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Metabolic modeling of single Th17 cells reveals regulators of autoimmunity.

Cell

Wagner A, Wang C, Fessler J, DeTomaso D, Avila-Pacheco J, Kaminski J, Zaghouani S, Christian E, Thakore P, Schellhaass B, Akama-Garren E, Pierce K, Singh V, Ron-Harel N, Douglas VP, Bod L, Schnell A, Puleston D, Sobel RA, Haigis M, Pearce EL, Soleimani M, Clish C, Regev A, Kuchroo VK, Yosef N.
PMID: 34216539
Cell. 2021 Aug 05;184(16):4168-4185.e21. doi: 10.1016/j.cell.2021.05.045. Epub 2021 Jul 02.

Metabolism is a major regulator of immune cell function, but it remains difficult to study the metabolic status of individual cells. Here, we present Compass, an algorithm to characterize cellular metabolic states based on single-cell RNA sequencing and flux...

Cite
Wagner A, Wang C, Fessler J, et al. Metabolic modeling of single Th17 cells reveals regulators of autoimmunity. Cell. 2021;184(16):4168-4185.e21doi: 10.1016/j.cell.2021.05.045.
Wagner, A., Wang, C., Fessler, J., DeTomaso, D., Avila-Pacheco, J., Kaminski, J., Zaghouani, S., Christian, E., Thakore, P., Schellhaass, B., Akama-Garren, E., Pierce, K., Singh, V., Ron-Harel, N., Douglas, V. P., Bod, L., Schnell, A., Puleston, D., Sobel, R. A., Haigis, M., Pearce, E. L., Soleimani, M., Clish, C., Regev, A., Kuchroo, V. K., & Yosef, N. (2021). Metabolic modeling of single Th17 cells reveals regulators of autoimmunity. Cell, 184(16), 4168-4185.e21. https://doi.org/10.1016/j.cell.2021.05.045
Wagner, Allon, et al. "Metabolic modeling of single Th17 cells reveals regulators of autoimmunity." Cell vol. 184,16 (2021): 4168-4185.e21. doi: https://doi.org/10.1016/j.cell.2021.05.045
Wagner A, Wang C, Fessler J, DeTomaso D, Avila-Pacheco J, Kaminski J, Zaghouani S, Christian E, Thakore P, Schellhaass B, Akama-Garren E, Pierce K, Singh V, Ron-Harel N, Douglas VP, Bod L, Schnell A, Puleston D, Sobel RA, Haigis M, Pearce EL, Soleimani M, Clish C, Regev A, Kuchroo VK, Yosef N. Metabolic modeling of single Th17 cells reveals regulators of autoimmunity. Cell. 2021 Aug 05;184(16):4168-4185.e21. doi: 10.1016/j.cell.2021.05.045. Epub 2021 Jul 02. PMID: 34216539; PMCID: PMC8621950.
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Type I Interferon Transcriptional Network Regulates Expression of Coinhibitory Receptors in Human T cells.

Research square

Hafler D, Sumida T, Dulberg S, Schupp J, Stillwell H, Axisa PP, Comi M, Lincoln M, Unterman A, Kaminski N, Madi A, Kuchroo V.
PMID: 34127967
Res Sq. 2021 Jun 08; doi: 10.21203/rs.3.rs-133494/v1.

While inhibition of T cell co-inhibitory receptors has revolutionized cancer therapy, the mechanisms governing their expression on human T cells have not been elucidated. Type 1 interferon (IFN-I) modulates T cell immunity in viral infection, autoimmunity, and cancer, and...

