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Use of a flumazenil infusion to treat chlordiazepoxide toxicity.

Acute medicine

Wallace IR, Campbell EC, Trimble M.
PMID: 28424803
Acute Med. 2017;16(1):30-34.

"Alcohol detox" is a common presentation to acute medical services and is usually managed via standardised guidelines and protocols. We present a case of chlordiazepoxide toxicity, requiring repeated bolus doses and subsequently 24 hours of an intravenous infusion of...

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Wallace IR, Campbell EC, Trimble M. Use of a flumazenil infusion to treat chlordiazepoxide toxicity. Acute Med. 2017;16(1):30-34
Wallace, I. R., Campbell, E. C., & Trimble, M. (2017). Use of a flumazenil infusion to treat chlordiazepoxide toxicity. Acute medicine, 16(1), 30-34.
Wallace, I R, et al. "Use of a flumazenil infusion to treat chlordiazepoxide toxicity." Acute medicine vol. 16,1 (2017): 30-34.
Wallace IR, Campbell EC, Trimble M. Use of a flumazenil infusion to treat chlordiazepoxide toxicity. Acute Med. 2017;16(1):30-34. PMID: 28424803.
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Antidepressant/anxiolytic and anti-nociceptive effects of novel 2-substituted 1,4-benzodiazepine-2-ones.

Scientia pharmaceutica

Singh H, Sattayasai J, Lattmann P, Boonprakob Y, Lattmann E.
PMID: 21179341
Sci Pharm. 2010 Apr-Jun;78(2):155-69. doi: 10.3797/scipharm.1004-12. Epub 2010 May 17.

Oxazepam (4a) has been used as overall starting material in the synthesis of novel 2-substituted 1,4-benzodiazepines.By reacting Oxazepam 4a with commercially available hydrazines, hydrazides, semicarbazide, aminoguanidine and N,N-dimethylamino aniline in ethanol under acetic conditions, a series of diazenyl-1,4-benzodiazepines 5aâ5i...

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Singh H, Sattayasai J, Lattmann P, et al. Antidepressant/anxiolytic and anti-nociceptive effects of novel 2-substituted 1,4-benzodiazepine-2-ones. Sci Pharm. 2010;78(2):155-69doi: 10.3797/scipharm.1004-12.
Singh, H., Sattayasai, J., Lattmann, P., Boonprakob, Y., & Lattmann, E. (2010). Antidepressant/anxiolytic and anti-nociceptive effects of novel 2-substituted 1,4-benzodiazepine-2-ones. Scientia pharmaceutica, 78(2), 155-69. https://doi.org/10.3797/scipharm.1004-12
Singh, Harjit, et al. "Antidepressant/anxiolytic and anti-nociceptive effects of novel 2-substituted 1,4-benzodiazepine-2-ones." Scientia pharmaceutica vol. 78,2 (2010): 155-69. doi: https://doi.org/10.3797/scipharm.1004-12
Singh H, Sattayasai J, Lattmann P, Boonprakob Y, Lattmann E. Antidepressant/anxiolytic and anti-nociceptive effects of novel 2-substituted 1,4-benzodiazepine-2-ones. Sci Pharm. 2010 Apr-Jun;78(2):155-69. doi: 10.3797/scipharm.1004-12. Epub 2010 May 17. PMID: 21179341; PMCID: PMC3002793.
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Differential illness intrusiveness associated with sleep-promoting medications.

European psychiatry : the journal of the Association of European Psychiatrists

Devins G, Flanigan M, Fleming J, Morehouse R, Moscovitch A, Plamondon J, Reinish L, Shapiro C.
PMID: 19698412
Eur Psychiatry. 1995;10:153s-9s. doi: 10.1016/0924-9338(96)80097-6.

