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Showing 1 to 12 of 22 entries
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Maytansinol Derivatives: Side Reactions as a Chance for New Tubulin Binders.

Chemistry (Weinheim an der Bergstrasse, Germany)

Marzullo P, Boiarska Z, Pérez-Peña H, Abel AC, Álvarez-Bernad B, Lucena-Agell D, Vasile F, Sironi M, Altmann KH, Prota AE, Díaz JF, Pieraccini S, Passarella D.
PMID: 34788896
Chemistry. 2022 Jan 10;28(2):e202103520. doi: 10.1002/chem.202103520. Epub 2021 Nov 29.

Maytansinol is a valuable precursor for the preparation of maytansine derivatives (known as maytansinoids). Inspired by the intriguing structure of the macrocycle and the success in targeted cancer therapy of the derivatives, we explored the maytansinol acylation reaction. As...

Incorporation of a Hydrophilic Spacer Reduces Hepatic Uptake of HER2-Targeting Affibody-DM1 Drug Conjugates.

Cancers

Ding H, Altai M, Rinne SS, Vorobyeva A, Tolmachev V, Gräslund T, Orlova A.
PMID: 31416167
Cancers (Basel). 2019 Aug 14;11(8). doi: 10.3390/cancers11081168.

Affibody molecules are small affinity-engineered scaffold proteins which can be engineered to bind to desired targets. The therapeutic potential of using an affibody molecule targeting HER2, fused to an albumin-binding domain (ABD) and conjugated with the cytotoxic maytansine derivate...

Maytansinol Derivatives: Side Reactions as a Chance for New Tubulin Binders.

Chemistry (Weinheim an der Bergstrasse, Germany)

Marzullo P, Boiarska Z, Pérez-Peña H, Abel AC, Álvarez-Bernad B, Lucena-Agell D, Vasile F, Sironi M, Altmann KH, Prota AE, Díaz JF, Pieraccini S, Passarella D.
PMID: 34788896
Chemistry. 2021 Nov 17; doi: 10.1002/chem.202103520. Epub 2021 Nov 17.

Maytansinol is a valuable precursor for the preparation of maytansine derivatives (known as maytansinoids). Inspired by the intriguing structure of the macrocycle and the success in targeted cancer therapy of the derivatives, we explored the maytansinol acylation reaction. As...

Tissue biodistribution and tumor targeting of near-infrared labelled anti-CD38 antibody-drug conjugate in preclinical multiple myeloma.

Oncotarget

Cho N, Ko S, Shokeen M.
PMID: 34611478
Oncotarget. 2021 Sep 28;12(20):2039-2050. doi: 10.18632/oncotarget.28074. eCollection 2021 Sep 28.

Daratumumab (DARA) is an FDA-approved high-affinity monoclonal antibody targeting CD38 that has shown promising therapeutic efficacy in double refractory multiple myeloma (MM) patients. Despite the well-established clinical efficacy of DARA, not all heavily pretreated patients respond to single-agent DARA,...

Antibody-Drug Conjugates Targeting the Urokinase Receptor (uPAR) as a Possible Treatment of Aggressive Breast Cancer.

Antibodies (Basel, Switzerland)

Harel ET, Drake PM, Barfield RM, Lui I, Farr-Jones S, Van't Veer L, Gartner ZJ, Green EM, Lourenço AL, Cheng Y, Hann BC, Rabuka D, Craik CS.
PMID: 31694242
Antibodies (Basel). 2019 Nov 05;8(4). doi: 10.3390/antib8040054.

A promising molecular target for aggressive cancers is the urokinase receptor (uPAR). A fully human, recombinant antibody that binds uPAR to form a stable complex that blocks uPA-uPAR interactions (2G10) and is internalized primarily through endocytosis showed efficacy in...

Therapeutic potential of nimotuzumab PEGylated-maytansine antibody drug conjugates against EGFR positive xenograft.

Oncotarget

Hartimath SV, El-Sayed A, Makhlouf A, Bernhard W, Gonzalez C, Hill W, Parada AC, Barreto K, Geyer CR, Fonge H.
PMID: 30800216
Oncotarget. 2019 Feb 01;10(10):1031-1044. doi: 10.18632/oncotarget.26613. eCollection 2019 Feb 01.

