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Nonparenchymal fluid is the source of increased mean diffusivity in preclinical Alzheimer's disease.

Alzheimer's & dementia (Amsterdam, Netherlands)

Sepehrband F, Cabeen RP, Barisano G, Sheikh-Bahaei N, Choupan J, Law M, Toga AW.
PMID: 31049392
Alzheimers Dement (Amst). 2019 Apr 22;11:348-354. doi: 10.1016/j.dadm.2019.03.002. eCollection 2019 Dec.

INTRODUCTION: Although increased mean diffusivity of the white matter has been repeatedly linked to Alzheimer's disease pathology, the underlying mechanism is not known.METHODS: Here, we used ADNI-3 multishell diffusion magnetic resonance imaging data to separate the diffusion signal of...

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Sepehrband F, Cabeen RP, Barisano G, et al. Nonparenchymal fluid is the source of increased mean diffusivity in preclinical Alzheimer's disease. Alzheimers Dement (Amst). 2019;11:348-354doi: 10.1016/j.dadm.2019.03.002.
Sepehrband, F., Cabeen, R. P., Barisano, G., Sheikh-Bahaei, N., Choupan, J., Law, M., & Toga, A. W. (2019). Nonparenchymal fluid is the source of increased mean diffusivity in preclinical Alzheimer's disease. Alzheimer's & dementia (Amsterdam, Netherlands), 11348-354. https://doi.org/10.1016/j.dadm.2019.03.002
Sepehrband, Farshid, et al. "Nonparenchymal fluid is the source of increased mean diffusivity in preclinical Alzheimer's disease." Alzheimer's & dementia (Amsterdam, Netherlands) vol. 11 (2019): 348-354. doi: https://doi.org/10.1016/j.dadm.2019.03.002
Sepehrband F, Cabeen RP, Barisano G, Sheikh-Bahaei N, Choupan J, Law M, Toga AW. Nonparenchymal fluid is the source of increased mean diffusivity in preclinical Alzheimer's disease. Alzheimers Dement (Amst). 2019 Apr 22;11:348-354. doi: 10.1016/j.dadm.2019.03.002. eCollection 2019 Dec. PMID: 31049392; PMCID: PMC6479267.
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Prion Protein Antagonists Rescue Alzheimer's Amyloid-β-Related Cognitive Deficits.

Trends in molecular medicine

Sagare AP, Sweeney MD, Nelson AR, Zhao Z, Zlokovic BV.
PMID: 30661727
Trends Mol Med. 2019 Feb;25(2):74-76. doi: 10.1016/j.molmed.2019.01.001. Epub 2019 Jan 17.

Recent studies revealed that cellular prion protein on neurons bind Alzheimer's amyloid-β oligomers, causing neurotoxic effects. A new article in Cell Reports by Gunther and colleagues (Cell Rep. 2019; 26:145-158) shows that an orally administered cellular prion protein antagonist...

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Sagare AP, Sweeney MD, Nelson AR, et al. Prion Protein Antagonists Rescue Alzheimer's Amyloid-β-Related Cognitive Deficits. Trends Mol Med. 2019;25(2):74-76doi: 10.1016/j.molmed.2019.01.001.
Sagare, A. P., Sweeney, M. D., Nelson, A. R., Zhao, Z., & Zlokovic, B. V. (2019). Prion Protein Antagonists Rescue Alzheimer's Amyloid-β-Related Cognitive Deficits. Trends in molecular medicine, 25(2), 74-76. https://doi.org/10.1016/j.molmed.2019.01.001
Sagare, Abhay P, et al. "Prion Protein Antagonists Rescue Alzheimer's Amyloid-β-Related Cognitive Deficits." Trends in molecular medicine vol. 25,2 (2019): 74-76. doi: https://doi.org/10.1016/j.molmed.2019.01.001
Sagare AP, Sweeney MD, Nelson AR, Zhao Z, Zlokovic BV. Prion Protein Antagonists Rescue Alzheimer's Amyloid-β-Related Cognitive Deficits. Trends Mol Med. 2019 Feb;25(2):74-76. doi: 10.1016/j.molmed.2019.01.001. Epub 2019 Jan 17. PMID: 30661727; PMCID: PMC6377285.
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Channelrhodopsin Excitation Contracts Brain Pericytes and Reduces Blood Flow in the Aging Mouse Brain .

