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Showing 1 to 12 of 277 entries
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Synergistic Inhibition of Tumor Necrosis Factor-Alpha-Stimulated Pro-Inflammatory Cytokine Expression in HaCaT Cells by a Combination of Rapamycin and Mycophenolic Acid.

Annals of dermatology

Kim MY, Lim YY, Kim HM, Park YM, Kang H, Kim BJ.
PMID: 25673929
Ann Dermatol. 2015 Feb;27(1):32-9. doi: 10.5021/ad.2015.27.1.32. Epub 2015 Feb 03.

BACKGROUND: Keratinocytes release various pro-inflammatory cytokines, chemokines, and adhesion molecules such as intercellular adhesion molecule 1 (ICAM-1) in response to cytokines such as tumor necrosis factor (TNF)-α and interferon (IFN)-γ. Rapamycin and mycophenolic acid (MPA) have potent immunosuppressive activity...

Intra-individual variability of mycophenolic acid concentration according to renal function in liver transplant recipients receiving mycophenolate monotherapy.

Annals of hepato-biliary-pancreatic surgery

Hwang S, Song GW, Jung DH, Park GC, Ahn CS, Moon DB, Ha TY, Kim KH, Lee SG.
PMID: 28317040
Ann Hepatobiliary Pancreat Surg. 2017 Feb;21(1):11-16. doi: 10.14701/ahbps.2017.21.1.11. Epub 2017 Feb 28.

BACKGROUNDS/AIMS: Mycophenolate mofetil (MMF) has wide inter- and intra-individual variability of mycophenolic acid (MPA) after liver transplantation (LT). On this study, we aimed to analyse the intra-individual variability of MPA concentration in stable adult LT recipients receiving MMF monotherapy...

Induction by anti-thymocyte globulins in kidney transplantation: a review of the literature and current usage.

Journal of nephropathology

Malvezzi P, Jouve T, Rostaing L.
PMID: 26457257
J Nephropathol. 2015 Oct;4(4):110-5. doi: 10.12860/jnp.2015.21. Epub 2015 Oct 01.

CONTEXT: Preventing acute rejection (AR) after kidney transplantation is of utmost importance because an AR can have a negative impact on long-term allograft survival.EVIDENCE ACQUISITION: Directory of Open Access Journals (DOAJ), Google Scholar, PubMed, EBSCO, and Web of Science...

Simultaneous Single Dexamethasone Implant and Ranibizumab Injection in a Case with Active Serpiginous Choroiditis and Choroidal Neovascular Membrane.

Case reports in ophthalmology

Saatci AO, Ayhan Z, Engin Durmaz C, Takes O.
PMID: 26955341
Case Rep Ophthalmol. 2015 Dec 01;6(3):408-14. doi: 10.1159/000442346. eCollection 2015.

Intravitreal anti-vascular endothelial growth factor (VEGF) agents seem to be effective in choroidal neovascular membranes (CNV) in association with various entities of posterior uveitis. We herein report a 46-year-old woman who was treated with a simultaneous single intravitreal dexamethasone...

Severe Enteropathy From Mycophenolate Mofetil.

ACG case reports journal

Jehangir A, Shaikh B, Hunt J, Spiegel A.
PMID: 26958559
ACG Case Rep J. 2016 Jan 20;3(2):101-3. doi: 10.14309/crj.2016.13. eCollection 2016 Jan.

The adverse effects of mycophenolate mofetil on the colon are well known. However, isolated small intestinal involvement resulting in diarrhea and severe weight loss is infrequently reported in the literature. We present the case of a 45-year-old woman on...

Guanylate requirement for patterning the postcephalic body region of the brine shrimp Artemia.

Roux's archives of developmental biology : the official organ of the EDBO

Hernandorena A.
PMID: 28305982
Rouxs Arch Dev Biol. 1993 Jan;203(1):74-82. doi: 10.1007/BF00539892.

Mycophenolic acid (MA) reduces growth and survival rates of Artemia larvae fed hypoxanthine. The inhibitory effect of MA is suppressed by dietary guanosine as expected for inosinate dehydrogenase inhibition. Pulse MA treatments lasting 24 h imposed on larvae from...

Immunosuppressant MPA Modulates Tight Junction through Epigenetic Activation of MLCK/MLC-2 Pathway via p38MAPK.

Frontiers in physiology

Khan N, Pantakani DV, Binder L, Qasim M, Asif AR.
PMID: 26733876
Front Physiol. 2015 Dec 22;6:381. doi: 10.3389/fphys.2015.00381. eCollection 2015.

BACKGROUND: Mycophenolic acid (MPA) is an important immunosuppressive drug (ISD) prescribed to prevent graft rejection in the organ transplanted patients, however, its use is also associated with adverse side effects like sporadic gastrointestinal (GI) disturbances. Recently, we reported the...

Antibody induction therapy in adult kidney transplantation: A controversy continues.

World journal of transplantation

Chouhan KK, Zhang R.
PMID: 24175192
World J Transplant. 2012 Apr 24;2(2):19-26. doi: 10.5500/wjt.v2.i2.19.

Antibody induction therapy is frequently used as an adjunct to the maintenance immunosuppression in adult kidney transplant recipients. Published data support antibody induction in patients with immunologic risk to reduce the incidence of acute rejection (AR) and graft loss...

Immunoadsorption: a new strategy to induce remission in membranous lupus nephritis.

Case reports in nephrology and urology

Ulinski T, Davourie-Salandre A, Brocheriou I, Aoun B.
PMID: 24803916
Case Rep Nephrol Urol. 2014 Mar 19;4(1):37-41. doi: 10.1159/000361014. eCollection 2014 Jan.

We report the case of an 11-year-old previously healthy girl who presented for microscopic hematuria and nephrotic proteinuria with normal renal function, which persisted after 6 months of steroids, angiotensin-converting enzyme inhibitors (ACEi)/angiotensin receptor blockers, hydroxychloroquine, mycophenolic acid and...

Mycophenolic Acid: a one hundred year odyssey from antibiotic to immunosuppressant.

Chemical reviews

Bentley R.
PMID: 11749328
Chem Rev. 2000 Oct 11;100(10):3801-26. doi: 10.1021/cr990097b.

No abstract available.

Gateways to clinical trials.

Methods and findings in experimental and clinical pharmacology

Tomillero A, Moral MA.
PMID: 18985183
Methods Find Exp Clin Pharmacol. 2008 Sep;30(7):543-88.

Gateways to Clinical Trials are a guide to the most recent clinical trials in current literature and congresses. The data in the following tables has been retrieved from the Clinical Trials Knowledge Area of Prous Science Integrity, the drug...

Mycophenolate mofetil: effects on clinical transplantation.

BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy

Holt CD, Sievers TM, Ghobrial RM, Rossi SJ, Goss JA, McDiarmid SV.
PMID: 18020609
BioDrugs. 1998 Nov;10(5):373-84. doi: 10.2165/00063030-199810050-00004.

Mycophenolate mofetil (MMF) is the morpholinoethylester prodrug of mycophenolic acid, an agent which inhibits the proliferation of B and T lymphocytes through the noncompetitive, reversible inhibition of inosine monophosphate dehydrogenase, itself a key enzyme in the de novo synthetic...

Showing 1 to 12 of 277 entries