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Showing 1 to 12 of 105 entries
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Phospholipase A2-responsive antibiotic delivery via nanoparticle-stabilized liposomes for the treatment of bacterial infection.

Journal of materials chemistry. B

Thamphiwatana S, Gao W, Pornpattananangkul D, Zhang Q, Fu V, Li J, Li J, Obonyo M, Zhang L.
PMID: 25544886
J Mater Chem B. 2014 Dec 14;2(46):8201-8207. doi: 10.1039/C4TB01110D.

Adsorbing small charged nanoparticles onto liposome surfaces to stabilize them against fusion and payload leakage has resulted in a new class of liposomes capable of environment-responsive drug delivery. Herein, we engineered a liposome formulation with a lipid composition sensitive...

Insulin Resistance Increases MRI-Estimated Pancreatic Fat in Nonalcoholic Fatty Liver Disease and Normal Controls.

Gastroenterology research and practice

Patel NS, Peterson MR, Lin GY, Feldstein A, Schnabl B, Bettencourt R, Seki E, Sirlin CB, Loomba R.
PMID: 24348536
Gastroenterol Res Pract. 2013;2013:498296. doi: 10.1155/2013/498296. Epub 2013 Nov 17.

Background. Ectopic fat deposition in the pancreas and its relationship with hepatic steatosis and insulin resistance have not been compared between patients with nonalcoholic fatty liver disease (NAFLD) and healthy controls. Aim. Using a novel magnetic resonance imaging (MRI)...

The role of C1q in recognition of apoptotic epithelial cells and inflammatory cytokine production by phagocytes during Helicobacter pylori infection.

Journal of inflammation (London, England)

Fox S, Ryan KA, Berger AH, Petro K, Das S, Crowe SE, Ernst PB.
PMID: 26357509
J Inflamm (Lond). 2015 Sep 08;12:51. doi: 10.1186/s12950-015-0098-8. eCollection 2015.

BACKGROUND: Gastric epithelial cells (GECs) undergo apoptosis during H. pylori infection and phagocytes within the mucosa engulf these cells. The recognition and clearance of apoptotic cells is a multifactorial process, enhanced by the presence of various bridging molecules and...

ELMO1 has an essential role in the internalization of .

Cellular and molecular gastroenterology and hepatology

Das S, Sarkar A, Choudhury SS, Owen KA, Castillo V, Fox S, Eckmann L, Elliott MR, Casanova JE, Ernst PB.
PMID: 26878033
Cell Mol Gastroenterol Hepatol. 2015 Apr 01;1(3):311-324. doi: 10.1016/j.jcmgh.2015.02.003.

BACKGROUNDS AND AIMS: 4-6 million people die of enteric infections each year. After invading intestinal epithelial cells, enteric bacteria encounter phagocytes. However, little is known about how phagocytes internalize the bacteria to generate host responses. Previously, we have shown...

Leptomeningeal metastases in breast cancer.

American journal of cancer research

Scott BJ, Kesari S.
PMID: 23593536
Am J Cancer Res. 2013 Apr 03;3(2):117-26. Print 2013.

Central nervous system (CNS) metastasis from breast cancer may be characterized as either parenchymal brain metastasis (BM) or leptomeningeal (LM) metastasis. BM are much more common (about 80% of all CNS metastases), and have been more extensively studied than...

Psychometric Evaluation of the Brief Acculturation Scale for Hispanics.

Hispanic journal of behavioral sciences

Mills SD, Malcarne VL, Fox RS, Sadler GR.
PMID: 25110387
Hisp J Behav Sci. 2014 May 01;36(2):164-174. doi: 10.1177/0739986314526697.

This study examined the psychometric properties of the Brief Acculturation Scale for Hispanics (BASH), a four-item, language-based measure of acculturation. Participants in the study were 435 Hispanic Americans from a large metropolitan area with English or Spanish language preference....

Physical Activity Decreases Kidney Cancer Mortality.

