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Addiction is a Reward Deficit and Stress Surfeit Disorder.

Frontiers in psychiatry

Koob GF.
PMID: 23914176
Front Psychiatry. 2013 Aug 01;4:72. doi: 10.3389/fpsyt.2013.00072. eCollection 2013.

Drug addiction can be defined by a three-stage cycle - binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation - that involves allostatic changes in the brain reward and stress systems. Two primary sources of reinforcement, positive and negative reinforcement, have been hypothesized...

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Koob GF. Addiction is a Reward Deficit and Stress Surfeit Disorder. Front Psychiatry. 2013;4:72doi: 10.3389/fpsyt.2013.00072.
Koob, G. F. (2013). Addiction is a Reward Deficit and Stress Surfeit Disorder. Frontiers in psychiatry, 472. https://doi.org/10.3389/fpsyt.2013.00072
Koob, George F. "Addiction is a Reward Deficit and Stress Surfeit Disorder." Frontiers in psychiatry vol. 4 (2013): 72. doi: https://doi.org/10.3389/fpsyt.2013.00072
Koob GF. Addiction is a Reward Deficit and Stress Surfeit Disorder. Front Psychiatry. 2013 Aug 01;4:72. doi: 10.3389/fpsyt.2013.00072. eCollection 2013. PMID: 23914176; PMCID: PMC3730086.
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Neurobiology of dysregulated motivational systems in drug addiction.

Future neurology

Edwards S, Koob GF.
PMID: 20563312
Future Neurol. 2010 May 01;5(3):393-401. doi: 10.2217/fnl.10.14.

The progression from recreational drug use to drug addiction impacts multiple neurobiological processes and can be conceptualized as a transition from positive to negative reinforcement mechanisms driving both drug-taking and drug-seeking behaviors. Neurobiological mechanisms for negative reinforcement, defined as...

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Edwards S, Koob GF. Neurobiology of dysregulated motivational systems in drug addiction. Future Neurol. 2010;5(3):393-401doi: 10.2217/fnl.10.14.
Edwards, S., & Koob, G. F. (2010). Neurobiology of dysregulated motivational systems in drug addiction. Future neurology, 5(3), 393-401. https://doi.org/10.2217/fnl.10.14
Edwards, Scott, and Koob, George F. "Neurobiology of dysregulated motivational systems in drug addiction." Future neurology vol. 5,3 (2010): 393-401. doi: https://doi.org/10.2217/fnl.10.14
Edwards S, Koob GF. Neurobiology of dysregulated motivational systems in drug addiction. Future Neurol. 2010 May 01;5(3):393-401. doi: 10.2217/fnl.10.14. PMID: 20563312; PMCID: PMC2886284.
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Hedonic Homeostatic Dysregulation as a Driver of Drug-Seeking Behavior.

Drug discovery today. Disease models

Koob GF.
PMID: 20054425
Drug Discov Today Dis Models. 2008;5(4):207-215. doi: 10.1016/j.ddmod.2009.04.002.

Drug addiction can be defined by a compulsion to seek and take drug and loss of control in limiting intake, and the excessive drug taking derives from multiple motivational mechanisms. One such mechanism is the emergence of a negative...

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Koob GF. Hedonic Homeostatic Dysregulation as a Driver of Drug-Seeking Behavior. Drug Discov Today Dis Models. 2008;5(4):207-215doi: 10.1016/j.ddmod.2009.04.002.
Koob, G. F. (2008). Hedonic Homeostatic Dysregulation as a Driver of Drug-Seeking Behavior. Drug discovery today. Disease models, 5(4), 207-215. https://doi.org/10.1016/j.ddmod.2009.04.002
Koob, George F. "Hedonic Homeostatic Dysregulation as a Driver of Drug-Seeking Behavior." Drug discovery today. Disease models vol. 5,4 (2008): 207-215. doi: https://doi.org/10.1016/j.ddmod.2009.04.002
Koob GF. Hedonic Homeostatic Dysregulation as a Driver of Drug-Seeking Behavior. Drug Discov Today Dis Models. 2008;5(4):207-215. doi: 10.1016/j.ddmod.2009.04.002. PMID: 20054425; PMCID: PMC2801885.
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Differential changes in amygdala and frontal cortex Pde10a expression during acute and protracted withdrawal.

Frontiers in integrative neuroscience

Logrip ML, Zorrilla EP.
PMID: 24782725
Front Integr Neurosci. 2014 Apr 08;8:30. doi: 10.3389/fnint.2014.00030. eCollection 2014.

Alcohol use disorders are persistent problems with high recidivism rates despite repeated efforts to quit drinking. Neuroadaptations that result from alcohol exposure and that persist during periods of abstinence represent putative molecular determinants of the propensity to relapse. Previously...

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Logrip ML, Zorrilla EP. Differential changes in amygdala and frontal cortex Pde10a expression during acute and protracted withdrawal. Front Integr Neurosci. 2014;8:30doi: 10.3389/fnint.2014.00030.
Logrip, M. L., & Zorrilla, E. P. (2014). Differential changes in amygdala and frontal cortex Pde10a expression during acute and protracted withdrawal. Frontiers in integrative neuroscience, 830. https://doi.org/10.3389/fnint.2014.00030
Logrip, Marian L, and Zorrilla, Eric P. "Differential changes in amygdala and frontal cortex Pde10a expression during acute and protracted withdrawal." Frontiers in integrative neuroscience vol. 8 (2014): 30. doi: https://doi.org/10.3389/fnint.2014.00030
Logrip ML, Zorrilla EP. Differential changes in amygdala and frontal cortex Pde10a expression during acute and protracted withdrawal. Front Integr Neurosci. 2014 Apr 08;8:30. doi: 10.3389/fnint.2014.00030. eCollection 2014. PMID: 24782725; PMCID: PMC3986522.
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The Neurobiology of Addiction: Where We Have Been and Where We Are Going.