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Hafler D, Sumida T, Dulberg S, et al. Type I Interferon Transcriptional Network Regulates Expression of Coinhibitory Receptors in Human T cells. Res Sq. 2021;doi: 10.21203/rs.3.rs-133494/v1.
Hafler, D., Sumida, T., Dulberg, S., Schupp, J., Stillwell, H., Axisa, P. P., Comi, M., Lincoln, M., Unterman, A., Kaminski, N., Madi, A., & Kuchroo, V. (2021). Type I Interferon Transcriptional Network Regulates Expression of Coinhibitory Receptors in Human T cells. Research square, . https://doi.org/10.21203/rs.3.rs-133494/v1
Hafler, David, et al. "Type I Interferon Transcriptional Network Regulates Expression of Coinhibitory Receptors in Human T cells." Research square vol. (2021). doi: https://doi.org/10.21203/rs.3.rs-133494/v1
Hafler D, Sumida T, Dulberg S, Schupp J, Stillwell H, Axisa PP, Comi M, Lincoln M, Unterman A, Kaminski N, Madi A, Kuchroo V. Type I Interferon Transcriptional Network Regulates Expression of Coinhibitory Receptors in Human T cells. Res Sq. 2021 Jun 08; doi: 10.21203/rs.3.rs-133494/v1. PMID: 34127967; PMCID: PMC8202434.
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Metabolic modeling of single Th17 cells reveals regulators of autoimmunity.

Cell

Wagner A, Wang C, Fessler J, DeTomaso D, Avila-Pacheco J, Kaminski J, Zaghouani S, Christian E, Thakore P, Schellhaass B, Akama-Garren E, Pierce K, Singh V, Ron-Harel N, Douglas VP, Bod L, Schnell A, Puleston D, Sobel RA, Haigis M, Pearce EL, Soleimani M, Clish C, Regev A, Kuchroo VK, Yosef N.
PMID: 34216539
Cell. 2021 Aug 05;184(16):4168-4185.e21. doi: 10.1016/j.cell.2021.05.045. Epub 2021 Jul 02.

Metabolism is a major regulator of immune cell function, but it remains difficult to study the metabolic status of individual cells. Here, we present Compass, an algorithm to characterize cellular metabolic states based on single-cell RNA sequencing and flux...

Cite
Wagner A, Wang C, Fessler J, et al. Metabolic modeling of single Th17 cells reveals regulators of autoimmunity. Cell. 2021;184(16):4168-4185.e21doi: 10.1016/j.cell.2021.05.045.
Wagner, A., Wang, C., Fessler, J., DeTomaso, D., Avila-Pacheco, J., Kaminski, J., Zaghouani, S., Christian, E., Thakore, P., Schellhaass, B., Akama-Garren, E., Pierce, K., Singh, V., Ron-Harel, N., Douglas, V. P., Bod, L., Schnell, A., Puleston, D., Sobel, R. A., Haigis, M., Pearce, E. L., Soleimani, M., Clish, C., Regev, A., Kuchroo, V. K., & Yosef, N. (2021). Metabolic modeling of single Th17 cells reveals regulators of autoimmunity. Cell, 184(16), 4168-4185.e21. https://doi.org/10.1016/j.cell.2021.05.045
Wagner, Allon, et al. "Metabolic modeling of single Th17 cells reveals regulators of autoimmunity." Cell vol. 184,16 (2021): 4168-4185.e21. doi: https://doi.org/10.1016/j.cell.2021.05.045
Wagner A, Wang C, Fessler J, DeTomaso D, Avila-Pacheco J, Kaminski J, Zaghouani S, Christian E, Thakore P, Schellhaass B, Akama-Garren E, Pierce K, Singh V, Ron-Harel N, Douglas VP, Bod L, Schnell A, Puleston D, Sobel RA, Haigis M, Pearce EL, Soleimani M, Clish C, Regev A, Kuchroo VK, Yosef N. Metabolic modeling of single Th17 cells reveals regulators of autoimmunity. Cell. 2021 Aug 05;184(16):4168-4185.e21. doi: 10.1016/j.cell.2021.05.045. Epub 2021 Jul 02. PMID: 34216539; PMCID: PMC8621950.
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Emerging concepts in PD-1 checkpoint biology.

Seminars in immunology

Pauken KE, Torchia JA, Chaudhri A, Sharpe AH, Freeman GJ.
PMID: 34006473
Semin Immunol. 2021 Feb;52:101480. doi: 10.1016/j.smim.2021.101480. Epub 2021 May 15.