Frontiers in aging neuroscience

Nelson AR, Sagare MA, Wang Y, Kisler K, Zhao Z, Zlokovic BV.
PMID: 32410982
Front Aging Neurosci. 2020 Apr 29;12:108. doi: 10.3389/fnagi.2020.00108. eCollection 2020.

Brains depend on blood flow for the delivery of oxygen and nutrients essential for proper neuronal and synaptic functioning. French physiologist Rouget was the first to describe pericytes in 1873 as regularly arranged longitudinal amoeboid cells on capillaries that...

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Nelson AR, Sagare MA, Wang Y, et al. Channelrhodopsin Excitation Contracts Brain Pericytes and Reduces Blood Flow in the Aging Mouse Brain . Front Aging Neurosci. 2020;12:108doi: 10.3389/fnagi.2020.00108.
Nelson, A. R., Sagare, M. A., Wang, Y., Kisler, K., Zhao, Z., & Zlokovic, B. V. (2020). Channelrhodopsin Excitation Contracts Brain Pericytes and Reduces Blood Flow in the Aging Mouse Brain . Frontiers in aging neuroscience, 12108. https://doi.org/10.3389/fnagi.2020.00108
Nelson, Amy R, et al. "Channelrhodopsin Excitation Contracts Brain Pericytes and Reduces Blood Flow in the Aging Mouse Brain ." Frontiers in aging neuroscience vol. 12 (2020): 108. doi: https://doi.org/10.3389/fnagi.2020.00108
Nelson AR, Sagare MA, Wang Y, Kisler K, Zhao Z, Zlokovic BV. Channelrhodopsin Excitation Contracts Brain Pericytes and Reduces Blood Flow in the Aging Mouse Brain . Front Aging Neurosci. 2020 Apr 29;12:108. doi: 10.3389/fnagi.2020.00108. eCollection 2020. PMID: 32410982; PMCID: PMC7201096.
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Blood-Brain Barrier Crossing Renin-Angiotensin Drugs and Cognition in the Elderly: A Meta-Analysis.

Hypertension (Dallas, Tex. : 1979)

Ho JK, Moriarty F, Manly JJ, Larson EB, Evans DA, Rajan KB, Hudak EM, Hassan L, Liu E, Sato N, Hasebe N, Laurin D, Carmichael PH, Nation DA.
PMID: 34148364
Hypertension. 2021 Sep;78(3):629-643. doi: 10.1161/HYPERTENSIONAHA.121.17049. Epub 2021 Jun 21.

[Figure: see text].

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Ho JK, Moriarty F, Manly JJ, et al. Blood-Brain Barrier Crossing Renin-Angiotensin Drugs and Cognition in the Elderly: A Meta-Analysis. Hypertension. 2021;78(3):629-643doi: 10.1161/HYPERTENSIONAHA.121.17049.
Ho, J. K., Moriarty, F., Manly, J. J., Larson, E. B., Evans, D. A., Rajan, K. B., Hudak, E. M., Hassan, L., Liu, E., Sato, N., Hasebe, N., Laurin, D., Carmichael, P. H., & Nation, D. A. (2021). Blood-Brain Barrier Crossing Renin-Angiotensin Drugs and Cognition in the Elderly: A Meta-Analysis. Hypertension (Dallas, Tex. : 1979), 78(3), 629-643. https://doi.org/10.1161/HYPERTENSIONAHA.121.17049
Ho, Jean K, et al. "Blood-Brain Barrier Crossing Renin-Angiotensin Drugs and Cognition in the Elderly: A Meta-Analysis." Hypertension (Dallas, Tex. : 1979) vol. 78,3 (2021): 629-643. doi: https://doi.org/10.1161/HYPERTENSIONAHA.121.17049
Ho JK, Moriarty F, Manly JJ, Larson EB, Evans DA, Rajan KB, Hudak EM, Hassan L, Liu E, Sato N, Hasebe N, Laurin D, Carmichael PH, Nation DA. Blood-Brain Barrier Crossing Renin-Angiotensin Drugs and Cognition in the Elderly: A Meta-Analysis. Hypertension. 2021 Sep;78(3):629-643. doi: 10.1161/HYPERTENSIONAHA.121.17049. Epub 2021 Jun 21. PMID: 34148364.
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Role of Notch signaling in neurovascular aging and Alzheimer's disease.

Seminars in cell & developmental biology

Kapoor A, Nation DA.
PMID: 33384205
Semin Cell Dev Biol. 2021 Aug;116:90-97. doi: 10.1016/j.semcdb.2020.12.011. Epub 2020 Dec 28.

