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Functioning of Microsomal Cytochrome P450s: Murburn Concept Explains the Metabolism of Xenobiotics in Hepatocytes.

Frontiers in pharmacology

Manoj KM, Parashar A, Gade SK, Venkatachalam A.
PMID: 27445805
Front Pharmacol. 2016 Jun 23;7:161. doi: 10.3389/fphar.2016.00161. eCollection 2016.

Using oxygen and NADPH, the redox enzymes cytochrome P450 (CYP) and its reductase (CPR) work in tandem to carry out the phase I metabolism of a vast majority of drugs and xenobiotics. As per the erstwhile understanding of the...

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Manoj KM, Parashar A, Gade SK, et al. Functioning of Microsomal Cytochrome P450s: Murburn Concept Explains the Metabolism of Xenobiotics in Hepatocytes. Front Pharmacol. 2016;7:161doi: 10.3389/fphar.2016.00161.
Manoj, K. M., Parashar, A., Gade, S. K., & Venkatachalam, A. (2016). Functioning of Microsomal Cytochrome P450s: Murburn Concept Explains the Metabolism of Xenobiotics in Hepatocytes. Frontiers in pharmacology, 7161. https://doi.org/10.3389/fphar.2016.00161
Manoj, Kelath Murali, et al. "Functioning of Microsomal Cytochrome P450s: Murburn Concept Explains the Metabolism of Xenobiotics in Hepatocytes." Frontiers in pharmacology vol. 7 (2016): 161. doi: https://doi.org/10.3389/fphar.2016.00161
Manoj KM, Parashar A, Gade SK, Venkatachalam A. Functioning of Microsomal Cytochrome P450s: Murburn Concept Explains the Metabolism of Xenobiotics in Hepatocytes. Front Pharmacol. 2016 Jun 23;7:161. doi: 10.3389/fphar.2016.00161. eCollection 2016. PMID: 27445805; PMCID: PMC4918403.
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p53 Contributes to Differentiating Gene Expression Following Exposure to Acetaminophen and Its Less Hepatotoxic Regioisomer Both In Vitro and In Vivo.

Gene regulation and systems biology

Stamper BD, Garcia ML, Nguyen DQ, Beyer RP, Bammler TK, Farin FM, Kavanagh TJ, Nelson SD.
PMID: 26056430
Gene Regul Syst Bio. 2015 Jun 01;9:1-14. doi: 10.4137/GRSB.S25388. eCollection 2015.

The goal of the present study was to compare hepatic toxicogenomic signatures across in vitro and in vivo mouse models following exposure to acetaminophen (APAP) or its relatively nontoxic regioisomer 3'-hydroxyacetanilide (AMAP). Two different Affymetrix microarray platforms and one...

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Stamper BD, Garcia ML, Nguyen DQ, et al. p53 Contributes to Differentiating Gene Expression Following Exposure to Acetaminophen and Its Less Hepatotoxic Regioisomer Both In Vitro and In Vivo. Gene Regul Syst Bio. 2015;9:1-14doi: 10.4137/GRSB.S25388.
Stamper, B. D., Garcia, M. L., Nguyen, D. Q., Beyer, R. P., Bammler, T. K., Farin, F. M., Kavanagh, T. J., & Nelson, S. D. (2015). p53 Contributes to Differentiating Gene Expression Following Exposure to Acetaminophen and Its Less Hepatotoxic Regioisomer Both In Vitro and In Vivo. Gene regulation and systems biology, 91-14. https://doi.org/10.4137/GRSB.S25388
Stamper, Brendan D, et al. "p53 Contributes to Differentiating Gene Expression Following Exposure to Acetaminophen and Its Less Hepatotoxic Regioisomer Both In Vitro and In Vivo." Gene regulation and systems biology vol. 9 (2015): 1-14. doi: https://doi.org/10.4137/GRSB.S25388
Stamper BD, Garcia ML, Nguyen DQ, Beyer RP, Bammler TK, Farin FM, Kavanagh TJ, Nelson SD. p53 Contributes to Differentiating Gene Expression Following Exposure to Acetaminophen and Its Less Hepatotoxic Regioisomer Both In Vitro and In Vivo. Gene Regul Syst Bio. 2015 Jun 01;9:1-14. doi: 10.4137/GRSB.S25388. eCollection 2015. PMID: 26056430; PMCID: PMC4454132.
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