Differences in daytime sleepiness, lifestyle disruptions, and emotional distress were compared across nine groups taking sleep-promoting substances. Groups included individuals taking zopiclone (n = 274), amitriptyline (n = 107), lorazepam (n = 258), oxazepam (n= 141), diphenhydramine HCl (n...

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Devins G, Flanigan M, Fleming J, et al. Differential illness intrusiveness associated with sleep-promoting medications. Eur Psychiatry. 1995;10:153s-9sdoi: 10.1016/0924-9338(96)80097-6.
Devins, G., Flanigan, M., Fleming, J., Morehouse, R., Moscovitch, A., Plamondon, J., Reinish, L., & Shapiro, C. (1995). Differential illness intrusiveness associated with sleep-promoting medications. European psychiatry : the journal of the Association of European Psychiatrists, 10153s-9s. https://doi.org/10.1016/0924-9338(96)80097-6
Devins, G, et al. "Differential illness intrusiveness associated with sleep-promoting medications." European psychiatry : the journal of the Association of European Psychiatrists vol. 10 (1995): 153s-9s. doi: https://doi.org/10.1016/0924-9338(96)80097-6
Devins G, Flanigan M, Fleming J, Morehouse R, Moscovitch A, Plamondon J, Reinish L, Shapiro C. Differential illness intrusiveness associated with sleep-promoting medications. Eur Psychiatry. 1995;10:153s-9s. doi: 10.1016/0924-9338(96)80097-6. PMID: 19698412.
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Comparative amnesic and sedative effects of lorazepam and oxazepam in healthy volunteers.

Journal of psychopharmacology (Oxford, England)

Curran HV, Gorenstein C, Lader M.
PMID: 22290838
J Psychopharmacol. 1993 Jan;7(3):249-56. doi: 10.1177/026988119300700303.

Oxazepam and its chlorinated derivative, lorazepam, have similar half-lives but differing potencies. This study compared the effects of these two benzodiazepines with a placebo on memory, mood and psychomotor function. Thirty six volunteers took part in a double-blind, independent...

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Curran HV, Gorenstein C, Lader M. Comparative amnesic and sedative effects of lorazepam and oxazepam in healthy volunteers. J Psychopharmacol. 1993;7(3):249-56doi: 10.1177/026988119300700303.
Curran, H. V., Gorenstein, C., & Lader, M. (1993). Comparative amnesic and sedative effects of lorazepam and oxazepam in healthy volunteers. Journal of psychopharmacology (Oxford, England), 7(3), 249-56. https://doi.org/10.1177/026988119300700303
Curran, H V, et al. "Comparative amnesic and sedative effects of lorazepam and oxazepam in healthy volunteers." Journal of psychopharmacology (Oxford, England) vol. 7,3 (1993): 249-56. doi: https://doi.org/10.1177/026988119300700303
Curran HV, Gorenstein C, Lader M. Comparative amnesic and sedative effects of lorazepam and oxazepam in healthy volunteers. J Psychopharmacol. 1993 Jan;7(3):249-56. doi: 10.1177/026988119300700303. PMID: 22290838.
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The capillary gap sampler, a new microfluidic platform for direct coupling of automated solid-phase microextraction with ESI-MS.

Analytical and bioanalytical chemistry

Ghiasikhou S, da Silva MF, Zhu Y, Zenobi R.
PMID: 29046923
Anal Bioanal Chem. 2017 Nov;409(29):6873-6883. doi: 10.1007/s00216-017-0652-8. Epub 2017 Oct 18.

A new technology for rapid, automated coupling of solid-phase microextraction and mass spectrometry is introduced. Use of a so-called capillary gap sampler for automated solid-phase microextraction and direct delivery of the extracted analytes to a mass spectrometer provides certain...

