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Showing 1 to 12 of 152 entries
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Trans-pQTL study identifies immune crosstalk between Parkinson and Alzheimer loci.

Neurology. Genetics

Chan G, White CC, Winn PA, Cimpean M, Replogle JM, Glick LR, Cuerdon NE, Ryan KJ, Johnson KA, Schneider JA, Bennett DA, Chibnik LB, Sperling RA, De Jager PL, Bradshaw EM.
PMID: 27504496
Neurol Genet. 2016 Jul 26;2(4):e90. doi: 10.1212/NXG.0000000000000090. eCollection 2016 Aug.

OBJECTIVE: Given evidence from genetic studies, we hypothesized that there may be a shared component to the role of myeloid function in Parkinson and Alzheimer disease (PD and AD) and assessed whether PD susceptibility variants influenced protein expression of...

Relation of neuropathology with cognitive decline among older persons without dementia.

Frontiers in aging neuroscience

Boyle PA, Yu L, Wilson RS, Schneider JA, Bennett DA.
PMID: 24058343
Front Aging Neurosci. 2013 Sep 09;5:50. doi: 10.3389/fnagi.2013.00050. eCollection 2013.

OBJECTIVE: Although it is now widely accepted that dementia has a long preclinical phase during which neuropathology accumulates and cognition declines, little is known about the relation of neuropathology with the longitudinal rate of change in cognition among older...

Static and Dynamic Cognitive Reserve Proxy Measures: Interactions with Alzheimer's Disease Neuropathology and Cognition.

Journal of Alzheimer's disease & Parkinsonism

Malek-Ahmadi M, Lu S, Chan Y, Perez SE, Chen K, Mufson EJ.
PMID: 29423338
J Alzheimers Dis Parkinsonism. 2017;7(6). doi: 10.4172/2161-0460.1000390. Epub 2017 Oct 25.

OBJECTIVE: Years of education are the most common proxy for measuring cognitive reserve (CR) when assessing the relationship between Alzheimer's disease (AD) neuropathology and cognition. However, years of education may be limited as a CR proxy given that it...

Journal of clinical medicine

Choi KY, Lee JJ, Gunasekaran TI, Kang S, Lee W, Jeong J, Lim HJ, Zhang X, Zhu C, Won SY, Choi YY, Seo EH, Lee SC, Gim J, Chung JY, Chong A, Byun MS, Seo S, Ko PW, Han JW, McLean C, Farrell J, Lunetta KL, Miyashita A, Hara N, Won S, Choi SM, Ha JM, Jeong JH, Kuwano R, Song MK, An SSA, Lee YM, Park KW, Lee HW, Choi SH, Rhee S, Song WK, Lee JS, Mayeux R, Haines JL, Pericak-Vance MA, Choo ILH, Nho K, Kim KW, Lee DY, Kim S, Kim BC, Kim H, Jun GR, Schellenberg GD, Ikeuchi T, Farrer LA, Lee KH, Neuroimaging Initative AD.
PMID: 31426376
J Clin Med. 2019 Aug 16;8(8). doi: 10.3390/jcm8081236.

Variants in the

Bivariate Genome-Wide Association Study of Depressive Symptoms With Type 2 Diabetes and Quantitative Glycemic Traits.

Psychosomatic medicine

Haljas K, Amare AT, Alizadeh BZ, Hsu YH, Mosley T, Newman A, Murabito J, Tiemeier H, Tanaka T, van Duijn C, Ding J, Llewellyn DJ, Bennett DA, Terracciano A, Launer L, Ladwig KH, Cornelis MC, Teumer A, Grabe H, Kardia SLR, Ware EB, Smith JA, Snieder H, Eriksson JG, Groop L, Räikkönen K, Lahti J.
PMID: 29280852
Psychosom Med. 2018 Apr;80(3):242-251. doi: 10.1097/PSY.0000000000000555.

OBJECTIVE: Shared genetic background may explain phenotypic associations between depression and Type 2 diabetes (T2D). We aimed to study, on a genome-wide level, if genetic correlation and pleiotropic loci exist between depressive symptoms and T2D or glycemic traits.METHODS: We...

Erratum to "Altered bile acid profile associates with cognitive impairment in Alzheimer's disease-An emerging role for gut microbiome" [Alzheimer's & Dementia 2019;15:76-92.].