The PD-1 pathway is a cornerstone in immune regulation. While the PD-1 pathway has received considerable attention for its role in contributing to the maintenance of T cell exhaustion in chronic infection and cancer, the PD-1 pathway plays diverse...

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Pauken KE, Torchia JA, Chaudhri A, et al. Emerging concepts in PD-1 checkpoint biology. Semin Immunol. 2021;52:101480doi: 10.1016/j.smim.2021.101480.
Pauken, K. E., Torchia, J. A., Chaudhri, A., Sharpe, A. H., & Freeman, G. J. (2021). Emerging concepts in PD-1 checkpoint biology. Seminars in immunology, 52101480. https://doi.org/10.1016/j.smim.2021.101480
Pauken, Kristen E, et al. "Emerging concepts in PD-1 checkpoint biology." Seminars in immunology vol. 52 (2021): 101480. doi: https://doi.org/10.1016/j.smim.2021.101480
Pauken KE, Torchia JA, Chaudhri A, Sharpe AH, Freeman GJ. Emerging concepts in PD-1 checkpoint biology. Semin Immunol. 2021 Feb;52:101480. doi: 10.1016/j.smim.2021.101480. Epub 2021 May 15. PMID: 34006473; PMCID: PMC8545711.
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Stem-like intestinal Th17 cells give rise to pathogenic effector T cells during autoimmunity.

Cell

Schnell A, Huang L, Singer M, Singaraju A, Barilla RM, Regan BML, Bollhagen A, Thakore PI, Dionne D, Delorey TM, Pawlak M, Meyer Zu Horste G, Rozenblatt-Rosen O, Irizarry RA, Regev A, Kuchroo VK.
PMID: 34875227
Cell. 2021 Dec 22;184(26):6281-6298.e23. doi: 10.1016/j.cell.2021.11.018. Epub 2021 Dec 06.

While intestinal Th17 cells are critical for maintaining tissue homeostasis, recent studies have implicated their roles in the development of extra-intestinal autoimmune diseases including multiple sclerosis. However, the mechanisms by which tissue Th17 cells mediate these dichotomous functions remain...

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Schnell A, Huang L, Singer M, et al. Stem-like intestinal Th17 cells give rise to pathogenic effector T cells during autoimmunity. Cell. 2021;184(26):6281-6298.e23doi: 10.1016/j.cell.2021.11.018.
Schnell, A., Huang, L., Singer, M., Singaraju, A., Barilla, R. M., Regan, B. M. L., Bollhagen, A., Thakore, P. I., Dionne, D., Delorey, T. M., Pawlak, M., Meyer Zu Horste, G., Rozenblatt-Rosen, O., Irizarry, R. A., Regev, A., & Kuchroo, V. K. (2021). Stem-like intestinal Th17 cells give rise to pathogenic effector T cells during autoimmunity. Cell, 184(26), 6281-6298.e23. https://doi.org/10.1016/j.cell.2021.11.018
Schnell, Alexandra, et al. "Stem-like intestinal Th17 cells give rise to pathogenic effector T cells during autoimmunity." Cell vol. 184,26 (2021): 6281-6298.e23. doi: https://doi.org/10.1016/j.cell.2021.11.018
Schnell A, Huang L, Singer M, Singaraju A, Barilla RM, Regan BML, Bollhagen A, Thakore PI, Dionne D, Delorey TM, Pawlak M, Meyer Zu Horste G, Rozenblatt-Rosen O, Irizarry RA, Regev A, Kuchroo VK. Stem-like intestinal Th17 cells give rise to pathogenic effector T cells during autoimmunity. Cell. 2021 Dec 22;184(26):6281-6298.e23. doi: 10.1016/j.cell.2021.11.018. Epub 2021 Dec 06. PMID: 34875227.
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Metabolic modeling of single Th17 cells reveals regulators of autoimmunity.