Nimotuzumab is a humanized anti-epidermal growth factor receptor I (EGFR) monoclonal antibody. We have developed antibody drug conjugates (ADCs) with nimotuzumab conjugated to PEGylated-maytansine (PEG

Assessment of General Public's Knowledge and Opinions towards Antibiotic Use and Bacterial Resistance: A Cross-Sectional Study in an Urban Setting, Rufisque, Senegal.

Pharmacy (Basel, Switzerland)

Bassoum O, Sougou NM, Diongue M, Lèye MMM, Mbodji M, Fall D, Seck I, Faye A, Tal-Dia A.
PMID: 30241307
Pharmacy (Basel). 2018 Sep 20;6(4). doi: 10.3390/pharmacy6040103.

No abstract available.

Trastuzumab Emtansine (T-DM1): Hitching a Ride on a Therapeutic Antibody.

American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting

Burris HA.
PMID: 24451727
Am Soc Clin Oncol Educ Book. 2012;159-61. doi: 10.14694/EdBook_AM.2012.32.109.

The treatment of cancers with chemotherapy is frequently limited by side effects. The effectiveness may be improved by the use of monoclonal antibodies to deliver cytotoxic agents to cancer cells while limiting exposure to normal tissues. The use of...

Trastuzumab-emtansine induced pleural and pericardial effusions.

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

Lombardi J, Lory P, Martin N, Mayeur D, Combret S, Grandvuillemin A, Boulay C, Schmitt A.
PMID: 34000917
J Oncol Pharm Pract. 2021 May 18;10781552211015772. doi: 10.1177/10781552211015772. Epub 2021 May 18.

INTRODUCTION: Trastuzumab emtansine (T-DM1) is an antibody-drug conjugate which combine trastuzumab (T), a monoclonal antibody targeting the human epidermal growth factor receptor-2 (HER2), and a cytotoxic molecule derived from maytansine (DM1).CASE REPORT: We report the first case of T-DM1-associated...

Systemic toxicities of trastuzumab-emtansine predict tumor response in HER2+ metastatic breast cancer.

International journal of cancer

Tang SC, Capra CL, Ajebo GH, Meza-Junco J, Mairs S, Craft BS, Zhu X, Maihle N, Hillegass WB.
PMID: 33844843
Int J Cancer. 2021 Apr 12; doi: 10.1002/ijc.33597. Epub 2021 Apr 12.

The mechanism by which trastuzumab-emtansine (T-DM1) causes systemic toxicities apart from trastuzumab alone is currently unknown. We hypothesized that the systemic toxicities from T-DM1 may have been caused by the free and active maytansine released from the lysed HER2+...

Novel approaches to target HER2-positive breast cancer: trastuzumab emtansine.

Cancer management and research

Recondo G, de la Vega M, Galanternik F, Díaz-Cantón E, Leone BA, Leone JP.
PMID: 27274311
Cancer Manag Res. 2016 May 19;8:57-65. doi: 10.2147/CMAR.S104447. eCollection 2016.

The human epidermal growth factor receptor 2 (HER2) is overexpressed in 20% of breast carcinomas. Prior to the development of targeted therapies, HER2-positive breast cancer was associated with more aggressive disease and poor prognosis. Trastuzumab emtansine (T-DM1) is an...

Aptamer-Drug Conjugates of Active Metabolites of Nucleoside Analogs and Cytotoxic Agents Inhibit Pancreatic Tumor Cell Growth.

Molecular therapy. Nucleic acids

Yoon S, Huang KW, Reebye V, Spalding D, Przytycka TM, Wang Y, Swiderski P, Li L, Armstrong B, Reccia I, Zacharoulis D, Dimas K, Kusano T, Shively J, Habib N, Rossi JJ.
PMID: 28325302
Mol Ther Nucleic Acids. 2017 Mar 17;6:80-88. doi: 10.1016/j.omtn.2016.11.008. Epub 2016 Dec 10.

Aptamer-drug conjugates (ApDCs) have the potential to improve the therapeutic index of traditional chemotherapeutic agents due to their ability to deliver cytotoxic drugs specifically to cancer cells while sparing normal cells. This study reports on the conjugation of cytotoxic...

Showing 1 to 12 of 22 entries