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Showing 1 to 12 of 29 entries
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Trans-pQTL study identifies immune crosstalk between Parkinson and Alzheimer loci.

Neurology. Genetics

Chan G, White CC, Winn PA, Cimpean M, Replogle JM, Glick LR, Cuerdon NE, Ryan KJ, Johnson KA, Schneider JA, Bennett DA, Chibnik LB, Sperling RA, De Jager PL, Bradshaw EM.
PMID: 27504496
Neurol Genet. 2016 Jul 26;2(4):e90. doi: 10.1212/NXG.0000000000000090. eCollection 2016 Aug.

OBJECTIVE: Given evidence from genetic studies, we hypothesized that there may be a shared component to the role of myeloid function in Parkinson and Alzheimer disease (PD and AD) and assessed whether PD susceptibility variants influenced protein expression of...

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Chan G, White CC, Winn PA, et al. Trans-pQTL study identifies immune crosstalk between Parkinson and Alzheimer loci. Neurol Genet. 2016;2(4):e90doi: 10.1212/NXG.0000000000000090.
Chan, G., White, C. C., Winn, P. A., Cimpean, M., Replogle, J. M., Glick, L. R., Cuerdon, N. E., Ryan, K. J., Johnson, K. A., Schneider, J. A., Bennett, D. A., Chibnik, L. B., Sperling, R. A., De Jager, P. L., & Bradshaw, E. M. (2016). Trans-pQTL study identifies immune crosstalk between Parkinson and Alzheimer loci. Neurology. Genetics, 2(4), e90. https://doi.org/10.1212/NXG.0000000000000090
Chan, Gail, et al. "Trans-pQTL study identifies immune crosstalk between Parkinson and Alzheimer loci." Neurology. Genetics vol. 2,4 (2016): e90. doi: https://doi.org/10.1212/NXG.0000000000000090
Chan G, White CC, Winn PA, Cimpean M, Replogle JM, Glick LR, Cuerdon NE, Ryan KJ, Johnson KA, Schneider JA, Bennett DA, Chibnik LB, Sperling RA, De Jager PL, Bradshaw EM. Trans-pQTL study identifies immune crosstalk between Parkinson and Alzheimer loci. Neurol Genet. 2016 Jul 26;2(4):e90. doi: 10.1212/NXG.0000000000000090. eCollection 2016 Aug. PMID: 27504496; PMCID: PMC4962525.
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Permutation Tests for General Dependent Truncation.

Computational statistics & data analysis

Chiou SH, Qian J, Mormino E, Betensky RA.
PMID: 30613119
Comput Stat Data Anal. 2018 Dec;128:308-324. doi: 10.1016/j.csda.2018.07.012. Epub 2018 Jul 29.

Truncated survival data arise when the event time is observed only if it falls within a subject-specific region, known as the truncation set. Left-truncated data arise when there is delayed entry into a study, such that subjects are included...

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Chiou SH, Qian J, Mormino E, et al. Permutation Tests for General Dependent Truncation. Comput Stat Data Anal. 2018;128:308-324doi: 10.1016/j.csda.2018.07.012.
Chiou, S. H., Qian, J., Mormino, E., Betensky, R. A. (2018). Permutation Tests for General Dependent Truncation. Computational statistics & data analysis, 128308-324. https://doi.org/10.1016/j.csda.2018.07.012
Chiou, Sy Han, et al. "Permutation Tests for General Dependent Truncation." Computational statistics & data analysis vol. 128 (2018): 308-324. doi: https://doi.org/10.1016/j.csda.2018.07.012
Chiou SH, Qian J, Mormino E, Betensky RA. Permutation Tests for General Dependent Truncation. Comput Stat Data Anal. 2018 Dec;128:308-324. doi: 10.1016/j.csda.2018.07.012. Epub 2018 Jul 29. PMID: 30613119; PMCID: PMC6317381.
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Plasma IL-12/IFN-γ axis predicts cognitive trajectories in cognitively unimpaired older adults.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Yang HS, Zhang C, Carlyle BC, Zhen SY, Trombetta BA, Schultz AP, Pruzin JJ, Fitzpatrick CD, Yau WW, Kirn DR, Rentz DM, Arnold SE, Johnson KA, Sperling RA, Chhatwal JP, Tanzi RE.
PMID: 34160128
Alzheimers Dement. 2021 Jun 23; doi: 10.1002/alz.12399. Epub 2021 Jun 23.