Cell

Wagner A, Wang C, Fessler J, DeTomaso D, Avila-Pacheco J, Kaminski J, Zaghouani S, Christian E, Thakore P, Schellhaass B, Akama-Garren E, Pierce K, Singh V, Ron-Harel N, Douglas VP, Bod L, Schnell A, Puleston D, Sobel RA, Haigis M, Pearce EL, Soleimani M, Clish C, Regev A, Kuchroo VK, Yosef N.
PMID: 34216539
Cell. 2021 Aug 05;184(16):4168-4185.e21. doi: 10.1016/j.cell.2021.05.045. Epub 2021 Jul 02.

Metabolism is a major regulator of immune cell function, but it remains difficult to study the metabolic status of individual cells. Here, we present Compass, an algorithm to characterize cellular metabolic states based on single-cell RNA sequencing and flux...

Cite
Wagner A, Wang C, Fessler J, et al. Metabolic modeling of single Th17 cells reveals regulators of autoimmunity. Cell. 2021;184(16):4168-4185.e21doi: 10.1016/j.cell.2021.05.045.
Wagner, A., Wang, C., Fessler, J., DeTomaso, D., Avila-Pacheco, J., Kaminski, J., Zaghouani, S., Christian, E., Thakore, P., Schellhaass, B., Akama-Garren, E., Pierce, K., Singh, V., Ron-Harel, N., Douglas, V. P., Bod, L., Schnell, A., Puleston, D., Sobel, R. A., Haigis, M., Pearce, E. L., Soleimani, M., Clish, C., Regev, A., Kuchroo, V. K., & Yosef, N. (2021). Metabolic modeling of single Th17 cells reveals regulators of autoimmunity. Cell, 184(16), 4168-4185.e21. https://doi.org/10.1016/j.cell.2021.05.045
Wagner, Allon, et al. "Metabolic modeling of single Th17 cells reveals regulators of autoimmunity." Cell vol. 184,16 (2021): 4168-4185.e21. doi: https://doi.org/10.1016/j.cell.2021.05.045
Wagner A, Wang C, Fessler J, DeTomaso D, Avila-Pacheco J, Kaminski J, Zaghouani S, Christian E, Thakore P, Schellhaass B, Akama-Garren E, Pierce K, Singh V, Ron-Harel N, Douglas VP, Bod L, Schnell A, Puleston D, Sobel RA, Haigis M, Pearce EL, Soleimani M, Clish C, Regev A, Kuchroo VK, Yosef N. Metabolic modeling of single Th17 cells reveals regulators of autoimmunity. Cell. 2021 Aug 05;184(16):4168-4185.e21. doi: 10.1016/j.cell.2021.05.045. Epub 2021 Jul 02. PMID: 34216539; PMCID: PMC8621950.
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Concurrent Dexamethasone Limits the Clinical Benefit of Immune Checkpoint Blockade in Glioblastoma.

Clinical cancer research : an official journal of the American Association for Cancer Research

Iorgulescu JB, Gokhale PC, Speranza MC, Eschle BK, Poitras MJ, Wilkens MK, Soroko KM, Chhoeu C, Knott A, Gao Y, Lim-Fat MJ, Baker GJ, Bonal DM, Nguyen QD, Grant GRL, Ligon KL, Sorger PK, Chiocca EA, Anderson AC, Kirschmeier PT, Sharpe AH, Freeman GJ, Reardon DA.
PMID: 33239433
Clin Cancer Res. 2021 Jan 01;27(1):276-287. doi: 10.1158/1078-0432.CCR-20-2291. Epub 2020 Nov 25.

PURPOSE: Dexamethasone, a uniquely potent corticosteroid, is frequently administered to patients with brain tumors to decrease tumor-associated edema, but limited data exist describing how dexamethasone affects the immune system systemically and intratumorally in patients with glioblastoma (GBM), particularly in...

