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ATP as a multi-target danger signal in the brain.

Frontiers in neuroscience

Rodrigues RJ, Tomé AR, Cunha RA.
PMID: 25972780
Front Neurosci. 2015 Apr 28;9:148. doi: 10.3389/fnins.2015.00148. eCollection 2015.

ATP is released in an activity-dependent manner from different cell types in the brain, fulfilling different roles as a neurotransmitter, neuromodulator, in astrocyte-to-neuron communication, propagating astrocytic responses and formatting microglia responses. This involves the activation of different ATP P2...

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Rodrigues RJ, Tomé AR, Cunha RA. ATP as a multi-target danger signal in the brain. Front Neurosci. 2015;9:148doi: 10.3389/fnins.2015.00148.
Rodrigues, R. J., Tomé, A. R., & Cunha, R. A. (2015). ATP as a multi-target danger signal in the brain. Frontiers in neuroscience, 9148. https://doi.org/10.3389/fnins.2015.00148
Rodrigues, Ricardo J, et al. "ATP as a multi-target danger signal in the brain." Frontiers in neuroscience vol. 9 (2015): 148. doi: https://doi.org/10.3389/fnins.2015.00148
Rodrigues RJ, Tomé AR, Cunha RA. ATP as a multi-target danger signal in the brain. Front Neurosci. 2015 Apr 28;9:148. doi: 10.3389/fnins.2015.00148. eCollection 2015. PMID: 25972780; PMCID: PMC4412015.
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Phosphoprotein Phosphatase of Soybean Hypocotyls: PURIFICATION, PROPERTIES, AND SUBSTRATE SPECIFICITIES .

Plant physiology

Lin PP.
PMID: 16661438
Plant Physiol. 1980 Sep;66(3):368-74. doi: 10.1104/pp.66.3.368.

A soybean histone-type protein kinase was used to prepare (32)P-labeled histone H1 as substrate for purification and characterization of a phosphoprotein phosphatase (EC 3.1.3.16) from soybean hypocotyls. The phosphatase has been purified 169-fold by ammonium sulfate fractionation, ethanol precipitation,...

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Lin PP. Phosphoprotein Phosphatase of Soybean Hypocotyls: PURIFICATION, PROPERTIES, AND SUBSTRATE SPECIFICITIES . Plant Physiol. 1980;66(3):368-74doi: 10.1104/pp.66.3.368.
Lin, P. P. (1980). Phosphoprotein Phosphatase of Soybean Hypocotyls: PURIFICATION, PROPERTIES, AND SUBSTRATE SPECIFICITIES . Plant physiology, 66(3), 368-74. https://doi.org/10.1104/pp.66.3.368
Lin, P P. "Phosphoprotein Phosphatase of Soybean Hypocotyls: PURIFICATION, PROPERTIES, AND SUBSTRATE SPECIFICITIES ." Plant physiology vol. 66,3 (1980): 368-74. doi: https://doi.org/10.1104/pp.66.3.368
Lin PP. Phosphoprotein Phosphatase of Soybean Hypocotyls: PURIFICATION, PROPERTIES, AND SUBSTRATE SPECIFICITIES . Plant Physiol. 1980 Sep;66(3):368-74. doi: 10.1104/pp.66.3.368. PMID: 16661438; PMCID: PMC440636.
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Physiological level of norepinephrine increases adenine nucleotides hydrolysis in rat blood serum.

Purinergic signalling

Detanico BC, Rozisky JR, Battastini AM, Torres IL.
PMID: 21833697
Purinergic Signal. 2011 Dec;7(4):373-9. doi: 10.1007/s11302-011-9253-8. Epub 2011 Aug 11.

Extracellular adenosine 5'-triphosphate (ATP) and its breakdown products, adenosine 5'-diphosphate (ADP) and adenosine, have significant effects on a variety of biological processes. NTPDase enzymes, responsible for adenine nucleotides hydrolysis, are considered the major regulators of purinergic signaling in the...

