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Pharmacology of excitatory amino acid receptors coupled to inositol phosphate metabolism in neonatal rat striatum.

Neurochemistry international

Doble A, Perrier ML.
PMID: 20504458
Neurochem Int. 1989;15(1):1-8. doi: 10.1016/0197-0186(89)90069-7.

The production of inositol phosphate from tritiated inositol was studied in striatal slices of neonatal rats. The excitatory amino acids glutamic, aspartic, quisqualic and ibotenic acids directly stimulated the formation of inositol phosphate in this system. The receptor mediating...

Effect of flupirtine on the growth and viability of U373 malignant glioma cells.

Cancer biology & medicine

Panchanathan E, Ramanathan G, Lakkakula BV.
PMID: 24379989
Cancer Biol Med. 2013 Sep;10(3):142-7. doi: 10.7497/j.issn.2095-3941.2013.03.004.

OBJECTIVE: Flupirtine is a non-opioid analgesic without antipyretic or antiphlogistic properties but with favorable tolerability in humans. This analgesic also exhibits neuroprotective activities. Furthermore, flupirtine antagonizes glutamate- and NMDA-induced intracellular levels of Ca(2+) and counteracts the effects of focal...

The Vulnerability of the Neonatal Rodent Brain to Glutamate and Aspartate.

Nutrition reviews

[No authors listed]
PMID: 31252973
Nutr Rev. 1982 Jan 01;40(1):30-32. doi: 10.1111/j.1753-4887.1982.tb06825.x.

Microhistochemical analyses of the circumventricular organs of the four-day-old mouse or rat brain show very high levels of these amino acids after an excitotoxic subcutaneous dose. Nearby regions protected by the blood-brain barrier do not.

Showing 1 to 3 of 3 entries