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Serum- and glucocorticoid-inducible kinase sgk2 stimulates the transport activity of human organic anion transporters 1 by enhancing the stability of the transporter.

International journal of biochemistry and molecular biology

Xu D, Huang H, Toh MF, You G.
PMID: 27335683
Int J Biochem Mol Biol. 2016 Jun 01;7(1):19-26. eCollection 2016.

Human organic anion transporter 1 (hOAT1) belongs to a family of organic anion transporters that play critical roles in the body disposition of clinically important drugs, including anti-viral therapeutics, anti-cancer drugs, antibiotics, antihypertensives, and anti-inflammatories. hOAT1 is abundantly expressed...

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Xu D, Huang H, Toh MF, et al. Serum- and glucocorticoid-inducible kinase sgk2 stimulates the transport activity of human organic anion transporters 1 by enhancing the stability of the transporter. Int J Biochem Mol Biol. 2016;7(1):19-26
Xu, D., Huang, H., Toh, M. F., & You, G. (2016). Serum- and glucocorticoid-inducible kinase sgk2 stimulates the transport activity of human organic anion transporters 1 by enhancing the stability of the transporter. International journal of biochemistry and molecular biology, 7(1), 19-26.
Xu, Da, et al. "Serum- and glucocorticoid-inducible kinase sgk2 stimulates the transport activity of human organic anion transporters 1 by enhancing the stability of the transporter." International journal of biochemistry and molecular biology vol. 7,1 (2016): 19-26.
Xu D, Huang H, Toh MF, You G. Serum- and glucocorticoid-inducible kinase sgk2 stimulates the transport activity of human organic anion transporters 1 by enhancing the stability of the transporter. Int J Biochem Mol Biol. 2016 Jun 01;7(1):19-26. eCollection 2016. PMID: 27335683; PMCID: PMC4913228.
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Intestinal absorption of drugs mediated by drug transporters: mechanisms and regulation.

Drug metabolism and pharmacokinetics

Katsura T, Inui K.
PMID: 15618714
Drug Metab Pharmacokinet. 2003;18(1):1-15. doi: 10.2133/dmpk.18.1.

The absorption of drugs from the gastrointestinal tract is one of the important determinants for oral bioavailability. Development of in vitro experimental techniques such as isolated membrane vesicles and cell culture systems has allowed us to elucidate the transport...

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Katsura T, Inui K. Intestinal absorption of drugs mediated by drug transporters: mechanisms and regulation. Drug Metab Pharmacokinet. 2003;18(1):1-15doi: 10.2133/dmpk.18.1.
Katsura, T., & Inui, K. (2003). Intestinal absorption of drugs mediated by drug transporters: mechanisms and regulation. Drug metabolism and pharmacokinetics, 18(1), 1-15. https://doi.org/10.2133/dmpk.18.1
Katsura, Toshiya, and Inui, Ken-Ichi. "Intestinal absorption of drugs mediated by drug transporters: mechanisms and regulation." Drug metabolism and pharmacokinetics vol. 18,1 (2003): 1-15. doi: https://doi.org/10.2133/dmpk.18.1
Katsura T, Inui K. Intestinal absorption of drugs mediated by drug transporters: mechanisms and regulation. Drug Metab Pharmacokinet. 2003;18(1):1-15. doi: 10.2133/dmpk.18.1. PMID: 15618714.
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Use of monolayers of primary rat kidney cortex cells for nephrotoxicity studies.

Toxicology in vitro : an international journal published in association with BIBRA

Bruggeman IM, Mertens JJ, Temmink JH, Lans MC, Vos RM, van Bladeren PJ.
PMID: 20702291
Toxicol In Vitro. 1989;3(4):261-9. doi: 10.1016/0887-2333(89)90032-5.

Kidney cells were isolated from rat kidney cortex and maintained in short-term monolayer cultures. A number of important parameters were studied in order to establish the usefulness of these cells for toxicity studies. Despite morphological differences between the cultured...