INTRODUCTION: Immune dysregulation is implicated in neurodegeneration and altered cytokine levels are seen in people with dementia. However, whether cytokine levels are predictive of cognitive decline in cognitively unimpaired (CU) elderly, especially in the setting of elevated amyloid beta...

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Yang HS, Zhang C, Carlyle BC, et al. Plasma IL-12/IFN-γ axis predicts cognitive trajectories in cognitively unimpaired older adults. Alzheimers Dement. 2021;doi: 10.1002/alz.12399.
Yang, H. S., Zhang, C., Carlyle, B. C., Zhen, S. Y., Trombetta, B. A., Schultz, A. P., Pruzin, J. J., Fitzpatrick, C. D., Yau, W. W., Kirn, D. R., Rentz, D. M., Arnold, S. E., Johnson, K. A., Sperling, R. A., Chhatwal, J. P., & Tanzi, R. E. (2021). Plasma IL-12/IFN-γ axis predicts cognitive trajectories in cognitively unimpaired older adults. Alzheimer's & dementia : the journal of the Alzheimer's Association, . https://doi.org/10.1002/alz.12399
Yang, Hyun-Sik, et al. "Plasma IL-12/IFN-γ axis predicts cognitive trajectories in cognitively unimpaired older adults." Alzheimer's & dementia : the journal of the Alzheimer's Association vol. (2021). doi: https://doi.org/10.1002/alz.12399
Yang HS, Zhang C, Carlyle BC, Zhen SY, Trombetta BA, Schultz AP, Pruzin JJ, Fitzpatrick CD, Yau WW, Kirn DR, Rentz DM, Arnold SE, Johnson KA, Sperling RA, Chhatwal JP, Tanzi RE. Plasma IL-12/IFN-γ axis predicts cognitive trajectories in cognitively unimpaired older adults. Alzheimers Dement. 2021 Jun 23; doi: 10.1002/alz.12399. Epub 2021 Jun 23. PMID: 34160128.
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Disparities by Race and Ethnicity Among Adults Recruited for a Preclinical Alzheimer Disease Trial.

JAMA network open

Raman R, Quiroz YT, Langford O, Choi J, Ritchie M, Baumgartner M, Rentz D, Aggarwal NT, Aisen P, Sperling R, Grill JD.
PMID: 34228129
JAMA Netw Open. 2021 Jul 01;4(7):e2114364. doi: 10.1001/jamanetworkopen.2021.14364.

IMPORTANCE: Underrepresentation of many racial/ethnic groups in Alzheimer disease (AD) clinical trials limits generalizability of results and hinders opportunities to examine potential effect modification of candidate treatments.OBJECTIVE: To examine racial and ethnic differences in recruitment methods and trial eligibility...

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Raman R, Quiroz YT, Langford O, et al. Disparities by Race and Ethnicity Among Adults Recruited for a Preclinical Alzheimer Disease Trial. JAMA Netw Open. 2021;4(7):e2114364doi: 10.1001/jamanetworkopen.2021.14364.
Raman, R., Quiroz, Y. T., Langford, O., Choi, J., Ritchie, M., Baumgartner, M., Rentz, D., Aggarwal, N. T., Aisen, P., Sperling, R., & Grill, J. D. (2021). Disparities by Race and Ethnicity Among Adults Recruited for a Preclinical Alzheimer Disease Trial. JAMA network open, 4(7), e2114364. https://doi.org/10.1001/jamanetworkopen.2021.14364
Raman, Rema, et al. "Disparities by Race and Ethnicity Among Adults Recruited for a Preclinical Alzheimer Disease Trial." JAMA network open vol. 4,7 (2021): e2114364. doi: https://doi.org/10.1001/jamanetworkopen.2021.14364
Raman R, Quiroz YT, Langford O, Choi J, Ritchie M, Baumgartner M, Rentz D, Aggarwal NT, Aisen P, Sperling R, Grill JD. Disparities by Race and Ethnicity Among Adults Recruited for a Preclinical Alzheimer Disease Trial. JAMA Netw Open. 2021 Jul 01;4(7):e2114364. doi: 10.1001/jamanetworkopen.2021.14364. PMID: 34228129; PMCID: PMC8261604.
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Amyloid-associated increases in longitudinal report of subjective cognitive complaints.