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Ghiasikhou S, da Silva MF, Zhu Y, et al. The capillary gap sampler, a new microfluidic platform for direct coupling of automated solid-phase microextraction with ESI-MS. Anal Bioanal Chem. 2017;409(29):6873-6883doi: 10.1007/s00216-017-0652-8.
Ghiasikhou, S., da Silva, M. F., Zhu, Y., & Zenobi, R. (2017). The capillary gap sampler, a new microfluidic platform for direct coupling of automated solid-phase microextraction with ESI-MS. Analytical and bioanalytical chemistry, 409(29), 6873-6883. https://doi.org/10.1007/s00216-017-0652-8
Ghiasikhou, Sahar, et al. "The capillary gap sampler, a new microfluidic platform for direct coupling of automated solid-phase microextraction with ESI-MS." Analytical and bioanalytical chemistry vol. 409,29 (2017): 6873-6883. doi: https://doi.org/10.1007/s00216-017-0652-8
Ghiasikhou S, da Silva MF, Zhu Y, Zenobi R. The capillary gap sampler, a new microfluidic platform for direct coupling of automated solid-phase microextraction with ESI-MS. Anal Bioanal Chem. 2017 Nov;409(29):6873-6883. doi: 10.1007/s00216-017-0652-8. Epub 2017 Oct 18. PMID: 29046923.
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A Molecular Imprinted Polymer as a Flow-Through Optical Sensor for Oxazepam.

Journal of analytical methods in chemistry

Machicote RG, Castillo MA, Pacheco ME, Bruzzone L.
PMID: 29850374
J Anal Methods Chem. 2018 Apr 04;2018:6302609. doi: 10.1155/2018/6302609. eCollection 2018.

A flow-through optosensing system for oxazepam recognition with fluorescence detection was performed by means of a molecular imprinted polymer based on its acid hydrolysis product, 2-amino-5-chlorobenzophenone. The synthesis was conducted via a noncovalent imprinting methodology, using methacrylic acid as...

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Machicote RG, Castillo MA, Pacheco ME, et al. A Molecular Imprinted Polymer as a Flow-Through Optical Sensor for Oxazepam. J Anal Methods Chem. 2018;2018:6302609doi: 10.1155/2018/6302609.
Machicote, R. G., Castillo, M. A., Pacheco, M. E., & Bruzzone, L. (2018). A Molecular Imprinted Polymer as a Flow-Through Optical Sensor for Oxazepam. Journal of analytical methods in chemistry, 20186302609. https://doi.org/10.1155/2018/6302609
Machicote, Roberta G, et al. "A Molecular Imprinted Polymer as a Flow-Through Optical Sensor for Oxazepam." Journal of analytical methods in chemistry vol. 2018 (2018): 6302609. doi: https://doi.org/10.1155/2018/6302609
Machicote RG, Castillo MA, Pacheco ME, Bruzzone L. A Molecular Imprinted Polymer as a Flow-Through Optical Sensor for Oxazepam. J Anal Methods Chem. 2018 Apr 04;2018:6302609. doi: 10.1155/2018/6302609. eCollection 2018. PMID: 29850374; PMCID: PMC5904820.
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Total Release of 21 Indicator Pharmaceuticals Listed by the Swedish Medical Products Agency from Wastewater Treatment Plants to Surface Water Bodies in the 1.3 Million Populated County Skåne (Scania), Sweden.

Molecules (Basel, Switzerland)

Björklund E, Svahn O.
PMID: 35011310
Molecules. 2021 Dec 23;27(1). doi: 10.3390/molecules27010077.

In 2017, the Swedish Environmental Protection Agency published a report on advanced wastewater treatment for the removal of pharmaceutical residues and stated that advanced treatment should be implemented where it will make the largest difference from an environmental perspective....