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Detanico BC, Rozisky JR, Battastini AM, et al. Physiological level of norepinephrine increases adenine nucleotides hydrolysis in rat blood serum. Purinergic Signal. 2011;7(4):373-9doi: 10.1007/s11302-011-9253-8.
Detanico, B. C., Rozisky, J. R., Battastini, A. M., & Torres, I. L. (2011). Physiological level of norepinephrine increases adenine nucleotides hydrolysis in rat blood serum. Purinergic signalling, 7(4), 373-9. https://doi.org/10.1007/s11302-011-9253-8
Detanico, Bernardo Carraro, et al. "Physiological level of norepinephrine increases adenine nucleotides hydrolysis in rat blood serum." Purinergic signalling vol. 7,4 (2011): 373-9. doi: https://doi.org/10.1007/s11302-011-9253-8
Detanico BC, Rozisky JR, Battastini AM, Torres IL. Physiological level of norepinephrine increases adenine nucleotides hydrolysis in rat blood serum. Purinergic Signal. 2011 Dec;7(4):373-9. doi: 10.1007/s11302-011-9253-8. Epub 2011 Aug 11. PMID: 21833697; PMCID: PMC3224644.
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Metabolic Aspects of Adenosine Functions in the Brain.

Frontiers in pharmacology

Garcia-Gil M, Camici M, Allegrini S, Pesi R, Tozzi MG.
PMID: 34054547
Front Pharmacol. 2021 May 14;12:672182. doi: 10.3389/fphar.2021.672182. eCollection 2021.

Adenosine, acting both through G-protein coupled adenosine receptors and intracellularly, plays a complex role in multiple physiological and pathophysiological processes by modulating neuronal plasticity, astrocytic activity, learning and memory, motor function, feeding, control of sleep and aging. Adenosine is...

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Garcia-Gil M, Camici M, Allegrini S, et al. Metabolic Aspects of Adenosine Functions in the Brain. Front Pharmacol. 2021;12:672182doi: 10.3389/fphar.2021.672182.
Garcia-Gil, M., Camici, M., Allegrini, S., Pesi, R., & Tozzi, M. G. (2021). Metabolic Aspects of Adenosine Functions in the Brain. Frontiers in pharmacology, 12672182. https://doi.org/10.3389/fphar.2021.672182
Garcia-Gil, Mercedes, et al. "Metabolic Aspects of Adenosine Functions in the Brain." Frontiers in pharmacology vol. 12 (2021): 672182. doi: https://doi.org/10.3389/fphar.2021.672182
Garcia-Gil M, Camici M, Allegrini S, Pesi R, Tozzi MG. Metabolic Aspects of Adenosine Functions in the Brain. Front Pharmacol. 2021 May 14;12:672182. doi: 10.3389/fphar.2021.672182. eCollection 2021. PMID: 34054547; PMCID: PMC8160517.
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Transcriptional and Metabolic Investigation in 5'-Nucleotidase Deficient Cancer Cell Lines.

Cells

Cadassou O, Forey P, Machon C, Petrotto E, Chettab K, Tozzi MG, Guitton J, Dumontet C, Cros-Perrial E, Jordheim LP.
PMID: 34831141
Cells. 2021 Oct 28;10(11). doi: 10.3390/cells10112918.

Enzymes of nucleoside and nucleotide metabolism regulate important cellular processes with potential impacts on nucleotide-unrelated parameters. We have used a set of CRISPR/Cas9-modified cell models expressing both, one, or none of the 5'-nucleotidases cN-II and CD73, together with RNA...

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Cadassou O, Forey P, Machon C, et al. Transcriptional and Metabolic Investigation in 5'-Nucleotidase Deficient Cancer Cell Lines. Cells. 2021;10(11)doi: 10.3390/cells10112918.
Cadassou, O., Forey, P., Machon, C., Petrotto, E., Chettab, K., Tozzi, M. G., Guitton, J., Dumontet, C., Cros-Perrial, E., & Jordheim, L. P. (2021). Transcriptional and Metabolic Investigation in 5'-Nucleotidase Deficient Cancer Cell Lines. Cells, 10(11), . https://doi.org/10.3390/cells10112918
Cadassou, Octavia, et al. "Transcriptional and Metabolic Investigation in 5'-Nucleotidase Deficient Cancer Cell Lines." Cells vol. 10,11 (2021). doi: https://doi.org/10.3390/cells10112918
Cadassou O, Forey P, Machon C, Petrotto E, Chettab K, Tozzi MG, Guitton J, Dumontet C, Cros-Perrial E, Jordheim LP. Transcriptional and Metabolic Investigation in 5'-Nucleotidase Deficient Cancer Cell Lines. Cells. 2021 Oct 28;10(11). doi: 10.3390/cells10112918. PMID: 34831141; PMCID: PMC8616413.
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Extracellular ATP reduces tumor sphere growth and cancer stem cell population in glioblastoma cells.