Alzheimer's & dementia (New York, N. Y.)

Amariglio RE, Buckley RF, Mormino EC, Marshall GA, Johnson KA, Rentz DM, Sperling RA.
PMID: 30258973
Alzheimers Dement (N Y). 2018 Sep 06;4:444-449. doi: 10.1016/j.trci.2018.08.005. eCollection 2018.

INTRODUCTION: To investigate whether baseline subjective cognitive complaints (SCCs) predict longitudinal decline on neuropsychological testing and whether SCC increases longitudinally, in the setting of high levels of amyloid burden.METHODS: Two hundred seventy-nine clinically normal older participants (mean age =...

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Amariglio RE, Buckley RF, Mormino EC, et al. Amyloid-associated increases in longitudinal report of subjective cognitive complaints. Alzheimers Dement (N Y). 2018;4:444-449doi: 10.1016/j.trci.2018.08.005.
Amariglio, R. E., Buckley, R. F., Mormino, E. C., Marshall, G. A., Johnson, K. A., Rentz, D. M., & Sperling, R. A. (2018). Amyloid-associated increases in longitudinal report of subjective cognitive complaints. Alzheimer's & dementia (New York, N. Y.), 4444-449. https://doi.org/10.1016/j.trci.2018.08.005
Amariglio, Rebecca E, et al. "Amyloid-associated increases in longitudinal report of subjective cognitive complaints." Alzheimer's & dementia (New York, N. Y.) vol. 4 (2018): 444-449. doi: https://doi.org/10.1016/j.trci.2018.08.005
Amariglio RE, Buckley RF, Mormino EC, Marshall GA, Johnson KA, Rentz DM, Sperling RA. Amyloid-associated increases in longitudinal report of subjective cognitive complaints. Alzheimers Dement (N Y). 2018 Sep 06;4:444-449. doi: 10.1016/j.trci.2018.08.005. eCollection 2018. PMID: 30258973; PMCID: PMC6153378.
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Activities of daily living measured by the Harvard Automated Phone Task track with cognitive decline over time in non-demented elderly.

The journal of prevention of Alzheimer's disease

Marshall GA, Aghjayan SL, Dekhtyar M, Locascio JJ, Jethwani K, Amariglio RE, Johnson KA, Sperling RA, Rentz DM.
PMID: 29124043
J Prev Alzheimers Dis. 2017;4(2):81-86. doi: 10.14283/jpad.2017.10.

BACKGROUND: Impairment in activities of daily living is a major burden to both patients and caregivers. Mild impairment in instrumental activities of daily living is often seen at the stage of mild cognitive impairment. The field of Alzheimer's disease...

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Marshall GA, Aghjayan SL, Dekhtyar M, et al. Activities of daily living measured by the Harvard Automated Phone Task track with cognitive decline over time in non-demented elderly. J Prev Alzheimers Dis. 2017;4(2):81-86doi: 10.14283/jpad.2017.10.
Marshall, G. A., Aghjayan, S. L., Dekhtyar, M., Locascio, J. J., Jethwani, K., Amariglio, R. E., Johnson, K. A., Sperling, R. A., & Rentz, D. M. (2017). Activities of daily living measured by the Harvard Automated Phone Task track with cognitive decline over time in non-demented elderly. The journal of prevention of Alzheimer's disease, 4(2), 81-86. https://doi.org/10.14283/jpad.2017.10
Marshall, Gad A, et al. "Activities of daily living measured by the Harvard Automated Phone Task track with cognitive decline over time in non-demented elderly." The journal of prevention of Alzheimer's disease vol. 4,2 (2017): 81-86. doi: https://doi.org/10.14283/jpad.2017.10
Marshall GA, Aghjayan SL, Dekhtyar M, Locascio JJ, Jethwani K, Amariglio RE, Johnson KA, Sperling RA, Rentz DM. Activities of daily living measured by the Harvard Automated Phone Task track with cognitive decline over time in non-demented elderly. J Prev Alzheimers Dis. 2017;4(2):81-86. doi: 10.14283/jpad.2017.10. PMID: 29124043; PMCID: PMC5675571.
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Multiple Imputation of a Randomly Censored Covariate Improves Logistic Regression Analysis.

