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Showing 1 to 12 of 55 entries
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Proteomic profiles for Alzheimer's disease and mild cognitive impairment among adults with Down syndrome spanning serum and plasma: An Alzheimer's Biomarker Consortium-Down Syndrome (ABC-DS) study.

Alzheimer's & dementia (Amsterdam, Netherlands)

Petersen ME, Zhang F, Schupf N, Krinsky-McHale SJ, Hall J, Mapstone M, Cheema A, Silverman W, Lott I, Rafii MS, Handen B, Klunk W, Head E, Christian B, Foroud T, Lai F, Rosas HD, Zaman S, Ances BM, Wang MC, Tycko B, Lee JH, O'Bryant S.
PMID: 32626817
Alzheimers Dement (Amst). 2020 Jun 30;12(1):e12039. doi: 10.1002/dad2.12039. eCollection 2020.

INTRODUCTION: Previously generated serum and plasma proteomic profiles were examined among adults with Down syndrome (DS) to determine whether these profiles could discriminate those with mild cognitive impairment (MCI-DS) and Alzheimer's disease (DS-AD) from those cognitively stable (CS).METHODS: Data...

General and domain-specific cognitive reserve, mild cognitive impairment, and dementia risk in older women.

Alzheimer's & dementia (New York, N. Y.)

Petkus AJ, Resnick SM, Rapp SR, Espeland MA, Gatz M, Widaman KF, Wang X, Younan D, Casanova R, Chui H, Barnard RT, Gaussoin S, Goveas JS, Hayden KM, Henderson VW, Sachs BC, Saldana S, Shadyab AH, Shumaker SA, Chen JC.
PMID: 31011622
Alzheimers Dement (N Y). 2019 Apr 10;5:118-128. doi: 10.1016/j.trci.2019.02.003. eCollection 2019.

INTRODUCTION: In a geographically diverse sample of women, we asked whether cognitive reserve (CR) is best viewed as a general or cognitive domain-specific construct and whether some cognitive reserve domains but not others exert protective effects on risk of...

Harmonizing 1.5T/3T Diffusion Weighted MRI through Development of Deep Learning Stabilized Microarchitecture Estimators.

Proceedings of SPIE--the International Society for Optical Engineering

Nath V, Remedios S, Parvathaneni P, Hansen CB, Bayrak RG, Bermudez C, Blaber JA, Schilling KG, Janve VA, Gao Y, Huo Y, Lyu I, Williams O, Resnick S, Beason-Held L, Rogers BP, Stepniewska I, Anderson AW, Landman BA.
PMID: 32089583
Proc SPIE Int Soc Opt Eng. 2019 Feb;10949. doi: 10.1117/12.2512902. Epub 2019 Mar 15.

Diffusion weighted magnetic resonance imaging (DW-MRI) is interpreted as a quantitative method that is sensitive to tissue microarchitecture at a millimeter scale. However, the sensitization is dependent on acquisition sequences (e.g., diffusion time, gradient strength, etc.) and susceptible to...

Psychometric Tests and Spatial Navigation: Data From the Baltimore Longitudinal Study of Aging.

Frontiers in neurology

Wei EX, Anson ER, Resnick SM, Agrawal Y.
PMID: 32595588
Front Neurol. 2020 Jun 11;11:484. doi: 10.3389/fneur.2020.00484. eCollection 2020.

Spatial cognition is the process by which individuals interact with their spatial environment. Spatial cognition encompasses the specific skills of spatial memory, spatial orientation, and spatial navigation. Prior studies have shown an association between psychometric tests of spatial ability...

WeCareAdvisor, an Online Platform to Help Family Caregivers Manage Dementia-Related Behavioral Symptoms: an Efficacy Trial in the Time of COVID-19.

Journal of technology in behavioral science

Gitlin LN, Bouranis N, Kern V, Koeuth S, Marx KA, McClure LA, Lyketsos CG, Kales HC.
PMID: 33786370
J Technol Behav Sci. 2021 Mar 25;1-12. doi: 10.1007/s41347-021-00204-8. Epub 2021 Mar 25.

Dementia-related behavioral and psychology symptoms (BPSD) are undertreated and have negative consequences. However, families do not have access to disease information, tailored problem-solving  and effective management strategies, and with COVID-19, are more socially isolated and distressed. To address this...

Effect of Methylphenidate on Apathy in Patients With Alzheimer Disease: The ADMET 2 Randomized Clinical Trial.

