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Showing 1 to 12 of 155 entries
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Salivary biomarkers in psychobiological medicine.

Bioinformation

Chiappelli F, Iribarren FJ, Prolo P.
PMID: 17597915
Bioinformation. 2006 Dec 29;1(8):331-4. doi: 10.6026/97320630001331.

The value of salivary biomarkers for diagnostic and prognostic assessments has become increasingly well established in medicine, pharmacology, and dentistry. Certain salivary components mirror the neuro-endocrine status of the organism. Other saliva products are protein in nature, and can...

Comments on: A review on empirical likelihood methods for regression.

Test (Madrid, Spain)

Li G, Lu X.
PMID: 21152356
Test (Madr). 2009 Nov 01;18(3):463-467. doi: 10.1007/s11749-009-0165-7.

No abstract available.

Molecular epigenetics, chromatin, and NeuroAIDS/HIV: immunopathological implications.

Bioinformation

Chiappelli F, Shapshak P, Commins D, Singer E, Minagar A, Oluwadara O, Prolo P, Pellionisz AJ.
PMID: 19052666
Bioinformation. 2008;3(1):47-52. doi: 10.6026/97320630003047. Epub 2008 Oct 07.

Epigenetics studies factors related to the organism and environment that modulate inheritance from generation to generation. Molecular epigenetics examines non-coding DNA (ncdDNA) vs. coding DNA (cdDNA), and pertains to every domain of physiology, including immune and brain function. Molecular...

Empirical likelihood analysis of the Buckley-James estimator.

Journal of multivariate analysis

Zhou M, Li G.
PMID: 19018294
J Multivar Anal. 2008 Apr;99(4):649-664. doi: 10.1016/j.jmva.2007.02.007.

The censored linear regression model, also referred to as the accelerated failure time (AFT) model when the logarithm of the survival time is used as the response variable, is widely seen as an alternative to the popular Cox model...

Analysis of Two-sample Censored Data Using a Semiparametric Mixture Model.

Acta mathematica Sinica, English series

Li G, Lin CT.
PMID: 20622987
Acta Math Sin Engl Ser. 2009 Jul;25(3):389-398. doi: 10.1007/s10255-008-8804-4.

In this article we study a semiparametric mixture model for the two-sample problem with right censored data. The model implies that the densities for the continuous outcomes are related by a parametric tilt but otherwise unspecified. It provides a...

Serum Fatty acids and risk of cutaneous melanoma: a population-based case-control study.

Dermatology research and practice

Vinceti M, Malagoli C, Iacuzio L, Crespi CM, Sieri S, Krogh V, Marmiroli S, Pellacani G, Venturelli E.
PMID: 23431289
Dermatol Res Pract. 2013;2013:659394. doi: 10.1155/2013/659394. Epub 2013 Jan 28.

Background. Some observational studies have suggested that excess dietary intake of polyunsaturated fatty acids such as linoleic acid increases cutaneous melanoma risk. We aimed at examining the association between serum fatty acids and melanoma risk by conducting a population-based...

Clinical use of bone-targeting radiopharmaceuticals with focus on alpha-emitters.

World journal of radiology

Wieder HA, Lassmann M, Allen-Auerbach MS, Czernin J, Herrmann K.
PMID: 25071888
World J Radiol. 2014 Jul 28;6(7):480-5. doi: 10.4329/wjr.v6.i7.480.

Various single or multi-modality therapeutic options are available to treat pain of bone metastasis in patients with prostate cancer. Different radionuclides that emit β-rays such as (153)Samarium and (89)Strontium and achieve palliation are commercially available. In contrast to β-emitters,...

Minibodies and Multimodal Chromatography Methods: A Convergence of Challenge and Opportunity.

BioProcess international

Gagnon P, Cheung CW, Lepin EJ, Wu AM, Sherman MA, Raubitschek AA, Yazaki PJ.
PMID: 21984873
Bioprocess Int. 2010 Feb;8(2):26-35.

This case study describes early phase purification process development for a recombinant anticancer minibody produced in mammalian cell culture. The minibody did not bind to protein A. Cation-exchange, anion-exchange, hydrophobic-interaction, and hydroxyapatite (eluted by phosphate gradient) chromatographic methods were...

Metabolic characterization of isocitrate dehydrogenase (IDH) mutant and IDH wildtype gliomaspheres uncovers cell type-specific vulnerabilities.

Cancer & metabolism

Garrett M, Sperry J, Braas D, Yan W, Le TM, Mottahedeh J, Ludwig K, Eskin A, Qin Y, Levy R, Breunig JJ, Pajonk F, Graeber TG, Radu CG, Christofk H, Prins RM, Lai A, Liau LM, Coppola G, Kornblum HI.
PMID: 29692895
Cancer Metab. 2018 Apr 17;6:4. doi: 10.1186/s40170-018-0177-4. eCollection 2018.

BACKGROUND: There is considerable interest in defining the metabolic abnormalities of IDH mutant tumors to exploit for therapy. While most studies have attempted to discern function by using cell lines transduced with exogenous IDH mutant enzyme, in this study,...

Progress and Challenges in the Design and Clinical Development of Antibodies for Cancer Therapy.

Frontiers in immunology

Almagro JC, Daniels-Wells TR, Perez-Tapia SM, Penichet ML.
PMID: 29379493
Front Immunol. 2018 Jan 04;8:1751. doi: 10.3389/fimmu.2017.01751. eCollection 2017.

The remarkable progress in engineering and clinical development of therapeutic antibodies in the last 40 years, after the seminal work by Köhler and Milstein, has led to the approval by the United States Food and Drug Administration (FDA) of...

Recombinant methioninase (rMETase) is an effective therapeutic for BRAF-V600E-negative as well as -positive melanoma in patient-derived orthotopic xenograft (PDOX) mouse models.

Oncotarget

Kawaguchi K, Igarashi K, Li S, Han Q, Tan Y, Miyake K, Kiyuna T, Miyake M, Murakami T, Chmielowski B, Nelson SD, Russell TA, Dry SM, Li Y, Unno M, Eilber FC, Hoffman RM.
PMID: 29416666
Oncotarget. 2017 Dec 12;9(1):915-923. doi: 10.18632/oncotarget.23185. eCollection 2018 Jan 02.

Melanoma is a recalcitrant disease. Melanoma patients with the BRAF-V600E mutation have been treated with the drug vemurafenib (VEM) which targets this mutation. However, we previously showed that VEM is not very effective against a BRAF-V600E melanoma mutant in...

PD-1 blockade enhances the vaccination-induced immune response in glioma.

JCI insight

Antonios JP, Soto H, Everson RG, Orpilla J, Moughon D, Shin N, Sedighim S, Yong WH, Li G, Cloughesy TF, Liau LM, Prins RM.
PMID: 27453950
JCI Insight. 2016 Jul 07;1(10). doi: 10.1172/jci.insight.87059.

DC vaccination with autologous tumor lysate has demonstrated promising results for the treatment of glioblastoma (GBM) in preclinical and clinical studies. While the vaccine appears capable of inducing T cell infiltration into tumors, the effectiveness of active vaccination in...

Showing 1 to 12 of 155 entries