Purinergic signalling

Ledur PF, Villodre ES, Paulus R, Cruz LA, Flores DG, Lenz G.
PMID: 21818572
Purinergic Signal. 2012 Mar;8(1):39-48. doi: 10.1007/s11302-011-9252-9. Epub 2011 Aug 05.

Glioblastoma is the most aggressive tumor in the CNS and is characterized by having a cancer stem cell (CSC) subpopulation essential for tumor survival. The purinergic system plays an important role in glioma growth, since adenosine triphosphate (ATP) can...

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Ledur PF, Villodre ES, Paulus R, et al. Extracellular ATP reduces tumor sphere growth and cancer stem cell population in glioblastoma cells. Purinergic Signal. 2011;8(1):39-48doi: 10.1007/s11302-011-9252-9.
Ledur, P. F., Villodre, E. S., Paulus, R., Cruz, L. A., Flores, D. G., & Lenz, G. (2012). Extracellular ATP reduces tumor sphere growth and cancer stem cell population in glioblastoma cells. Purinergic signalling, 8(1), 39-48. https://doi.org/10.1007/s11302-011-9252-9
Ledur, Pítia Flores, et al. "Extracellular ATP reduces tumor sphere growth and cancer stem cell population in glioblastoma cells." Purinergic signalling vol. 8,1 (2012): 39-48. doi: https://doi.org/10.1007/s11302-011-9252-9
Ledur PF, Villodre ES, Paulus R, Cruz LA, Flores DG, Lenz G. Extracellular ATP reduces tumor sphere growth and cancer stem cell population in glioblastoma cells. Purinergic Signal. 2012 Mar;8(1):39-48. doi: 10.1007/s11302-011-9252-9. Epub 2011 Aug 05. PMID: 21818572; PMCID: PMC3286536.
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Liver damage and systemic inflammatory responses are exacerbated by the genetic deletion of CD39 in total hepatic ischemia.

Purinergic signalling

Sun X, Imai M, Nowak-Machen M, Guckelberger O, Enjyoji K, Wu Y, Khalpey Z, Berberat P, Munasinghe J, Robson SC.
PMID: 21656186
Purinergic Signal. 2011 Dec;7(4):427-34. doi: 10.1007/s11302-011-9239-6. Epub 2011 Jun 09.

Liver ischemia reperfusion injury is associated with both local damage to the hepatic vasculature and systemic inflammatory responses. CD39 is the dominant vascular endothelial cell ectonucleotidase and rapidly hydrolyses both adenosine triphosphate (ATP) and adenosine diphosphate to adenosine monophosphate....

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Sun X, Imai M, Nowak-Machen M, et al. Liver damage and systemic inflammatory responses are exacerbated by the genetic deletion of CD39 in total hepatic ischemia. Purinergic Signal. 2011;7(4):427-34doi: 10.1007/s11302-011-9239-6.
Sun, X., Imai, M., Nowak-Machen, M., Guckelberger, O., Enjyoji, K., Wu, Y., Khalpey, Z., Berberat, P., Munasinghe, J., & Robson, S. C. (2011). Liver damage and systemic inflammatory responses are exacerbated by the genetic deletion of CD39 in total hepatic ischemia. Purinergic signalling, 7(4), 427-34. https://doi.org/10.1007/s11302-011-9239-6
Sun, Xiaofeng, et al. "Liver damage and systemic inflammatory responses are exacerbated by the genetic deletion of CD39 in total hepatic ischemia." Purinergic signalling vol. 7,4 (2011): 427-34. doi: https://doi.org/10.1007/s11302-011-9239-6
Sun X, Imai M, Nowak-Machen M, Guckelberger O, Enjyoji K, Wu Y, Khalpey Z, Berberat P, Munasinghe J, Robson SC. Liver damage and systemic inflammatory responses are exacerbated by the genetic deletion of CD39 in total hepatic ischemia. Purinergic Signal. 2011 Dec;7(4):427-34. doi: 10.1007/s11302-011-9239-6. Epub 2011 Jun 09. PMID: 21656186; PMCID: PMC3224647.
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Ecto-5'-nucleotidase: Structure function relationships.

Purinergic signalling

Sträter N.
PMID: 18404474
Purinergic Signal. 2006 Jun;2(2):343-50. doi: 10.1007/s11302-006-9000-8. Epub 2006 May 16.

