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Showing 1 to 12 of 13 entries
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Antiaggregatory Properties of Beta-adrenoceptor Blocking Drugs are Related to their Physico-chemical Properties.

Platelets

Nosál R, Jancinová V, Petriková M.
PMID: 21043897
Platelets. 1992;3(1):29-33. doi: 10.3109/09537109209013165.

The effects of the beta-adrenoceptor blockers (BAB) alprenolol, atenolol, metipranolol, oxprenolol, practolol and propranolol on platelet aggregation stimulated by ADP, thrombin and collagen were investigated. The BAB were divided into three groups according to their liposolubility and antiaggregatory activity....

Comparison of once daily atenolol with slow release oxprenolol in hypertension.

Proceedings of the Royal Society of Medicine

Cunnington AR, Waite MA.
PMID: 20919339
Proc R Soc Med. 1977;70:21-3.

No abstract available.

Determination of thermodynamic binding constants by affinity capillary electrophoresis.

Talanta

Lancioni C, Keunchkarian S, Castells CB, Gagliardi LG.
PMID: 30348416
Talanta. 2019 Jan 15;192:448-454. doi: 10.1016/j.talanta.2018.09.044. Epub 2018 Sep 14.

A strategy to study thermodynamic binding constants by affinity capillary electrophoresis (ACE) is presented. In order to simplify mathematical treatment, analogy with acid-base dissociation equilibrium is proposed: instead of ligand concentration [X], negative logarithm of ligand concentration (or activity),...

HPLC Enantioseparation of β-Blockers on Ovomucoid Stationary Phase†.

Journal of chromatographic science

Imre S, Ormenişan A, Tero-Vescan A, Muntean DL, Vari CE.
PMID: 27402671
J Chromatogr Sci. 2016 Oct 17;54(9):1578-1583. doi: 10.1093/chromsci/bmw107.

The purpose of this study was to separate single and multiple pairs of six β-blockers enantiomers by high performance liquid chromatography on ovomucoid (OM) column in optimal conditions. The separation was performed isocratically or in gradient elution at 25°C,...

The Pharmacokinetics of Single Dose vs Steady-State Doses of Propranolol in Cirrhotic Malay Patients.

The Malaysian journal of medical sciences : MJMS

Zain-Hamid R, Ismail Z, Mahendra Raj S, Shuaib IL, Mohsin SS.
PMID: 22969313
Malays J Med Sci. 2002 Jan;9(1):16-20.

Pharmacokinetics of propranolol (PRN) given orally were studied in twelve cirrhotic Malay patients [10 males, 2 females], aged 33-62 years [49.83±9.17], body weight 39-72 kg [58.0±8.46] and height 142-168 cm [158.8±7.89] following single 20 mg and steady-state 20 mg...

Quantitative analysis of beta-adrenergic blocking agents by NMR spectroscopy.

Journal of pharmaceutical and biomedical analysis

Iorio MA, Farina AM, Doldo A.
PMID: 16867541
J Pharm Biomed Anal. 1987;5(1):1-10. doi: 10.1016/0731-7085(87)80002-x.

The quantitative analysis by (1)H NMR of labetalol, oxprenolol and four other beta-adrenergic blocking agents is described. The method depends on the integration of selected resonances of the analyte and an internal reference which do not overlap. Procedures for...

Comprehensive identification of active compounds in tablets by flow-injection data-dependent tandem mass spectrometry combined with library search.

Forensic science international

Pavlic M, Schubert B, Libiseller K, Oberacher H.
PMID: 20097023
Forensic Sci Int. 2010 Apr 15;197(1):40-7. doi: 10.1016/j.forsciint.2009.12.019. Epub 2010 Jan 22.

A convenient mass spectrometric approach for the identification of toxicologically relevant compounds in tablets and tablet residues is presented. For comprehensive forensic-toxicological analysis electrospray ionization mass spectrometry was accomplished in positive as well as in negative ion mode on...

How Do Antihypertensive Drugs Work? Insights from Studies of the Renal Regulation of Arterial Blood Pressure.

Frontiers in physiology

Digne-Malcolm H, Frise MC, Dorrington KL.
PMID: 27524972
Front Physiol. 2016 Jul 29;7:320. doi: 10.3389/fphys.2016.00320. eCollection 2016.

Though antihypertensive drugs have been in use for many decades, the mechanisms by which they act chronically to reduce blood pressure remain unclear. Over long periods, mean arterial blood pressure must match the perfusion pressure necessary for the kidney...

A Small Footprint and Robust Interface for Solid Phase Microextraction and Mass Spectrometry Based on Vibrating Sharp-Edge Spray Ionization.

Journal of the American Society for Mass Spectrometry

Wang J, Li C, Li P.
PMID: 35040644
J Am Soc Mass Spectrom. 2022 Jan 18; doi: 10.1021/jasms.1c00305. Epub 2022 Jan 18.

Combining solid phase microextraction (SPME) and mass spectrometry (MS) analysis has become increasingly important to many bioanalytical, environmental, and forensic applications due to its simplicity, rapid analysis, and capability of reducing matrix effects for complex samples. To further promote...

A Review on Pharmacokinetic and Pharmacodynamic Drug Interactions of Adrenergic β-blockers with Clinically Relevant Drugs-An Overview.

Current drug metabolism

Maideen NMP, Rajkapoor B, Muthusamy S, Ramanathan S, Thangadurai SA, Sughir AA.
PMID: 34182907
Curr Drug Metab. 2021;22(9):672-682. doi: 10.2174/1389200222666210614112529.

Adrenergic β-blockers are used to treat many conditions, including hypertension, cardiac arrhythmias, heart failure, angina pectoris, migraine, and tremors. The majority of the β-blockers including Propranolol, Metoprolol, Acebutolol, Alprenolol, Betaxolol, Carvedilol, Nebivolol and Oxprenolol are metabolised majorly by CYP2D6,...

Phenyl ring structures as stationary phases for the high performance liquid chromatography electrospray ionization mass spectrometric analysis of basic pharmaceuticals.

Rapid communications in mass spectrometry : RCM

Needham SR, Brown PR, Duff K.
PMID: 10547629
Rapid Commun Mass Spectrom. 1999;13(22):2231-6. doi: 10.1002/(SICI)1097-0231(19991130)13:22<2231::AID-RCM779>3.0.CO;2-4.

To produce a large mass spectral signal in the analysis of basic drugs by high performance liquid chromatography/electrospray ionization mass spectrometry (HPLC/ESI-MS), a high percentage of organic solvent is needed in the mobile phase. With the commonly used reversed...

Occurrence of betablockers in effluents of wastewater treatment plants from the Lyon area (France) and risk assessment for the downstream rivers.

Talanta

Miège C, Favier M, Brosse C, Canler JP, Coquery M.
PMID: 18970833
Talanta. 2006 Nov 15;70(4):739-44. doi: 10.1016/j.talanta.2006.07.002. Epub 2006 Aug 17.

Five betablockers (oxprenolol, metoprolol, propranolol, bisoprolol, betaxolol) were analysed in effluents collected over a 3-month period from wastewater treatment plants (WTP) from the Lyon area in France. The analytical protocol consisted of solid phase extraction of the dissolved aqueous...

Showing 1 to 12 of 13 entries