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Interleukin-10 protects against aging-induced endothelial dysfunction.

Physiological reports

Kinzenbaw DA, Chu Y, Peña Silva RA, Didion SP, Faraci FM.
PMID: 24400151
Physiol Rep. 2013 Nov;1(6):e00149. doi: 10.1002/phy2.149. Epub 2013 Nov 11.

Carotid and cerebrovascular disease increase markedly with age contributing to stroke and cognitive impairment. Inflammation is a key element of vascular disease. In these studies, we tested the hypothesis that interleukin-10 (IL-10), a potent anti-inflammatory cytokine, protects against aging-induced...

Effects of angiotensin II on the cerebral circulation: role of oxidative stress.

Frontiers in physiology

De Silva TM, Faraci FM.
PMID: 23316164
Front Physiol. 2013 Jan 03;3:484. doi: 10.3389/fphys.2012.00484. eCollection 2012.

Oxidative stress has emerged as a key component of many diseases that affect the vasculature. Oxidative stress is characterized as a cellular environment where the generation of oxidant molecules overwhelms endogenous anti-oxidant defense mechanisms. NADPH oxidases are a family...

Nox2 deficiency prevents hypertension-induced vascular dysfunction and hypertrophy in cerebral arterioles.

International journal of hypertension

Chan SL, Baumbach GL.
PMID: 23573415
Int J Hypertens. 2013;2013:793630. doi: 10.1155/2013/793630. Epub 2013 Mar 14.

Oxidative stress is involved in many hypertension-related vascular diseases in the brain, including stroke and dementia. Thus, we examined the role of genetic deficiency of NADPH oxidase subunit Nox2 in the function and structure of cerebral arterioles during hypertension....

Showing 1 to 3 of 3 entries