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17-AAG-Induced Activation of the Autophagic Pathway in .

Microorganisms

Petersen ALOA, Cull B, Dias BRS, Palma LC, Luz YDS, de Menezes JPB, Mottram JC, Veras PST.
PMID: 34069389
Microorganisms. 2021 May 19;9(5). doi: 10.3390/microorganisms9051089.

The heat shock protein 90 (Hsp90) is thought to be an excellent drug target against parasitic diseases. The leishmanicidal effect of an Hsp90 inhibitor, 17-N-allylamino-17-demethoxygeldanamycin (17-AAG), was previously demonstrated in both in vitro and in vivo models of cutaneous...

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