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Bruggeman IM, Mertens JJ, Temmink JH, et al. Use of monolayers of primary rat kidney cortex cells for nephrotoxicity studies. Toxicol In Vitro. 1989;3(4):261-9doi: 10.1016/0887-2333(89)90032-5.
Bruggeman, I. M., Mertens, J. J., Temmink, J. H., Lans, M. C., Vos, R. M., & van Bladeren, P. J. (1989). Use of monolayers of primary rat kidney cortex cells for nephrotoxicity studies. Toxicology in vitro : an international journal published in association with BIBRA, 3(4), 261-9. https://doi.org/10.1016/0887-2333(89)90032-5
Bruggeman, I M, et al. "Use of monolayers of primary rat kidney cortex cells for nephrotoxicity studies." Toxicology in vitro : an international journal published in association with BIBRA vol. 3,4 (1989): 261-9. doi: https://doi.org/10.1016/0887-2333(89)90032-5
Bruggeman IM, Mertens JJ, Temmink JH, Lans MC, Vos RM, van Bladeren PJ. Use of monolayers of primary rat kidney cortex cells for nephrotoxicity studies. Toxicol In Vitro. 1989;3(4):261-9. doi: 10.1016/0887-2333(89)90032-5. PMID: 20702291.
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Cytotoxicity of 2-tert-butyl hydroquinone glutathione conjugates after apical and basolateral exposure of rat renal proximal tubular cell monolayers.

Toxicology in vitro : an international journal published in association with BIBRA

Haenen HE, Bleijlevens E, Elzerman H, Temmink JH, Koeman JH, Van Bladeren PJ.
PMID: 20650192
Toxicol In Vitro. 1996 Apr;10(2):141-8. doi: 10.1016/0887-2333(95)00116-6.

Confluent monolayers of renal proximal tubular (RPT) cells cultured on porous supports were used to investigate the cytotoxicity induced by glutathione conjugates of 2-tert-butyl-(1,4)-hydroquinone (SG-TBHQ) after apical and basolateral exposure. As judged from lactate dehydrogenase (LDH) leakage, cytotoxicity was...

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Haenen HE, Bleijlevens E, Elzerman H, et al. Cytotoxicity of 2-tert-butyl hydroquinone glutathione conjugates after apical and basolateral exposure of rat renal proximal tubular cell monolayers. Toxicol In Vitro. 1996;10(2):141-8doi: 10.1016/0887-2333(95)00116-6.
Haenen, H. E., Bleijlevens, E., Elzerman, H., Temmink, J. H., Koeman, J. H., & Van Bladeren, P. J. (1996). Cytotoxicity of 2-tert-butyl hydroquinone glutathione conjugates after apical and basolateral exposure of rat renal proximal tubular cell monolayers. Toxicology in vitro : an international journal published in association with BIBRA, 10(2), 141-8. https://doi.org/10.1016/0887-2333(95)00116-6
Haenen, H E, et al. "Cytotoxicity of 2-tert-butyl hydroquinone glutathione conjugates after apical and basolateral exposure of rat renal proximal tubular cell monolayers." Toxicology in vitro : an international journal published in association with BIBRA vol. 10,2 (1996): 141-8. doi: https://doi.org/10.1016/0887-2333(95)00116-6
Haenen HE, Bleijlevens E, Elzerman H, Temmink JH, Koeman JH, Van Bladeren PJ. Cytotoxicity of 2-tert-butyl hydroquinone glutathione conjugates after apical and basolateral exposure of rat renal proximal tubular cell monolayers. Toxicol In Vitro. 1996 Apr;10(2):141-8. doi: 10.1016/0887-2333(95)00116-6. PMID: 20650192.
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Interaction of Natural Dietary and Herbal Anionic Compounds and Flavonoids with Human Organic Anion Transporters 1 (SLC22A6), 3 (SLC22A8), and 4 (SLC22A11).