Current urology

Liss M, Natarajan L, Hasan A, Noguchi JL, White M, Parsons JK.
PMID: 29234262
Curr Urol. 2017 Nov;10(4):193-198. doi: 10.1159/000447180. Epub 2017 Oct 22.

BACKGROUND: To investigate associations of kidney cancer mortality with modifiable risk factors of obesity, physical activity, and smoking.METHODS: We evaluate baseline data from US National Health Information Survey from 1998 through 2004 linked to mortality data reporting deaths through...

Mobile and Wearable Device Features that Matter in Promoting Physical Activity.

Journal of mobile technology in medicine

Wang JB, Cataldo JK, Ayala GX, Natarajan L, Cadmus-Bertram LA, White MM, Madanat H, Nichols JF, Pierce JP.
PMID: 27493694
J Mob Technol Med. 2016 Jul;5(2):2-11. doi: 10.7309/jmtm.5.2.2.

BACKGROUND: As wearable sensors/devices become increasingly popular to promote physical activity (PA), research is needed to examine how and which components of these devices people use to increase their PA levels.AIMS: (1) To assess usability and level of engagement...

Individual cognitive behavioral therapy for insomnia in breast cancer survivors: a randomized controlled crossover pilot study.

Nature and science of sleep

Fiorentino L, McQuaid JR, Liu L, Natarajan L, He F, Cornejo M, Lawton S, Parker BA, Sadler GR, Ancoli-Israel S.
PMID: 23616695
Nat Sci Sleep. 2010 Dec 16;2:1-8. doi: 10.2147/nss.s8004. Print 2010.

PURPOSE: Estimates of insomnia in breast cancer patients are high, with reports of poor sleep lasting years after completion of cancer treatment. This randomized controlled crossover pilot study looked at the effects of individual cognitive behavioral therapy for insomnia...

Comprehensive Genomic Profiling Reveals Diverse but Actionable Molecular Portfolios across Hematologic Malignancies: Implications for Next Generation Clinical Trials.

Cancers

Galanina N, Bejar R, Choi M, Goodman A, Wieduwilt M, Mulroney C, Kim L, Yeerna H, Tamayo P, Vergilio JA, Mughal TI, Miller V, Jamieson C, Kurzrock R.
PMID: 30583461
Cancers (Basel). 2018 Dec 21;11(1). doi: 10.3390/cancers11010011.

No abstract available.

Duodenal-Jejunal Flexure GI Stromal Tumor Frequently Heralds Somatic .

JCO precision oncology

Burgoyne AM, De Siena M, Alkhuziem M, Tang CM, Medina B, Fanta PT, Belinsky MG, von Mehren M, Thorson JA, Madlensky L, Bowler T, D'Angelo F, Stupack DG, Harismendy O, DeMatteo RP, Sicklick JK.
PMID: 29938249
JCO Precis Oncol. 2017;2017. doi: 10.1200/PO.17.00014. Epub 2017 Aug 15.

PURPOSE: GI stromal tumors (GISTs) are commonly associated with somatic mutations in METHODS: We describe the demographic/clinicopathologic features of 177 patients from two institutions whose GISTs underwent next-generation sequencing of ≥315 cancer-related genes.RESULTS: We initially identified six (9.7%) of...

Neuronal SIRT1 Regulates Metabolic and Reproductive Function and the Response to Caloric Restriction.

Journal of the Endocrine Society

Rickert E, Fernandez MO, Choi I, Gorman M, Olefsky JM, Webster NJG.
PMID: 30746504
J Endocr Soc. 2018 Dec 24;3(2):427-445. doi: 10.1210/js.2018-00318. eCollection 2019 Feb 01.

Sirt1 is an NAD-dependent, class III deacetylase that functions as a cellular energy sensor. In addition to its well-characterized effects in peripheral tissues, emerging evidence suggests that neuronal Sirt1 activity plays a role in the central regulation of energy...

Showing 1 to 12 of 105 entries