Ecto-5'-nucleotidase (ecto-5'-NT) is attached via a GPI anchor to the extracellular membrane, where it hydrolyses AMP to adenosine and phosphate. Related 5'-nucleotidases exist in bacteria, where they are exported into the periplasmic space. X-ray structures of the 5'-nucleotidase from...

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Sträter N. Ecto-5'-nucleotidase: Structure function relationships. Purinergic Signal. 2006;2(2):343-50doi: 10.1007/s11302-006-9000-8.
Sträter, N. (2006). Ecto-5'-nucleotidase: Structure function relationships. Purinergic signalling, 2(2), 343-50. https://doi.org/10.1007/s11302-006-9000-8
Sträter, Norbert. "Ecto-5'-nucleotidase: Structure function relationships." Purinergic signalling vol. 2,2 (2006): 343-50. doi: https://doi.org/10.1007/s11302-006-9000-8
Sträter N. Ecto-5'-nucleotidase: Structure function relationships. Purinergic Signal. 2006 Jun;2(2):343-50. doi: 10.1007/s11302-006-9000-8. Epub 2006 May 16. PMID: 18404474; PMCID: PMC2254484.
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The calcium activated nucleotidases: A diverse family of soluble and membrane associated nucleotide hydrolyzing enzymes.

Purinergic signalling

Smith TM, Kirley TL.
PMID: 18404472
Purinergic Signal. 2006 Jun;2(2):327-33. doi: 10.1007/s11302-005-5300-7. Epub 2006 Jun 01.

It has long been known that the salivary glands of hematophagous (blood-feeding) arthropods secrete soluble apyrases, which are potent nucleotide hydrolyzing enzymes capable of hydrolyzing extracellular ATP and ADP, the latter being a major agonist contributing to platelet aggregation....

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Smith TM, Kirley TL. The calcium activated nucleotidases: A diverse family of soluble and membrane associated nucleotide hydrolyzing enzymes. Purinergic Signal. 2006;2(2):327-33doi: 10.1007/s11302-005-5300-7.
Smith, T. M., & Kirley, T. L. (2006). The calcium activated nucleotidases: A diverse family of soluble and membrane associated nucleotide hydrolyzing enzymes. Purinergic signalling, 2(2), 327-33. https://doi.org/10.1007/s11302-005-5300-7
Smith, Thomas M, and Kirley, Terence L. "The calcium activated nucleotidases: A diverse family of soluble and membrane associated nucleotide hydrolyzing enzymes." Purinergic signalling vol. 2,2 (2006): 327-33. doi: https://doi.org/10.1007/s11302-005-5300-7
Smith TM, Kirley TL. The calcium activated nucleotidases: A diverse family of soluble and membrane associated nucleotide hydrolyzing enzymes. Purinergic Signal. 2006 Jun;2(2):327-33. doi: 10.1007/s11302-005-5300-7. Epub 2006 Jun 01. PMID: 18404472; PMCID: PMC2254480.
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Identification of Novel CD39 Inhibitors Based on Virtual Screening and Enzymatic Assays.

Journal of chemical information and modeling

Zhao Y, Chen X, Ding Z, He C, Gao G, Lyu S, Gao Y, Du J.
PMID: 34648290
J Chem Inf Model. 2021 Oct 14; doi: 10.1021/acs.jcim.1c00590. Epub 2021 Oct 14.

The accumulation of adenosine in the tumor microenvironment mediates immunosuppression and promotes tumor growth and proliferation. Intervention of the adenosine pathway is an important direction of antitumor immunity research. CD39 is an important ecto-nucleotidases for adenosine generation, therefore targeting...

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Zhao Y, Chen X, Ding Z, et al. Identification of Novel CD39 Inhibitors Based on Virtual Screening and Enzymatic Assays. J Chem Inf Model. 2021;doi: 10.1021/acs.jcim.1c00590.
Zhao, Y., Chen, X., Ding, Z., He, C., Gao, G., Lyu, S., Gao, Y., & Du, J. (2021). Identification of Novel CD39 Inhibitors Based on Virtual Screening and Enzymatic Assays. Journal of chemical information and modeling, . https://doi.org/10.1021/acs.jcim.1c00590
Zhao, Yunshuo, et al. "Identification of Novel CD39 Inhibitors Based on Virtual Screening and Enzymatic Assays." Journal of chemical information and modeling vol. (2021). doi: https://doi.org/10.1021/acs.jcim.1c00590
Zhao Y, Chen X, Ding Z, He C, Gao G, Lyu S, Gao Y, Du J. Identification of Novel CD39 Inhibitors Based on Virtual Screening and Enzymatic Assays. J Chem Inf Model. 2021 Oct 14; doi: 10.1021/acs.jcim.1c00590. Epub 2021 Oct 14. PMID: 34648290.
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ATPe Dynamics in Protozoan Parasites. Adapt or Perish.

