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Supraphysiological doses of performance enhancing anabolic-androgenic steroids exert direct toxic effects on neuron-like cells.

Frontiers in cellular neuroscience

Basile JR, Binmadi NO, Zhou H, Yang YH, Paoli A, Proia P.
PMID: 23675320
Front Cell Neurosci. 2013 May 09;7:69. doi: 10.3389/fncel.2013.00069. eCollection 2013.

Anabolic-androgenic steroids (AAS) are lipophilic hormones often taken in excessive quantities by athletes and bodybuilders to enhance performance and increase muscle mass. AAS exert well known toxic effects on specific cell and tissue types and organ systems. The attention...

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Basile JR, Binmadi NO, Zhou H, et al. Supraphysiological doses of performance enhancing anabolic-androgenic steroids exert direct toxic effects on neuron-like cells. Front Cell Neurosci. 2013;7:69doi: 10.3389/fncel.2013.00069.
Basile, J. R., Binmadi, N. O., Zhou, H., Yang, Y. H., Paoli, A., & Proia, P. (2013). Supraphysiological doses of performance enhancing anabolic-androgenic steroids exert direct toxic effects on neuron-like cells. Frontiers in cellular neuroscience, 769. https://doi.org/10.3389/fncel.2013.00069
Basile, John R, et al. "Supraphysiological doses of performance enhancing anabolic-androgenic steroids exert direct toxic effects on neuron-like cells." Frontiers in cellular neuroscience vol. 7 (2013): 69. doi: https://doi.org/10.3389/fncel.2013.00069
Basile JR, Binmadi NO, Zhou H, Yang YH, Paoli A, Proia P. Supraphysiological doses of performance enhancing anabolic-androgenic steroids exert direct toxic effects on neuron-like cells. Front Cell Neurosci. 2013 May 09;7:69. doi: 10.3389/fncel.2013.00069. eCollection 2013. PMID: 23675320; PMCID: PMC3648690.
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The effect of feeding three anabolic steroids in different combinations on the growth, food conversion efficiency and protein and nucleic acid levels of liver, kidney, brain and muscle of mirror carp (Cyprinus carpio).

Fish physiology and biochemistry

Lone KP.
PMID: 24227070
Fish Physiol Biochem. 1989 May;6(3):149-56. doi: 10.1007/BF01874771.

A study on the effect of three different anabolic-androgenic steroids on the growth, food conversion efficiency and nucleic acid contents of liver, kidney, brain and muscle of carp,Cyprinus carpio was undertaken. The three steroids, methyltestosterone (MT), ethylestrenol (EE) and...

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Lone KP. The effect of feeding three anabolic steroids in different combinations on the growth, food conversion efficiency and protein and nucleic acid levels of liver, kidney, brain and muscle of mirror carp (Cyprinus carpio). Fish Physiol Biochem. 1989;6(3):149-56doi: 10.1007/BF01874771.
Lone, K. P. (1989). The effect of feeding three anabolic steroids in different combinations on the growth, food conversion efficiency and protein and nucleic acid levels of liver, kidney, brain and muscle of mirror carp (Cyprinus carpio). Fish physiology and biochemistry, 6(3), 149-56. https://doi.org/10.1007/BF01874771
Lone, K P. "The effect of feeding three anabolic steroids in different combinations on the growth, food conversion efficiency and protein and nucleic acid levels of liver, kidney, brain and muscle of mirror carp (Cyprinus carpio)." Fish physiology and biochemistry vol. 6,3 (1989): 149-56. doi: https://doi.org/10.1007/BF01874771
Lone KP. The effect of feeding three anabolic steroids in different combinations on the growth, food conversion efficiency and protein and nucleic acid levels of liver, kidney, brain and muscle of mirror carp (Cyprinus carpio). Fish Physiol Biochem. 1989 May;6(3):149-56. doi: 10.1007/BF01874771. PMID: 24227070.
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NTP Toxicology and Carcinogenesis Studies of Oxymetholone (CAS NO. 434-07-1) in F344/N Rats and Toxicology Studies of Oxymetholone in B6C3F1 Mice (Gavage Studies).

National Toxicology Program technical report series

[No authors listed]
PMID: 12571678
Natl Toxicol Program Tech Rep Ser. 1999 Aug;485:1-233.

Oxymetholone is a synthetic anabolic steroid used to treat a variety of conditions, including hypogonadism and delayed puberty. It is also used to correct hereditary angioneurotic edema, manage carcinoma of the breast, promote a positive nitrogen balance following injury...