The Notch signaling pathway is an evolutionarily conserved cell signaling system known to be involved in vascular development and function. Recent evidence suggests that dysfunctional Notch signaling could play a critical role in the pathophysiology of neurodegenerative diseases. We...

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Kapoor A, Nation DA. Role of Notch signaling in neurovascular aging and Alzheimer's disease. Semin Cell Dev Biol. 2020;116:90-97doi: 10.1016/j.semcdb.2020.12.011.
Kapoor, A., & Nation, D. A. (2021). Role of Notch signaling in neurovascular aging and Alzheimer's disease. Seminars in cell & developmental biology, 11690-97. https://doi.org/10.1016/j.semcdb.2020.12.011
Kapoor, Arunima, and Nation, Daniel A. "Role of Notch signaling in neurovascular aging and Alzheimer's disease." Seminars in cell & developmental biology vol. 116 (2021): 90-97. doi: https://doi.org/10.1016/j.semcdb.2020.12.011
Kapoor A, Nation DA. Role of Notch signaling in neurovascular aging and Alzheimer's disease. Semin Cell Dev Biol. 2021 Aug;116:90-97. doi: 10.1016/j.semcdb.2020.12.011. Epub 2020 Dec 28. PMID: 33384205; PMCID: PMC8236496.
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Acute Ablation of Cortical Pericytes Leads to Rapid Neurovascular Uncoupling.

Frontiers in cellular neuroscience

Kisler K, Nikolakopoulou AM, Sweeney MD, Lazic D, Zhao Z, Zlokovic BV.
PMID: 32116568
Front Cell Neurosci. 2020 Feb 14;14:27. doi: 10.3389/fncel.2020.00027. eCollection 2020.

Pericytes are perivascular mural cells that enwrap brain capillaries and maintain blood-brain barrier (BBB) integrity. Most studies suggest that pericytes regulate cerebral blood flow (CBF) and oxygen delivery to activated brain structures, known as neurovascular coupling. While we have...

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Kisler K, Nikolakopoulou AM, Sweeney MD, et al. Acute Ablation of Cortical Pericytes Leads to Rapid Neurovascular Uncoupling. Front Cell Neurosci. 2020;14:27doi: 10.3389/fncel.2020.00027.
Kisler, K., Nikolakopoulou, A. M., Sweeney, M. D., Lazic, D., Zhao, Z., & Zlokovic, B. V. (2020). Acute Ablation of Cortical Pericytes Leads to Rapid Neurovascular Uncoupling. Frontiers in cellular neuroscience, 1427. https://doi.org/10.3389/fncel.2020.00027
Kisler, Kassandra, et al. "Acute Ablation of Cortical Pericytes Leads to Rapid Neurovascular Uncoupling." Frontiers in cellular neuroscience vol. 14 (2020): 27. doi: https://doi.org/10.3389/fncel.2020.00027
Kisler K, Nikolakopoulou AM, Sweeney MD, Lazic D, Zhao Z, Zlokovic BV. Acute Ablation of Cortical Pericytes Leads to Rapid Neurovascular Uncoupling. Front Cell Neurosci. 2020 Feb 14;14:27. doi: 10.3389/fncel.2020.00027. eCollection 2020. PMID: 32116568; PMCID: PMC7033444.
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Value of pituitary gland MRI at 7 T in Cushing's disease and relationship to inferior petrosal sinus sampling: case report.

Journal of neurosurgery

Law M, Wang R, Liu CJ, Shiroishi MS, Carmichael JD, Mack WJ, Weiss M, Wang DJJ, Toga AW, Zada G.
PMID: 29570013
J Neurosurg. 2018 Mar 01;1-5. doi: 10.3171/2017.9.JNS171969. Epub 2018 Mar 01.

Cushing's disease is caused by adrenocorticotrophic hormone (ACTH)-secreting pituitary adenomas, which are often difficult to identify on standard 1.5-T or 3-T MRI, including dynamic contrast imaging. Inferior petrosal and cavernous sinus sampling remains the gold standard for MRI-negative Cushing's...

