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Showing 1 to 12 of 31 entries
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Journal of medical devices

Rahman T, Page R, Page C, Bonnefoy JR, Cox T, Shaffer TH.
PMID: 28289485
J Med Device. 2017 Mar;11(1):0110101-110106. doi: 10.1115/1.4035546. Epub 2017 Jan 24.

Objective pulmonary function (PF) evaluation is essential for the diagnosis, monitoring, and management of many pediatric respiratory diseases as seen in the emergency room, intensive care, and outpatient settings. In this paper, the development and testing of a new...

Complexity of Human Antibody Response to Dengue Virus: Implication for Vaccine Development.

Frontiers in microbiology

Tsai WY, Lin HE, Wang WK.
PMID: 28775720
Front Microbiol. 2017 Jul 20;8:1372. doi: 10.3389/fmicb.2017.01372. eCollection 2017.

The four serotypes of dengue virus (DENV) are the leading cause of arboviral diseases in humans. Decades of efforts have made remarkable progress in dengue vaccine development. Despite the first dengue vaccine (dengvaxia from Sanofi Pasteur), a live-attenuated tetravalent...

Selenoprotein K deficiency inhibits melanoma by reducing calcium flux required for tumor growth and metastasis.

Oncotarget

Marciel MP, Khadka VS, Deng Y, Kilicaslan P, Pham A, Bertino P, Lee K, Chen S, Glibetic N, Hoffmann FW, Matter ML, Hoffmann PR.
PMID: 29568366
Oncotarget. 2018 Feb 03;9(17):13407-13422. doi: 10.18632/oncotarget.24388. eCollection 2018 Mar 02.

Interest has emerged in the therapeutic potential of inhibiting store operated calcium (Ca

The function of LncRNAs and their role in the prediction, diagnosis, and prognosis of lung cancer.

Clinical and translational medicine

Chen Y, Zitello E, Guo R, Deng Y.
PMID: 33931980
Clin Transl Med. 2021 Apr;11(4):e367. doi: 10.1002/ctm2.367.

Lung cancer remains a major threat to human health. Low dose CT scan (LDCT) has become the main method of early screening for lung cancer due to the low sensitivity of chest X-ray. However, LDCT not only has a...

Predicting the Severity of Disease Progression in COVID-19 at the Individual and Population Level: A Mathematical Model.

Clinical & experimental pharmacology

Chirmule N, Khare R, Nair P, Desai B, Nerurkar V, Gaur A.
PMID: 34367726
Clin Exp Pharmacol. 2021;11(5).

The impact of COVID-19 disease on health and economy has been global, and the magnitude of devastation is unparalleled in modern history. Any potential course of action to manage this complex disease requires the systematic and efficient analysis of...

Female Mice with Selenocysteine tRNA Deletion in Agrp Neurons Maintain Leptin Sensitivity and Resist Weight Gain While on a High-Fat Diet.

International journal of molecular sciences

Torres DJ, Pitts MW, Seale LA, Hashimoto AC, An KJ, Hanato AN, Hui KW, Remigio SMA, Carlson BA, Hatfield DL, Berry MJ.
PMID: 34681674
Int J Mol Sci. 2021 Oct 12;22(20). doi: 10.3390/ijms222011010.

The role of the essential trace element selenium in hypothalamic physiology has begun to come to light over recent years. Selenium is used to synthesize a family of proteins participating in redox reactions called selenoproteins, which contain a selenocysteine...

The Evaluation of Serum Biomarkers for Non-small Cell Lung Cancer (NSCLC) Diagnosis.

Frontiers in physiology

Fang R, Zhu Y, Khadka VS, Zhang F, Jiang B, Deng Y.
PMID: 30555348
Front Physiol. 2018 Nov 29;9:1710. doi: 10.3389/fphys.2018.01710. eCollection 2018.

No abstract available.

Deletion of Pregnancy Zone Protein and Murinoglobulin-1 Restricts the Pathogenesis of West Nile Virus Infection in Mice.

Frontiers in microbiology

Krause K, Azouz F, Nakano E, Nerurkar VR, Kumar M.
PMID: 30814992
Front Microbiol. 2019 Feb 13;10:259. doi: 10.3389/fmicb.2019.00259. eCollection 2019.

West Nile virus (WNV) is an enveloped positive-stranded RNA virus that causes meningitis, encephalitis, and acute flaccid paralysis in humans. There are no therapeutic agents available for use against WNV infection. Alpha-2 macroglobulin (A2M) is a major plasma proteinase...

Recombinant Zika Virus Subunits Are Immunogenic and Efficacious in Mice.

mSphere

To A, Medina LO, Mfuh KO, Lieberman MM, Wong TAS, Namekar M, Nakano E, Lai CY, Kumar M, Nerurkar VR, Lehrer AT.
PMID: 29359186
mSphere. 2018 Jan 10;3(1). doi: 10.1128/mSphere.00576-17. eCollection 2018.

Following the 2015 Zika virus (ZIKV) outbreaks in the South Pacific, Caribbean, and Americas, ZIKV has emerged as a serious threat due to its association with infantile microcephaly and other neurologic disorders. Despite an international effort to develop a...

Ebola Virus Glycoprotein Induces an Innate Immune Response .

Frontiers in microbiology

Lai CY, Strange DP, Wong TAS, Lehrer AT, Verma S.
PMID: 28861075
Front Microbiol. 2017 Aug 17;8:1571. doi: 10.3389/fmicb.2017.01571. eCollection 2017.

Ebola virus (EBOV), a member of the

Upregulated ethanolamine phospholipid synthesis via selenoprotein I is required for effective metabolic reprogramming during T cell activation.

Molecular metabolism

Ma C, Hoffmann FW, Marciel MP, Page KE, Williams-Aduja MA, Akana ENL, Gojanovich GS, Gerschenson M, Urschitz J, Moisyadi S, Khadka VS, Rozovsky S, Deng Y, Horgen FD, Hoffmann PR.
PMID: 33484950
Mol Metab. 2021 May;47:101170. doi: 10.1016/j.molmet.2021.101170. Epub 2021 Jan 20.

OBJECTIVE: T cell activation triggers metabolic reprogramming to meet increased demands for energy and metabolites required for cellular proliferation. Ethanolamine phospholipid synthesis has emerged as a regulator of metabolic shifts in stem cells and cancer cells, which led us...

Selenoprotein M Promotes Hypothalamic Leptin Signaling and Thioredoxin Antioxidant Activity.

Antioxidants & redox signaling

Gong T, Hashimoto AC, Sasuclark AR, Khadka VS, Gurary A, Pitts MW.
PMID: 30648404
Antioxid Redox Signal. 2021 Oct 01;35(10):775-787. doi: 10.1089/ars.2018.7594. Epub 2019 Mar 06.

No abstract available.

Showing 1 to 12 of 31 entries