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Showing 1 to 12 of 19 entries
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Central Serotonergic Modulation of Carrageenin-induced Pedal Inflammation in Rats.

Pharmaceutical research

Bhattacharya SK, Das N.
PMID: 24271133
Pharm Res. 1985 Nov;2(6):315-8. doi: 10.1023/A:1016358004907.

Putative central serotonergic modulation of acute peripheral inflammation was investigated in rats, using the carrageenin-induced pedal edema as the experimental model. Serotonin and the serotonin precursor 5-hydroxytryptophan (5HTP) produced a dose-related inhibition of the peripheral edema when given intracerebroventricularly...

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Bhattacharya SK, Das N. Central Serotonergic Modulation of Carrageenin-induced Pedal Inflammation in Rats. Pharm Res. 1985;2(6):315-8doi: 10.1023/A:1016358004907.
Bhattacharya, S. K., & Das, N. (1985). Central Serotonergic Modulation of Carrageenin-induced Pedal Inflammation in Rats. Pharmaceutical research, 2(6), 315-8. https://doi.org/10.1023/A:1016358004907
Bhattacharya, S K, and Das, N. "Central Serotonergic Modulation of Carrageenin-induced Pedal Inflammation in Rats." Pharmaceutical research vol. 2,6 (1985): 315-8. doi: https://doi.org/10.1023/A:1016358004907
Bhattacharya SK, Das N. Central Serotonergic Modulation of Carrageenin-induced Pedal Inflammation in Rats. Pharm Res. 1985 Nov;2(6):315-8. doi: 10.1023/A:1016358004907. PMID: 24271133.
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The role of monoamine uptake in the discriminative stimulus effects of cocaine and related compounds.

Behavioural pharmacology

Baker LE, Riddle EE, Saunders RB, Appel JB.
PMID: 11224173
Behav Pharmacol. 1993 Feb;4(1):69-79.

The involvement of monoamine neurotransmitter uptake in the discriminative stimulus effects of cocaine was examined in rats (n = 48) trained to discriminate 10mg/kg of this substance from saline in a two-level, water-reinforced (FR 20), drug discrimination situation. Compounds...

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Baker LE, Riddle EE, Saunders RB, et al. The role of monoamine uptake in the discriminative stimulus effects of cocaine and related compounds. Behav Pharmacol. 1993;4(1):69-79
Baker, L. E., Riddle, E. E., Saunders, R. B., & Appel, J. B. (1993). The role of monoamine uptake in the discriminative stimulus effects of cocaine and related compounds. Behavioural pharmacology, 4(1), 69-79.
Baker, L.E., et al. "The role of monoamine uptake in the discriminative stimulus effects of cocaine and related compounds." Behavioural pharmacology vol. 4,1 (1993): 69-79.
Baker LE, Riddle EE, Saunders RB, Appel JB. The role of monoamine uptake in the discriminative stimulus effects of cocaine and related compounds. Behav Pharmacol. 1993 Feb;4(1):69-79. PMID: 11224173.
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Assessment of the discriminative stimulus effects of the optical isomers of ecstasy (3,4-methylenedioxymethamphetamine; MDMA).

Behavioural pharmacology

Baker LE, Broadbent J, Michael EK, Matthews PK, Metosh CA, Saunders RB, West WB, Appel JB.
PMID: 11224335
Behav Pharmacol. 1995 Apr;6(3):263-275.

The discriminative stimulus effects of the stereoisomers of 3,4-methylenedioxymethamphetamine (MDMA) were studied in rats trained to discriminate 1.25mg/kg of (+)-MDMA or 3.5mg/kg of (-)-MDMA from saline, in a two lever, water-reinforced, drug discrimination situation. The isomers of MDMA and...

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Baker LE, Broadbent J, Michael EK, et al. Assessment of the discriminative stimulus effects of the optical isomers of ecstasy (3,4-methylenedioxymethamphetamine; MDMA). Behav Pharmacol. 1995;6(3):263-275
Baker, L. E., Broadbent, J., Michael, E. K., Matthews, P. K., Metosh, C. A., Saunders, R. B., West, W. B., & Appel, J. B. (1995). Assessment of the discriminative stimulus effects of the optical isomers of ecstasy (3,4-methylenedioxymethamphetamine; MDMA). Behavioural pharmacology, 6(3), 263-275.
Baker, L.E., et al. "Assessment of the discriminative stimulus effects of the optical isomers of ecstasy (3,4-methylenedioxymethamphetamine; MDMA)." Behavioural pharmacology vol. 6,3 (1995): 263-275.
Baker LE, Broadbent J, Michael EK, Matthews PK, Metosh CA, Saunders RB, West WB, Appel JB. Assessment of the discriminative stimulus effects of the optical isomers of ecstasy (3,4-methylenedioxymethamphetamine; MDMA). Behav Pharmacol. 1995 Apr;6(3):263-275. PMID: 11224335.
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The effect of metergoline on endocrine responses to L-tryptophan.