Genes

Lauri N, Bazzi Z, Alvarez CL, Leal Denis MF, Schachter J, Herlax V, Ostuni MA, Schwarzbaum PJ.
PMID: 30591699
Genes (Basel). 2018 Dec 27;10(1). doi: 10.3390/genes10010016.

In most animals, transient increases of extracellular ATP (ATPe) are used for physiological signaling or as a danger signal in pathological conditions. ATPe dynamics are controlled by ATP release from viable cells and cell lysis, ATPe degradation and interconversion...

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Lauri N, Bazzi Z, Alvarez CL, et al. ATPe Dynamics in Protozoan Parasites. Adapt or Perish. Genes (Basel). 2018;10(1)doi: 10.3390/genes10010016.
Lauri, N., Bazzi, Z., Alvarez, C. L., Leal Denis, M. F., Schachter, J., Herlax, V., Ostuni, M. A., & Schwarzbaum, P. J. (2018). ATPe Dynamics in Protozoan Parasites. Adapt or Perish. Genes, 10(1), . https://doi.org/10.3390/genes10010016
Lauri, Natalia, et al. "ATPe Dynamics in Protozoan Parasites. Adapt or Perish." Genes vol. 10,1 (2018). doi: https://doi.org/10.3390/genes10010016
Lauri N, Bazzi Z, Alvarez CL, Leal Denis MF, Schachter J, Herlax V, Ostuni MA, Schwarzbaum PJ. ATPe Dynamics in Protozoan Parasites. Adapt or Perish. Genes (Basel). 2018 Dec 27;10(1). doi: 10.3390/genes10010016. PMID: 30591699; PMCID: PMC6356682.
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Guanosine, a guanine-based nucleoside relaxed isolated corpus cavernosum from mice through cGMP accumulation.

Purinergic signalling

de Souza Nicoletti A, Passos GR, Bertollotto GM, Lescano CH, de Oliveira MG, Antunes E, Mónica FZ.
PMID: 32458299
Purinergic Signal. 2020 Jun;16(2):241-249. doi: 10.1007/s11302-020-09702-5. Epub 2020 May 27.

In corpus cavernosum (CC), guanosine triphosphate (GTP) is converted into cyclic guanosine monophosphate (cGMP) to induce erection. The action of cGMP is terminated by phosphodiesterases and efflux transporters, which pump cGMP out of the cell. The nucleotides, GTP, and...

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de Souza Nicoletti A, Passos GR, Bertollotto GM, et al. Guanosine, a guanine-based nucleoside relaxed isolated corpus cavernosum from mice through cGMP accumulation. Purinergic Signal. 2020;16(2):241-249doi: 10.1007/s11302-020-09702-5.
de Souza Nicoletti, A., Passos, G. R., Bertollotto, G. M., Lescano, C. H., de Oliveira, M. G., Antunes, E., & Mónica, F. Z. (2020). Guanosine, a guanine-based nucleoside relaxed isolated corpus cavernosum from mice through cGMP accumulation. Purinergic signalling, 16(2), 241-249. https://doi.org/10.1007/s11302-020-09702-5
de Souza Nicoletti, Aline, et al. "Guanosine, a guanine-based nucleoside relaxed isolated corpus cavernosum from mice through cGMP accumulation." Purinergic signalling vol. 16,2 (2020): 241-249. doi: https://doi.org/10.1007/s11302-020-09702-5
de Souza Nicoletti A, Passos GR, Bertollotto GM, Lescano CH, de Oliveira MG, Antunes E, Mónica FZ. Guanosine, a guanine-based nucleoside relaxed isolated corpus cavernosum from mice through cGMP accumulation. Purinergic Signal. 2020 Jun;16(2):241-249. doi: 10.1007/s11302-020-09702-5. Epub 2020 May 27. PMID: 32458299; PMCID: PMC7367940.
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Showing 1 to 12 of 31 entries