Evidence-based complementary and alternative medicine : eCAM

Wang L, Sweet DH.
PMID: 23573138
Evid Based Complement Alternat Med. 2013;2013:612527. doi: 10.1155/2013/612527. Epub 2013 Mar 21.

Active components of complementary/alternative medicines and natural supplements are often anionic compounds and flavonoids. As such, organic anion transporters (OATs) may play a key role in their pharmacokinetic and pharmacological profiles, and represent sites for adverse drug-drug interactions. Therefore,...

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Wang L, Sweet DH. Interaction of Natural Dietary and Herbal Anionic Compounds and Flavonoids with Human Organic Anion Transporters 1 (SLC22A6), 3 (SLC22A8), and 4 (SLC22A11). Evid Based Complement Alternat Med. 2013;2013:612527doi: 10.1155/2013/612527.
Wang, L., & Sweet, D. H. (2013). Interaction of Natural Dietary and Herbal Anionic Compounds and Flavonoids with Human Organic Anion Transporters 1 (SLC22A6), 3 (SLC22A8), and 4 (SLC22A11). Evidence-based complementary and alternative medicine : eCAM, 2013612527. https://doi.org/10.1155/2013/612527
Wang, Li, and Sweet, Douglas H. "Interaction of Natural Dietary and Herbal Anionic Compounds and Flavonoids with Human Organic Anion Transporters 1 (SLC22A6), 3 (SLC22A8), and 4 (SLC22A11)." Evidence-based complementary and alternative medicine : eCAM vol. 2013 (2013): 612527. doi: https://doi.org/10.1155/2013/612527
Wang L, Sweet DH. Interaction of Natural Dietary and Herbal Anionic Compounds and Flavonoids with Human Organic Anion Transporters 1 (SLC22A6), 3 (SLC22A8), and 4 (SLC22A11). Evid Based Complement Alternat Med. 2013;2013:612527. doi: 10.1155/2013/612527. Epub 2013 Mar 21. PMID: 23573138; PMCID: PMC3618943.
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Lesinurad: A significant advancement or just another addition to existing therapies of gout?.

Journal of pharmacology & pharmacotherapeutics

Gupta A, Sharma PK, Misra AK, Singh S.
PMID: 28163535
J Pharmacol Pharmacother. 2016 Oct-Dec;7(4):155-158. doi: 10.4103/0976-500X.195897.

Gout is a metabolic disorder that usually presents as recurrent episodes of acute arthritis due to deposition of crystals in joints and cartilages. Despite the availability of several drugs for gout, its management is still less than adequate. There...

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Gupta A, Sharma PK, Misra AK, et al. Lesinurad: A significant advancement or just another addition to existing therapies of gout?. J Pharmacol Pharmacother. 2016;7(4):155-158doi: 10.4103/0976-500X.195897.
Gupta, A., Sharma, P. K., Misra, A. K., & Singh, S. (2016). Lesinurad: A significant advancement or just another addition to existing therapies of gout?. Journal of pharmacology & pharmacotherapeutics, 7(4), 155-158. https://doi.org/10.4103/0976-500X.195897
Gupta, Ajay, et al. "Lesinurad: A significant advancement or just another addition to existing therapies of gout?." Journal of pharmacology & pharmacotherapeutics vol. 7,4 (2016): 155-158. doi: https://doi.org/10.4103/0976-500X.195897
Gupta A, Sharma PK, Misra AK, Singh S. Lesinurad: A significant advancement or just another addition to existing therapies of gout?. J Pharmacol Pharmacother. 2016 Oct-Dec;7(4):155-158. doi: 10.4103/0976-500X.195897. PMID: 28163535; PMCID: PMC5242027.
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Investigating the interaction between organic anion transporter 1 and ochratoxin A: An in silico structural study to depict early molecular events of substrate recruitment and the impact of single point mutations.

Toxicology letters

Louisse J, Dorne JLCM, Dellafiora L.
PMID: 34748852
Toxicol Lett. 2021 Nov 05;355:19-30. doi: 10.1016/j.toxlet.2021.11.001. Epub 2021 Nov 05.

