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Dimerization of Aromatic C-Nitroso Compounds.

Chemical reviews

Beaudoin D, Wuest JD.
PMID: 26730505
Chem Rev. 2016 Jan 13;116(1):258-86. doi: 10.1021/cr500520s. Epub 2016 Jan 05.

Aromatic C-nitroso compounds (Ar-N═O) and related species have a rich chemical history, and they continue to interest researchers in many fields. Among the most distinctive and puzzling properties of these compounds is their ability to dimerize reversibly to form...

Selecting spatial scale of covariates in regression models of environmental exposures.

Cancer informatics

Grant LP, Gennings C, Wheeler DC.
PMID: 25983543
Cancer Inform. 2015 Apr 27;14:81-96. doi: 10.4137/CIN.S17302. eCollection 2015.

Environmental factors or socioeconomic status variables used in regression models to explain environmental chemical exposures or health outcomes are often in practice modeled at the same buffer distance or spatial scale. In this paper, we present four model selection...

Carcinogenic tryptophan pyrolysis products in cigarette smoke condensate and cigarette smoke-polluted indoor air.

Environmental pollution (Barking, Essex : 1987)

Manabe S, Wada O.
PMID: 15092297
Environ Pollut. 1990;64(2):121-32. doi: 10.1016/0269-7491(90)90109-p.

The carcinogenic tryptophan pyrolysis products, 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) and 3-amino-1-methyl-5H-pyrido-[4,3-b]indole (Trp-P-2), have been measured in condensate of cigarette mainstream smoke by high-performance liquid chromatography. These carcinogens have been detected in indoor air as well as in the air of the...

Can the nitroso ene reaction proceed concertedly?.

Organic letters

Lu X.
PMID: 15281776
Org Lett. 2004 Aug 05;6(16):2813-5. doi: 10.1021/ol048912j.

All nitroso ene reactions so far reported follow exclusively stepwise reaction paths. Herein, we report the first concerted nitroso ene reaction that occurs between o-isotoluene (or its naphthalenic analogues) and nitroso compounds (e.g., nitrosomethane and 4-nitronitrosobenzene). [reaction: see text]

An unexpected N-heterocyclic carbene-catalyzed annulation of enals and nitroso compounds.

The Journal of organic chemistry

Yang L, Tan B, Wang F, Zhong G.
PMID: 19170534
J Org Chem. 2009 Feb 20;74(4):1744-6. doi: 10.1021/jo802515g.

The N-heterocyclic carbene (NHC)-catalyzed annulation of enals with nitroso compounds in the presence of DBU in THF has been described. Unexpected seven-membered 4-azalactones were formed according to a process involving a 1,2-Bamberger-type rearrangement.

A screening procedure for total N-nitroso contaminants in personal care products: results of collaborative studies undertaken by a CTPA Working Group.

International journal of cosmetic science

Challis BC, Colling J, Cromie DD, Guthrie WG, Pollock JR, Taylor P, Telling GM, Wallace L.
PMID: 19245470
Int J Cosmet Sci. 1995 Dec;17(6):219-31. doi: 10.1111/j.1467-2494.1995.tb00127.x.

Synopsis A modified procedure for the determination of total N-nitroso compounds in personal care products was evaluated in collaborative studies organized through the UK Cosmetic Toiletry and Perfumery Association (CTPA). The method offers a true 'totals'determination in that a...

Construction of an N-nitroso database for assessing dietary intake.

Journal of food composition and analysis : an official publication of the United Nations University, International Network of Food Data Systems

Stuff JE, Goh ET, Barrera SL, Bondy ML, Forman MR.
PMID: 20161416
J Food Compost Anal. 2009 Dec 01;22:S42-S47. doi: 10.1016/j.jfca.2009.01.008.

Dietary N-nitroso compounds are carcinogens synthesized during food processing from two main classes of precursors, oxides of nitrogen and amines or amides. Quantification of the dietary intake of N-nitroso compounds is significant to human cancers, including those of the...

Identification of nitroso compounds from biotransformation of 2,4-dinitrotoluene.

Applied and environmental microbiology

Liu D, Thomson K, Anderson AC.
PMID: 16346568
Appl Environ Microbiol. 1984 Jun;47(6):1295-8. doi: 10.1128/aem.47.6.1295-1298.1984.

The intermediates of microbial transformation of 2,4-dinitrotoluene by a mixed bacterial culture derived from activated sludge were identified as 2-amino-4-nitrotoluene, 4-amino-2-nitrotoluene, 2-nitroso-4-nitrotoluene, and 4-nitroso-2-nitrotoluene. The biotransformation of 2,4-dinitrotoluene occurred only under anaerobic conditions with an exogenous carbon source. The...

Quantum Chemical Calculations of Monomer-Dimer Equilibria of Aromatic C-Nitroso Compounds.

The journal of physical chemistry. A

Varga K, Biljan I, Tomišić V, Mihalić Z, Vančik H.
PMID: 29381362
J Phys Chem A. 2018 Mar 08;122(9):2542-2549. doi: 10.1021/acs.jpca.7b12179. Epub 2018 Feb 22.

Monomer-dimer equilibria of nitrosobenzene and 2-nitrosopyridine in gas phase and solution were studied by range of quantum chemical methods in an attempt to find the level of theory suitable for modeling dimerization reactions of aromatic C-nitroso compounds in general....

Dissecting the mechanisms and molecules underlying the potential carcinogenicity of red and processed meat in colorectal cancer (CRC): an overview on the current state of knowledge.

Infectious agents and cancer

Cascella M, Bimonte S, Barbieri A, Del Vecchio V, Caliendo D, Schiavone V, Fusco R, Granata V, Arra C, Cuomo A.
PMID: 29371880
Infect Agent Cancer. 2018 Jan 15;13:3. doi: 10.1186/s13027-018-0174-9. eCollection 2018.

Meat is a crucial nutrient for human health since it represents a giant supply of proteins, minerals, and vitamins. On the opposite hand, the intake of red and processed meat is taken into account dangerous due to its potential...

Prenatal nitrosatable prescription drug intake, drinking water nitrate, and the risk of stillbirth: a register- and population-based cohort of Danish pregnancies, 1997-2017.

Environmental health : a global access science source

Thomsen AML, Ramlau-Hansen CH, Schullehner J, Ebdrup NH, Liew Z, Coffman V, Stayner L, Hansen B, Olsen J.
PMID: 34781958
Environ Health. 2021 Nov 16;20(1):118. doi: 10.1186/s12940-021-00805-z.

BACKGROUND: Nitrosatable drugs commonly prescribed during pregnancy can react with nitrite to form N-nitroso compounds which have been associated with an increased risk of stillbirth. Whether maternal residential drinking water nitrate modifies this association is unknown. We investigated, if...

Dietary N-Nitroso Compounds and Risk of Hepatocellular Carcinoma: A USA-Based Study.

Hepatology (Baltimore, Md.)

Zheng J, Daniel CR, Hatia RI, Stuff J, Abdelhakeem AA, Rashid A, Chun YS, Jalal PK, Kaseb AO, Li D, Hassan MM.
PMID: 34233041
Hepatology. 2021 Dec;74(6):3161-3173. doi: 10.1002/hep.32046. Epub 2021 Aug 26.

BACKGROUND AND AIMS: N-nitroso compounds (NOCs) are among the most potent dietary carcinogens. N-nitrosodiethylamine (NDEA), N-nitrosodimethylamine (NDMA), and N-nitrosopiperidine (NPIP) are abundant in foods and carcinogenic to the liver. We investigated the relationship between dietary NOCs and HCC risk.APPROACH...

Showing 1 to 12 of 118 entries