormone production in youth and ageing.

Endocrinology, diabetes & metabolism

Abdulla H, Bass JJ, Stokes T, Gorissen SHM, McGlory C, Phillips BE, Phillips SM, Smith K, Idris I, Atherton PJ.
PMID: 31592446
Endocrinol Diabetes Metab. 2019 Jul 26;2(4):e00085. doi: 10.1002/edm2.85. eCollection 2019 Oct.

BACKGROUND: The effect of substantive doses of essential amino acids (EAA) on incretin and insulin production, and the impact of age upon this effect, is ill-defined.METHODS: A 15-g oral EAA drink was administered to young (N = 8; 26...

Immunohistochemical Inflammation in Histologically Normal Appendices in Patients with Right Iliac Fossa Pain.

World journal of surgery

Psaltis E, Zaitoun AM, Neal KR, Lobo DN.
PMID: 34392384
World J Surg. 2021 Dec;45(12):3592-3602. doi: 10.1007/s00268-021-06288-w. Epub 2021 Aug 15.

BACKGROUND: Histologically normal appendices resected for right iliac fossa pain in children demonstrate immunohistochemical markers of inflammation. We aimed to establish if subclinical inflammation was present in histologically normal appendices resected from adults with right iliac fossa pain.METHODS: Immunohistochemistry...

Vitamin D and SARS-CoV-2 virus/COVID-19 disease.

BMJ nutrition, prevention & health

Lanham-New SA, Webb AR, Cashman KD, Buttriss JL, Fallowfield JL, Masud T, Hewison M, Mathers JC, Kiely M, Welch AA, Ward KA, Magee P, Darling AL, Hill TR, Greig C, Smith CP, Murphy R, Leyland S, Bouillon R, Ray S, Kohlmeier M.
PMID: 33230499
BMJ Nutr Prev Health. 2020 May 13;3(1):106-110. doi: 10.1136/bmjnph-2020-000089. eCollection 2020.

No abstract available.

A novel stable isotope tracer method to simultaneously quantify skeletal muscle protein synthesis and breakdown.

Metabolism open

Crossland H, Smith K, Atherton PJ, Wilkinson DJ.
PMID: 32494771
Metabol Open. 2020 Mar;5:100022. doi: 10.1016/j.metop.2020.100022.

BACKGROUND/AIMS: Methodological challenges have been associated with the dynamic measurement of muscle protein breakdown (MPB), as have the measurement of both muscle protein synthesis (MPS) and MPB within the same experiment. Our aim was to use the transmethylation properties...

Acute Sarcopenia Secondary to Hospitalisation - An Emerging Condition Affecting Older Adults.

Aging and disease

Welch C, K Hassan-Smith Z, A Greig C, M Lord J, A Jackson T.
PMID: 29392090
Aging Dis. 2018 Feb 01;9(1):151-164. doi: 10.14336/AD.2017.0315. eCollection 2018 Feb.

There has been increasing interest and research into sarcopenia in community-dwelling older adults since the European Working Group on Sarcopenia in Older People (EWGSOP) agreed a consensus definition in 2010. Sarcopenia has been defined as loss of muscle mass...

SFRP2 Is Associated with Increased Adiposity and VEGF Expression.

PloS one

Crowley RK, O'Reilly MW, Bujalska IJ, Hassan-Smith ZK, Hazlehurst JM, Foucault DR, Stewart PM, Tomlinson JW.
PMID: 27685706
PLoS One. 2016 Sep 29;11(9):e0163777. doi: 10.1371/journal.pone.0163777. eCollection 2016.

AIMS: The aim of this study was to assess depot-specific expression and secretion of secreted frizzled-related protein 2 (sFRP2) by adipose tissue and its effect on adipocyte biology. We measured serum sFRP2 concentrations in 106 patients in vivo to...

Evaluation of the Fluids Mixing Enclosure System for Life Science Experiments During a Commercial .

Advances in space research : the official journal of the Committee on Space Research (COSPAR)

Warren P, Golden A, Hanover J, Love D, Shephard F, Szewczyk NJ.
PMID: 23794777
Adv Space Res. 2013 Jun 01;51(12):2241-2250. doi: 10.1016/j.asr.2013.02.002.

The Student Spaceflight Experiments Program (SSEP) is a United States national science, technology, engineering, and mathematics initiative that aims to increase student interest in science by offering opportunities to perform spaceflight experiments. The experiment detailed here was selected and...

Burnout Among Surgeons in the UK During the COVID-19 Pandemic: A Cohort Study.

World journal of surgery

Houdmont J, Daliya P, Theophilidou E, Adiamah A, Hassard J, Lobo DN.
PMID: 34704146
World J Surg. 2021 Oct 26; doi: 10.1007/s00268-021-06351-6. Epub 2021 Oct 26.

BACKGROUND: Surgeon burnout has implications for patient safety and workforce sustainability. The aim of this study was to establish the prevalence of burnout among surgeons in the UK during the COVID-19 pandemic.METHODS: This cross-sectional online survey was set in...

Burnout Among Surgeons in the UK During the COVID-19 Pandemic: A Cohort Study.

World journal of surgery

Houdmont J, Daliya P, Theophilidou E, Adiamah A, Hassard J, Lobo DN.
PMID: 34704146
World J Surg. 2022 Jan;46(1):1-9. doi: 10.1007/s00268-021-06351-6. Epub 2021 Oct 26.

BACKGROUND: Surgeon burnout has implications for patient safety and workforce sustainability. The aim of this study was to establish the prevalence of burnout among surgeons in the UK during the COVID-19 pandemic.METHODS: This cross-sectional online survey was set in...

Bearings in Hip Arthroplasty: Joint Registries vs Precision Medicine: Review Article.

HSS journal : the musculoskeletal journal of Hospital for Special Surgery

Pearson MJ, Grover LM, Lord JM, Jones SW, Davis ET.
PMID: 28167869
HSS J. 2017 Feb;13(1):20-27. doi: 10.1007/s11420-016-9531-7. Epub 2016 Nov 14.

BACKGROUND: Precision medicine has been adopted in a range of clinical settings where omics data have led to greater characterisation of disease and stratification of patients into subcategories of phenotypes and pathologies. However, in orthopaedics, precision medicine lags behind...

A novel behavioural INTErvention to REduce Sitting Time in older adults undergoing orthopaedic surgery (INTEREST): protocol for a randomised controlled feasibility study.

Pilot and feasibility studies

Aunger JA, Greaves CJ, Davis ET, Greig CA.
PMID: 30997142
Pilot Feasibility Stud. 2019 Apr 06;5:54. doi: 10.1186/s40814-019-0437-2. eCollection 2019.

BACKGROUND: Osteoarthritis is a highly prevalent condition in older adults, that causes many sufferers to require a hip or knee replacement in order to improve their quality of life and reduce pain. Individuals waiting for hip or knee replacements...

Antecubital Vein Cannula Position Impacts Assessment of Forearm Glucose Uptake During an Oral Glucose Challenge in Healthy Volunteers.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association

Bétry C, Nixon AV, Greenhaff PL, Simpson EJ.
PMID: 33096578
Exp Clin Endocrinol Diabetes. 2020 Oct 23; doi: 10.1055/a-1275-4038. Epub 2020 Oct 23.

INTRODUCTION: Skeletal muscle is a major site for whole-body glucose disposal, and determination of skeletal muscle glucose uptake is an important metabolic measurement, particularly in research focussed on interventions that impact muscle insulin sensitivity. Calculating arterial-venous difference in blood...

Showing 1 to 12 of 19 entries