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NTP Toxicology and Carcinogenesis Studies of Oxymetholone (CAS NO. 434-07-1) in F344/N Rats and Toxicology Studies of Oxymetholone in B6C3F1 Mice (Gavage Studies). Natl Toxicol Program Tech Rep Ser. 1999;485:1-233
(1999). NTP Toxicology and Carcinogenesis Studies of Oxymetholone (CAS NO. 434-07-1) in F344/N Rats and Toxicology Studies of Oxymetholone in B6C3F1 Mice (Gavage Studies). National Toxicology Program technical report series, 4851-233.
"NTP Toxicology and Carcinogenesis Studies of Oxymetholone (CAS NO. 434-07-1) in F344/N Rats and Toxicology Studies of Oxymetholone in B6C3F1 Mice (Gavage Studies)." National Toxicology Program technical report series vol. 485 (1999): 1-233.
NTP Toxicology and Carcinogenesis Studies of Oxymetholone (CAS NO. 434-07-1) in F344/N Rats and Toxicology Studies of Oxymetholone in B6C3F1 Mice (Gavage Studies). Natl Toxicol Program Tech Rep Ser. 1999 Aug;485:1-233. PMID: 12571678.
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The effect of 3,3',5-triiodo-L-thyronine and 17-α-methyltestosterone on growth and body composition of the glass stage of the eel (Anguilla anguilla L).

Fish physiology and biochemistry

Degani G, Dosoretz C.
PMID: 24234666
Fish Physiol Biochem. 1986 Jun;1(3):145-51. doi: 10.1007/BF02290255.

This study was undertaken to determine the influence of orally administered 3,3',5-triiodo-L-thyronine (T3) or 17-α-methyltestosterone (MT) on growth and body composition of the eel (Anguilla anguilla L.) during the glass stage.Elvers receiving 20 or 40 ppm of T3 in...

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Degani G, Dosoretz C. The effect of 3,3',5-triiodo-L-thyronine and 17-α-methyltestosterone on growth and body composition of the glass stage of the eel (Anguilla anguilla L). Fish Physiol Biochem. 1986;1(3):145-51doi: 10.1007/BF02290255.
Degani, G., & Dosoretz, C. (1986). The effect of 3,3',5-triiodo-L-thyronine and 17-α-methyltestosterone on growth and body composition of the glass stage of the eel (Anguilla anguilla L). Fish physiology and biochemistry, 1(3), 145-51. https://doi.org/10.1007/BF02290255
Degani, G, and Dosoretz, C. "The effect of 3,3',5-triiodo-L-thyronine and 17-α-methyltestosterone on growth and body composition of the glass stage of the eel (Anguilla anguilla L)." Fish physiology and biochemistry vol. 1,3 (1986): 145-51. doi: https://doi.org/10.1007/BF02290255
Degani G, Dosoretz C. The effect of 3,3',5-triiodo-L-thyronine and 17-α-methyltestosterone on growth and body composition of the glass stage of the eel (Anguilla anguilla L). Fish Physiol Biochem. 1986 Jun;1(3):145-51. doi: 10.1007/BF02290255. PMID: 24234666.
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Effect of 17α-methyltestosterone (MT) on oxidation stress in the liver of juvenile GIFT tilapia, Oreochromis niloticus.

SpringerPlus

Zheng Y, Qu J, Qiu L, Fan L, Meng S, Song C, Bing X, Chen J.
PMID: 27066359
Springerplus. 2016 Mar 15;5:338. doi: 10.1186/s40064-016-1946-6. eCollection 2016.

The normal dose of 17α-methyltestosterone (MT) used in fish farming was 60 mg/L, and now the analysis of residual androgens was carried out in waste water obtained from the Beijing area, which could be detected in levels ranging from...

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Zheng Y, Qu J, Qiu L, et al. Effect of 17α-methyltestosterone (MT) on oxidation stress in the liver of juvenile GIFT tilapia, Oreochromis niloticus. Springerplus. 2016;5:338doi: 10.1186/s40064-016-1946-6.
Zheng, Y., Qu, J., Qiu, L., Fan, L., Meng, S., Song, C., Bing, X., & Chen, J. (2016). Effect of 17α-methyltestosterone (MT) on oxidation stress in the liver of juvenile GIFT tilapia, Oreochromis niloticus. SpringerPlus, 5338. https://doi.org/10.1186/s40064-016-1946-6
Zheng, Yao, et al. "Effect of 17α-methyltestosterone (MT) on oxidation stress in the liver of juvenile GIFT tilapia, Oreochromis niloticus." SpringerPlus vol. 5 (2016): 338. doi: https://doi.org/10.1186/s40064-016-1946-6
Zheng Y, Qu J, Qiu L, Fan L, Meng S, Song C, Bing X, Chen J. Effect of 17α-methyltestosterone (MT) on oxidation stress in the liver of juvenile GIFT tilapia, Oreochromis niloticus. Springerplus. 2016 Mar 15;5:338. doi: 10.1186/s40064-016-1946-6. eCollection 2016. PMID: 27066359; PMCID: PMC4792819.
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Effects of spray-drying on w/o/w multiple emulsions prepared from a stearic acid matrix.