JAMA neurology

Mintzer J, Lanctôt KL, Scherer RW, Rosenberg PB, Herrmann N, van Dyck CH, Padala PR, Brawman-Mintzer O, Porsteinsson AP, Lerner AJ, Craft S, Levey AI, Burke W, Perin J, Shade D.
PMID: 34570180
JAMA Neurol. 2021 Nov 01;78(11):1324-1332. doi: 10.1001/jamaneurol.2021.3356.

IMPORTANCE: Apathy, characterized by diminished will or initiative and one of the most prevalent neuropsychiatric symptoms in individuals with Alzheimer disease, is associated with significant caregiver burden, excess disability, increased medical costs, and mortality.OBJECTIVE: To measure whether methylphenidate compared...

Effect of Methylphenidate on Apathy in Patients With Alzheimer Disease: The ADMET 2 Randomized Clinical Trial.

JAMA neurology

Mintzer J, Lanctôt KL, Scherer RW, Rosenberg PB, Herrmann N, van Dyck CH, Padala PR, Brawman-Mintzer O, Porsteinsson AP, Lerner AJ, Craft S, Levey AI, Burke W, Perin J, Shade D.
PMID: 34570180
JAMA Neurol. 2021 Nov 01;78(11):1324-1332. doi: 10.1001/jamaneurol.2021.3356.

IMPORTANCE: Apathy, characterized by diminished will or initiative and one of the most prevalent neuropsychiatric symptoms in individuals with Alzheimer disease, is associated with significant caregiver burden, excess disability, increased medical costs, and mortality.OBJECTIVE: To measure whether methylphenidate compared...

Caring for Older Adults With Vision Impairment and Dementia.

Innovation in aging

Varadaraj V, Chung SE, Swiatek KS, Sheehan OC, Deemer A, Ehrlich JR, Wolff JL, Assi L, Roth DL, Swenor BK.
PMID: 33209994
Innov Aging. 2020 Sep 11;4(6):igaa043. doi: 10.1093/geroni/igaa043. eCollection 2020.

BACKGROUND AND OBJECTIVES: Dementia and vision impairment (VI) are common among older adults but little is known about caregiving in this context.RESEARCH DESIGN AND METHODS: We used data from the 2011 National Health and Aging Trends Study, a nationally...

Hearing Impairment and Cognition in an Aging World.

Journal of the Association for Research in Otolaryngology : JARO

Powell DS, Oh ES, Lin FR, Deal JA.
PMID: 34008037
J Assoc Res Otolaryngol. 2021 Jul;22(4):387-403. doi: 10.1007/s10162-021-00799-y. Epub 2021 May 18.

With the increasing number of older adults around the world, the overall number of dementia cases is expected to rise dramatically in the next 40 years. In 2020, nearly 6 million individuals in the USA were living with Alzheimer's...

Diffeomorphic Registration With Intensity Transformation and Missing Data: Application to 3D Digital Pathology of Alzheimer's Disease.

Frontiers in neuroscience

Tward D, Brown T, Kageyama Y, Patel J, Hou Z, Mori S, Albert M, Troncoso J, Miller M.
PMID: 32116503
Front Neurosci. 2020 Feb 11;14:52. doi: 10.3389/fnins.2020.00052. eCollection 2020.

This paper examines the problem of diffeomorphic image registration in the presence of differing image intensity profiles and sparsely sampled, missing, or damaged tissue. Our motivation comes from the problem of aligning 3D brain MRI with 100-micron isotropic resolution...

Identifying Changepoints in Biomarkers During the Preclinical Phase of Alzheimer's Disease.

Frontiers in aging neuroscience

Younes L, Albert M, Moghekar A, Soldan A, Pettigrew C, Miller MI.
PMID: 31001108
Front Aging Neurosci. 2019 Apr 02;11:74. doi: 10.3389/fnagi.2019.00074. eCollection 2019.

No abstract available.

Plasma proteomic signatures predict dementia and cognitive impairment.

Alzheimer's & dementia (New York, N. Y.)

Tanaka T, Lavery R, Varma V, Fantoni G, Colpo M, Thambisetty M, Candia J, Resnick SM, Bennett DA, Biancotto A, Bandinelli S, Ferrucci L.
PMID: 32607407
Alzheimers Dement (N Y). 2020 May 09;6(1):e12018. doi: 10.1002/trc2.12018. eCollection 2020.

INTRODUCTION: Biomarker discovery of dementia and cognitive impairment is important to gather insight into mechanisms underlying the pathogenesis of these conditions.METHODS: In 997 adults from the InCHIANTI study, we assessed the association of 1301 plasma proteins with dementia and...

Showing 1 to 12 of 55 entries