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Showing 1 to 12 of 105 entries
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Fear and Uncertainty Do Not Influence Reported Willingness to Undergo Lumbar Punctures in a U.S. Multi-Cultural Cohort.

Frontiers in aging neuroscience

Tsvetkova DZ, Bergquist SH, Parker MW, Jarrett TL, Howell JC, Watts KD, Kollhoff A, Roberts DL, Hu WT.
PMID: 28239349
Front Aging Neurosci. 2017 Feb 10;9:22. doi: 10.3389/fnagi.2017.00022. eCollection 2017.

Cerebrospinal fluid (CSF) biomarkers for Alzheimer's disease and related disorders can provide early and accurate prediction of underlying neuropathology even when the clinical symptoms are mild, but lumbar punctures (LP) to obtain CSF can be perceived as frightening and...

Multimodal Imaging Signatures of Parkinson's Disease.

Frontiers in neuroscience

Bowman FD, Drake DF, Huddleston DE.
PMID: 27147942
Front Neurosci. 2016 Apr 18;10:131. doi: 10.3389/fnins.2016.00131. eCollection 2016.

Parkinson's disease (PD) is a complex neurodegenerative disorder that manifests through hallmark motor symptoms, often accompanied by a range of non-motor symptoms. There is a putative delay between the onset of the neurodegenerative process, marked by the death of...

Periodic Leg Movements in Sleep and Restless Legs Syndrome: Considerations in Geriatrics.

Sleep medicine clinics

Bliwise DL.
PMID: 19881897
Sleep Med Clin. 2006 Jun 01;1(2):263-271. doi: 10.1016/j.jsmc.2006.04.005.

No abstract available.

Targeting norepinephrine in mild cognitive impairment and Alzheimer's disease.

Alzheimer's research & therapy

Chalermpalanupap T, Kinkead B, Hu WT, Kummer MP, Hammerschmidt T, Heneka MT, Weinshenker D, Levey AI.
PMID: 23634965
Alzheimers Res Ther. 2013 Apr 29;5(2):21. doi: 10.1186/alzrt175. eCollection 2013.

The Alzheimer's disease (AD) epidemic is a looming crisis, with an urgent need for new therapies to delay or prevent symptom onset and progression. There is growing awareness that clinical trials must target stage-appropriate pathophysiological mechanisms to effectively develop...

Continuous measurement of object location memory is sensitive to effects of age and mild cognitive impairment and related to medial temporal lobe volume.

Alzheimer's & dementia (Amsterdam, Netherlands)

Hampstead BM, Towler S, Stringer AY, Sathian K.
PMID: 29255787
Alzheimers Dement (Amst). 2017 Nov 11;10:76-85. doi: 10.1016/j.dadm.2017.10.007. eCollection 2018.

INTRODUCTION: We present findings of a novel and ecologically relevant associative memory test, the Object Location Touchscreen Test (OLTT), which was posited as sensitive to early medial temporal lobe compromise associated with mild cognitive impairment (MCI).METHODS: A total of...

Polypharmacy in an Elderly Population: Enhancing Medication Management Through the Use of Clinical Decision Support Software Platforms.

Neurology and therapy

Keine D, Zelek M, Walker JQ, Sabbagh MN.
PMID: 30900186
Neurol Ther. 2019 Jun;8(1):79-94. doi: 10.1007/s40120-019-0131-6. Epub 2019 Mar 21.

INTRODUCTION: Polypharmacy is a growing problem in the United States. The use of multiple medications increases the likelihood that a patient will experience potential drug interactions and adverse drug reactions (ADRs). Those individuals with dementia or Alzheimer's disease (AD)...

Reliability of Medical History Reporting in Older Adults With and Without Cognitive Impairment.

Journal of central nervous system disease

Curcio N, Wilmoth K, LoBue C, Cullum CM.
PMID: 31040738
J Cent Nerv Syst Dis. 2019 Apr 22;11:1179573519843874. doi: 10.1177/1179573519843874. eCollection 2019.

BACKGROUND: Clinical diagnosis of cognitive disorders depends on accurate reporting of medical history, yet little is known about the reliability and the validity of such reports, particularly in older patients with and without cognitive impairment.METHODS: In 2 studies, we...

Sex as a Risk Factor for Developing Cognitive Impairments in National Alzheimer's Coordinating Center Participants.

Journal of Alzheimer's disease reports

Wang G, Li W.
PMID: 33681711
J Alzheimers Dis Rep. 2021 Jan 11;5(1):1-6. doi: 10.3233/ADR-200275.

BACKGROUND: It is inconclusive on how sex affects the risk of developing mild cognitive impairment (MCI) or dementia.OBJECTIVE: To investigate how sex affects the risk of developing MCI or dementia.METHODS: A secondary data analysis was performed on data collected...

A national cohort study (2000-2018) of long-term air pollution exposure and incident dementia in older adults in the United States.

Nature communications

Shi L, Steenland K, Li H, Liu P, Zhang Y, Lyles RH, Requia WJ, Ilango SD, Chang HH, Wingo T, Weber RJ, Schwartz J.
PMID: 34799599
Nat Commun. 2021 Nov 19;12(1):6754. doi: 10.1038/s41467-021-27049-2.

Air pollution may increase risk of Alzheimer's disease and related dementias (ADRD) in the U.S., but the extent of this relationship is unclear. Here, we constructed two national U.S. population-based cohorts of those aged ≥65 from the Medicare Chronic...

Cortical Proteins Associated With Cognitive Resilience in Community-Dwelling Older Persons.

JAMA psychiatry

Yu L, Tasaki S, Schneider JA, Arfanakis K, Duong DM, Wingo AP, Wingo TS, Kearns N, Thatcher GRJ, Seyfried NT, Levey AI, De Jager PL, Bennett DA.
PMID: 32609320
JAMA Psychiatry. 2020 Nov 01;77(11):1172-1180. doi: 10.1001/jamapsychiatry.2020.1807.

IMPORTANCE: Identifying genes and proteins for cognitive resilience (ie, targets that may be associated with slowing or preventing cognitive decline regardless of the presence, number, or combination of common neuropathologic conditions) provides a complementary approach to developing novel therapeutics...

Comprehensive Evaluation of the Functional Activities Questionnaire (FAQ) and Its Reliability and Validity.

Assessment

González DA, Gonzales MM, Resch ZJ, Sullivan AC, Soble JR.
PMID: 33543638
Assessment. 2021 Feb 05;1073191121991215. doi: 10.1177/1073191121991215. Epub 2021 Feb 05.

The Functional Activities Questionnaire (FAQ) is a collateral-report measure of difficulties in activities of daily living. Despite its widespread use, psychometric analyses have been limited in scope, piecemeal across samples, and limited primarily to classical test theory. This article...

Estimating Progression Rates Across the Spectrum of Alzheimer's Disease for Amyloid-Positive Individuals Using National Alzheimer's Coordinating Center Data.

Neurology and therapy

Potashman M, Buessing M, Levitchi Benea M, Cummings J, Borson S, Pemberton-Ross P, Epstein AJ.
PMID: 34431074
Neurol Ther. 2021 Dec;10(2):941-953. doi: 10.1007/s40120-021-00272-1. Epub 2021 Aug 24.

INTRODUCTION: Published estimates of Alzheimer's disease (AD) progression do not capture the full disease continuum. This study provides transition probabilities of individuals with amyloid-β (Aβ+) pathology across the disease continuum.METHODS: Patient-level longitudinal data from the National Alzheimer's Coordinating Center...

Showing 1 to 12 of 105 entries