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Showing 1 to 12 of 126 entries
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GCAP1, Rab6, and HSP27: Novel Autoantibody Targets in Cancer-Associated Retinopathy and Autoimmune Retinopathy.

Translational vision science & technology

Yang S, Dizhoor A, Wilson DJ, Adamus G.
PMID: 27152249
Transl Vis Sci Technol. 2016 May 02;5(3):1. doi: 10.1167/tvst.5.3.1. eCollection 2016 May.

PURPOSE: Autoantibodies (AAbs) with different retinal specificities were reported in cancer-associated retinopathy (CAR) and autoimmune retinopathy (AR). The goal was to identify the small retinal proteins of apparent molecular mass of 23-kDa often recognized by patients' AAbs.METHODS: Sera specific...

Computer-Based Image Analysis for Plus Disease Diagnosis in Retinopathy of Prematurity: Performance of the "i-ROP" System and Image Features Associated With Expert Diagnosis.

Translational vision science & technology

Ataer-Cansizoglu E, Bolon-Canedo V, Campbell JP, Bozkurt A, Erdogmus D, Kalpathy-Cramer J, Patel S, Jonas K, Chan RV, Ostmo S, Chiang MF.
PMID: 26644965
Transl Vis Sci Technol. 2015 Nov 30;4(6):5. doi: 10.1167/tvst.4.6.5. eCollection 2015 Nov.

PURPOSE: We developed and evaluated the performance of a novel computer-based image analysis system for grading plus disease in retinopathy of prematurity (ROP), and identified the image features, shapes, and sizes that best correlate with expert diagnosis.METHODS: A dataset...

Automated volumetric segmentation of retinal fluid on optical coherence tomography.

Biomedical optics express

Wang J, Zhang M, Pechauer AD, Liu L, Hwang TS, Wilson DJ, Li D, Jia Y.
PMID: 27446676
Biomed Opt Express. 2016 Mar 30;7(4):1577-89. doi: 10.1364/BOE.7.001577. eCollection 2016 Apr 01.

We propose a novel automated volumetric segmentation method to detect and quantify retinal fluid on optical coherence tomography (OCT). The fuzzy level set method was introduced for identifying the boundaries of fluid filled regions on B-scans (x and y-axes)...

Automated detection of dilated capillaries on optical coherence tomography angiography.

Biomedical optics express

Dongye C, Zhang M, Hwang TS, Wang J, Gao SS, Liu L, Huang D, Wilson DJ, Jia Y.
PMID: 28271005
Biomed Opt Express. 2017 Jan 25;8(2):1101-1109. doi: 10.1364/BOE.8.001101. eCollection 2017 Feb 01.

Automated detection and grading of angiographic high-risk features in diabetic retinopathy can potentially enhance screening and clinical care. We have previously identified capillary dilation in angiograms of the deep plexus in optical coherence tomography angiography as a feature associated...

Data detailing the platelet acetyl-lysine proteome.

Data in brief

Aslan JE, David LL, McCarty OJ.
PMID: 26904711
Data Brief. 2015 Oct 09;5:368-71. doi: 10.1016/j.dib.2015.09.020. eCollection 2015 Dec.

Here we detail proteomics data that describe the acetyl-lysine proteome of blood platelets (Aslan et al., 2015 [1]). An affinity purification - mass spectrometry (AP-MS) approach was used to identify proteins modified by Nε-lysine acetylation in quiescent, washed human...

Alterations in Kainate Receptor and TRPM1 Localization in Bipolar Cells after Retinal Photoreceptor Degeneration.

Frontiers in cellular neuroscience

Gayet-Primo J, Puthussery T.
PMID: 26733812
Front Cell Neurosci. 2015 Dec 22;9:486. doi: 10.3389/fncel.2015.00486. eCollection 2015.

Photoreceptor degeneration differentially impacts glutamatergic signaling in downstream On and Off bipolar cells. In rodent models, photoreceptor degeneration leads to loss of glutamatergic signaling in On bipolar cells, whereas Off bipolar cells appear to retain glutamate sensitivity, even after...

