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Showing 1 to 12 of 30 entries
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Separation of 32P-labelled ribonucleic acid components. The use of polyethylenimine-cellulose (TLC) as a second dimension in separating oligoribonucleotides of '4.5 S' and 5 S from E. coli.

FEBS letters

Griffin BE.
PMID: 11945838
FEBS Lett. 1971 Jun 24;15(3):165-168. doi: 10.1016/0014-5793(71)80304-6.

No abstract available.

Chloride channels and the reactions of cells to topography.

European cells & materials

Tobasnick G, Curtis AS.
PMID: 14562255
Eur Cell Mater. 2001 Dec 13;2:49-61. doi: 10.22203/ecm.v002a06.

The reactions of rat epitenon cells to substratum topography on the micrometric and nanometric scale such as groove-ridge structures include cell extension, elongation and orientation reactions. In this paper we report that stretch-sensitive chloride channels may be involved in...

Photooxidation of nucleic acids on metal oxides: physico-chemical and astrobiological perspectives.

The journal of physical chemistry. C, Nanomaterials and interfaces

Shkrob IA, Marin TM, Adhikary A, Sevilla MD.
PMID: 21399705
J Phys Chem C Nanomater Interfaces. 2011 Feb 07;115(8):3393-3403. doi: 10.1021/jp110682c.

Photocatalytic oxidation of nucleic acid components on aqueous metal oxides (TiO(2), α-FeOOH, and α-Fe(2)O(3)) has been studied. The oxidation of purine nucleotides results in the formation of the purine radical cations and sugar-phosphate radicals, whereas the oxidation of pyrimidine...

Pre-Clinical and Clinical Efficiency of Complexes of Oligoribonucleotides with D-Mannitol against Respiratory Viruses.

Pharmaceutics

Melnichuk N, Zarubaev V, Iosyk I, Andreychyn M, Semernikova L, Tkachuk Z.
PMID: 29783756
Pharmaceutics. 2018 May 19;10(2). doi: 10.3390/pharmaceutics10020059.

Oligoribonucleotides-D-mannitol (ORNs-D-M) complexes possess antiviral, anti-inflammatory, and immunomodulatory actions. The aim of the present study was to evaluated an antiviral effect of ORNs-D-M against parainfluenza virus type 3 (PIV3); influenza CA709, PR834; avian influenza virus H5N2 (AIV) in vitro...

Efficient access to .

Monatshefte fur chemie

Falschlunger C, Micura R.
PMID: 31178603
Monatsh Chem. 2019;150(5):795-800. doi: 10.1007/s00706-019-02390-x. Epub 2019 Apr 29.

No abstract available.

The Cellular Processing Capacity Limits the Amounts of Chimeric U7 snRNA Available for Antisense Delivery.

Molecular therapy. Nucleic acids

Eckenfelder A, Tordo J, Babbs A, Davies KE, Goyenvalle A, Danos O.
PMID: 23344083
Mol Ther Nucleic Acids. 2012 Jun 26;1:e31. doi: 10.1038/mtna.2012.24.

Many genetic diseases are induced by mutations disturbing the maturation of pre-mRNAs, often affecting splicing. Antisense oligoribonucleotides (AONs) have been used to modulate splicing thereby circumventing the deleterious effects of mutations. Stable delivery of antisense sequences is achieved by...

Draft Genome Sequence of Bacillus pumilus 7P, Isolated from the Soil of the Tatarstan Republic, Russia.

Genome announcements

Shagimardanova EI, Toymentseva AA, Balaban NP, Mardanova AM, Danilova YV, Gusev OA, Kostryukova E, Karpova I, Manolov A, Alexeev D, Sharipova MR.
PMID: 24926064
Genome Announc. 2014 Jun 12;2(3). doi: 10.1128/genomeA.00599-14.

Here, we present a draft genome sequence of Bacillus pumilus strain 7P. This strain was isolated from soil as an extracellular RNase-producing microorganism. The RNase of B. pumilus 7P is considered to be a potential antiviral and therapeutic antitumor...

Oligoarginine peptides slow strand annealing and assist non-enzymatic RNA replication.

Nature chemistry

Jia TZ, Fahrenbach AC, Kamat NP, Adamala KP, Szostak JW.
PMID: 27657866
Nat Chem. 2016 Oct;8(10):915-21. doi: 10.1038/nchem.2551. Epub 2016 Jun 27.

The non-enzymatic replication of RNA is thought to have been a critical process required for the origin of life. One unsolved difficulty with non-enzymatic RNA replication is that template-directed copying of RNA results in a double-stranded product. After strand...

The model structure of the hammerhead ribozyme formed by RNAs of reciprocal chirality.

Bioscience reports

Wyszko E, Popenda M, Gudanis D, Sarzyńska J, Belter A, Perrigue P, Skowronek P, Rolle K, Barciszewski J.
PMID: 33351058
Biosci Rep. 2021 Jan 29;41(1). doi: 10.1042/BSR20203424.

RNA-based tools are frequently used to modulate gene expression in living cells. However, the stability and effectiveness of such RNA-based tools is limited by cellular nuclease activity. One way to increase RNA's resistance to nucleases is to replace its...

Assessment of configurations and chemistries of bridged nucleic acids-containing oligomers as external guide sequences: a methodology for inhibition of expression of antibiotic resistance genes.

Biology methods & protocols

Jackson A, Jani S, Sala CD, Soler-Bistué AJ, Zorreguieta A, Tolmasky ME.
PMID: 27857983
Biol Methods Protoc. 2016 Mar;1(1). doi: 10.1093/biomethods/bpw001. Epub 2016 Mar 01.

EGSs (external guide sequences) are short antisense oligoribonucleotides that elicit RNase P-mediated cleavage of a target mRNA, which results in inhibition of gene expression. EGS technology is used to inhibit expression of a wide variety of genes, a strategy...

Oligoribonucleotides as primer for terminal deoxynucleotidyl transferase.

FEBS letters

Feix G.
PMID: 11946141
FEBS Lett. 1971 Nov 01;18(2):280-282. doi: 10.1016/0014-5793(71)80465-9.

No abstract available.

Evidence for RNA-Oligonucleotides in Plant Vacuoles Isolated from Cultured Tomato Cells.

Plant physiology

Abel S, Blume B, Glund K.
PMID: 16667812
Plant Physiol. 1990 Nov;94(3):1163-71. doi: 10.1104/pp.94.3.1163.

We have shown that highly purified vacuoles of suspension-cultured tomato (Lycopersicon esculentum) cells contain RNA-oligonucleotides, using two different approaches to label and detect RNA: (a) in vivo labeling of cellular RNA with [5-(3)H]uridine, followed by preparation of vacuoles from...

Showing 1 to 12 of 30 entries