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Björklund E, Svahn O. Total Release of 21 Indicator Pharmaceuticals Listed by the Swedish Medical Products Agency from Wastewater Treatment Plants to Surface Water Bodies in the 1.3 Million Populated County Skåne (Scania), Sweden. Molecules. 2021;27(1)doi: 10.3390/molecules27010077.
Björklund, E., & Svahn, O. (2021). Total Release of 21 Indicator Pharmaceuticals Listed by the Swedish Medical Products Agency from Wastewater Treatment Plants to Surface Water Bodies in the 1.3 Million Populated County Skåne (Scania), Sweden. Molecules (Basel, Switzerland), 27(1), . https://doi.org/10.3390/molecules27010077
Björklund, Erland, and Svahn, Ola. "Total Release of 21 Indicator Pharmaceuticals Listed by the Swedish Medical Products Agency from Wastewater Treatment Plants to Surface Water Bodies in the 1.3 Million Populated County Skåne (Scania), Sweden." Molecules (Basel, Switzerland) vol. 27,1 (2021). doi: https://doi.org/10.3390/molecules27010077
Björklund E, Svahn O. Total Release of 21 Indicator Pharmaceuticals Listed by the Swedish Medical Products Agency from Wastewater Treatment Plants to Surface Water Bodies in the 1.3 Million Populated County Skåne (Scania), Sweden. Molecules. 2021 Dec 23;27(1). doi: 10.3390/molecules27010077. PMID: 35011310; PMCID: PMC8746806.
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Total Release of 21 Indicator Pharmaceuticals Listed by the Swedish Medical Products Agency from Wastewater Treatment Plants to Surface Water Bodies in the 1.3 Million Populated County Skåne (Scania), Sweden.

Molecules (Basel, Switzerland)

Björklund E, Svahn O.
PMID: 35011310
Molecules. 2021 Dec 23;27(1). doi: 10.3390/molecules27010077.

In 2017, the Swedish Environmental Protection Agency published a report on advanced wastewater treatment for the removal of pharmaceutical residues and stated that advanced treatment should be implemented where it will make the largest difference from an environmental perspective....

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Björklund E, Svahn O. Total Release of 21 Indicator Pharmaceuticals Listed by the Swedish Medical Products Agency from Wastewater Treatment Plants to Surface Water Bodies in the 1.3 Million Populated County Skåne (Scania), Sweden. Molecules. 2021;27(1)doi: 10.3390/molecules27010077.
Björklund, E., & Svahn, O. (2021). Total Release of 21 Indicator Pharmaceuticals Listed by the Swedish Medical Products Agency from Wastewater Treatment Plants to Surface Water Bodies in the 1.3 Million Populated County Skåne (Scania), Sweden. Molecules (Basel, Switzerland), 27(1), . https://doi.org/10.3390/molecules27010077
Björklund, Erland, and Svahn, Ola. "Total Release of 21 Indicator Pharmaceuticals Listed by the Swedish Medical Products Agency from Wastewater Treatment Plants to Surface Water Bodies in the 1.3 Million Populated County Skåne (Scania), Sweden." Molecules (Basel, Switzerland) vol. 27,1 (2021). doi: https://doi.org/10.3390/molecules27010077
Björklund E, Svahn O. Total Release of 21 Indicator Pharmaceuticals Listed by the Swedish Medical Products Agency from Wastewater Treatment Plants to Surface Water Bodies in the 1.3 Million Populated County Skåne (Scania), Sweden. Molecules. 2021 Dec 23;27(1). doi: 10.3390/molecules27010077. PMID: 35011310.
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Prevalence and concentrations of sedative-hypnotic drugs in blood of drivers involved in road traffic crashes in the Padova region of Italy - not so easy to interpret.

Forensic science international

Favretto D, Visentin S, Jones AW.
PMID: 34814082
Forensic Sci Int. 2021 Nov 06;330:111097. doi: 10.1016/j.forsciint.2021.111097. Epub 2021 Nov 06.

BACKGROUND & OBJECTIVES: This study reports the prevalence and concentrations of sedative-hypnotic drugs as exemplified by benzodiazepines (BZD) and zolpidem (Z-hypnotic) in blood samples from drivers involved in road traffic accidents (RTA) in the Padova region of Italy. Another...