Organic anion transporters (OATs) belong to a subgroup of the solute carrier 22 transporter family. OATs have a central role in xenobiotic disposition affecting the toxicokinetics of its substrates and inter-individual differences in their expression, activity and function impact...

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Louisse J, Dorne JLCM, Dellafiora L. Investigating the interaction between organic anion transporter 1 and ochratoxin A: An in silico structural study to depict early molecular events of substrate recruitment and the impact of single point mutations. Toxicol Lett. 2021;355:19-30doi: 10.1016/j.toxlet.2021.11.001.
Louisse, J., Dorne, J. L. C. M., & Dellafiora, L. (2021). Investigating the interaction between organic anion transporter 1 and ochratoxin A: An in silico structural study to depict early molecular events of substrate recruitment and the impact of single point mutations. Toxicology letters, 35519-30. https://doi.org/10.1016/j.toxlet.2021.11.001
Louisse, Jochem, et al. "Investigating the interaction between organic anion transporter 1 and ochratoxin A: An in silico structural study to depict early molecular events of substrate recruitment and the impact of single point mutations." Toxicology letters vol. 355 (2021): 19-30. doi: https://doi.org/10.1016/j.toxlet.2021.11.001
Louisse J, Dorne JLCM, Dellafiora L. Investigating the interaction between organic anion transporter 1 and ochratoxin A: An in silico structural study to depict early molecular events of substrate recruitment and the impact of single point mutations. Toxicol Lett. 2021 Nov 05;355:19-30. doi: 10.1016/j.toxlet.2021.11.001. Epub 2021 Nov 05. PMID: 34748852.
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Characterization of Novel Fluorescent Bile Salt Derivatives for Studying Human Bile Salt and Organic Anion Transporters.

The Journal of pharmacology and experimental therapeutics

Leuenberger M, Häusler S, Höhn V, Euler A, Stieger B, Lochner M.
PMID: 33782042
J Pharmacol Exp Ther. 2021 Jun;377(3):346-357. doi: 10.1124/jpet.120.000449. Epub 2021 Mar 29.

Bile salts, such as cholate, glycocholate, taurocholate, and glycochenodeoxycholate, are taken up from the portal blood into hepatocytes via transporters, such as the Na

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Leuenberger M, Häusler S, Höhn V, et al. Characterization of Novel Fluorescent Bile Salt Derivatives for Studying Human Bile Salt and Organic Anion Transporters. J Pharmacol Exp Ther. 2021;377(3):346-357doi: 10.1124/jpet.120.000449.
Leuenberger, M., Häusler, S., Höhn, V., Euler, A., Stieger, B., & Lochner, M. (2021). Characterization of Novel Fluorescent Bile Salt Derivatives for Studying Human Bile Salt and Organic Anion Transporters. The Journal of pharmacology and experimental therapeutics, 377(3), 346-357. https://doi.org/10.1124/jpet.120.000449
Leuenberger, Michele, et al. "Characterization of Novel Fluorescent Bile Salt Derivatives for Studying Human Bile Salt and Organic Anion Transporters." The Journal of pharmacology and experimental therapeutics vol. 377,3 (2021): 346-357. doi: https://doi.org/10.1124/jpet.120.000449
Leuenberger M, Häusler S, Höhn V, Euler A, Stieger B, Lochner M. Characterization of Novel Fluorescent Bile Salt Derivatives for Studying Human Bile Salt and Organic Anion Transporters. J Pharmacol Exp Ther. 2021 Jun;377(3):346-357. doi: 10.1124/jpet.120.000449. Epub 2021 Mar 29. PMID: 33782042.
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[Visualization of research on Chinese medicine-induced kidney injury by CiteSpace].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

Cheng FJ, Wang LX, Xie YM.
PMID: 34951199
Zhongguo Zhong Yao Za Zhi. 2021 Nov;46(21):5475-5485. doi: 10.19540/j.cnki.cjcmm.20210413.502.

