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Adolescent Alcohol Exposure Persistently Impacts Adult Neurobiology and Behavior.

Pharmacological reviews

Crews FT, Vetreno RP, Broadwater MA, Robinson DL.
PMID: 27677720
Pharmacol Rev. 2016 Oct;68(4):1074-1109. doi: 10.1124/pr.115.012138.

Adolescence is a developmental period when physical and cognitive abilities are optimized, when social skills are consolidated, and when sexuality, adolescent behaviors, and frontal cortical functions mature to adult levels. Adolescents also have unique responses to alcohol compared with...

Chronic alcohol exposure during critical developmental periods differentially impacts persistence of deficits in cognitive flexibility and related circuitry.

International review of neurobiology

Dannenhoffer CA, Robertson MM, Macht VA, Mooney SM, Boettiger CA, Robinson DL.
PMID: 34696872
Int Rev Neurobiol. 2021;160:117-173. doi: 10.1016/bs.irn.2021.07.004. Epub 2021 Aug 11.

Cognitive flexibility in decision making depends on prefrontal cortical function and is used by individuals to adapt to environmental changes in circumstances. Cognitive flexibility can be measured in the laboratory using a variety of discrete, translational tasks, including those...

Increased alcohol self-administration following exposure to the predator odor TMT in active coping female rats.

Behavioural brain research

Ornelas LC, Tyler RE, Irukulapati P, Paladugu S, Besheer J.
PMID: 33333108
Behav Brain Res. 2021 Mar 26;402:113068. doi: 10.1016/j.bbr.2020.113068. Epub 2020 Dec 14.

Post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) are highly comorbid. Additionally, individual differences in response to stress suggest resilient and susceptible populations. The current study exposed male and female Long Evans rats to the synthetically produced predator...

Sex-specific plasticity in CRF regulation of inhibitory control in central amygdala CRF1 neurons after chronic voluntary alcohol drinking.

Addiction biology

Agoglia AE, Zhu M, Quadir SG, Bluitt MN, Douglass E, Hanback T, Tella J, Ying R, Hodge CW, Herman MA.
PMID: 34075665
Addict Biol. 2022 Jan;27(1):e13067. doi: 10.1111/adb.13067. Epub 2021 Jun 02.

Despite strong preclinical evidence for the ability of corticotropin releasing factor 1 (CRF1) antagonists to regulate alcohol consumption, clinical trials have not yet demonstrated therapeutic effects of these compounds in alcohol use disorder (AUD) patients. Several confounding factors may...

Increased Toll-like Receptor-MyD88-NFκB-Proinflammatory neuroimmune signaling in the orbitofrontal cortex of humans with alcohol use disorder.

Alcoholism, clinical and experimental research

Vetreno RP, Qin L, Coleman LG, Crews FT.
PMID: 34415075
Alcohol Clin Exp Res. 2021 Sep;45(9):1747-1761. doi: 10.1111/acer.14669. Epub 2021 Aug 20.

BACKGROUND: Many brain disorders, including alcohol use disorder (AUD), are associated with induction of multiple proinflammatory genes. One aspect of proinflammatory signaling is progressive increases in expression across cells and induction of other innate immune genes. High-mobility group box...

Inflammasome-IL-1β Signaling Mediates Ethanol Inhibition of Hippocampal Neurogenesis.

Frontiers in neuroscience

Zou J, Crews FT.
PMID: 22661925
Front Neurosci. 2012 May 30;6:77. doi: 10.3389/fnins.2012.00077. eCollection 2012.

Regulation of hippocampal neurogenesis is poorly understood, but appears to contribute to mood and cognition. Ethanol and neuroinflammation are known to reduce neurogenesis. We have found that ethanol induces neuroinflammation supporting the hypothesis that ethanol induction of neuroinflammation contributes...

Chronic alcohol exposure during critical developmental periods differentially impacts persistence of deficits in cognitive flexibility and related circuitry.