Projection-resolved optical coherence tomography angiography exhibiting early flow prior to clinically observed retinal angiomatous proliferation.

American journal of ophthalmology case reports

Bhavsar KV, Jia Y, Wang J, Patel RC, Lauer AK, Huang D, Bailey ST.
PMID: 29260118
Am J Ophthalmol Case Rep. 2017 Oct 06;8:53-57. doi: 10.1016/j.ajoc.2017.10.001. eCollection 2017 Dec.

PURPOSE: The purpose of this study is to analyze early retinal angiomatous proliferation (RAP) utilizing a novel imaging modality, Projection-Resolved Optical Coherence Tomography Angiography (PR-OCTA).OBSERVATIONS: Five months prior to the diagnosis of a RAP lesion, cross-sectional PR-OCTA demonstrated flow...

OCT Angiography Changes in the 3 Parafoveal Retinal Plexuses in Response to Hyperoxia.

Ophthalmology. Retina

Hagag AM, Pechauer AD, Liu L, Wang J, Zhang M, Jia Y, Huang D.
PMID: 29888339
Ophthalmol Retina. 2018 Apr;2(4):329-336. doi: 10.1016/j.oret.2017.07.022. Epub 2017 Oct 16.

PURPOSE: Use projection-resolved OCT angiography to investigate the autoregulatory response in the 3 parafoveal retinal plexuses under hyperoxia.DESIGN: Prospective cohort study.PARTICIPANTS: Nine eyes from 9 healthy participants.METHODS: One eye from each participant was scanned using a commercial spectral-domain OCT...

Quantitative OCT Angiography Evaluation of Peripapillary Retinal Circulation after Plaque Brachytherapy.

Ophthalmology. Retina

Skalet AH, Liu L, Binder C, Miller AK, Wang J, Wilson DJ, Crilly R, Thomas CR, Hung AY, Huang D, Jia Y.
PMID: 29732441
Ophthalmol Retina. 2018 Mar;2(3):244-250. doi: 10.1016/j.oret.2017.06.005.

OBJECTIVE: To study peripapillary retinal capillary circulation in eyes treated with I-125 plaque brachytherapy for uveal melanoma using optical coherence tomography angiography (OCTA).DESIGN: Cross-sectional study of 10 subjects imaged with OCTA prior to uveal melanoma treatment and 15 subjects...

Optical coherence tomography angiography: Technical principles and clinical applications in ophthalmology.

Taiwan journal of ophthalmology

Hagag AM, Gao SS, Jia Y, Huang D.
PMID: 28966909
Taiwan J Ophthalmol. 2017 Jul-Sep;7(3):115-129. doi: 10.4103/tjo.tjo_31_17. Epub 2017 Sep 19.

Optical coherence tomography angiography (OCTA) is a functional extension of OCT that provides information on retinal and choroidal circulations without the need for dye injections. With the recent development of high-speed OCT systems and efficient algorithms, OCTA has become...

Increased Hemodynamic Load in Early Embryonic Stages Alters Myofibril and Mitochondrial Organization in the Myocardium.

Frontiers in physiology

Midgett M, López CS, David L, Maloyan A, Rugonyi S.
PMID: 28912723
Front Physiol. 2017 Aug 30;8:631. doi: 10.3389/fphys.2017.00631. eCollection 2017.

Normal blood flow is essential for proper heart formation during embryonic development, as abnormal hemodynamic load (blood pressure and shear stress) results in cardiac defects seen in congenital heart disease (CHD). However, the detrimental remodeling processes that relate altered...

Real-time cross-sectional and en face OCT angiography guiding high-quality scan acquisition.

Optics letters

Wei X, Camino A, Pi S, Hormel TT, Cepurna W, Huang D, Morrison JC, Jia Y.
PMID: 30874667
Opt Lett. 2019 Mar 15;44(6):1431-1434. doi: 10.1364/OL.44.001431.

Defocusing, vignetting, and bulk motion degrade the image quality of optical coherence tomography angiography (OCTA) more significantly than structural OCT. The assessment of focus, alignment conditions, and stability of imaging subjects in commercially available OCTA systems are currently based...

Showing 1 to 12 of 126 entries