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Iorgulescu JB, Gokhale PC, Speranza MC, et al. Concurrent Dexamethasone Limits the Clinical Benefit of Immune Checkpoint Blockade in Glioblastoma. Clin Cancer Res. 2020;27(1):276-287doi: 10.1158/1078-0432.CCR-20-2291.
Iorgulescu, J. B., Gokhale, P. C., Speranza, M. C., Eschle, B. K., Poitras, M. J., Wilkens, M. K., Soroko, K. M., Chhoeu, C., Knott, A., Gao, Y., Lim-Fat, M. J., Baker, G. J., Bonal, D. M., Nguyen, Q. D., Grant, G. R. L., Ligon, K. L., Sorger, P. K., Chiocca, E. A., Anderson, A. C., Kirschmeier, P. T., Sharpe, A. H., Freeman, G. J., & Reardon, D. A. (2021). Concurrent Dexamethasone Limits the Clinical Benefit of Immune Checkpoint Blockade in Glioblastoma. Clinical cancer research : an official journal of the American Association for Cancer Research, 27(1), 276-287. https://doi.org/10.1158/1078-0432.CCR-20-2291
Iorgulescu, J Bryan, et al. "Concurrent Dexamethasone Limits the Clinical Benefit of Immune Checkpoint Blockade in Glioblastoma." Clinical cancer research : an official journal of the American Association for Cancer Research vol. 27,1 (2021): 276-287. doi: https://doi.org/10.1158/1078-0432.CCR-20-2291
Iorgulescu JB, Gokhale PC, Speranza MC, Eschle BK, Poitras MJ, Wilkens MK, Soroko KM, Chhoeu C, Knott A, Gao Y, Lim-Fat MJ, Baker GJ, Bonal DM, Nguyen QD, Grant GRL, Ligon KL, Sorger PK, Chiocca EA, Anderson AC, Kirschmeier PT, Sharpe AH, Freeman GJ, Reardon DA. Concurrent Dexamethasone Limits the Clinical Benefit of Immune Checkpoint Blockade in Glioblastoma. Clin Cancer Res. 2021 Jan 01;27(1):276-287. doi: 10.1158/1078-0432.CCR-20-2291. Epub 2020 Nov 25. PMID: 33239433; PMCID: PMC8034990.
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The double-edged sword: Harnessing PD-1 blockade in tumor and autoimmunity.

Science immunology

Kuchroo JR, Hafler DA, Sharpe AH, Lucca LE.
PMID: 34739340
Sci Immunol. 2021 Nov 05;6(65):eabf4034. doi: 10.1126/sciimmunol.abf4034. Epub 2021 Nov 05.

[Figure: see text].

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Kuchroo JR, Hafler DA, Sharpe AH, et al. The double-edged sword: Harnessing PD-1 blockade in tumor and autoimmunity. Sci Immunol. 2021;6(65):eabf4034doi: 10.1126/sciimmunol.abf4034.
Kuchroo, J. R., Hafler, D. A., Sharpe, A. H., & Lucca, L. E. (2021). The double-edged sword: Harnessing PD-1 blockade in tumor and autoimmunity. Science immunology, 6(65), eabf4034. https://doi.org/10.1126/sciimmunol.abf4034
Kuchroo, Juhi R, et al. "The double-edged sword: Harnessing PD-1 blockade in tumor and autoimmunity." Science immunology vol. 6,65 (2021): eabf4034. doi: https://doi.org/10.1126/sciimmunol.abf4034
Kuchroo JR, Hafler DA, Sharpe AH, Lucca LE. The double-edged sword: Harnessing PD-1 blockade in tumor and autoimmunity. Sci Immunol. 2021 Nov 05;6(65):eabf4034. doi: 10.1126/sciimmunol.abf4034. Epub 2021 Nov 05. PMID: 34739340.
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PD-1 marks dysfunctional regulatory T cells in malignant gliomas.

JCI insight

Lowther DE, Goods BA, Lucca LE, Lerner BA, Raddassi K, van Dijk D, Hernandez AL, Duan X, Gunel M, Coric V, Krishnaswamy S, Love JC, Hafler DA.
PMID: 27182555
JCI Insight. 2016 Apr 21;1(5). doi: 10.1172/jci.insight.85935.

