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Showing 1 to 12 of 104 entries
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Common alleles contribute to schizophrenia in CNV carriers.

Molecular psychiatry

Tansey KE, Rees E, Linden DE, Ripke S, Chambert KD, Moran JL, McCarroll SA, Holmans P, Kirov G, Walters J, Owen MJ, O'Donovan MC.
PMID: 26643540
Mol Psychiatry. 2016 Aug;21(8):1153. doi: 10.1038/mp.2015.170. Epub 2015 Dec 08.

No abstract available.

A Modular Assembly of Spinal Cord-Like Tissue Allows Targeted Tissue Repair in the Transected Spinal Cord.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Lai BQ, Feng B, Che MT, Wang LJ, Cai S, Huang MY, Gu HY, Jiang B, Ling EA, Li M, Zeng X, Zeng YS.
PMID: 30250785
Adv Sci (Weinh). 2018 Jul 20;5(9):1800261. doi: 10.1002/advs.201800261. eCollection 2018 Sep.

Tissue engineering-based neural construction holds promise in providing organoids with defined differentiation and therapeutic potentials. Here, a bioengineered transplantable spinal cord-like tissue (SCLT) is assembled in vitro by simulating the white matter and gray matter composition of the spinal...

The presentation of depression symptoms in attention-deficit/hyperactivity disorder: comparing child and parent reports.

Child and adolescent mental health

Fraser A, Cooper M, Agha SS, Collishaw S, Rice F, Thapar A, Eyre O.
PMID: 30197576
Child Adolesc Ment Health. 2018 Sep;23(3):243-250. doi: 10.1111/camh.12253. Epub 2017 Nov 10.

BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) frequently co-occurs with depression, and outcomes are poor when both are present. Little is known about whether depression symptoms present differently in ADHD compared to the general population, or how reliable young people with ADHD...

Schizophrenia liability shares common molecular genetic risk factors with sleep duration and nightmares in childhood.

Wellcome open research

Reed ZE, Jones HJ, Hemani G, Zammit S, Davis OSP.
PMID: 31544153
Wellcome Open Res. 2019 Aug 20;4:15. doi: 10.12688/wellcomeopenres.15060.2. eCollection 2019.

No abstract available.

A protocol for a randomised controlled, double-blind feasibility trial investigating fluoxetine treatment in improving memory and learning impairments in patients with mesial temporal lobe epilepsy: Fluoxetine, Learning and Memory in Epilepsy (FLAME trial).

Pilot and feasibility studies

Drew CJG, Postans M, Petralia C, McNamara R, Pallmann P, Gillespie D, Evans LH, Muhlert N, Winter M, Hamandi K, Gray WP.
PMID: 31321071
Pilot Feasibility Stud. 2019 Jul 06;5:87. doi: 10.1186/s40814-019-0474-x. eCollection 2019.

BACKGROUND: People with temporal lobe epilepsy (TLE) report significant problems with learning and memory. There are no effective therapies for combatting these problems in people with TLE, resulting in an unmet therapeutic need. The lack of treatment is, in...

Glutamate Transport and Preterm Brain Injury.

Frontiers in physiology

Pregnolato S, Chakkarapani E, Isles AR, Luyt K.
PMID: 31068830
Front Physiol. 2019 Apr 24;10:417. doi: 10.3389/fphys.2019.00417. eCollection 2019.

Preterm birth complications are the leading cause of child death worldwide and a top global health priority. Among the survivors, the risk of life-long disabilities is high, including cerebral palsy and impairment of movement, cognition, and behavior. Understanding the...

Assessment of emotions and behaviour by the Developmental Behaviour Checklist in young people with neurodevelopmental CNVs.

Psychological medicine

Cunningham AC, Hall J, Einfeld S, Owen MJ, van den Bree MBM.
PMID: 32643597
Psychol Med. 2020 Jul 09;1-13. doi: 10.1017/S0033291720002330. Epub 2020 Jul 09.

BACKGROUND: A number of genomic conditions caused by copy number variants (CNVs) are associated with a high risk of neurodevelopmental and psychiatric disorders (ND-CNVs). Although these patients also tend to have cognitive impairments, few studies have investigated the range...

Genetic contributors to risk of schizophrenia in the presence of a 22q11.2 deletion.