Journal of psychopharmacology (Oxford, England)

McCance SL, Cowen PJ, Waller H, Grahame-Smith DG.
PMID: 22158889
J Psychopharmacol. 1987 Jan;1(2):90-4. doi: 10.1177/026988118700100205.

The effects of the 5-HT receptor antagonist, metergoline, on the prolactin and growth hormone responses to intravenous L-tryptophan were assessed in seven normal subjects. Pretreatment with metergoline lowered baseline prolactin concentration and abol ished the increase in prolactin following...

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McCance SL, Cowen PJ, Waller H, et al. The effect of metergoline on endocrine responses to L-tryptophan. J Psychopharmacol. 1987;1(2):90-4doi: 10.1177/026988118700100205.
McCance, S. L., Cowen, P. J., Waller, H., & Grahame-Smith, D. G. (1987). The effect of metergoline on endocrine responses to L-tryptophan. Journal of psychopharmacology (Oxford, England), 1(2), 90-4. https://doi.org/10.1177/026988118700100205
McCance, S L, et al. "The effect of metergoline on endocrine responses to L-tryptophan." Journal of psychopharmacology (Oxford, England) vol. 1,2 (1987): 90-4. doi: https://doi.org/10.1177/026988118700100205
McCance SL, Cowen PJ, Waller H, Grahame-Smith DG. The effect of metergoline on endocrine responses to L-tryptophan. J Psychopharmacol. 1987 Jan;1(2):90-4. doi: 10.1177/026988118700100205. PMID: 22158889.
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The unique effect of methiothepin on the terminal serotonin autoreceptor in the rat hypothalamus could be an example of inverse agonism.

Journal of psychopharmacology (Oxford, England)

Moret C, Briley M.
PMID: 22290996
J Psychopharmacol. 1993 Jan;7(4):331-7. doi: 10.1177/026988119300700404.

Slices of rat hypothalamus were pre-incubated with [(3)H] 5-hydroxytryptamine ([(3)H ] 5-HT), then superfused continuously and twice stimulated electrically. The effects of methiothepin, metergoline and alprenolol, all considered to be terminal 5-HT autoreceptor antagonists (although they also act at...

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Moret C, Briley M. The unique effect of methiothepin on the terminal serotonin autoreceptor in the rat hypothalamus could be an example of inverse agonism. J Psychopharmacol. 1993;7(4):331-7doi: 10.1177/026988119300700404.
Moret, C., & Briley, M. (1993). The unique effect of methiothepin on the terminal serotonin autoreceptor in the rat hypothalamus could be an example of inverse agonism. Journal of psychopharmacology (Oxford, England), 7(4), 331-7. https://doi.org/10.1177/026988119300700404
Moret, C, and Briley, M. "The unique effect of methiothepin on the terminal serotonin autoreceptor in the rat hypothalamus could be an example of inverse agonism." Journal of psychopharmacology (Oxford, England) vol. 7,4 (1993): 331-7. doi: https://doi.org/10.1177/026988119300700404
Moret C, Briley M. The unique effect of methiothepin on the terminal serotonin autoreceptor in the rat hypothalamus could be an example of inverse agonism. J Psychopharmacol. 1993 Jan;7(4):331-7. doi: 10.1177/026988119300700404. PMID: 22290996.
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Stimulation of central 5-HT1D receptors causes hypothermia in the guinea-pig.

Journal of psychopharmacology (Oxford, England)

Skingle M, Higgins GA, Feniuk W.
PMID: 22298475
J Psychopharmacol. 1994 Jan;8(1):14-21. doi: 10.1177/026988119400800103.

The 5-HT(1) receptor agonist GR46611 (3-30 mg/kg s.c.) caused a dose-related decrease in rectal temperature in the adult guinea-pig. A lower dose (20 μg) administered directly into the lateral cerebral ventricle also caused a hypothermic response, suggesting that this...