Journal of applied statistics

Atem FD, Qian J, Maye JE, Johnson KA, Betensky RA.
PMID: 27713593
J Appl Stat. 2016;43(15):2886-2896. doi: 10.1080/02664763.2016.1155110. Epub 2016 Mar 16.

Randomly censored covariates arise frequently in epidemiologic studies. The most commonly used methods, including complete case and single imputation or substitution, suffer from inefficiency and bias. They make strong parametric assumptions or they consider limit of detection censoring only....

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Atem FD, Qian J, Maye JE, et al. Multiple Imputation of a Randomly Censored Covariate Improves Logistic Regression Analysis. J Appl Stat. 2016;43(15):2886-2896doi: 10.1080/02664763.2016.1155110.
Atem, F. D., Qian, J., Maye, J. E., Johnson, K. A., & Betensky, R. A. (2016). Multiple Imputation of a Randomly Censored Covariate Improves Logistic Regression Analysis. Journal of applied statistics, 43(15), 2886-2896. https://doi.org/10.1080/02664763.2016.1155110
Atem, Folefac D, et al. "Multiple Imputation of a Randomly Censored Covariate Improves Logistic Regression Analysis." Journal of applied statistics vol. 43,15 (2016): 2886-2896. doi: https://doi.org/10.1080/02664763.2016.1155110
Atem FD, Qian J, Maye JE, Johnson KA, Betensky RA. Multiple Imputation of a Randomly Censored Covariate Improves Logistic Regression Analysis. J Appl Stat. 2016;43(15):2886-2896. doi: 10.1080/02664763.2016.1155110. Epub 2016 Mar 16. PMID: 27713593; PMCID: PMC5047523.
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Treatment of dementia with lewy bodies.

Current treatment options in neurology

Boot BP, McDade EM, McGinnis SM, Boeve BF.
PMID: 24222315
Curr Treat Options Neurol. 2013 Dec;15(6):738-64. doi: 10.1007/s11940-013-0261-6.

OPINION STATEMENT: Dementia with Lewy bodies (DLB) is a multisystem disorder with diverse disease expression. A treatment regime restricted to the cognitive aspects of the disease does no favor to patients. Instead, patients should be educated to recognize the...

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Boot BP, McDade EM, McGinnis SM, et al. Treatment of dementia with lewy bodies. Curr Treat Options Neurol. 2013;15(6):738-64doi: 10.1007/s11940-013-0261-6.
Boot, B. P., McDade, E. M., McGinnis, S. M., & Boeve, B. F. (2013). Treatment of dementia with lewy bodies. Current treatment options in neurology, 15(6), 738-64. https://doi.org/10.1007/s11940-013-0261-6
Boot, Brendon P, et al. "Treatment of dementia with lewy bodies." Current treatment options in neurology vol. 15,6 (2013): 738-64. doi: https://doi.org/10.1007/s11940-013-0261-6
Boot BP, McDade EM, McGinnis SM, Boeve BF. Treatment of dementia with lewy bodies. Curr Treat Options Neurol. 2013 Dec;15(6):738-64. doi: 10.1007/s11940-013-0261-6. PMID: 24222315; PMCID: PMC3913181.
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The Harvard Automated Phone Task: new performance-based activities of daily living tests for early Alzheimer's disease.

The journal of prevention of Alzheimer's disease

Marshall GA, Dekhtyar M, Bruno JM, Jethwani K, Amariglio RE, Johnson KA, Sperling RA, Rentz DM.
PMID: 26665121
J Prev Alzheimers Dis. 2015 Dec;2(4):242-253. doi: 10.14283/jpad.2015.72.

BACKGROUND: Impairment in activities of daily living is a major burden for Alzheimer's disease dementia patients and caregivers. Multiple subjective scales and a few performance-based instruments have been validated and proven to be reliable in measuring instrumental activities of...