Alzheimer's & dementia : the journal of the Alzheimer's Association

[No authors listed]
PMID: 30905591
Alzheimers Dement. 2019 Apr;15(4):604. doi: 10.1016/j.jalz.2019.03.002. Epub 2019 Mar 21.

No abstract available.

Polypharmacy in an Elderly Population: Enhancing Medication Management Through the Use of Clinical Decision Support Software Platforms.

Neurology and therapy

Keine D, Zelek M, Walker JQ, Sabbagh MN.
PMID: 30900186
Neurol Ther. 2019 Jun;8(1):79-94. doi: 10.1007/s40120-019-0131-6. Epub 2019 Mar 21.

INTRODUCTION: Polypharmacy is a growing problem in the United States. The use of multiple medications increases the likelihood that a patient will experience potential drug interactions and adverse drug reactions (ADRs). Those individuals with dementia or Alzheimer's disease (AD)...

Alzheimer's loci: epigenetic associations and interaction with genetic factors.

Annals of clinical and translational neurology

Chibnik LB, Yu L, Eaton ML, Srivastava G, Schneider JA, Kellis M, Bennett DA, De Jager PL.
PMID: 26125039
Ann Clin Transl Neurol. 2015 Jun;2(6):636-47. doi: 10.1002/acn3.201. Epub 2015 Apr 24.

OBJECTIVE: We explore the role of DNA methylation in Alzheimer's disease (AD). To elucidate where DNA methylation falls along the causal pathway linking risk factors to disease, we examine causal models to assess its role in the pathology of...

Reliability of Medical History Reporting in Older Adults With and Without Cognitive Impairment.

Journal of central nervous system disease

Curcio N, Wilmoth K, LoBue C, Cullum CM.
PMID: 31040738
J Cent Nerv Syst Dis. 2019 Apr 22;11:1179573519843874. doi: 10.1177/1179573519843874. eCollection 2019.

BACKGROUND: Clinical diagnosis of cognitive disorders depends on accurate reporting of medical history, yet little is known about the reliability and the validity of such reports, particularly in older patients with and without cognitive impairment.METHODS: In 2 studies, we...

Sex as a Risk Factor for Developing Cognitive Impairments in National Alzheimer's Coordinating Center Participants.

Journal of Alzheimer's disease reports

Wang G, Li W.
PMID: 33681711
J Alzheimers Dis Rep. 2021 Jan 11;5(1):1-6. doi: 10.3233/ADR-200275.

BACKGROUND: It is inconclusive on how sex affects the risk of developing mild cognitive impairment (MCI) or dementia.OBJECTIVE: To investigate how sex affects the risk of developing MCI or dementia.METHODS: A secondary data analysis was performed on data collected...

The genetics of circulating BDNF: towards understanding the role of BDNF in brain structure and function in middle and old ages.

Brain communications

Li S, Weinstein G, Zare H, Teumer A, Völker U, Friedrich N, Knol MJ, Satizabal CL, Petyuk VA, Adams HHH, Launer LJ, Bennett DA, De Jager PL, Grabe HJ, Ikram MA, Gudnason V, Yang Q, Seshadri S.
PMID: 33345186
Brain Commun. 2020 Oct 28;2(2):fcaa176. doi: 10.1093/braincomms/fcaa176. eCollection 2020.

Brain-derived neurotrophic factor (BDNF) plays an important role in brain development and function. Substantial amounts of BDNF are present in peripheral blood, and may serve as biomarkers for Alzheimer's disease incidence as well as targets for intervention to reduce...

Comprehensive Evaluation of the Functional Activities Questionnaire (FAQ) and Its Reliability and Validity.

Assessment

González DA, Gonzales MM, Resch ZJ, Sullivan AC, Soble JR.
PMID: 33543638
Assessment. 2021 Feb 05;1073191121991215. doi: 10.1177/1073191121991215. Epub 2021 Feb 05.

The Functional Activities Questionnaire (FAQ) is a collateral-report measure of difficulties in activities of daily living. Despite its widespread use, psychometric analyses have been limited in scope, piecemeal across samples, and limited primarily to classical test theory. This article...

Showing 1 to 12 of 152 entries