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Skingle M, Higgins GA, Feniuk W. Stimulation of central 5-HT1D receptors causes hypothermia in the guinea-pig. J Psychopharmacol. 1994;8(1):14-21doi: 10.1177/026988119400800103.
Skingle, M., Higgins, G. A., & Feniuk, W. (1994). Stimulation of central 5-HT1D receptors causes hypothermia in the guinea-pig. Journal of psychopharmacology (Oxford, England), 8(1), 14-21. https://doi.org/10.1177/026988119400800103
Skingle, M, et al. "Stimulation of central 5-HT1D receptors causes hypothermia in the guinea-pig." Journal of psychopharmacology (Oxford, England) vol. 8,1 (1994): 14-21. doi: https://doi.org/10.1177/026988119400800103
Skingle M, Higgins GA, Feniuk W. Stimulation of central 5-HT1D receptors causes hypothermia in the guinea-pig. J Psychopharmacol. 1994 Jan;8(1):14-21. doi: 10.1177/026988119400800103. PMID: 22298475.
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Are 5-HT receptors involved in the sprouting of serotoninergic terminals following neonatal 5,7-dihydroxytryptamine treatment in the rat?.

Neurochemistry international

Hamon M, Nelson DL, Mallat M, Bourgoin S.
PMID: 20487810
Neurochem Int. 1981 Mar;3(1):69-79. doi: 10.1016/0197-0186(81)90051-6.

The neonatal administration of 5,7-dihydroxytryptamine to rats (100 mg kg(?1) s.c. on the 1st and 2nd day after birth) resulted in marked reductions in serotoninergic presynaptic markers ([(3)H]-5-HT synaptosomal uptake, tryptophan hydroxylase activity and endogenous 5-HT content) in various...

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Hamon M, Nelson DL, Mallat M, et al. Are 5-HT receptors involved in the sprouting of serotoninergic terminals following neonatal 5,7-dihydroxytryptamine treatment in the rat?. Neurochem Int. 1981;3(1):69-79doi: 10.1016/0197-0186(81)90051-6.
Hamon, M., Nelson, D. L., Mallat, M., & Bourgoin, S. (1981). Are 5-HT receptors involved in the sprouting of serotoninergic terminals following neonatal 5,7-dihydroxytryptamine treatment in the rat?. Neurochemistry international, 3(1), 69-79. https://doi.org/10.1016/0197-0186(81)90051-6
Hamon, M, et al. "Are 5-HT receptors involved in the sprouting of serotoninergic terminals following neonatal 5,7-dihydroxytryptamine treatment in the rat?." Neurochemistry international vol. 3,1 (1981): 69-79. doi: https://doi.org/10.1016/0197-0186(81)90051-6
Hamon M, Nelson DL, Mallat M, Bourgoin S. Are 5-HT receptors involved in the sprouting of serotoninergic terminals following neonatal 5,7-dihydroxytryptamine treatment in the rat?. Neurochem Int. 1981 Mar;3(1):69-79. doi: 10.1016/0197-0186(81)90051-6. PMID: 20487810.
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Increased slow wave sleep with 5-HT2 receptor antagonists: detection by ambulatory EEG recording and automatic sleep stage analysis.

Journal of psychopharmacology (Oxford, England)

Solomon RA, Sharpley AL, Cowen PJ.
PMID: 22282895
J Psychopharmacol. 1989 Jan;3(3):125-9. doi: 10.1177/026988118900300301.

The effect on slow wave sleep (SWS) of 5-HT antagonists with different affinities for 5-HT(1) and 5-HT(2) receptors was investigated using ambulatory EEG monitoring in normal volunteers. The selective 5-HT( 2) antagonists, ritanserin and cypropheptadine, increased SWS while the...