Nanotechnology, science and applications

Mlalila N, Swai H, Kalombo L, Hilonga A.
PMID: 25489238
Nanotechnol Sci Appl. 2014 Dec 01;7:105-12. doi: 10.2147/NSA.S72083. eCollection 2014.

The goal of this study was to explore the effects of spray-drying on w/o/w double emulsions of methyltestosterone (MT) loaded in a stearic acid matrix. MT-loaded nanoparticles were formulated by a water-in-oil-in-water emulsion technique using 50, 75, and 100...

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Mlalila N, Swai H, Kalombo L, et al. Effects of spray-drying on w/o/w multiple emulsions prepared from a stearic acid matrix. Nanotechnol Sci Appl. 2014;7:105-12doi: 10.2147/NSA.S72083.
Mlalila, N., Swai, H., Kalombo, L., & Hilonga, A. (2014). Effects of spray-drying on w/o/w multiple emulsions prepared from a stearic acid matrix. Nanotechnology, science and applications, 7105-12. https://doi.org/10.2147/NSA.S72083
Mlalila, Nichrous, et al. "Effects of spray-drying on w/o/w multiple emulsions prepared from a stearic acid matrix." Nanotechnology, science and applications vol. 7 (2014): 105-12. doi: https://doi.org/10.2147/NSA.S72083
Mlalila N, Swai H, Kalombo L, Hilonga A. Effects of spray-drying on w/o/w multiple emulsions prepared from a stearic acid matrix. Nanotechnol Sci Appl. 2014 Dec 01;7:105-12. doi: 10.2147/NSA.S72083. eCollection 2014. PMID: 25489238; PMCID: PMC4257357.
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Potential role of DNA methylation of cyp19a1a promoter during sex change in protogynous orange-spotted grouper, Epinephelus coioides.

General and comparative endocrinology

Guo CY, Tseng PW, Hwang JS, Wu GC, Chang CF.
PMID: 34216589
Gen Comp Endocrinol. 2021 Sep 15;311:113840. doi: 10.1016/j.ygcen.2021.113840. Epub 2021 Jun 30.

Estrogen has a pivotal role in early female differentiation and further ovarian development. Aromatase (Cyp19a) is responsible for the conversion of androgens to estrogens in vertebrates. In teleosts, cyp19a1a and it paralog cyp19a1b are mainly expressed in the ovary...

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Guo CY, Tseng PW, Hwang JS, et al. Potential role of DNA methylation of cyp19a1a promoter during sex change in protogynous orange-spotted grouper, Epinephelus coioides. Gen Comp Endocrinol. 2021;311:113840doi: 10.1016/j.ygcen.2021.113840.
Guo, C. Y., Tseng, P. W., Hwang, J. S., Wu, G. C., & Chang, C. F. (2021). Potential role of DNA methylation of cyp19a1a promoter during sex change in protogynous orange-spotted grouper, Epinephelus coioides. General and comparative endocrinology, 311113840. https://doi.org/10.1016/j.ygcen.2021.113840
Guo, Chun-Yang, et al. "Potential role of DNA methylation of cyp19a1a promoter during sex change in protogynous orange-spotted grouper, Epinephelus coioides." General and comparative endocrinology vol. 311 (2021): 113840. doi: https://doi.org/10.1016/j.ygcen.2021.113840
Guo CY, Tseng PW, Hwang JS, Wu GC, Chang CF. Potential role of DNA methylation of cyp19a1a promoter during sex change in protogynous orange-spotted grouper, Epinephelus coioides. Gen Comp Endocrinol. 2021 Sep 15;311:113840. doi: 10.1016/j.ygcen.2021.113840. Epub 2021 Jun 30. PMID: 34216589.
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Cross-reactivity of steroid hormone immunoassays: clinical significance and two-dimensional molecular similarity prediction.

BMC clinical pathology

Krasowski MD, Drees D, Morris CS, Maakestad J, Blau JL, Ekins S.
PMID: 25071417
BMC Clin Pathol. 2014 Jul 14;14:33. doi: 10.1186/1472-6890-14-33. eCollection 2014.

