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Showing 1 to 12 of 19 entries
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Transcriptome-metabolome wide association study (TMWAS) of maneb and paraquat neurotoxicity reveals network level interactions in toxicologic mechanism.

Toxicology reports

Roede JR, Uppal K, Park Y, Tran V, Jones DP.
PMID: 27722094
Toxicol Rep. 2014;1:435-444. doi: 10.1016/j.toxrep.2014.07.006. Epub 2014 Jul 24.

A combination of the herbicide paraquat (PQ) and fungicide maneb (MB) has been linked to Parkinson's disease. Previous studies show that this involves an additive toxicity with at least two different mechanisms. However, detailed understanding of mixtures is often...

A BAYESIAN NONPARAMETRIC MIXTURE MODEL FOR SELECTING GENES AND GENE SUBNETWORKS.

The annals of applied statistics

Zhao Y, Kang J, Yu T.
PMID: 25984253
Ann Appl Stat. 2014 Jun;8(2):999-1021. doi: 10.1214/14-AOAS719.

It is very challenging to select informative features from tens of thousands of measured features in high-throughput data analysis. Recently, several parametric/regression models have been developed utilizing the gene network information to select genes or pathways strongly associated with...

Restoration of Monotonicity Respecting in Dynamic Regression.

Journal of the American Statistical Association

Huang Y.
PMID: 29430068
J Am Stat Assoc. 2017;112(518):613-622. doi: 10.1080/01621459.2016.1149070. Epub 2017 Mar 30.

Dynamic regression models, including the quantile regression model and Aalen's additive hazards model, are widely adopted to investigate evolving covariate effects. Yet lack of monotonicity respecting with standard estimation procedures remains an outstanding issue. Advances have recently been made,...

Circulating Progenitor Cells in Patients With Coronary Artery Disease and Renal Insufficiency.

JACC. Basic to translational science

Mehta A, Tahhan AS, Liu C, Dhindsa DS, Nayak A, Hooda A, Moazzami K, Islam SJ, Rogers SC, Almuwaqqat Z, Mokhtari A, Hesaroieh I, Ko YA, Waller EK, Quyyumi AA.
PMID: 32875168
JACC Basic Transl Sci. 2020 Aug 12;5(8):770-782. doi: 10.1016/j.jacbts.2020.06.006. eCollection 2020 Aug.

Patients with coronary artery disease and renal insufficiency (RI) (estimated glomerular filtration rate 

Progenitor Cell Therapy to Treat Acute Myocardial Infarction: The Promise of High-Dose Autologous CD34(+) Bone Marrow Mononuclear Cells.

Stem cells international

Poole JC, Quyyumi AA.
PMID: 23737803
Stem Cells Int. 2013;2013:658480. doi: 10.1155/2013/658480. Epub 2013 Apr 28.

ST elevation myocardial infarction (STEMI) is associated with an increased risk for congestive heart failure and long-term mortality despite the widespread use of thrombolysis and catheter-based revascularization. The need for improved post-STEMI therapies has led to a surge of...

Bootstrap for the case-cohort design.

Biometrika

Huang Y.
PMID: 25170175
Biometrika. 2014 Jun;101(2):465-476. doi: 10.1093/biomet/asu004.

The case-cohort design facilitates economical investigation of risk factors in a large survival study, with covariate data collected only from the cases and a simple random subset of the full cohort. Methods that accommodate the design have been developed...

Cardiovascular Disease Biomarkers and suPAR in Predicting Decline in Renal Function: A Prospective Cohort Study.

Kidney international reports

Hayek SS, Ko YA, Awad M, Ahmed H, Gray B, Hosny KM, Aida H, Tracy MJ, Wei C, Sever S, Reiser J, Quyyumi AA.
PMID: 29142970
Kidney Int Rep. 2017 Feb 09;2(3):425-432. doi: 10.1016/j.ekir.2017.02.001. eCollection 2017 May.

INTRODUCTION: Soluble urokinase-type plasminogen activator receptor (suPAR) strongly predicts outcomes and incident chronic kidney disease (CKD) in patients with cardiovascular disease (CVD). Whether the association between suPAR and CKD is a reflection of its overall association with chronic inflammation...

Pilot randomized controlled trial of a Mediterranean diet or diet supplemented with fish oil, walnuts, and grape juice in overweight or obese US adults.

BMC nutrition

Jaacks LM, Sher S, Staercke C, Porkert M, Alexander WR, Jones DP, Vaccarino V, Ziegler TR, Quyyumi AA.
PMID: 30271610
BMC Nutr. 2018;4:26. doi: 10.1186/s40795-018-0234-y. Epub 2018 May 31.

BACKGROUND: The 2015-2020 Dietary Guidelines for Americans recommend a Mediterranean-type diet as one of three healthful eating patterns. However, only one previous trial has evaluated the effects of a Mediterranean diet intervention in a US sample population.METHODS: To address...

Development of immortalized mouse aortic endothelial cell lines.

Vascular cell

Ni CW, Kumar S, Ankeny CJ, Jo H.
PMID: 24690145
Vasc Cell. 2014 Apr 01;6(1):7. doi: 10.1186/2045-824X-6-7.

BACKGROUND: The understanding of endothelial cell biology has been facilitated by the availability of primary endothelial cell cultures from a variety of sites and species; however, the isolation and maintenance of primary mouse aortic endothelial cells (MAECs) remain a...

Blood transcriptomics and metabolomics for personalized medicine.

Computational and structural biotechnology journal

Li S, Todor A, Luo R.
PMID: 26702339
Comput Struct Biotechnol J. 2015 Oct 31;14:1-7. doi: 10.1016/j.csbj.2015.10.005. eCollection 2016.

Molecular analysis of blood samples is pivotal to clinical diagnosis and has been intensively investigated since the rise of systems biology. Recent developments have opened new opportunities to utilize transcriptomics and metabolomics for personalized and precision medicine. Efforts from...

Generalizing Quantile Regression for Counting Processes with Applications to Recurrent Events.

Journal of the American Statistical Association

Sun X, Peng L, Huang Y, Lai HJ.
PMID: 27212738
J Am Stat Assoc. 2016;111(513):145-156. doi: 10.1080/01621459.2014.995795. Epub 2016 May 05.

In survival analysis, quantile regression has become a useful approach to account for covariate effects on the distribution of an event time of interest. In this paper, we discuss how quantile regression can be extended to model counting processes,...

Sequencing the exposome: A call to action.

Toxicology reports

Jones DP.
PMID: 26722641
Toxicol Rep. 2016;3:29-45. doi: 10.1016/j.toxrep.2015.11.009.

The exposome is a complement to the genome that includes non-genetic causes of disease. Multiple definitions are available, with salient points being global inclusion of exposures and behaviors, and cumulative integration of associated biologic responses. As such, the concept...

Showing 1 to 12 of 19 entries