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Solomon RA, Sharpley AL, Cowen PJ. Increased slow wave sleep with 5-HT2 receptor antagonists: detection by ambulatory EEG recording and automatic sleep stage analysis. J Psychopharmacol. 1989;3(3):125-9doi: 10.1177/026988118900300301.
Solomon, R. A., Sharpley, A. L., & Cowen, P. J. (1989). Increased slow wave sleep with 5-HT2 receptor antagonists: detection by ambulatory EEG recording and automatic sleep stage analysis. Journal of psychopharmacology (Oxford, England), 3(3), 125-9. https://doi.org/10.1177/026988118900300301
Solomon, R A, et al. "Increased slow wave sleep with 5-HT2 receptor antagonists: detection by ambulatory EEG recording and automatic sleep stage analysis." Journal of psychopharmacology (Oxford, England) vol. 3,3 (1989): 125-9. doi: https://doi.org/10.1177/026988118900300301
Solomon RA, Sharpley AL, Cowen PJ. Increased slow wave sleep with 5-HT2 receptor antagonists: detection by ambulatory EEG recording and automatic sleep stage analysis. J Psychopharmacol. 1989 Jan;3(3):125-9. doi: 10.1177/026988118900300301. PMID: 22282895.
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Alterations in dopamine and 5-hydroxytryptamine (5-HT) function during barbiturate dependence and withdrawal in mice.

Journal of psychopharmacology (Oxford, England)

Gray PL, Dawbarn D, Taberner PV.
PMID: 22158891
J Psychopharmacol. 1987 Jan;1(2):101-8. doi: 10.1177/026988118700100207.

Mice were rendered barbiturate-dependent by chronic feeding with barbital-con taining food. Brain dopamine turnover was significantly increased in barbital withdrawal, whereas 5-hydroxytryptamine (5-HT) turnover was significantly decreased. Severity of with drawal was assessed by measuring the convulsions following a...

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Gray PL, Dawbarn D, Taberner PV. Alterations in dopamine and 5-hydroxytryptamine (5-HT) function during barbiturate dependence and withdrawal in mice. J Psychopharmacol. 1987;1(2):101-8doi: 10.1177/026988118700100207.
Gray, P. L., Dawbarn, D., & Taberner, P. V. (1987). Alterations in dopamine and 5-hydroxytryptamine (5-HT) function during barbiturate dependence and withdrawal in mice. Journal of psychopharmacology (Oxford, England), 1(2), 101-8. https://doi.org/10.1177/026988118700100207
Gray, P L, et al. "Alterations in dopamine and 5-hydroxytryptamine (5-HT) function during barbiturate dependence and withdrawal in mice." Journal of psychopharmacology (Oxford, England) vol. 1,2 (1987): 101-8. doi: https://doi.org/10.1177/026988118700100207
Gray PL, Dawbarn D, Taberner PV. Alterations in dopamine and 5-hydroxytryptamine (5-HT) function during barbiturate dependence and withdrawal in mice. J Psychopharmacol. 1987 Jan;1(2):101-8. doi: 10.1177/026988118700100207. PMID: 22158891.
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Computer-Aided Drug Discovery Identifies Alkaloid Inhibitors of Parkinson's Disease Associated Protein, Prolyl Oligopeptidase.

Evidence-based complementary and alternative medicine : eCAM

Kulkarni AM, Rampogu S, Lee KW.
PMID: 33897801
Evid Based Complement Alternat Med. 2021 Apr 08;2021:6687572. doi: 10.1155/2021/6687572. eCollection 2021.

Parkinson's disease is a common neurodegenerative disorder marked by the accumulation of the protein alpha synuclein. Studies have indicated the role of prolyl oligopeptidase (POP), a serine protease, in alpha synuclein accumulation. Therefore, POP emerges as an attractive medicinal...

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Kulkarni AM, Rampogu S, Lee KW. Computer-Aided Drug Discovery Identifies Alkaloid Inhibitors of Parkinson's Disease Associated Protein, Prolyl Oligopeptidase. Evid Based Complement Alternat Med. 2021;2021:6687572doi: 10.1155/2021/6687572.
Kulkarni, A. M., Rampogu, S., & Lee, K. W. (2021). Computer-Aided Drug Discovery Identifies Alkaloid Inhibitors of Parkinson's Disease Associated Protein, Prolyl Oligopeptidase. Evidence-based complementary and alternative medicine : eCAM, 20216687572. https://doi.org/10.1155/2021/6687572
Kulkarni, Apoorva M, et al. "Computer-Aided Drug Discovery Identifies Alkaloid Inhibitors of Parkinson's Disease Associated Protein, Prolyl Oligopeptidase." Evidence-based complementary and alternative medicine : eCAM vol. 2021 (2021): 6687572. doi: https://doi.org/10.1155/2021/6687572
Kulkarni AM, Rampogu S, Lee KW. Computer-Aided Drug Discovery Identifies Alkaloid Inhibitors of Parkinson's Disease Associated Protein, Prolyl Oligopeptidase. Evid Based Complement Alternat Med. 2021 Apr 08;2021:6687572. doi: 10.1155/2021/6687572. eCollection 2021. PMID: 33897801; PMCID: PMC8052153.
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Influence of the serotonin antagonist, metergoline, on the anxiogenic effects of carbon dioxide, and on heart rate and neuroendocrine measures, in healthy volunteers.