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Marshall GA, Dekhtyar M, Bruno JM, et al. The Harvard Automated Phone Task: new performance-based activities of daily living tests for early Alzheimer's disease. J Prev Alzheimers Dis. 2015;2(4):242-253doi: 10.14283/jpad.2015.72.
Marshall, G. A., Dekhtyar, M., Bruno, J. M., Jethwani, K., Amariglio, R. E., Johnson, K. A., Sperling, R. A., & Rentz, D. M. (2015). The Harvard Automated Phone Task: new performance-based activities of daily living tests for early Alzheimer's disease. The journal of prevention of Alzheimer's disease, 2(4), 242-253. https://doi.org/10.14283/jpad.2015.72
Marshall, Gad A, et al. "The Harvard Automated Phone Task: new performance-based activities of daily living tests for early Alzheimer's disease." The journal of prevention of Alzheimer's disease vol. 2,4 (2015): 242-253. doi: https://doi.org/10.14283/jpad.2015.72
Marshall GA, Dekhtyar M, Bruno JM, Jethwani K, Amariglio RE, Johnson KA, Sperling RA, Rentz DM. The Harvard Automated Phone Task: new performance-based activities of daily living tests for early Alzheimer's disease. J Prev Alzheimers Dis. 2015 Dec;2(4):242-253. doi: 10.14283/jpad.2015.72. PMID: 26665121; PMCID: PMC4671513.
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Unsupervised mobile cognitive testing for use in preclinical Alzheimer's disease.

Alzheimer's & dementia (Amsterdam, Netherlands)

Papp KV, Samaroo A, Chou HC, Buckley R, Schneider OR, Hsieh S, Soberanes D, Quiroz Y, Properzi M, Schultz A, García-Magariño I, Marshall GA, Burke JG, Kumar R, Snyder N, Johnson K, Rentz DM, Sperling RA, Amariglio RE.
PMID: 34621977
Alzheimers Dement (Amst). 2021 Sep 30;13(1):e12243. doi: 10.1002/dad2.12243. eCollection 2021.

INTRODUCTION: Unsupervised digital cognitive testing is an appealing means to capture subtle cognitive decline in preclinical Alzheimer's disease (AD). Here, we describe development, feasibility, and validity of the Boston Remote Assessment for Neurocognitive Health (BRANCH) against in-person cognitive testing...

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Papp KV, Samaroo A, Chou HC, et al. Unsupervised mobile cognitive testing for use in preclinical Alzheimer's disease. Alzheimers Dement (Amst). 2021;13(1):e12243doi: 10.1002/dad2.12243.
Papp, K. V., Samaroo, A., Chou, H. C., Buckley, R., Schneider, O. R., Hsieh, S., Soberanes, D., Quiroz, Y., Properzi, M., Schultz, A., García-Magariño, I., Marshall, G. A., Burke, J. G., Kumar, R., Snyder, N., Johnson, K., Rentz, D. M., Sperling, R. A., & Amariglio, R. E. (2021). Unsupervised mobile cognitive testing for use in preclinical Alzheimer's disease. Alzheimer's & dementia (Amsterdam, Netherlands), 13(1), e12243. https://doi.org/10.1002/dad2.12243
Papp, Kathryn V, et al. "Unsupervised mobile cognitive testing for use in preclinical Alzheimer's disease." Alzheimer's & dementia (Amsterdam, Netherlands) vol. 13,1 (2021): e12243. doi: https://doi.org/10.1002/dad2.12243
Papp KV, Samaroo A, Chou HC, Buckley R, Schneider OR, Hsieh S, Soberanes D, Quiroz Y, Properzi M, Schultz A, García-Magariño I, Marshall GA, Burke JG, Kumar R, Snyder N, Johnson K, Rentz DM, Sperling RA, Amariglio RE. Unsupervised mobile cognitive testing for use in preclinical Alzheimer's disease. Alzheimers Dement (Amst). 2021 Sep 30;13(1):e12243. doi: 10.1002/dad2.12243. eCollection 2021. PMID: 34621977; PMCID: PMC8481881.
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Diminished Learning Over Repeated Exposures (LORE) in preclinical Alzheimer's disease.

Alzheimer's & dementia (Amsterdam, Netherlands)

Samaroo A, Amariglio RE, Burnham S, Sparks P, Properzi M, Schultz AP, Buckley R, Johnson KA, Sperling RA, Rentz DM, Papp KV.
PMID: 33426266
Alzheimers Dement (Amst). 2021 Jan 05;12(1):e12132. doi: 10.1002/dad2.12132. eCollection 2020.

