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Linking of Glycine Receptor Transmembrane Segments Three and Four Allows Assignment of Intrasubunit-Facing Residues.

ACS chemical neuroscience

McCracken LM, McCracken ML, Gong DH, Trudell JR, Harris RA.
PMID: 21326622
ACS Chem Neurosci. 2010 Jul;1(7):482. doi: 10.1021/cn100019g.

Glycine receptors (GlyRs) are pentameric ligand-gated ion channels that mediate inhibitory neurotransmission in the brain and spinal cord and are targets of alcohols and anesthetics. The transmembrane (TM) domain of GlyR subunits is composed of four α-helical segments (TM1-4),...

CPP impairs contextual learning at concentrations below those that block pyramidal neuron NMDARs and LTP in the CA1 region of the hippocampus.

Neuropharmacology

Laha K, Zhu M, Gemperline E, Rau V, Li L, Fanselow MS, Lennertz R, Pearce RA.
PMID: 34687710
Neuropharmacology. 2022 Jan 01;202:108846. doi: 10.1016/j.neuropharm.2021.108846. Epub 2021 Oct 20.

Drugs that block N-methyl-d-aspartate receptors (NMDARs) suppress hippocampus-dependent memory formation; they also block long-term potentiation (LTP), a cellular model of learning and memory. However, the fractional block that is required to achieve these effects is unknown. Here, we measured...

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