International review of neurobiology

Dannenhoffer CA, Robertson MM, Macht VA, Mooney SM, Boettiger CA, Robinson DL.
PMID: 34696872
Int Rev Neurobiol. 2021;160:117-173. doi: 10.1016/bs.irn.2021.07.004. Epub 2021 Aug 11.

Cognitive flexibility in decision making depends on prefrontal cortical function and is used by individuals to adapt to environmental changes in circumstances. Cognitive flexibility can be measured in the laboratory using a variety of discrete, translational tasks, including those...

Sex-specific plasticity in CRF regulation of inhibitory control in central amygdala CRF1 neurons after chronic voluntary alcohol drinking.

Addiction biology

Agoglia AE, Zhu M, Quadir SG, Bluitt MN, Douglass E, Hanback T, Tella J, Ying R, Hodge CW, Herman MA.
PMID: 34075665
Addict Biol. 2021 Jun 02;e13067. doi: 10.1111/adb.13067. Epub 2021 Jun 02.

Despite strong preclinical evidence for the ability of corticotropin releasing factor 1 (CRF1) antagonists to regulate alcohol consumption, clinical trials have not yet demonstrated therapeutic effects of these compounds in alcohol use disorder (AUD) patients. Several confounding factors may...

Sex-specific plasticity in CRF regulation of inhibitory control in central amygdala CRF1 neurons after chronic voluntary alcohol drinking.

Addiction biology

Agoglia AE, Zhu M, Quadir SG, Bluitt MN, Douglass E, Hanback T, Tella J, Ying R, Hodge CW, Herman MA.
PMID: 34075665
Addict Biol. 2022 Jan;27(1):e13067. doi: 10.1111/adb.13067. Epub 2021 Jun 02.

Despite strong preclinical evidence for the ability of corticotropin releasing factor 1 (CRF1) antagonists to regulate alcohol consumption, clinical trials have not yet demonstrated therapeutic effects of these compounds in alcohol use disorder (AUD) patients. Several confounding factors may...

Sex-specific plasticity in CRF regulation of inhibitory control in central amygdala CRF1 neurons after chronic voluntary alcohol drinking.

Addiction biology

Agoglia AE, Zhu M, Quadir SG, Bluitt MN, Douglass E, Hanback T, Tella J, Ying R, Hodge CW, Herman MA.
PMID: 34075665
Addict Biol. 2022 Jan;27(1):e13067. doi: 10.1111/adb.13067. Epub 2021 Jun 02.

Despite strong preclinical evidence for the ability of corticotropin releasing factor 1 (CRF1) antagonists to regulate alcohol consumption, clinical trials have not yet demonstrated therapeutic effects of these compounds in alcohol use disorder (AUD) patients. Several confounding factors may...

Stress and Withdrawal from Chronic Ethanol Induce Selective Changes in Neuroimmune mRNAs in Differing Brain Sites.

Brain sciences

Knapp DJ, Harper KM, Whitman BA, Zimomra Z, Breese GR.
PMID: 27472367
Brain Sci. 2016 Jul 27;6(3). doi: 10.3390/brainsci6030025.

Stress is a strong risk factor in alcoholic relapse and may exert effects that mimic aspects of chronic alcohol exposure on neurobiological systems. With the neuroimmune system becoming a prominent focus in the study of the neurobiological consequences of...

Sex-specific plasticity in CRF regulation of inhibitory control in central amygdala CRF1 neurons after chronic voluntary alcohol drinking.

Addiction biology

Agoglia AE, Zhu M, Quadir SG, Bluitt MN, Douglass E, Hanback T, Tella J, Ying R, Hodge CW, Herman MA.
PMID: 34075665
Addict Biol. 2022 Jan;27(1):e13067. doi: 10.1111/adb.13067. Epub 2021 Jun 02.

Despite strong preclinical evidence for the ability of corticotropin releasing factor 1 (CRF1) antagonists to regulate alcohol consumption, clinical trials have not yet demonstrated therapeutic effects of these compounds in alcohol use disorder (AUD) patients. Several confounding factors may...

Showing 1 to 12 of 20 entries