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Showing 1 to 6 of 6 entries
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The role of cyclic nucleotide signaling pathways in cancer: targets for prevention and treatment.

Cancers

Fajardo AM, Piazza GA, Tinsley HN.
PMID: 24577242
Cancers (Basel). 2014 Feb 26;6(1):436-58. doi: 10.3390/cancers6010436.

For more than four decades, the cyclic nucleotides cyclic AMP (cAMP) and cyclic GMP (cGMP) have been recognized as important signaling molecules within cells. Under normal physiological conditions, cyclic nucleotides regulate a myriad of biological processes such as cell...

The effect of cyclic nucleotide analog drugs on the mediators release from basophils.

Advanced biomedical research

Eskandari N, Bastan R, Esfahani SH, Peachell PT.
PMID: 26261827
Adv Biomed Res. 2015 Jun 04;4:125. doi: 10.4103/2277-9175.158040. eCollection 2015.

BACKGROUND: The cyclic nucleotides, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), are intracellular second messengers that play an important role in modulating inflammatory cells involved in allergic diseases. In general, cAMP suppresses the activity of immune and...

Cyclic nucleotide signaling and pacemaker activity.

Progress in biophysics and molecular biology

Mika D, Fischmeister R.
PMID: 34298001
Prog Biophys Mol Biol. 2021 Nov;166:29-38. doi: 10.1016/j.pbiomolbio.2021.07.007. Epub 2021 Jul 20.

The sinoatrial node (SAN) is the natural pacemaker of the heart, producing the electrical impulse that initiates every heart beat. Its activity is tightly controlled by the autonomic nervous system, and by circulating and locally released factors. Neurohumoral regulation...

A short review on structure and role of cyclic-3',5'-adenosine monophosphate-specific phosphodiesterase 4 as a treatment tool.

Journal of research in pharmacy practice

Eskandari N, Mirmosayyeb O, Bordbari G, Bastan R, Yousefi Z, Andalib A.
PMID: 26645022
J Res Pharm Pract. 2015 Oct-Dec;4(4):175-81. doi: 10.4103/2279-042X.167043.

Cyclic nucleotide phosphodiesterases (PDEs) are known as a super-family of enzymes which catalyze the metabolism of the intracellular cyclic nucleotides, cyclic-3',5'-adenosine monophosphate (cAMP), and cyclic-3',5'-guanosine monophosphate that are expressed in a variety of cell types that can exert various...

Platelet cAMP and cGMP Phosphodiesterases.

Platelets

Sheth SB, Colman RW.
PMID: 21043695
Platelets. 1995;6(2):61-70. doi: 10.3109/09537109509078445.

Platelets respond to a wide variety of exogenous agonists that bind to distinct receptors on the platelet surface resulting in the intracellular generation of second messengers or the opening of ion channels, setting off a cascade of events leading...

Effects of cyclic nucleotide-gated channels in vestibular nuclear neurons.

Chonnam medical journal

Heo T, Jang S, Jeong HS, Park JS.
PMID: 22247915
Chonnam Med J. 2011 Dec;47(3):155-9. doi: 10.4068/cmj.2011.47.3.155. Epub 2011 Dec 26.

This study was designed to investigate the effects an 8-Br-cGMP on the neuronal activity of rat vestibular nuclear cells. Sprague-Dawley rats aged 14 to 16 days were decapitated under ether anesthesia. After treatment with pronase and thermolysin, the dissociated...

Showing 1 to 6 of 6 entries