BACKGROUND: Immunoassays are widely used in clinical laboratories for measurement of plasma/serum concentrations of steroid hormones such as cortisol and testosterone. Immunoassays can be performed on a variety of standard clinical chemistry analyzers, thus allowing even small clinical laboratories...

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Krasowski MD, Drees D, Morris CS, et al. Cross-reactivity of steroid hormone immunoassays: clinical significance and two-dimensional molecular similarity prediction. BMC Clin Pathol. 2014;14:33doi: 10.1186/1472-6890-14-33.
Krasowski, M. D., Drees, D., Morris, C. S., Maakestad, J., Blau, J. L., & Ekins, S. (2014). Cross-reactivity of steroid hormone immunoassays: clinical significance and two-dimensional molecular similarity prediction. BMC clinical pathology, 1433. https://doi.org/10.1186/1472-6890-14-33
Krasowski, Matthew D, et al. "Cross-reactivity of steroid hormone immunoassays: clinical significance and two-dimensional molecular similarity prediction." BMC clinical pathology vol. 14 (2014): 33. doi: https://doi.org/10.1186/1472-6890-14-33
Krasowski MD, Drees D, Morris CS, Maakestad J, Blau JL, Ekins S. Cross-reactivity of steroid hormone immunoassays: clinical significance and two-dimensional molecular similarity prediction. BMC Clin Pathol. 2014 Jul 14;14:33. doi: 10.1186/1472-6890-14-33. eCollection 2014. PMID: 25071417; PMCID: PMC4112981.
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Induction of Primary Male in Juvenile Red Spotted Grouper Epinephelus akaara by Immersion of 17α-Methyltestosterone.

Development & reproduction

Lee CH, Hur SW, Na OS, Baek HJ, Noh CH, Han SH, Lee YD.
PMID: 25949180
Dev Reprod. 2014 Sep;18(3):127-31. doi: 10.12717/DR.2014.18.3.127.

We investigated the androgenic effects of 17α- methyltestosterone (MT) on gonadal sex reversal in juvenile red spotted grouper Epinephelus akaara. The fish were immersed in 17α-MT at 1 and 5 mg/L. Treatment method of 17α-MT was once weekly for...

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Lee CH, Hur SW, Na OS, et al. Induction of Primary Male in Juvenile Red Spotted Grouper Epinephelus akaara by Immersion of 17α-Methyltestosterone. Dev Reprod. 2014;18(3):127-31doi: 10.12717/DR.2014.18.3.127.
Lee, C. H., Hur, S. W., Na, O. S., Baek, H. J., Noh, C. H., Han, S. H., & Lee, Y. D. (2014). Induction of Primary Male in Juvenile Red Spotted Grouper Epinephelus akaara by Immersion of 17α-Methyltestosterone. Development & reproduction, 18(3), 127-31. https://doi.org/10.12717/DR.2014.18.3.127
Lee, Chi-Hoon, et al. "Induction of Primary Male in Juvenile Red Spotted Grouper Epinephelus akaara by Immersion of 17α-Methyltestosterone." Development & reproduction vol. 18,3 (2014): 127-31. doi: https://doi.org/10.12717/DR.2014.18.3.127
Lee CH, Hur SW, Na OS, Baek HJ, Noh CH, Han SH, Lee YD. Induction of Primary Male in Juvenile Red Spotted Grouper Epinephelus akaara by Immersion of 17α-Methyltestosterone. Dev Reprod. 2014 Sep;18(3):127-31. doi: 10.12717/DR.2014.18.3.127. PMID: 25949180; PMCID: PMC4282206.
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Gene Expression of Takifugu rubripes Gonads During AI- or MT-induced Masculinization and E2-induced Feminization.

Endocrinology

Yan H, Shen X, Jiang J, Zhang L, Yuan Z, Wu Y, Liu Q, Liu Y.
PMID: 33831176
Endocrinology. 2021 Oct 01;162(10). doi: 10.1210/endocr/bqab068.

Elucidating the global molecular changes that occur during aromatase inhibitor (AI)- or 17α-methyltestosterone (MT)-induced masculinization and estradiol-17β (E2)-induced feminization is critical to understanding the roles that endocrine and genetic factors play in regulating the process of sex differentiation in...