INTRODUCTION: We determine whether diminished Learning Over Repeated Exposures (LORE) identifies subtle memory decrements in cognitively unimpaired (CU) older adults with Alzheimer's disease (AD) biomarker burden.METHODS: Ninety-four CU participants (mean age = 77.6 ± 5.02) completed a challenging associative...

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Samaroo A, Amariglio RE, Burnham S, et al. Diminished Learning Over Repeated Exposures (LORE) in preclinical Alzheimer's disease. Alzheimers Dement (Amst). 2021;12(1):e12132doi: 10.1002/dad2.12132.
Samaroo, A., Amariglio, R. E., Burnham, S., Sparks, P., Properzi, M., Schultz, A. P., Buckley, R., Johnson, K. A., Sperling, R. A., Rentz, D. M., & Papp, K. V. (2020). Diminished Learning Over Repeated Exposures (LORE) in preclinical Alzheimer's disease. Alzheimer's & dementia (Amsterdam, Netherlands), 12(1), e12132. https://doi.org/10.1002/dad2.12132
Samaroo, Aubryn, et al. "Diminished Learning Over Repeated Exposures (LORE) in preclinical Alzheimer's disease." Alzheimer's & dementia (Amsterdam, Netherlands) vol. 12,1 (2020): e12132. doi: https://doi.org/10.1002/dad2.12132
Samaroo A, Amariglio RE, Burnham S, Sparks P, Properzi M, Schultz AP, Buckley R, Johnson KA, Sperling RA, Rentz DM, Papp KV. Diminished Learning Over Repeated Exposures (LORE) in preclinical Alzheimer's disease. Alzheimers Dement (Amst). 2021 Jan 05;12(1):e12132. doi: 10.1002/dad2.12132. eCollection 2020. PMID: 33426266; PMCID: PMC7784542.
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Plasma IL-12/IFN-γ axis predicts cognitive trajectories in cognitively unimpaired older adults.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Yang HS, Zhang C, Carlyle BC, Zhen SY, Trombetta BA, Schultz AP, Pruzin JJ, Fitzpatrick CD, Yau WW, Kirn DR, Rentz DM, Arnold SE, Johnson KA, Sperling RA, Chhatwal JP, Tanzi RE.
PMID: 34160128
Alzheimers Dement. 2021 Jun 23; doi: 10.1002/alz.12399. Epub 2021 Jun 23.

INTRODUCTION: Immune dysregulation is implicated in neurodegeneration and altered cytokine levels are seen in people with dementia. However, whether cytokine levels are predictive of cognitive decline in cognitively unimpaired (CU) elderly, especially in the setting of elevated amyloid beta...

Cite
Yang HS, Zhang C, Carlyle BC, et al. Plasma IL-12/IFN-γ axis predicts cognitive trajectories in cognitively unimpaired older adults. Alzheimers Dement. 2021;doi: 10.1002/alz.12399.
Yang, H. S., Zhang, C., Carlyle, B. C., Zhen, S. Y., Trombetta, B. A., Schultz, A. P., Pruzin, J. J., Fitzpatrick, C. D., Yau, W. W., Kirn, D. R., Rentz, D. M., Arnold, S. E., Johnson, K. A., Sperling, R. A., Chhatwal, J. P., & Tanzi, R. E. (2021). Plasma IL-12/IFN-γ axis predicts cognitive trajectories in cognitively unimpaired older adults. Alzheimer's & dementia : the journal of the Alzheimer's Association, . https://doi.org/10.1002/alz.12399
Yang, Hyun-Sik, et al. "Plasma IL-12/IFN-γ axis predicts cognitive trajectories in cognitively unimpaired older adults." Alzheimer's & dementia : the journal of the Alzheimer's Association vol. (2021). doi: https://doi.org/10.1002/alz.12399
Yang HS, Zhang C, Carlyle BC, Zhen SY, Trombetta BA, Schultz AP, Pruzin JJ, Fitzpatrick CD, Yau WW, Kirn DR, Rentz DM, Arnold SE, Johnson KA, Sperling RA, Chhatwal JP, Tanzi RE. Plasma IL-12/IFN-γ axis predicts cognitive trajectories in cognitively unimpaired older adults. Alzheimers Dement. 2021 Jun 23; doi: 10.1002/alz.12399. Epub 2021 Jun 23. PMID: 34160128; PMCID: PMC8695625.
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