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Showing 1 to 12 of 101 entries
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An update on brain imaging in parkinsonian dementia.

Imaging in medicine

Petrou M, Kotagal V, Bohnen NI.
PMID: 22768021
Imaging Med. 2012 Apr;4(2):201-213. doi: 10.2217/iim.12.10.

Disturbances of cognition are frequent in Parkinson's disease (PD). Unlike severe loss of dopamine early in PD, extensive cholinergic losses have been consistently reported in PD with dementia. Cholinergic imaging suggests that basal forebrain cholinergic system degeneration appears early...

Apolipoproteins and Alzheimer's pathophysiology.

Alzheimer's & dementia (Amsterdam, Netherlands)

Koch M, DeKosky ST, Fitzpatrick AL, Furtado JD, Lopez OL, Kuller LH, Mackey RH, Hughes TM, Mukamal KJ, Jensen MK.
PMID: 30370330
Alzheimers Dement (Amst). 2018 Aug 10;10:545-553. doi: 10.1016/j.dadm.2018.07.001. eCollection 2018.

INTRODUCTION: Apolipoproteins of demonstrated importance to brain cholesterol and ß-amyloid metabolism may serve as novel risk markers for Alzheimer's pathology.METHODS: We measured apolipoproteins (apoE, apoJ, apoA-I, and apoC-III and their uniquely defined subspecies) by enzyme-linked immunosorbent assay in plasma...

"I'm Not Sure We Had A Choice": Decision Quality and The Use of Cardiac Implantable Electronic Devices In Older Adults With Cognitive Impairment.

Cardiology and cardiovascular medicine

Fowler NR, Shaaban CE, Torke AM, Lane KA, Saba S, Barnato AE.
PMID: 29521380
Cardiol Cardiovasc Med. 2018;2(1):10-26. doi: 10.26502/fccm.92920032. Epub 2018 Feb 12.

BACKGROUND: The decision to implant a cardiac device in a person with Alzheimer's disease or related dementia requires considering the possible trade-offs of quality of life (QOL) and quantity of life. This study measured the decision-making experience of patients...

Polypharmacy in an Elderly Population: Enhancing Medication Management Through the Use of Clinical Decision Support Software Platforms.

Neurology and therapy

Keine D, Zelek M, Walker JQ, Sabbagh MN.
PMID: 30900186
Neurol Ther. 2019 Jun;8(1):79-94. doi: 10.1007/s40120-019-0131-6. Epub 2019 Mar 21.

INTRODUCTION: Polypharmacy is a growing problem in the United States. The use of multiple medications increases the likelihood that a patient will experience potential drug interactions and adverse drug reactions (ADRs). Those individuals with dementia or Alzheimer's disease (AD)...

A Brief Synopsis on the Genetics of Alzheimer's Disease.

Current genetic medicine reports

Kamboh MI.
PMID: 30460168
Curr Genet Med Rep. 2018;6(4):133-135. doi: 10.1007/s40142-018-0155-8. Epub 2018 Oct 30.

No abstract available.

Patients' and Family Members' Subjective Experiences of a Diagnostic Evaluation of Mild Cognitive Impairment.

Journal of patient experience

Morris JL, Hu L, Hunsaker A, Liptak A, Seaman JB, Lingler JH.
PMID: 32128381
J Patient Exp. 2020 Feb;7(1):124-131. doi: 10.1177/2374373518818204. Epub 2018 Dec 16.

BACKGROUND: People with a diagnosis of mild cognitive impairment (MCI) often struggle with uncertainty and fear when learning of and coping with their diagnosis. However, little is known about their experiences and perspectives, and those of their care partners,...

Activity patterns related to depression symptoms in stressed dementia caregivers.

International psychogeriatrics

Smagula SF, Hasler BP, Schulz R, Graves JL, Reynolds CF, Aizenstein HJ, Buysse DJ, Krafty RT, Hall MH.
PMID: 31658928
Int Psychogeriatr. 2019 Oct 29;1-8. doi: 10.1017/S1041610219001601. Epub 2019 Oct 29.

OBJECTIVES: Self-reported activity restriction is an established correlate of depression in dementia caregivers (dCGs). It is plausible that the daily distribution of objectively measured activity is also altered in dCGs with depression symptoms; if so, such activity characteristics could...

Reliability of Medical History Reporting in Older Adults With and Without Cognitive Impairment.

Journal of central nervous system disease

Curcio N, Wilmoth K, LoBue C, Cullum CM.
PMID: 31040738
J Cent Nerv Syst Dis. 2019 Apr 22;11:1179573519843874. doi: 10.1177/1179573519843874. eCollection 2019.

BACKGROUND: Clinical diagnosis of cognitive disorders depends on accurate reporting of medical history, yet little is known about the reliability and the validity of such reports, particularly in older patients with and without cognitive impairment.METHODS: In 2 studies, we...

The use of Centiloids for applying [.

Alzheimer's & dementia (Amsterdam, Netherlands)

Tudorascu DL, Minhas DS, Lao PJ, Betthauser TJ, Yu Z, Laymon CM, Lopresti BJ, Mathis CA, Klunk WE, Handen BL, Christian BT, Cohen AD.
PMID: 30014032
Alzheimers Dement (Amst). 2018 Apr 21;10:332-339. doi: 10.1016/j.dadm.2018.03.006. eCollection 2018.

INTRODUCTION: Centiloid standardization was developed to establish a quantitative outcome measure of amyloid burden that could accommodate the integration of different amyloid positron emission tomography radiotracers or different methods of quantifying the same tracer. The goal of this study...

Sex as a Risk Factor for Developing Cognitive Impairments in National Alzheimer's Coordinating Center Participants.

Journal of Alzheimer's disease reports

Wang G, Li W.
PMID: 33681711
J Alzheimers Dis Rep. 2021 Jan 11;5(1):1-6. doi: 10.3233/ADR-200275.

BACKGROUND: It is inconclusive on how sex affects the risk of developing mild cognitive impairment (MCI) or dementia.OBJECTIVE: To investigate how sex affects the risk of developing MCI or dementia.METHODS: A secondary data analysis was performed on data collected...

Tau Isoform Profile in Essential Tremor Diverges From Other Tauopathies.

Journal of neuropathology and experimental neurology

Kim SH, Farrell K, Cosentino S, Vonsattel JG, Faust PL, Cortes EP, Bennet DA, Louis ED, Crary JF.
PMID: 34363663
J Neuropathol Exp Neurol. 2021 Sep 27;80(9):835-843. doi: 10.1093/jnen/nlab073.

Patients with essential tremor (ET) frequently develop concurrent dementia, which is often assumed to represent co-morbid Alzheimer disease (AD). Autopsy studies have identified a spectrum of tau pathologies in ET and tau isoforms have not been examined in ET....

G protein-coupled receptor kinases are associated with Alzheimer's disease pathology.

Neuropathology and applied neurobiology

Guimarães TR, Swanson E, Kofler J, Thathiah A.
PMID: 34164834
Neuropathol Appl Neurobiol. 2021 Dec;47(7):942-957. doi: 10.1111/nan.12742. Epub 2021 Jul 19.

AIM: Alzheimer's disease (AD) is characterised by extracellular deposition of amyloid-β (Aβ) in amyloid plaques and intracellular aggregation and accumulation of hyperphosphorylated tau in neurofibrillary tangles (NFTs). Although several kinases have been identified to contribute to the pathological phosphorylation...

Showing 1 to 12 of 101 entries