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Favretto D, Visentin S, Jones AW. Prevalence and concentrations of sedative-hypnotic drugs in blood of drivers involved in road traffic crashes in the Padova region of Italy - not so easy to interpret. Forensic Sci Int. 2021;330:111097doi: 10.1016/j.forsciint.2021.111097.
Favretto, D., Visentin, S., & Jones, A. W. (2021). Prevalence and concentrations of sedative-hypnotic drugs in blood of drivers involved in road traffic crashes in the Padova region of Italy - not so easy to interpret. Forensic science international, 330111097. https://doi.org/10.1016/j.forsciint.2021.111097
Favretto, Donata, et al. "Prevalence and concentrations of sedative-hypnotic drugs in blood of drivers involved in road traffic crashes in the Padova region of Italy - not so easy to interpret." Forensic science international vol. 330 (2021): 111097. doi: https://doi.org/10.1016/j.forsciint.2021.111097
Favretto D, Visentin S, Jones AW. Prevalence and concentrations of sedative-hypnotic drugs in blood of drivers involved in road traffic crashes in the Padova region of Italy - not so easy to interpret. Forensic Sci Int. 2021 Nov 06;330:111097. doi: 10.1016/j.forsciint.2021.111097. Epub 2021 Nov 06. PMID: 34814082.
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PBPK Modeling as a Tool for Predicting and Understanding Intestinal Metabolism of Uridine 5'-Diphospho-glucuronosyltransferase Substrates.

Pharmaceutics

Reddy MB, Bolger MB, Fraczkiewicz G, Del Frari L, Luo L, Lukacova V, Mitra A, Macwan JS, Mullin JM, Parrott N, Heikkinen AT.
PMID: 34575401
Pharmaceutics. 2021 Aug 24;13(9). doi: 10.3390/pharmaceutics13091325.

Uridine 5'-diphospho-glucuronosyltransferases (UGTs) are expressed in the small intestines, but prediction of first-pass extraction from the related metabolism is not well studied. This work assesses physiologically based pharmacokinetic (PBPK) modeling as a tool for predicting intestinal metabolism due to...

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Reddy MB, Bolger MB, Fraczkiewicz G, et al. PBPK Modeling as a Tool for Predicting and Understanding Intestinal Metabolism of Uridine 5'-Diphospho-glucuronosyltransferase Substrates. Pharmaceutics. 2021;13(9)doi: 10.3390/pharmaceutics13091325.
Reddy, M. B., Bolger, M. B., Fraczkiewicz, G., Del Frari, L., Luo, L., Lukacova, V., Mitra, A., Macwan, J. S., Mullin, J. M., Parrott, N., & Heikkinen, A. T. (2021). PBPK Modeling as a Tool for Predicting and Understanding Intestinal Metabolism of Uridine 5'-Diphospho-glucuronosyltransferase Substrates. Pharmaceutics, 13(9), . https://doi.org/10.3390/pharmaceutics13091325
Reddy, Micaela B, et al. "PBPK Modeling as a Tool for Predicting and Understanding Intestinal Metabolism of Uridine 5'-Diphospho-glucuronosyltransferase Substrates." Pharmaceutics vol. 13,9 (2021). doi: https://doi.org/10.3390/pharmaceutics13091325
Reddy MB, Bolger MB, Fraczkiewicz G, Del Frari L, Luo L, Lukacova V, Mitra A, Macwan JS, Mullin JM, Parrott N, Heikkinen AT. PBPK Modeling as a Tool for Predicting and Understanding Intestinal Metabolism of Uridine 5'-Diphospho-glucuronosyltransferase Substrates. Pharmaceutics. 2021 Aug 24;13(9). doi: 10.3390/pharmaceutics13091325. PMID: 34575401; PMCID: PMC8468656.
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Enantioseparation and molecular modeling study of eight psychoactive drugs on a coated polysaccharide-based chiral stationary phase.