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Yan H, Shen X, Jiang J, et al. Gene Expression of Takifugu rubripes Gonads During AI- or MT-induced Masculinization and E2-induced Feminization. Endocrinology. 2021;162(10)doi: 10.1210/endocr/bqab068.
Yan, H., Shen, X., Jiang, J., Zhang, L., Yuan, Z., Wu, Y., Liu, Q., & Liu, Y. (2021). Gene Expression of Takifugu rubripes Gonads During AI- or MT-induced Masculinization and E2-induced Feminization. Endocrinology, 162(10), . https://doi.org/10.1210/endocr/bqab068
Yan, Hongwei, et al. "Gene Expression of Takifugu rubripes Gonads During AI- or MT-induced Masculinization and E2-induced Feminization." Endocrinology vol. 162,10 (2021). doi: https://doi.org/10.1210/endocr/bqab068
Yan H, Shen X, Jiang J, Zhang L, Yuan Z, Wu Y, Liu Q, Liu Y. Gene Expression of Takifugu rubripes Gonads During AI- or MT-induced Masculinization and E2-induced Feminization. Endocrinology. 2021 Oct 01;162(10). doi: 10.1210/endocr/bqab068. PMID: 33831176.
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Survey of protein-based sport supplements for illegally added anabolic steroids methyltestosterone and 4-androstenedione by UPLC-MS/MS.

Steroids

Alaedini S, Amirahmadi M, Kobarfard F, Rastegar H, Nasirahmadi S, Shoeibi S.
PMID: 33161054
Steroids. 2021 Jan;165:108758. doi: 10.1016/j.steroids.2020.108758. Epub 2020 Nov 05.

There is some evidence that marketable supplements contain hormones not declared on the product label. The presence of these androgenic anabolic steroids (AAS) in sports supplements can be considered an adulteration and affect the health of consumers, who are...

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Alaedini S, Amirahmadi M, Kobarfard F, et al. Survey of protein-based sport supplements for illegally added anabolic steroids methyltestosterone and 4-androstenedione by UPLC-MS/MS. Steroids. 2020;165:108758doi: 10.1016/j.steroids.2020.108758.
Alaedini, S., Amirahmadi, M., Kobarfard, F., Rastegar, H., Nasirahmadi, S., & Shoeibi, S. (2021). Survey of protein-based sport supplements for illegally added anabolic steroids methyltestosterone and 4-androstenedione by UPLC-MS/MS. Steroids, 165108758. https://doi.org/10.1016/j.steroids.2020.108758
Alaedini, Somaye, et al. "Survey of protein-based sport supplements for illegally added anabolic steroids methyltestosterone and 4-androstenedione by UPLC-MS/MS." Steroids vol. 165 (2021): 108758. doi: https://doi.org/10.1016/j.steroids.2020.108758
Alaedini S, Amirahmadi M, Kobarfard F, Rastegar H, Nasirahmadi S, Shoeibi S. Survey of protein-based sport supplements for illegally added anabolic steroids methyltestosterone and 4-androstenedione by UPLC-MS/MS. Steroids. 2021 Jan;165:108758. doi: 10.1016/j.steroids.2020.108758. Epub 2020 Nov 05. PMID: 33161054.
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The effects of methyltestosteone on reproductive function in male greyhounds.

Theriogenology

Freshman JL, Olson PN, Amann RP, Carlson ED, Twedt DC, Bowen RA.
PMID: 16726801
Theriogenology. 1990 May;33(5):1057-73. doi: 10.1016/0093-691x(90)90067-4.

Oral administration of methyltestosterone (MT) at 50 mg/dog/day to intact adult male greyhounds for 90 d resulted in decreased (P < 0.05) mean daily sperm output and mean testicular length. Additionally, the mean diameter of seminiferous tubules in MT-treated...

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Freshman JL, Olson PN, Amann RP, et al. The effects of methyltestosteone on reproductive function in male greyhounds. Theriogenology. 1990;33(5):1057-73doi: 10.1016/0093-691x(90)90067-4.
Freshman, J. L., Olson, P. N., Amann, R. P., Carlson, E. D., Twedt, D. C., & Bowen, R. A. (1990). The effects of methyltestosteone on reproductive function in male greyhounds. Theriogenology, 33(5), 1057-73. https://doi.org/10.1016/0093-691x(90)90067-4
Freshman, J L, et al. "The effects of methyltestosteone on reproductive function in male greyhounds." Theriogenology vol. 33,5 (1990): 1057-73. doi: https://doi.org/10.1016/0093-691x(90)90067-4
Freshman JL, Olson PN, Amann RP, Carlson ED, Twedt DC, Bowen RA. The effects of methyltestosteone on reproductive function in male greyhounds. Theriogenology. 1990 May;33(5):1057-73. doi: 10.1016/0093-691x(90)90067-4. PMID: 16726801.
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Showing 1 to 12 of 27 entries