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Showing 1 to 12 of 90 entries
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A highly sensitive novel immunoassay specifically detects low levels of soluble Aβ oligomers in human cerebrospinal fluid.

Alzheimer's research & therapy

Yang T, O'Malley TT, Kanmert D, Jerecic J, Zieske LR, Zetterberg H, Hyman BT, Walsh DM, Selkoe DJ.
PMID: 25802556
Alzheimers Res Ther. 2015 Mar 22;7(1):14. doi: 10.1186/s13195-015-0100-y. eCollection 2015.

INTRODUCTION: Amyloid β-protein oligomers play a key role in Alzheimer's disease (AD), but well-validated assays that routinely detect them in cerebrospinal fluid (CSF) are just emerging. We sought to confirm and extend a recent study using the Singulex Erenna...

Optical coherence tomography visualizes neurons in human entorhinal cortex.

Neurophotonics

Magnain C, Augustinack JC, Konukoglu E, Frosch MP, Sakadžić S, Varjabedian A, Garcia N, Wedeen VJ, Boas DA, Fischl B.
PMID: 25741528
Neurophotonics. 2015 Feb 09;2(1):015004. doi: 10.1117/1.NPh.2.1.015004.

The cytoarchitecture of the human brain is of great interest in diverse fields: neuroanatomy, neurology, neuroscience, and neuropathology. Traditional histology is a method that has been historically used to assess cell and fiber content in the

Uniform resolution of compact identifiers for biomedical data.

Scientific data

Wimalaratne SM, Juty N, Kunze J, Janée G, McMurry JA, Beard N, Jimenez R, Grethe JS, Hermjakob H, Martone ME, Clark T.
PMID: 29737976
Sci Data. 2018 May 08;5:180029. doi: 10.1038/sdata.2018.29.

Most biomedical data repositories issue locally-unique accessions numbers, but do not provide globally unique, machine-resolvable, persistent identifiers for their datasets, as required by publishers wishing to implement data citation in accordance with widely accepted principles. Local accessions may however...

The Role of Inflammation after Surgery for Elders (RISE) study: Study design, procedures, and cohort profile.

Alzheimer's & dementia (Amsterdam, Netherlands)

Hshieh TT, Vasunilashorn SM, D'Aquila ML, Arnold SE, Dickerson BC, Fong TG, Jones RN, Marcantonio ER, Schmitt EM, Xu G, Gou Y, Chen F, Kunze LJ, Vlassakov KV, Abdeen AR, Lange JK, Earp BE, Touroutoglou A, Carlyle BC, Kivisakk-Webb P, Travison TG, Dillon ST, Libermann TA, Inouye SK.
PMID: 31737775
Alzheimers Dement (Amst). 2019 Nov 06;11:752-762. doi: 10.1016/j.dadm.2019.09.004. eCollection 2019 Dec.

INTRODUCTION: The Role of Inflammation after Surgery for Elders study correlates novel inflammatory markers measured in blood, cerebrospinal fluid (CSF) assays, and [METHODS: This study involved a prospective cohort design with patients who underwent elective hip and knee arthroplasty...

PET Image Deblurring and Super-Resolution with an MR-Based Joint Entropy Prior.

IEEE transactions on computational imaging

Song TA, Yang F, Chowdhury SR, Kim K, Johnson KA, El Fakhri G, Li Q, Dutta J.
PMID: 31723575
IEEE Trans Comput Imaging. 2019 Dec;5(4):530-539. doi: 10.1109/TCI.2019.2913287. Epub 2019 Apr 25.

The intrinsically limited spatial resolution of PET confounds image quantitation. This paper presents an image deblurring and super-resolution framework for PET using anatomical guidance provided by high-resolution MR images. The framework relies on image-domain post-processing of already-reconstructed PET images...

Comprehensive Evaluation of the Functional Activities Questionnaire (FAQ) and Its Reliability and Validity.

Assessment

González DA, Gonzales MM, Resch ZJ, Sullivan AC, Soble JR.
PMID: 33543638
Assessment. 2021 Feb 05;1073191121991215. doi: 10.1177/1073191121991215. Epub 2021 Feb 05.

The Functional Activities Questionnaire (FAQ) is a collateral-report measure of difficulties in activities of daily living. Despite its widespread use, psychometric analyses have been limited in scope, piecemeal across samples, and limited primarily to classical test theory. This article...

