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Showing 1 to 12 of 66 entries
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Antioxidant Tocols as Radiation Countermeasures (Challenges to be Addressed to Use Tocols as Radiation Countermeasures in Humans).

Antioxidants (Basel, Switzerland)

Nukala U, Thakkar S, Krager KJ, Breen PJ, Compadre CM, Aykin-Burns N.
PMID: 29473853
Antioxidants (Basel). 2018 Feb 23;7(2). doi: 10.3390/antiox7020033.

Radiation countermeasures fall under three categories, radiation protectors, radiation mitigators, and radiation therapeutics. Radiation protectors are agents that are administered before radiation exposure to protect from radiation-induced injuries by numerous mechanisms, including scavenging free radicals that are generated by...

Dependability enhancing mechanisms for integrated clinical environments.

The Journal of supercomputing

Zhao W, Yang MQ.
PMID: 29081597
J Supercomput. 2017 Oct;73(10):4207-4220. doi: 10.1007/s11227-017-2003-0. Epub 2017 Mar 29.

In this article, we present a set of lightweight mechanisms to enhance the dependability of a safety-critical real-time distributed system referred to as an integrated clinical environment (ICE). In an ICE, medical devices are interconnected and work together with...

Quantitative Proteomics Identifies Activation of Hallmark Pathways of Cancer in Patient Melanoma.

Journal of proteomics & bioinformatics

Byrum SD, Larson SK, Avaritt NL, Moreland LE, Mackintosh SG, Cheung WL, Tackett AJ.
PMID: 23976835
J Proteomics Bioinform. 2013 Mar 01;6(3):43-50. doi: 10.4172/jpb.1000260.

Molecular pathways regulating melanoma initiation and progression are potential targets of therapeutic development for this aggressive cancer. Identification and molecular analysis of these pathways in patients has been primarily restricted to targeted studies on individual proteins. Here, we report...

A Proteomic Study of Human Merkel Cell Carcinoma.

Journal of proteomics & bioinformatics

Shao Q, Byrum SD, Moreland LE, Mackintosh SG, Kannan A, Lin Z, Morgan M, Stack BC, Cornelius LA, Tackett AJ, Gao L.
PMID: 25284964
J Proteomics Bioinform. 2013 Nov 25;6:275-282. doi: 10.4172/jpb.1000291.

Merkel Cell Carcinoma (MCC) is an aggressive neuroendocrine cancer of the skin. The incidence has been quadrupled with a 5-year mortality rate of 46%, presently there is no cure for metastatic disease. Despite the contribution of Merkel cell polyomavirus,...

Cytotoxic gallium complexes containing thiosemicarbazones derived from 9-anthraldehyde: Molecular docking with biomolecules.

Journal of molecular structure

Beckford FA, Brock A, Gonzalez-Sarrías A, Seeram NP.
PMID: 27980346
J Mol Struct. 2016 Oct 05;1121:156-166. doi: 10.1016/j.molstruc.2016.05.075. Epub 2016 May 24.

We have synthesized a trio of gallium complexes bearing 9-anthraldehyde thiosemicarbazones. The complexes were assessed for their anticancer activity and their biophysical reactivity was also investigated. The three complexes displayed good cytotoxic profiles against two human colon cancer cell...

Proceedings of the 2017 MidSouth Computational Biology and Bioinformatics Society (MCBIOS) Conference.

BMC bioinformatics

Wren JD, Dozmorov MG, Toby I, Nanduri B, Homayouni R, Manda P, Thakkar S.
PMID: 29297277
BMC Bioinformatics. 2017 Dec 28;18:498. doi: 10.1186/s12859-017-1887-2.

No abstract available.

Reversible Control of Third-Order Optical Nonlinearity of DNA Decorated Carbon Nanotube Hybrids.

The journal of physical chemistry. C, Nanomaterials and interfaces

Zhang L, Thomas J, Xu J, Rougeau B, Sullivan M, Reeve S, Allen SD, Watanabe F, Biris A, Zhao W.
PMID: 22523605
J Phys Chem C Nanomater Interfaces. 2010 Dec 30;114(51):22697-22702. doi: 10.1021/jp107726j. Epub 2010 Dec 03.

Positive and negative third-order optical nonlinearities have been investigated in single-stranded DNA wrapped semiconducting single-walled carbon nanotubes. It is found that the redox reactions of hydrogen peroxide can reverse the sign of the third-order nonlinearity. The observation proves that...

The complete mitochondrial genome of the scorpion .

Mitochondrial DNA. Part B, Resources

Yamashita T, Rhoads D, Pummill J.
PMID: 31435527
Mitochondrial DNA B Resour. 2017;2(2):841-842. doi: 10.1080/23802359.2017.1407685. Epub 2017 Nov 25.

The complete mitochondrial genome (mitogenome) of the Striped scorpion (

Genome Sequences of Four Cluster P Mycobacteriophages.

Genome announcements

Doyle EL, Fillman CL, Reyna NS, Tobiason DM, Westholm DE, Askins JL, Backus BP, Baker AC, Ballard HS, Bisesi PJ, Bond L, Byrnes D, Carlstedt H, Dodson KS, Fallert MJ, Foster KJ, Games DN, Grams TR, Guild NA, Hurd A, Iwata N, Kepler CR, Krenzke LR, Luekens K, Lewis J, McEntee C, McGee JC, Nalley N, Plymale RC, Prochaska J, Rogers RG, Schipper JB, Snyder K, Uhrich K, Vermillion CD, Vickers SK, Wenta MD, Yates TZ, Young CF, Stoner TH, Pope WH, Jacobs-Sera D, Garlena RA, Russell DA, Cresawn SG, Hatfull GF.
PMID: 29326199
Genome Announc. 2018 Jan 11;6(2). doi: 10.1128/genomeA.01101-17.

Four bacteriophages infecting

Comparison of machine learning approaches for enhancing Alzheimer's disease classification.

PeerJ

Li Q, Yang MQ.
PMID: 33665002
PeerJ. 2021 Feb 25;9:e10549. doi: 10.7717/peerj.10549. eCollection 2021.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder, accounting for nearly 60% of all dementia cases. The occurrence of the disease has been increasing rapidly in recent years. Presently about 46.8 million individuals suffer from AD worldwide. The current...

Synthesis of Chimeric Thiazolo-Nootkatone Derivatives as Potent Antimicrobial Agents.

ChemMedChem

Alkhaibari IS, Raj K C H, Alnufaie R, Gilmore D, Alam MA.
PMID: 33955181
ChemMedChem. 2021 Sep 06;16(17):2628-2637. doi: 10.1002/cmdc.202100230. Epub 2021 Jun 09.

Nootkatone, an approved insecticide, is a well-known natural product from grapefruit. A series of fused-thiazole derivatives of nootkatone have been synthesized, and these new compounds were tested against several strains of bacteria. Some of these compounds are found to...

Gene Regulation Analysis Reveals Perturbations of Autism Spectrum Disorder during Neural System Development.

Genes

Li D, Xu J, Yang MQ.
PMID: 34946850
Genes (Basel). 2021 Nov 27;12(12). doi: 10.3390/genes12121901.

Autism spectrum disorder (ASD) is a neurodevelopmental disorder that impedes patients' cognition, social, speech and communication skills. ASD is highly heterogeneous with a variety of etiologies and clinical manifestations. The prevalence rate of ASD increased steadily in recent years....

Showing 1 to 12 of 66 entries