Electrophoresis

Cai L, Xue M, Lun J, Li S, Yu J, Guo X.
PMID: 32885849
Electrophoresis. 2020 Sep 04; doi: 10.1002/elps.202000224. Epub 2020 Sep 04.

The enantioseparation of eight psychoactive drugs has been firstly performed on a coated cellulose-based chiral stationary phase (Chiralcel OJ-H). To obtain optimum separation conditions, the influences of alcohol modifiers and basic/acidic additives have been studied. As a result, except...

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Cai L, Xue M, Lun J, et al. Enantioseparation and molecular modeling study of eight psychoactive drugs on a coated polysaccharide-based chiral stationary phase. Electrophoresis. 2020;doi: 10.1002/elps.202000224.
Cai, L., Xue, M., Lun, J., Li, S., Yu, J., & Guo, X. (2020). Enantioseparation and molecular modeling study of eight psychoactive drugs on a coated polysaccharide-based chiral stationary phase. Electrophoresis, . https://doi.org/10.1002/elps.202000224
Cai, Liangzhao, et al. "Enantioseparation and molecular modeling study of eight psychoactive drugs on a coated polysaccharide-based chiral stationary phase." Electrophoresis vol. (2020). doi: https://doi.org/10.1002/elps.202000224
Cai L, Xue M, Lun J, Li S, Yu J, Guo X. Enantioseparation and molecular modeling study of eight psychoactive drugs on a coated polysaccharide-based chiral stationary phase. Electrophoresis. 2020 Sep 04; doi: 10.1002/elps.202000224. Epub 2020 Sep 04. PMID: 32885849.
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Dynamics of Soil Microbial Communities During Diazepam and Oxazepam Biodegradation in Soil Flooded by Water From a WWTP.

Frontiers in microbiology

Crampon M, Soulier C, Sidoli P, Hellal J, Joulian C, Charron M, Guillemoto Q, Picot-Colbeaux G, Pettenati M.
PMID: 34912306
Front Microbiol. 2021 Nov 29;12:742000. doi: 10.3389/fmicb.2021.742000. eCollection 2021.

The demand for energy and chemicals is constantly growing, leading to an increase of the amounts of contaminants discharged to the environment. Among these, pharmaceutical molecules are frequently found in treated wastewater that is discharged into superficial waters. Indeed,...

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Crampon M, Soulier C, Sidoli P, et al. Dynamics of Soil Microbial Communities During Diazepam and Oxazepam Biodegradation in Soil Flooded by Water From a WWTP. Front Microbiol. 2021;12:742000doi: 10.3389/fmicb.2021.742000.
Crampon, M., Soulier, C., Sidoli, P., Hellal, J., Joulian, C., Charron, M., Guillemoto, Q., Picot-Colbeaux, G., & Pettenati, M. (2021). Dynamics of Soil Microbial Communities During Diazepam and Oxazepam Biodegradation in Soil Flooded by Water From a WWTP. Frontiers in microbiology, 12742000. https://doi.org/10.3389/fmicb.2021.742000
Crampon, Marc, et al. "Dynamics of Soil Microbial Communities During Diazepam and Oxazepam Biodegradation in Soil Flooded by Water From a WWTP." Frontiers in microbiology vol. 12 (2021): 742000. doi: https://doi.org/10.3389/fmicb.2021.742000
Crampon M, Soulier C, Sidoli P, Hellal J, Joulian C, Charron M, Guillemoto Q, Picot-Colbeaux G, Pettenati M. Dynamics of Soil Microbial Communities During Diazepam and Oxazepam Biodegradation in Soil Flooded by Water From a WWTP. Front Microbiol. 2021 Nov 29;12:742000. doi: 10.3389/fmicb.2021.742000. eCollection 2021. PMID: 34912306; PMCID: PMC8667618.
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Showing 1 to 12 of 67 entries