This study aimed to provide researchers with a better understanding of the research status, progress and problems of Chinese medicine-induced kidney injury. The mapping knowledge domain(MKD) was chosen to visualize the research process, hotspots,and frontiers, thus providing a reference...

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Cheng FJ, Wang LX, Xie YM. [Visualization of research on Chinese medicine-induced kidney injury by CiteSpace]. Zhongguo Zhong Yao Za Zhi. 2021;46(21):5475-5485doi: 10.19540/j.cnki.cjcmm.20210413.502.
Cheng, F. J., Wang, L. X., & Xie, Y. M. (2021). [Visualization of research on Chinese medicine-induced kidney injury by CiteSpace]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 46(21), 5475-5485. https://doi.org/10.19540/j.cnki.cjcmm.20210413.502
Cheng, Feng-Jing-Ming, et al. "[Visualization of research on Chinese medicine-induced kidney injury by CiteSpace]." Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica vol. 46,21 (2021): 5475-5485. doi: https://doi.org/10.19540/j.cnki.cjcmm.20210413.502
Cheng FJ, Wang LX, Xie YM. [Visualization of research on Chinese medicine-induced kidney injury by CiteSpace]. Zhongguo Zhong Yao Za Zhi. 2021 Nov;46(21):5475-5485. doi: 10.19540/j.cnki.cjcmm.20210413.502. Chinese. PMID: 34951199.
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Investigating the interaction between organic anion transporter 1 and ochratoxin A: An in silico structural study to depict early molecular events of substrate recruitment and the impact of single point mutations.

Toxicology letters

Louisse J, Dorne JLCM, Dellafiora L.
PMID: 34748852
Toxicol Lett. 2022 Feb 01;355:19-30. doi: 10.1016/j.toxlet.2021.11.001. Epub 2021 Nov 05.

Organic anion transporters (OATs) belong to a subgroup of the solute carrier 22 transporter family. OATs have a central role in xenobiotic disposition affecting the toxicokinetics of its substrates and inter-individual differences in their expression, activity and function impact...

Cite
Louisse J, Dorne JLCM, Dellafiora L. Investigating the interaction between organic anion transporter 1 and ochratoxin A: An in silico structural study to depict early molecular events of substrate recruitment and the impact of single point mutations. Toxicol Lett. 2021;355:19-30doi: 10.1016/j.toxlet.2021.11.001.
Louisse, J., Dorne, J. L. C. M., & Dellafiora, L. (2022). Investigating the interaction between organic anion transporter 1 and ochratoxin A: An in silico structural study to depict early molecular events of substrate recruitment and the impact of single point mutations. Toxicology letters, 35519-30. https://doi.org/10.1016/j.toxlet.2021.11.001
Louisse, Jochem, et al. "Investigating the interaction between organic anion transporter 1 and ochratoxin A: An in silico structural study to depict early molecular events of substrate recruitment and the impact of single point mutations." Toxicology letters vol. 355 (2022): 19-30. doi: https://doi.org/10.1016/j.toxlet.2021.11.001
Louisse J, Dorne JLCM, Dellafiora L. Investigating the interaction between organic anion transporter 1 and ochratoxin A: An in silico structural study to depict early molecular events of substrate recruitment and the impact of single point mutations. Toxicol Lett. 2022 Feb 01;355:19-30. doi: 10.1016/j.toxlet.2021.11.001. Epub 2021 Nov 05. PMID: 34748852.
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Molecular Properties of Drugs Handled by Kidney OATs and Liver OATPs Revealed by Chemoinformatics and Machine Learning: Implications for Kidney and Liver Disease.

Pharmaceutics

Nigam AK, Ojha AA, Li JG, Shi D, Bhatnagar V, Nigam KB, Abagyan R, Nigam SK.
PMID: 34684013
Pharmaceutics. 2021 Oct 18;13(10). doi: 10.3390/pharmaceutics13101720.