Immunotherapies targeting the immune checkpoint receptor programmed cell death protein 1 (PD-1) have shown remarkable efficacy in treating cancer. CD4

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Lowther DE, Goods BA, Lucca LE, et al. PD-1 marks dysfunctional regulatory T cells in malignant gliomas. JCI Insight. 2016;1(5)doi: 10.1172/jci.insight.85935.
Lowther, D. E., Goods, B. A., Lucca, L. E., Lerner, B. A., Raddassi, K., van Dijk, D., Hernandez, A. L., Duan, X., Gunel, M., Coric, V., Krishnaswamy, S., Love, J. C., & Hafler, D. A. (2016). PD-1 marks dysfunctional regulatory T cells in malignant gliomas. JCI insight, 1(5), . https://doi.org/10.1172/jci.insight.85935
Lowther, Daniel E, et al. "PD-1 marks dysfunctional regulatory T cells in malignant gliomas." JCI insight vol. 1,5 (2016). doi: https://doi.org/10.1172/jci.insight.85935
Lowther DE, Goods BA, Lucca LE, Lerner BA, Raddassi K, van Dijk D, Hernandez AL, Duan X, Gunel M, Coric V, Krishnaswamy S, Love JC, Hafler DA. PD-1 marks dysfunctional regulatory T cells in malignant gliomas. JCI Insight. 2016 Apr 21;1(5). doi: 10.1172/jci.insight.85935. PMID: 27182555; PMCID: PMC4864991.
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Fluorescence intensity normalisation: correcting for time effects in large-scale flow cytometric analysis.

Advances in bioinformatics

Dendrou CA, Fung E, Esposito L, Todd JA, Wicker LS, Plagnol V.
PMID: 20049162
Adv Bioinformatics. 2009;476106. doi: 10.1155/2009/476106. Epub 2009 Nov 17.

A next step to interpret the findings generated by genome-wide association studies is to associate molecular quantitative traits with disease-associated alleles. To this end, researchers are linking disease risk alleles with gene expression quantitative trait loci (eQTL). However, gene...

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Dendrou CA, Fung E, Esposito L, et al. Fluorescence intensity normalisation: correcting for time effects in large-scale flow cytometric analysis. Adv Bioinformatics. 2009;476106doi: 10.1155/2009/476106.
Dendrou, C. A., Fung, E., Esposito, L., Todd, J. A., Wicker, L. S., & Plagnol, V. (2009). Fluorescence intensity normalisation: correcting for time effects in large-scale flow cytometric analysis. Advances in bioinformatics, 476106. https://doi.org/10.1155/2009/476106
Dendrou, Calliope A, et al. "Fluorescence intensity normalisation: correcting for time effects in large-scale flow cytometric analysis." Advances in bioinformatics vol. (2009): 476106. doi: https://doi.org/10.1155/2009/476106
Dendrou CA, Fung E, Esposito L, Todd JA, Wicker LS, Plagnol V. Fluorescence intensity normalisation: correcting for time effects in large-scale flow cytometric analysis. Adv Bioinformatics. 2009;476106. doi: 10.1155/2009/476106. Epub 2009 Nov 17. PMID: 20049162; PMCID: PMC2798117.
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Transcriptomic and clonal characterization of T cells in the human central nervous system.

Science immunology

Pappalardo JL, Zhang L, Pecsok MK, Perlman K, Zografou C, Raddassi K, Abulaban A, Krishnaswamy S, Antel J, van Dijk D, Hafler DA.
PMID: 32948672
Sci Immunol. 2020 Sep 18;5(51). doi: 10.1126/sciimmunol.abb8786.

T cells provide critical immune surveillance to the central nervous system (CNS), and the cerebrospinal fluid (CSF) is thought to be a main route for their entry. Further characterization of the state of T cells in the CSF in...