Estimating Progression Rates Across the Spectrum of Alzheimer's Disease for Amyloid-Positive Individuals Using National Alzheimer's Coordinating Center Data.

Neurology and therapy

Potashman M, Buessing M, Levitchi Benea M, Cummings J, Borson S, Pemberton-Ross P, Epstein AJ.
PMID: 34431074
Neurol Ther. 2021 Dec;10(2):941-953. doi: 10.1007/s40120-021-00272-1. Epub 2021 Aug 24.

INTRODUCTION: Published estimates of Alzheimer's disease (AD) progression do not capture the full disease continuum. This study provides transition probabilities of individuals with amyloid-β (Aβ+) pathology across the disease continuum.METHODS: Patient-level longitudinal data from the National Alzheimer's Coordinating Center...

Neural substrates of verbal repetition deficits in primary progressive aphasia.

Brain communications

Miller HE, Cordella C, Collins JA, Ezzo R, Quimby M, Hochberg D, Tourville JA, Dickerson BC, Guenther FH.
PMID: 33748756
Brain Commun. 2021 Feb 16;3(1):fcab015. doi: 10.1093/braincomms/fcab015. eCollection 2021.

In this cross-sectional study, we examined the relationship between cortical thickness and performance on several verbal repetition tasks in a cohort of patients with primary progressive aphasia in order to test predictions generated by theoretical accounts of phonological working...

Advances in neuroimaging to support translational medicine in dementia.

Journal of neurology, neurosurgery, and psychiatry

Cope TE, Weil RS, Düzel E, Dickerson BC, Rowe JB.
PMID: 33568448
J Neurol Neurosurg Psychiatry. 2021 Mar;92(3):263-270. doi: 10.1136/jnnp-2019-322402. Epub 2021 Feb 10.

Advances in neuroimaging are ideally placed to facilitate the translation from progress made in cellular genetics and molecular biology of neurodegeneration into improved diagnosis, prevention and treatment of dementia. New positron emission tomography (PET) ligands allow one to quantify...

Does Data-Independent Acquisition Data Contain Hidden Gems? A Case Study Related to Alzheimer's Disease.

Journal of proteome research

Hubbard EE, Heil LR, Merrihew GE, Chhatwal JP, Farlow MR, McLean CA, Ghetti B, Newell KL, Frosch MP, Bateman RJ, Larson EB, Keene CD, Perrin RJ, Montine TJ, MacCoss MJ, Julian RR.
PMID: 34818016
J Proteome Res. 2022 Jan 07;21(1):118-131. doi: 10.1021/acs.jproteome.1c00558. Epub 2021 Nov 24.

One of the potential benefits of using data-independent acquisition (DIA) proteomics protocols is that information not originally targeted by the study may be present and discovered by subsequent analysis. Herein, we reanalyzed DIA data originally recorded for global proteomic...

Plasma IL-12/IFN-γ axis predicts cognitive trajectories in cognitively unimpaired older adults.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Yang HS, Zhang C, Carlyle BC, Zhen SY, Trombetta BA, Schultz AP, Pruzin JJ, Fitzpatrick CD, Yau WW, Kirn DR, Rentz DM, Arnold SE, Johnson KA, Sperling RA, Chhatwal JP, Tanzi RE.
PMID: 34160128
Alzheimers Dement. 2021 Jun 23; doi: 10.1002/alz.12399. Epub 2021 Jun 23.

INTRODUCTION: Immune dysregulation is implicated in neurodegeneration and altered cytokine levels are seen in people with dementia. However, whether cytokine levels are predictive of cognitive decline in cognitively unimpaired (CU) elderly, especially in the setting of elevated amyloid beta...

Longitudinal differences in everyday preferences: Comparisons between people with cognitive impairment and their care partners.

International journal of geriatric psychiatry

Wilkins JM, Locascio JJ, Gunther JM, Gomez-Isla T, Hyman BT, Blacker D, Forester BP, Okereke OI.
PMID: 34498322
Int J Geriatr Psychiatry. 2021 Sep 08; doi: 10.1002/gps.5620. Epub 2021 Sep 08.

OBJECTIVES: Persons with progressive cognitive impairment (CI) increasingly rely on surrogate decision-makers for everyday activities. Yet, little is known about changes in everyday preferences over time or about concordance between persons with CI and their care partners regarding longitudinal...

Showing 1 to 12 of 90 entries