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Showing 1 to 12 of 12 entries
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Lipoprotein(a) Associated Molecules are Prominent Components in Plasma and Valve Leaflets in Calcific Aortic Valve Stenosis.

JACC. Basic to translational science

Torzewski M, Ravandi A, Yeang C, Edel A, Bhindi R, Kath S, Twardowski L, Schmid J, Yang X, Franke UFW, Witztum JL, Tsimikas S.
PMID: 29147686
JACC Basic Transl Sci. 2017 Jun;2(3):229-240. doi: 10.1016/j.jacbts.2017.02.004. Epub 2017 Jun 26.

The

Author Correction: Inflammation-induced IgA.

Nature

Shalapour S, Lin XJ, Bastian IN, Brain J, Burt AD, Aksenov AA, Vrbanac AF, Li W, Perkins A, Matsutani T, Zhong Z, Dhar D, Navas-Molina JA, Xu J, Loomba R, Downes M, Yu RT, Evans RM, Dorrestein PC, Knight R, Benner C, Anstee QM, Karin M.
PMID: 29973714
Nature. 2018 Sep;561(7721):E1. doi: 10.1038/s41586-018-0304-y.

In this Article, the sentence: "After 7 months of HFD, MUP-uPA mice developed HCC

Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease.

Cell metabolism

Loomba R, Seguritan V, Li W, Long T, Klitgord N, Bhatt A, Dulai PS, Caussy C, Bettencourt R, Highlander SK, Jones MB, Sirlin CB, Schnabl B, Brinkac L, Schork N, Chen CH, Brenner DA, Biggs W, Yooseph S, Venter JC, Nelson KE.
PMID: 31484056
Cell Metab. 2019 Sep 03;30(3):607. doi: 10.1016/j.cmet.2019.08.002.

No abstract available.

Corrigendum: ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer.

Nature medicine

Wang J, Zou JX, Xue X, Cai D, Zhang Y, Duan Z, Xiang Q, Yang JC, Louie MC, Borowsky AD, Gao AC, Evans CP, Lam KS, Xu J, Kung HJ, Evans RM, Xu Y, Chen HW.
PMID: 27270780
Nat Med. 2016 Jun 07;22(6):692. doi: 10.1038/nm0616-692b.

No abstract available.

Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP3-dependent IL-1 production.

Science (New York, N.Y.)

Orecchioni M, Kobiyama K, Winkels H, Ghosheh Y, McArdle S, Mikulski Z, Kiosses WB, Fan Z, Wen L, Jung Y, Roy P, Ali AJ, Miyamoto Y, Mangan M, Makings J, Wang Z, Denn A, Vallejo J, Owens M, Durant CP, Braumann S, Mader N, Li L, Matsunami H, Eckmann L, Latz E, Wang Z, Hazen SL, Ley K.
PMID: 35025664
Science. 2022 Jan 14;375(6577):214-221. doi: 10.1126/science.abg3067. Epub 2022 Jan 13.

[Figure: see text].

A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis.

Cell metabolism

Oh TG, Kim SM, Caussy C, Fu T, Guo J, Bassirian S, Singh S, Madamba EV, Bettencourt R, Richards L, Yu RT, Atkins AR, Huan T, Brenner DA, Sirlin CB, Downes M, Evans RM, Loomba R.
PMID: 33147487
Cell Metab. 2020 Nov 03;32(5):901. doi: 10.1016/j.cmet.2020.10.015.

No abstract available.

Purification of mouse hepatic non-parenchymal cells or nuclei for use in ChIP-seq and other next-generation sequencing approaches.

STAR protocols

Troutman TD, Bennett H, Sakai M, Seidman JS, Heinz S, Glass CK.
PMID: 33748781
STAR Protoc. 2021 Mar 10;2(1):100363. doi: 10.1016/j.xpro.2021.100363. eCollection 2021 Mar 19.

Significant advancements in understanding disease mechanisms can occur through combined analysis of next-generation sequencing datasets generated using purified cell populations. Here, we detail our optimized protocol for purification of mouse hepatic macrophages (or other liver non-parenchymal populations) suitable for...

Neutralization of oxidized phospholipids attenuates age-associated bone loss in mice.

Aging cell

Palmieri M, Almeida M, Nookaew I, Gomez-Acevedo H, Joseph TE, Que X, Tsimikas S, Sun X, Manolagas SC, Witztum JL, Ambrogini E.
PMID: 34278710
Aging Cell. 2021 Aug;20(8):e13442. doi: 10.1111/acel.13442. Epub 2021 Jul 19.

Oxidized phospholipids (OxPLs) are pro-inflammatory molecules that affect bone remodeling under physiological conditions. Transgenic expression of a single-chain variable fragment (scFv) of the antigen-binding domain of E06, an IgM natural antibody that recognizes the phosphocholine (PC) moiety of OxPLs,...

Erratum: Inflammation-induced IgA.

Nature

Shalapour S, Lin XJ, Bastian IN, Brain J, Burt AD, Aksenov AA, Vrbanac AF, Li W, Perkins A, Matsutani T, Zhong Z, Dhar D, Navas-Molina JA, Xu J, Loomba R, Downes M, Yu RT, Evans RM, Dorrestein PC, Knight R, Benner C, Anstee QM, Karin M.
PMID: 29168501
Nature. 2017 Dec 21;552(7685):430. doi: 10.1038/nature25028. Epub 2017 Nov 22.

This corrects the article DOI: 10.1038/nature24302.

Corrigendum: Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer.

Nature

Suh JM, Jonker JW, Ahmadian M, Goetz R, Lackey D, Osborn O, Huang Z, Liu W, Yoshihara E, van Dijk TH, Havinga R, Fan W, Yin YQ, Yu RT, Liddle C, Atkins AR, Olefsky JM, Mohammadi M, Downes M, Evans RM.
PMID: 25739500
Nature. 2015 Apr 16;520(7547):388. doi: 10.1038/nature14304. Epub 2015 Mar 04.

No abstract available.

Triptolide targets super-enhancer networks in pancreatic cancer cells and cancer-associated fibroblasts.

Oncogenesis

Noel P, Hussein S, Ng S, Antal CE, Lin W, Rodela E, Delgado P, Naveed S, Downes M, Lin Y, Evans RM, Von Hoff DD, Han H.
PMID: 33168807
Oncogenesis. 2020 Nov 09;9(11):100. doi: 10.1038/s41389-020-00285-9.

The tumor microenvironment in pancreatic ductal adenocarcinoma (PDAC) is highly heterogeneous, fibrotic, and hypovascular, marked by extensive desmoplasia and maintained by the tumor cells, cancer-associated fibroblasts (CAFs) and other stromal cells. There is an urgent need to identify and...

Bromodomain containing 9 (BRD9) regulates macrophage inflammatory responses by potentiating glucocorticoid receptor activity.

Proceedings of the National Academy of Sciences of the United States of America

Wang L, Oh TG, Magida J, Estepa G, Obayomi SMB, Chong LW, Gatchalian J, Yu RT, Atkins AR, Hargreaves D, Downes M, Wei Z, Evans RM.
PMID: 34446564
Proc Natl Acad Sci U S A. 2021 Aug 31;118(35). doi: 10.1073/pnas.2109517118.

In macrophages, homeostatic and immune signals induce distinct sets of transcriptional responses, defining cellular identity and functional states. The activity of lineage-specific and signal-induced transcription factors are regulated by chromatin accessibility and other epigenetic modulators. Glucocorticoids are potent antiinflammatory...

Showing 1 to 12 of 12 entries