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Law M, Wang R, Liu CJ, et al. Value of pituitary gland MRI at 7 T in Cushing's disease and relationship to inferior petrosal sinus sampling: case report. J Neurosurg. 2018;1-5doi: 10.3171/2017.9.JNS171969.
Law, M., Wang, R., Liu, C. J., Shiroishi, M. S., Carmichael, J. D., Mack, W. J., Weiss, M., Wang, D. J. J., Toga, A. W., & Zada, G. (2018). Value of pituitary gland MRI at 7 T in Cushing's disease and relationship to inferior petrosal sinus sampling: case report. Journal of neurosurgery, 1-5. https://doi.org/10.3171/2017.9.JNS171969
Law, Meng, et al. "Value of pituitary gland MRI at 7 T in Cushing's disease and relationship to inferior petrosal sinus sampling: case report." Journal of neurosurgery vol. (2018): 1-5. doi: https://doi.org/10.3171/2017.9.JNS171969
Law M, Wang R, Liu CJ, Shiroishi MS, Carmichael JD, Mack WJ, Weiss M, Wang DJJ, Toga AW, Zada G. Value of pituitary gland MRI at 7 T in Cushing's disease and relationship to inferior petrosal sinus sampling: case report. J Neurosurg. 2018 Mar 01;1-5. doi: 10.3171/2017.9.JNS171969. Epub 2018 Mar 01. PMID: 29570013; PMCID: PMC6483888.
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Visit-to-visit blood pressure variability and regional cerebral perfusion decline in older adults.

Neurobiology of aging

Sible IJ, Yew B, Dutt S, Bangen KJ, Li Y, Nation DA.
PMID: 34034215
Neurobiol Aging. 2021 Sep;105:57-63. doi: 10.1016/j.neurobiolaging.2021.04.009. Epub 2021 Apr 24.

Blood pressure variability (BPV) is linked to dementia risk, possibly through cerebral hypoperfusion. We investigated BPV over 1 year and concurrent regional cerebral perfusion decline in older adults without dementia. Participants underwent 4 blood pressure measurements across 12 months,...

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Sible IJ, Yew B, Dutt S, et al. Visit-to-visit blood pressure variability and regional cerebral perfusion decline in older adults. Neurobiol Aging. 2021;105:57-63doi: 10.1016/j.neurobiolaging.2021.04.009.
Sible, I. J., Yew, B., Dutt, S., Bangen, K. J., Li, Y., Nation, D. A. (2021). Visit-to-visit blood pressure variability and regional cerebral perfusion decline in older adults. Neurobiology of aging, 10557-63. https://doi.org/10.1016/j.neurobiolaging.2021.04.009
Sible, Isabel J, et al. "Visit-to-visit blood pressure variability and regional cerebral perfusion decline in older adults." Neurobiology of aging vol. 105 (2021): 57-63. doi: https://doi.org/10.1016/j.neurobiolaging.2021.04.009
Sible IJ, Yew B, Dutt S, Bangen KJ, Li Y, Nation DA. Visit-to-visit blood pressure variability and regional cerebral perfusion decline in older adults. Neurobiol Aging. 2021 Sep;105:57-63. doi: 10.1016/j.neurobiolaging.2021.04.009. Epub 2021 Apr 24. PMID: 34034215.
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Identification of Dysregulated Genes for Late-Onset Alzheimer's Disease Using Gene Expression Data in Brain.

Journal of Alzheimer's disease & Parkinsonism

Arzouni N, Matloff W, Zhao L, Ning K, Toga AW.
PMID: 33282526
J Alzheimers Dis Parkinsonism. 2020;10(6). Epub 2020 Oct 23.

BACKGROUND: Alzheimer's Disease (AD) is a neurodegenerative complex brain disease that represents a public health concern. AD is considered the fifth leading cause of death in Americans who are older than 65 years which prioritizes the importance of understanding...

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Arzouni N, Matloff W, Zhao L, et al. Identification of Dysregulated Genes for Late-Onset Alzheimer's Disease Using Gene Expression Data in Brain. J Alzheimers Dis Parkinsonism. 2020;10(6)
Arzouni, N., Matloff, W., Zhao, L., Ning, K., & Toga, A. W. (2020). Identification of Dysregulated Genes for Late-Onset Alzheimer's Disease Using Gene Expression Data in Brain. Journal of Alzheimer's disease & Parkinsonism, 10(6), .
Arzouni, Nibal, et al. "Identification of Dysregulated Genes for Late-Onset Alzheimer's Disease Using Gene Expression Data in Brain." Journal of Alzheimer's disease & Parkinsonism vol. 10,6 (2020).
Arzouni N, Matloff W, Zhao L, Ning K, Toga AW. Identification of Dysregulated Genes for Late-Onset Alzheimer's Disease Using Gene Expression Data in Brain. J Alzheimers Dis Parkinsonism. 2020;10(6). Epub 2020 Oct 23. PMID: 33282526; PMCID: PMC7717689.
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