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Showing 1 to 12 of 77 entries
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Culture conditions defining glioblastoma cells behavior: what is the impact for novel discoveries?.

Oncotarget

Ledur PF, Onzi GR, Zong H, Lenz G.
PMID: 28978189
Oncotarget. 2017 Aug 11;8(40):69185-69197. doi: 10.18632/oncotarget.20193. eCollection 2017 Sep 15.

In cancer research, the use of established cell lines has gradually been replaced by primary cell cultures due to their better representation of

Thienyl Difluoroboron β-Diketonates in Solution and Polylactide Media.

Australian journal of chemistry

Kolpaczynska M, DeRosa CA, Morris WA, Fraser CL.
PMID: 27833174
Aust J Chem. 2016;69(5):537-545. doi: 10.1071/CH15750. Epub 2016 Mar 07.

Difluoroboron β-diketonates have impressive optical properties in both solution and the solid state. In particular, both fluorescence and room-temperature phosphorescence are present when the dyes are confined to a rigid matrix, such as poly(lactic acid) (PLA). To expand current...

Evaluation of Novel .

Nanoscale research letters

Hu P, Cheng D, Huang T, Banizs AB, Xiao J, Liu G, Chen Q, Wang Y, He J, Shi H.
PMID: 28875472
Nanoscale Res Lett. 2017 Sep 06;12(1):523. doi: 10.1186/s11671-017-2292-5.

Radiation therapy of liver cancer is limited by low tolerance of the liver to radiation. Radiosensitizers can effectively reduce the required radiation dose. AGuIX nanoparticles are small, multifunctional gadolinium-based nanoparticles that can carry radioisotopes or fluorescent markers for single-photon...

Cas and NEDD9 Contribute to Tumor Progression through Dynamic Regulation of the Cytoskeleton.

Genes & cancer

Guerrero MS, Parsons JT, Bouton AH.
PMID: 23226575
Genes Cancer. 2012 May;3(5):371-81. doi: 10.1177/1947601912458585.

The Cas family proteins, p130(Cas) (Cas) and NEDD9, are adaptor molecules that regulate cytoskeletal dynamics to promote multiple cellular processes, including migration, invasion, proliferation, and survival. Because these functions are also critical for tumor initiation, growth, and metastasis, Cas...

Peripheral tissue homing receptor control of naïve, effector, and memory CD8 T cell localization in lymphoid and non-lymphoid tissues.

Frontiers in immunology

Brinkman CC, Peske JD, Engelhard VH.
PMID: 23966998
Front Immunol. 2013 Aug 19;4:241. doi: 10.3389/fimmu.2013.00241. eCollection 2013.

T cell activation induces homing receptors that bind ligands on peripheral tissue vasculature, programing movement to sites of infection and injury. There are three major types of CD8 effector T cells based on homing receptor expression, which arise in...

Legislative activity related to the human papillomavirus (HPV) vaccine in the United States (2006-2015): a need for evidence-based policy.

Risk management and healthcare policy

Keim-Malpass J, Mitchell EM, DeGuzman PB, Stoler MH, Kennedy C.
PMID: 28331378
Risk Manag Healthc Policy. 2017 Mar 13;10:29-32. doi: 10.2147/RMHP.S128247. eCollection 2017.

State-based policies to mandate HPV vaccination are politically challenging and have received broad criticisms. There is a critical need to understand the legislative activities that underpin subsequent policy implementation. The objective of this policy analysis was to analyze state...

A specialized pathway for erythroid iron delivery through lysosomal trafficking of transferrin receptor 2.

Blood advances

Khalil S, Holy M, Grado S, Fleming R, Kurita R, Nakamura Y, Goldfarb A.
PMID: 29296759
Blood Adv. 2017 Jun 27;1(15):1181-1194. doi: 10.1182/bloodadvances.2016003772. eCollection 2017 Jun 27.

Erythroid progenitors are the largest consumers of iron in the human body. In these cells, a high flux of iron must reach the mitochondrial matrix to form sufficient heme to support hemoglobinization. Canonical erythroid iron trafficking occurs via the...

Intercostal nerve blockade for thoracic surgery with liposomal bupivacaine: the devil is in the details.

Journal of thoracic disease

Martin LW, Mehran RJ.
PMID: 31245085
J Thorac Dis. 2019 May;11:S1202-S1205. doi: 10.21037/jtd.2019.03.62.

No abstract available.

Myeloid Cell Infiltration Correlates With Prognosis in Cholangiocarcinoma and Varies Based on Tumor Location.

Journal of immunotherapy (Hagerstown, Md. : 1997)

Kunk PR, Dougherty SC, Lynch K, Whitehair R, Meneveau M, Obeid JM, Winters K, Ju JY, Stelow EB, Bauer TW, Slingluff CL, Rahma OE.
PMID: 34191790
J Immunother. 2021 Sep 01;44(7):254-263. doi: 10.1097/CJI.0000000000000378.

Cholangiocarcinoma (CC) is an uncommon malignancy with increasing incidence and dismal prognosis. We conducted a comprehensive analysis of the CC tumor immune microenvironment (TIME) based on tumor location to identify therapeutic targets. We hypothesized that the TIME of CC...

Frequent somatic TET2 mutations in chronic NK-LGL leukemia with distinct patterns of cytopenias.

Blood

Olson TL, Cheon H, Xing JC, Olson KC, Paila U, Hamele CE, Neelamraju Y, Shemo BC, Schmachtenberg M, Sundararaman SK, Toro MF, Keller CA, Farber EA, Onengut-Gumuscu S, Garrett-Bakelman FE, Hardison RC, Feith DJ, Ratan A, Loughran TP.
PMID: 33786584
Blood. 2021 Aug 26;138(8):662-673. doi: 10.1182/blood.2020005831.

Chronic natural killer large granular lymphocyte (NK-LGL) leukemia, also referred to as chronic lymphoproliferative disorder of NK cells, is a rare disorder defined by prolonged expansion of clonal NK cells. Similar prevalence of STAT3 mutations in chronic T-LGL and...

UTX condensation underlies its tumour-suppressive activity.

Nature

Shi B, Li W, Song Y, Wang Z, Ju R, Ulman A, Hu J, Palomba F, Zhao Y, Le JP, Jarrard W, Dimoff D, Digman MA, Gratton E, Zang C, Jiang H.
PMID: 34526716
Nature. 2021 Sep;597(7878):726-731. doi: 10.1038/s41586-021-03903-7. Epub 2021 Sep 15.

UTX (also known as KDM6A) encodes a histone H3K27 demethylase and is an important tumour suppressor that is frequently mutated in human cancers

Development and biological applications of sulfur-triazole exchange (SuTEx) chemistry.

RSC chemical biology

Borne AL, Brulet JW, Yuan K, Hsu KL.
PMID: 34095850
RSC Chem Biol. 2021 Apr 01;2(2):322-337. doi: 10.1039/d0cb00180e. Epub 2021 Jan 19.

Sulfur electrophiles constitute an important class of covalent small molecules that have found widespread applications in synthetic chemistry and chemical biology. Various electrophilic scaffolds, including sulfonyl fluorides and arylfluorosulfates as recent examples, have been applied for protein bioconjugation to...

Showing 1 to 12 of 77 entries