Molecular psychiatry

Cleynen I, Engchuan W, Hestand MS, Heung T, Holleman AM, Johnston HR, Monfeuga T, McDonald-McGinn DM, Gur RE, Morrow BE, Swillen A, Vorstman JAS, Bearden CE, Chow EWC, van den Bree M, Emanuel BS, Vermeesch JR, Warren ST, Owen MJ, Chopra P, Cutler DJ, Duncan R, Kotlar AV, Mulle JG, Voss AJ, Zwick ME, Diacou A, Golden A, Guo T, Lin JR, Wang T, Zhang Z, Zhao Y, Marshall C, Merico D, Jin A, Lilley B, Salmons HI, Tran O, Holmans P, Pardinas A, Walters JTR, Demaerel W, Boot E, Butcher NJ, Costain GA, Lowther C, Evers R, van Amelsvoort TAMJ, van Duin E, Vingerhoets C, Breckpot J, Devriendt K, Vergaelen E, Vogels A, Crowley TB, McGinn DE, Moss EM, Sharkus RJ, Unolt M, Zackai EH, Calkins ME, Gallagher RS, Gur RC, Tang SX, Fritsch R, Ornstein C, Repetto GM, Breetvelt E, Duijff SN, Fiksinski A, Moss H, Niarchou M, Murphy KC, Prasad SE, Daly EM, Gudbrandsen M, Murphy CM, Murphy DG, Buzzanca A, Fabio FD, Digilio MC, Pontillo M, Marino B, Vicari S, Coleman K, Cubells JF, Ousley OY, Carmel M, Gothelf D, Mekori-Domachevsky E, Michaelovsky E, Weinberger R, Weizman A, Kushan L, Jalbrzikowski M, Armando M, Eliez S, Sandini C, Schneider M, Béna FS, Antshel KM, Fremont W, Kates WR, Belzeaux R, Busa T, Philip N, Campbell LE, McCabe KL, Hooper SR, Schoch K, Shashi V, Simon TJ, Tassone F, Arango C, Fraguas D, García-Miñaúr S, Morey-Canyelles J, Rosell J, Suñer DH, Raventos-Simic J, Epstein MP, Williams NM, Bassett AS.
PMID: 32015465
Mol Psychiatry. 2021 Aug;26(8):4496-4510. doi: 10.1038/s41380-020-0654-3. Epub 2020 Feb 03.

Schizophrenia occurs in about one in four individuals with 22q11.2 deletion syndrome (22q11.2DS). The aim of this International Brain and Behavior 22q11.2DS Consortium (IBBC) study was to identify genetic factors that contribute to schizophrenia, in addition to the ~20-fold...

Pilot study to establish a prospective neonatal cohort: Study of Preterm Infants and Neurodevelopmental Genes (SPRING).

BMJ paediatrics open

Wong HS, Hopkins L, O'Donovan MC, Thapar A, Modi N.
PMID: 32789195
BMJ Paediatr Open. 2020 Jul 30;4(1):e000648. doi: 10.1136/bmjpo-2020-000648. eCollection 2020.

BACKGROUND: Genetic risk variants and preterm birth are early and potent risk factors for later neuropsychiatric disorders. To understand the interrelationships between these factors, a large-scale genetic study of very preterm (VPT,

Global Brain Flexibility During Working Memory Is Reduced in a High-Genetic-Risk Group for Schizophrenia.

Biological psychiatry. Cognitive neuroscience and neuroimaging

Dimitriadis SI, Lancaster TM, Perry G, Tansey KE, Jones DK, Singh KD, Zammit S, Smith GD, Hall J, O'Donovan MC, Owen MJ, Linden DE.
PMID: 33524599
Biol Psychiatry Cogn Neurosci Neuroimaging. 2021 Dec;6(12):1176-1184. doi: 10.1016/j.bpsc.2021.01.007. Epub 2021 Jan 29.

BACKGROUND: Altered functional brain connectivity has been proposed as an intermediate phenotype between genetic risk loci and clinical expression of schizophrenia. Genetic high-risk groups of healthy subjects are particularly suited for the investigation of this proposition because they can...

Longitudinal Trends in Childhood Insulin Levels and Body Mass Index and Associations With Risks of Psychosis and Depression in Young Adults.

JAMA psychiatry

Perry BI, Stochl J, Upthegrove R, Zammit S, Wareham N, Langenberg C, Winpenny E, Dunger D, Jones PB, Khandaker GM.
PMID: 33439216
JAMA Psychiatry. 2021 Apr 01;78(4):416-425. doi: 10.1001/jamapsychiatry.2020.4180.

IMPORTANCE: Cardiometabolic disorders often occur concomitantly with psychosis and depression, contribute to high mortality rates, and are detectable from the onset of the psychiatric disorders. However, it is unclear whether longitudinal trends in cardiometabolic traits from childhood are associated...

The Relationship Between the Big Five Personality Factors, Anger-hostility, and Alcohol and Violence in Men and Women: A Nationally Representative Cohort of 15,701 Young Adults.

Journal of interpersonal violence

Jones RM, Van Den Bree M, Zammit S, Taylor PJ.
PMID: 33283620
J Interpers Violence. 2020 Dec 06;886260520978178. doi: 10.1177/0886260520978178. Epub 2020 Dec 06.

Alcohol consumption is known to have a disinhibiting effect and is associated with a higher likelihood of aggressive behavior, especially among men. People with certain personality traits maybe more likely to behave aggressively when intoxicated, and there may also...

Showing 1 to 12 of 104 entries