In patients with liver or kidney disease, it is especially important to consider the routes of metabolism and elimination of small-molecule pharmaceuticals. Once in the blood, numerous drugs are taken up by the liver for metabolism and/or biliary elimination,...

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Nigam AK, Ojha AA, Li JG, et al. Molecular Properties of Drugs Handled by Kidney OATs and Liver OATPs Revealed by Chemoinformatics and Machine Learning: Implications for Kidney and Liver Disease. Pharmaceutics. 2021;13(10)doi: 10.3390/pharmaceutics13101720.
Nigam, A. K., Ojha, A. A., Li, J. G., Shi, D., Bhatnagar, V., Nigam, K. B., Abagyan, R., & Nigam, S. K. (2021). Molecular Properties of Drugs Handled by Kidney OATs and Liver OATPs Revealed by Chemoinformatics and Machine Learning: Implications for Kidney and Liver Disease. Pharmaceutics, 13(10), . https://doi.org/10.3390/pharmaceutics13101720
Nigam, Anisha K, et al. "Molecular Properties of Drugs Handled by Kidney OATs and Liver OATPs Revealed by Chemoinformatics and Machine Learning: Implications for Kidney and Liver Disease." Pharmaceutics vol. 13,10 (2021). doi: https://doi.org/10.3390/pharmaceutics13101720
Nigam AK, Ojha AA, Li JG, Shi D, Bhatnagar V, Nigam KB, Abagyan R, Nigam SK. Molecular Properties of Drugs Handled by Kidney OATs and Liver OATPs Revealed by Chemoinformatics and Machine Learning: Implications for Kidney and Liver Disease. Pharmaceutics. 2021 Oct 18;13(10). doi: 10.3390/pharmaceutics13101720. PMID: 34684013; PMCID: PMC8538396.
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Inhibitory effects of indoxyl sulfate and creatinine on the renal transport of meropenem and biapenem in rats.

Drug metabolism and pharmacokinetics

Ichimura Y, Kudoh N, Murabe T, Akao T, Watanuki S, Suzuki T, Saito T, Oda M, Saitoh H.
PMID: 34352708
Drug Metab Pharmacokinet. 2021 Oct;40:100406. doi: 10.1016/j.dmpk.2021.100406. Epub 2021 May 31.

Carbapenem antibiotics are excreted preferentially in the urine after intravenous administration, with organic anion transporters (OATs) known to be involved in the renal tubular secretion of carbapenem antibiotics. Various uremic toxins (UTs) accumulate in the blood of patients with...

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Ichimura Y, Kudoh N, Murabe T, et al. Inhibitory effects of indoxyl sulfate and creatinine on the renal transport of meropenem and biapenem in rats. Drug Metab Pharmacokinet. 2021;40:100406doi: 10.1016/j.dmpk.2021.100406.
Ichimura, Y., Kudoh, N., Murabe, T., Akao, T., Watanuki, S., Suzuki, T., Saito, T., Oda, M., & Saitoh, H. (2021). Inhibitory effects of indoxyl sulfate and creatinine on the renal transport of meropenem and biapenem in rats. Drug metabolism and pharmacokinetics, 40100406. https://doi.org/10.1016/j.dmpk.2021.100406
Ichimura, Yuichi, et al. "Inhibitory effects of indoxyl sulfate and creatinine on the renal transport of meropenem and biapenem in rats." Drug metabolism and pharmacokinetics vol. 40 (2021): 100406. doi: https://doi.org/10.1016/j.dmpk.2021.100406
Ichimura Y, Kudoh N, Murabe T, Akao T, Watanuki S, Suzuki T, Saito T, Oda M, Saitoh H. Inhibitory effects of indoxyl sulfate and creatinine on the renal transport of meropenem and biapenem in rats. Drug Metab Pharmacokinet. 2021 Oct;40:100406. doi: 10.1016/j.dmpk.2021.100406. Epub 2021 May 31. PMID: 34352708.
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Showing 1 to 12 of 84 entries