Journal of drug issues

Koob GF, Simon EJ.
PMID: 20622969
J Drug Issues. 2009 Jan;39(1):115-132. doi: 10.1177/002204260903900110.

A number of dramatic breakthroughs in the neurobiology of addiction have occurred in the past 40 years. Two domains will be highlighted: the neurocircuitry of addiction and the molecular biology of addiction targets. The neurobiological substrates for the reinforcing...

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Koob GF, Simon EJ. The Neurobiology of Addiction: Where We Have Been and Where We Are Going. J Drug Issues. 2009;39(1):115-132doi: 10.1177/002204260903900110.
Koob, G. F., & Simon, E. J. (2009). The Neurobiology of Addiction: Where We Have Been and Where We Are Going. Journal of drug issues, 39(1), 115-132. https://doi.org/10.1177/002204260903900110
Koob, George F, and Simon, Eric J. "The Neurobiology of Addiction: Where We Have Been and Where We Are Going." Journal of drug issues vol. 39,1 (2009): 115-132. doi: https://doi.org/10.1177/002204260903900110
Koob GF, Simon EJ. The Neurobiology of Addiction: Where We Have Been and Where We Are Going. J Drug Issues. 2009 Jan;39(1):115-132. doi: 10.1177/002204260903900110. PMID: 20622969; PMCID: PMC2901107.
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Synthesis of protected norcysteines for SPPS compatible with Fmoc-strategy.

Tetrahedron letters

Samant MP, Rivier JE.
PMID: 19562100
Tetrahedron Lett. 2007 Jul 16;48(29):5107-5110. doi: 10.1016/j.tetlet.2007.05.082.

We report the synthesis of racemic Alloc-Ncy(Tmob)-OH, the resolution of its methyl ester, and demonstrate its application to form a norcystine bridge in octreotide-amide using the Fmoc-strategy on solid phase. N-Alloc and S-Tmob protections of norcysteine (Ncy) were found...

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Samant MP, Rivier JE. Synthesis of protected norcysteines for SPPS compatible with Fmoc-strategy. Tetrahedron Lett. 2007;48(29):5107-5110doi: 10.1016/j.tetlet.2007.05.082.
Samant, M. P., & Rivier, J. E. (2007). Synthesis of protected norcysteines for SPPS compatible with Fmoc-strategy. Tetrahedron letters, 48(29), 5107-5110. https://doi.org/10.1016/j.tetlet.2007.05.082
Samant, Manoj P, and Rivier, Jean E. "Synthesis of protected norcysteines for SPPS compatible with Fmoc-strategy." Tetrahedron letters vol. 48,29 (2007): 5107-5110. doi: https://doi.org/10.1016/j.tetlet.2007.05.082
Samant MP, Rivier JE. Synthesis of protected norcysteines for SPPS compatible with Fmoc-strategy. Tetrahedron Lett. 2007 Jul 16;48(29):5107-5110. doi: 10.1016/j.tetlet.2007.05.082. PMID: 19562100; PMCID: PMC2701708.
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Evaluation of Alcohol Preference and Drinking in msP Rats Bearing a .

Frontiers in psychiatry

Logrip ML, Walker JR, Ayanwuyi LO, Sabino V, Ciccocioppo R, Koob GF, Zorrilla EP.
PMID: 29497387
Front Psychiatry. 2018 Feb 15;9:28. doi: 10.3389/fpsyt.2018.00028. eCollection 2018.

Alcoholism is a pervasive societal problem, yet available pharmacotherapies fail to treat most sufferers. The type 1 corticotropin-releasing factor (CRF

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Logrip ML, Walker JR, Ayanwuyi LO, et al. Evaluation of Alcohol Preference and Drinking in msP Rats Bearing a . Front Psychiatry. 2018;9:28doi: 10.3389/fpsyt.2018.00028.
Logrip, M. L., Walker, J. R., Ayanwuyi, L. O., Sabino, V., Ciccocioppo, R., Koob, G. F., & Zorrilla, E. P. (2018). Evaluation of Alcohol Preference and Drinking in msP Rats Bearing a . Frontiers in psychiatry, 928. https://doi.org/10.3389/fpsyt.2018.00028
Logrip, Marian L, et al. "Evaluation of Alcohol Preference and Drinking in msP Rats Bearing a ." Frontiers in psychiatry vol. 9 (2018): 28. doi: https://doi.org/10.3389/fpsyt.2018.00028
Logrip ML, Walker JR, Ayanwuyi LO, Sabino V, Ciccocioppo R, Koob GF, Zorrilla EP. Evaluation of Alcohol Preference and Drinking in msP Rats Bearing a . Front Psychiatry. 2018 Feb 15;9:28. doi: 10.3389/fpsyt.2018.00028. eCollection 2018. PMID: 29497387; PMCID: PMC5818434.
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Showing 1 to 7 of 7 entries