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Showing 1 to 12 of 83 entries
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Effect of orotic acid on the mitosis of phytohaemagglutinin stimulated human lymphocytes in culture.

Wilhelm Roux' Archiv fur Entwicklungsmechanik der Organismen

Timson J.
PMID: 28304468
Wilhelm Roux Arch Entwickl Mech Org. 1969 Jun;164(2):199-200. doi: 10.1007/BF00581999.

The addition of excess orotic acid to cultures of normal human lymphocytes stimulated with phytohaemagglutinin causes a reduction in the mitotic rate. It is suggested that this is caused by competition for the available 5-phosphoribosyl-1-pyrophosphate in the cell leading...

Metabolism of cytidine and uridine in bean leaves.

Plant physiology

Ross C, Cole CV.
PMID: 16656905
Plant Physiol. 1968 Aug;43(8):1227-31. doi: 10.1104/pp.43.8.1227.

The metabolism of cytidine-2-(14)C and uridine-2-(14)C was studied in discs cut from leaflets of bean plants (Phaseolus vulgaris L.). Cytidine was degraded to carbon dioxide and incorporated into RNA at about the same rates as was uridine. Both nucleosides...

Polyamines and nucleic acid metabolism in chick embryo. Incorporation of labelled precursors into nucleic acids of subcellular fractions and polyribosomal patterns.

The Biochemical journal

Moruzzi G, Barbiroli B, Caldarera CM.
PMID: 16742581
Biochem J. 1968 May;107(5):609-13. doi: 10.1042/bj1070609.

1. An increase in polyamine concentration, caused by inhibiting the amine oxidase activities with iproniazid, increased the incorporation of [(3)H]orotic acid into chick-embryo RNA and DNA. On the other hand, a decrease in polyamine concentration, obtained by causing an...

Effect of CO(2) on labelling of nerve and liver cells by nucleic acid precursors.

Neurochemistry international

Pakkenberg H, Fog R, Kjeldsen C.
PMID: 20487846
Neurochem Int. 1982;4(1):23-5. doi: 10.1016/0197-0186(82)90022-5.

In vivo experiments in mice demonstrated that 5% CO(2) content in the air inhaled did not change the labelling in autoradiograms from animals injected with [(3)H]uridine, [(3)H]orotic acid, [(3)H]hypoxanthine, [(3)H]lysine or [(3)H]cytidine. At 20% CO(2) content there was a...

Development of Pyrimidine-metabolizing Enzymes in Cotyledons of Germinating Peas.

Plant physiology

Ross C, Murray MG.
PMID: 16657849
Plant Physiol. 1971 Nov;48(5):626-30. doi: 10.1104/pp.48.5.626.

Mechanisms controlling conversion of orotic acid-6-(14)C to uridine-5'-phosphate in cotyledons of germinating Alaska peas (Pisum sativum L.) were investigated. The content of 5-phosphoribosyl-1-pyrophosphate was very low in dry seeds, increased to a maximum after about 12 hours of imbibition,...

Hyperammonemic coma in a post-partum patient with undiagnosed urea cycle defect.

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine

Dash SK, Chauhan M, Varma V, Sharma R, Kansal S, Chawla R.
PMID: 23983417
Indian J Crit Care Med. 2013 Mar;17(2):107-10. doi: 10.4103/0972-5229.114816.

Urea cycle disorders (UCD) are common during neonatal period, and it is rarely reported in adults. We are reporting a patient presenting with post-partum neuropsychiatric symptoms rapidly progressing to coma. Markedly raised serum ammonia level on presentation with an...

[Precursors of ribosomal RNA in freely suspended callus cells of parsley (Petroselinum sativum)].

Planta

Richter G.
PMID: 24468848
Planta. 1973 Mar;113(1):79-95. doi: 10.1007/BF00385191.

Six high molecular weight, rapidly labelled RNA species were detected in freely suspended callus cells of Petroselinum sativum by means of isotope labelling and electrophoretic separation in agarose-polyacrylamide gels. On the basis of their migration in the latter the...

Dependence of gibberellic acid-induced dark germination of lettuce seed on RNA synthesis.

Planta

Khan AA.
PMID: 24554268
Planta. 1966 Sep;72(3):284-8. doi: 10.1007/BF00386754.

Gibberellicacid-induced dark germination of Grand Rapids lettude seed was completely inhibited by 6-azauracil and partly by 2-thiouracil. Other inhibitors of nucleic acid and protein synthesis used were without effect. Inhibition of gibberellic acid-induced dark germination was reversed by uracil...

Changes of purine and pyrimidine nucleotide biosynthesis during shoot initiation from epicotyl explants of white spruce (Picea glauca).

Plant science : an international journal of experimental plant biology

Stasolla C, Loukanina N, Ashihara H, Yeung EC, Thorpe TA.
PMID: 22980203
Plant Sci. 2006 Sep;171(3):345-54. doi: 10.1016/j.plantsci.2006.04.004. Epub 2006 May 15.

Nucleotide metabolism was investigated during white spruce organogenesis by following the metabolic fate of (14)C-labeled adenine, adenosine and inosine, as purine precursors, and orotic acid, uridine, and uracil, as pyrimidine intermediates. Key enzymes of purine and pyrimidine metabolism were...

[Rapidly labelled low molecular weight components in nucleic acid preparations from plant cells].

Planta

Richter G, Grotha R.
PMID: 24458196
Planta. 1974 Sep;116(3):273-8. doi: 10.1007/BF00390233.

After pulse-labelling with [(3)H]nucleosides and [(3)H]orotic acid of freely suspended callus cells of Petroselinum sativum and tissue fragments of the liverwort Riella helicophylla, rapidly labelled low molecular weight components were detected among the total nucleic acids when these were...

Synergistic effect of eicosapentaenoic acid-enriched phospholipids and sea cucumber saponin on orotic acid-induced non-alcoholic fatty liver disease in rats.

Royal Society open science

Guo Y, Han X, Che H, Li Z, Dong P, Xue C, Zhang T, Wang Y.
PMID: 30109054
R Soc Open Sci. 2018 Jul 11;5(7):172182. doi: 10.1098/rsos.172182. eCollection 2018 Jul.

Non-alcoholic fatty liver disease (NAFLD) is becoming an increasingly prevalent chronic liver disease all over the world. The present study was undertaken to explore the synergistic effects of sea cucumber saponins (SCS) and eicosapentaenoic acid-enriched phospholipids (EPA-PL) at ratios...

Ornithine Transcarbamylase Deficiency: If at First You Do Not Diagnose, Try and Try Again.

Case reports in critical care

Santos CD, Ratzlaff RA, Meder JC, Atwal PS, Joyce NE.
PMID: 29279777
Case Rep Crit Care. 2017;2017:8724810. doi: 10.1155/2017/8724810. Epub 2017 Nov 27.

Ornithine transcarbamylase (OTC) deficiency is well known for its diagnosis in the neonatal period. Presentation often occurs after protein feeding and manifests as poor oral intake, vomiting, lethargy progressing to seizure, respiratory difficulty, and eventually coma. Presentation at adulthood...

Showing 1 to 12 of 83 entries