Human psychopharmacology

Meiri G, Ben-Zion IZ, Greenberg BD, Murphy DL, Benjamin J.
PMID: 12404576
Hum Psychopharmacol. 2001 Apr;16(3):237-245. doi: 10.1002/hup.259.

The mechanism of action of carbon dioxide (CO(2)) angiogenesis is unknown; only recently have possible serotonergic (5-HT) influences begun to be studied. In separate double-blind challenges 1 week apart, 14 healthy volunteers received two vital capacity inhalations each of...

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Meiri G, Ben-Zion IZ, Greenberg BD, et al. Influence of the serotonin antagonist, metergoline, on the anxiogenic effects of carbon dioxide, and on heart rate and neuroendocrine measures, in healthy volunteers. Hum Psychopharmacol. 2001;16(3):237-245doi: 10.1002/hup.259.
Meiri, G., Ben-Zion, I. Z., Greenberg, B. D., Murphy, D. L., & Benjamin, J. (2001). Influence of the serotonin antagonist, metergoline, on the anxiogenic effects of carbon dioxide, and on heart rate and neuroendocrine measures, in healthy volunteers. Human psychopharmacology, 16(3), 237-245. https://doi.org/10.1002/hup.259
Meiri, Gal, et al. "Influence of the serotonin antagonist, metergoline, on the anxiogenic effects of carbon dioxide, and on heart rate and neuroendocrine measures, in healthy volunteers." Human psychopharmacology vol. 16,3 (2001): 237-245. doi: https://doi.org/10.1002/hup.259
Meiri G, Ben-Zion IZ, Greenberg BD, Murphy DL, Benjamin J. Influence of the serotonin antagonist, metergoline, on the anxiogenic effects of carbon dioxide, and on heart rate and neuroendocrine measures, in healthy volunteers. Hum Psychopharmacol. 2001 Apr;16(3):237-245. doi: 10.1002/hup.259. PMID: 12404576.
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Metergoline, pirenperone and pizotifen alter dopamine and 5-hydroxytryptamine synthesis in discrete rat brain nuclei.

Neurochemistry international

Nielsen JA.
PMID: 20493142
Neurochem Int. 1986;9(3):423-9. doi: 10.1016/0197-0186(86)90084-7.

The effects of the 5-hydroxytryptamine receptor antagonists metergoline, pirenperone and pizotifen on 5-hydroxytryptamine and dopamine synthesis were determined by measuring the rate of accumulation of 5-hydroxytryptamine and 3,4-dihydroxyphenylalanine, respectively, after administering l-tryptophan and m-hydroxybenzylhydrazine, an inhibitor of aromatic-l-amino acid...

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Nielsen JA. Metergoline, pirenperone and pizotifen alter dopamine and 5-hydroxytryptamine synthesis in discrete rat brain nuclei. Neurochem Int. 1986;9(3):423-9doi: 10.1016/0197-0186(86)90084-7.
Nielsen, J. A. (1986). Metergoline, pirenperone and pizotifen alter dopamine and 5-hydroxytryptamine synthesis in discrete rat brain nuclei. Neurochemistry international, 9(3), 423-9. https://doi.org/10.1016/0197-0186(86)90084-7
Nielsen, J A. "Metergoline, pirenperone and pizotifen alter dopamine and 5-hydroxytryptamine synthesis in discrete rat brain nuclei." Neurochemistry international vol. 9,3 (1986): 423-9. doi: https://doi.org/10.1016/0197-0186(86)90084-7
Nielsen JA. Metergoline, pirenperone and pizotifen alter dopamine and 5-hydroxytryptamine synthesis in discrete rat brain nuclei. Neurochem Int. 1986;9(3):423-9. doi: 10.1016/0197-0186(86)90084-7. PMID: 20493142.
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Showing 1 to 12 of 19 entries