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Pappalardo JL, Zhang L, Pecsok MK, et al. Transcriptomic and clonal characterization of T cells in the human central nervous system. Sci Immunol. 2020;5(51)doi: 10.1126/sciimmunol.abb8786.
Pappalardo, J. L., Zhang, L., Pecsok, M. K., Perlman, K., Zografou, C., Raddassi, K., Abulaban, A., Krishnaswamy, S., Antel, J., van Dijk, D., & Hafler, D. A. (2020). Transcriptomic and clonal characterization of T cells in the human central nervous system. Science immunology, 5(51), . https://doi.org/10.1126/sciimmunol.abb8786
Pappalardo, Jenna L, et al. "Transcriptomic and clonal characterization of T cells in the human central nervous system." Science immunology vol. 5,51 (2020). doi: https://doi.org/10.1126/sciimmunol.abb8786
Pappalardo JL, Zhang L, Pecsok MK, Perlman K, Zografou C, Raddassi K, Abulaban A, Krishnaswamy S, Antel J, van Dijk D, Hafler DA. Transcriptomic and clonal characterization of T cells in the human central nervous system. Sci Immunol. 2020 Sep 18;5(51). doi: 10.1126/sciimmunol.abb8786. PMID: 32948672; PMCID: PMC8567322.
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An IL-27-Driven Transcriptional Network Identifies Regulators of IL-10 Expression across T Helper Cell Subsets.

Cell reports

Zhang H, Madi A, Yosef N, Chihara N, Awasthi A, Pot C, Lambden C, Srivastava A, Burkett PR, Nyman J, Christian E, Etminan Y, Lee A, Stroh H, Xia J, Karwacz K, Thakore PI, Acharya N, Schnell A, Wang C, Apetoh L, Rozenblatt-Rosen O, Anderson AC, Regev A, Kuchroo VK.
PMID: 33238123
Cell Rep. 2020 Nov 24;33(8):108433. doi: 10.1016/j.celrep.2020.108433.

Interleukin-27 (IL-27) is an immunoregulatory cytokine that suppresses inflammation through multiple mechanisms, including induction of IL-10, but the transcriptional network mediating its diverse functions remains unclear. Combining temporal RNA profiling with computational algorithms, we predict 79 transcription factors induced...

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Zhang H, Madi A, Yosef N, et al. An IL-27-Driven Transcriptional Network Identifies Regulators of IL-10 Expression across T Helper Cell Subsets. Cell Rep. 2020;33(8):108433doi: 10.1016/j.celrep.2020.108433.
Zhang, H., Madi, A., Yosef, N., Chihara, N., Awasthi, A., Pot, C., Lambden, C., Srivastava, A., Burkett, P. R., Nyman, J., Christian, E., Etminan, Y., Lee, A., Stroh, H., Xia, J., Karwacz, K., Thakore, P. I., Acharya, N., Schnell, A., Wang, C., Apetoh, L., Rozenblatt-Rosen, O., Anderson, A. C., Regev, A., & Kuchroo, V. K. (2020). An IL-27-Driven Transcriptional Network Identifies Regulators of IL-10 Expression across T Helper Cell Subsets. Cell reports, 33(8), 108433. https://doi.org/10.1016/j.celrep.2020.108433
Zhang, Huiyuan, et al. "An IL-27-Driven Transcriptional Network Identifies Regulators of IL-10 Expression across T Helper Cell Subsets." Cell reports vol. 33,8 (2020): 108433. doi: https://doi.org/10.1016/j.celrep.2020.108433
Zhang H, Madi A, Yosef N, Chihara N, Awasthi A, Pot C, Lambden C, Srivastava A, Burkett PR, Nyman J, Christian E, Etminan Y, Lee A, Stroh H, Xia J, Karwacz K, Thakore PI, Acharya N, Schnell A, Wang C, Apetoh L, Rozenblatt-Rosen O, Anderson AC, Regev A, Kuchroo VK. An IL-27-Driven Transcriptional Network Identifies Regulators of IL-10 Expression across T Helper Cell Subsets. Cell Rep. 2020 Nov 24;33(8):108433. doi: 10.1016/j.celrep.2020.108433. PMID: 33238123; PMCID: PMC7771052.
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Showing 1 to 12 of 14 entries