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On-demand generation and mixing of liquid-in-gas slugs with digitally-programmable composition and size.

Journal of micromechanics and microengineering : structures, devices, and systems

Chen YC, Liu K, Shen CK, van Dam RM.
PMID: 29167603
J Micromech Microeng. 2015 Aug;25(8). doi: 10.1088/0960-1317/25/8/084006. Epub 2015 Jul 22.

Microscopic droplets or slugs of mixed reagents provide a convenient platform for performing large numbers of isolated biochemical or chemical reactions for many screening and optimization applications. Myriad microfluidic approaches have emerged for creating droplets or slugs with controllable...

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Chen YC, Liu K, Shen CK, et al. On-demand generation and mixing of liquid-in-gas slugs with digitally-programmable composition and size. J Micromech Microeng. 2015;25(8)doi: 10.1088/0960-1317/25/8/084006.
Chen, Y. C., Liu, K., Shen, C. K., & van Dam, R. M. (2015). On-demand generation and mixing of liquid-in-gas slugs with digitally-programmable composition and size. Journal of micromechanics and microengineering : structures, devices, and systems, 25(8), . https://doi.org/10.1088/0960-1317/25/8/084006
Chen, Yi-Chun, et al. "On-demand generation and mixing of liquid-in-gas slugs with digitally-programmable composition and size." Journal of micromechanics and microengineering : structures, devices, and systems vol. 25,8 (2015). doi: https://doi.org/10.1088/0960-1317/25/8/084006
Chen YC, Liu K, Shen CK, van Dam RM. On-demand generation and mixing of liquid-in-gas slugs with digitally-programmable composition and size. J Micromech Microeng. 2015 Aug;25(8). doi: 10.1088/0960-1317/25/8/084006. Epub 2015 Jul 22. PMID: 29167603; PMCID: PMC5695874.
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Discovery of new mutually orthogonal bioorthogonal cycloaddition pairs through computational screening.

Chemical science

Narayanam MK, Liang Y, Houk KN, Murphy JM.
PMID: 29910881
Chem Sci. 2016 Feb 01;7(2):1257-1261. doi: 10.1039/c5sc03259h. Epub 2015 Nov 11.

Density functional theory (DFT) calculations and experiments in tandem led to discoveries of new reactivities and selectivities involving bioorthogonal sydnone cycloadditions. Dibenzocyclooctyne derivatives (DIBAC and BARAC) were identified to be especially reactive dipolarophiles, which undergo the (3 + 2)...

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Narayanam MK, Liang Y, Houk KN, et al. Discovery of new mutually orthogonal bioorthogonal cycloaddition pairs through computational screening. Chem Sci. 2015;7(2):1257-1261doi: 10.1039/c5sc03259h.
Narayanam, M. K., Liang, Y., Houk, K. N., & Murphy, J. M. (2016). Discovery of new mutually orthogonal bioorthogonal cycloaddition pairs through computational screening. Chemical science, 7(2), 1257-1261. https://doi.org/10.1039/c5sc03259h
Narayanam, Maruthi Kumar, et al. "Discovery of new mutually orthogonal bioorthogonal cycloaddition pairs through computational screening." Chemical science vol. 7,2 (2016): 1257-1261. doi: https://doi.org/10.1039/c5sc03259h
Narayanam MK, Liang Y, Houk KN, Murphy JM. Discovery of new mutually orthogonal bioorthogonal cycloaddition pairs through computational screening. Chem Sci. 2016 Feb 01;7(2):1257-1261. doi: 10.1039/c5sc03259h. Epub 2015 Nov 11. PMID: 29910881; PMCID: PMC4763938.
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An automated synthesizer for electrochemical .

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

Waldmann CM, Lebedev A, Allison N, Sadeghi S.
PMID: 28662441
Appl Radiat Isot. 2017 Sep;127:245-252. doi: 10.1016/j.apradiso.2017.06.028. Epub 2017 Jun 21.

Electrochemical

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Waldmann CM, Lebedev A, Allison N, et al. An automated synthesizer for electrochemical . Appl Radiat Isot. 2017;127:245-252doi: 10.1016/j.apradiso.2017.06.028.
Waldmann, C. M., Lebedev, A., Allison, N., & Sadeghi, S. (2017). An automated synthesizer for electrochemical . Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 127245-252. https://doi.org/10.1016/j.apradiso.2017.06.028
Waldmann, Christopher M, et al. "An automated synthesizer for electrochemical ." Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine vol. 127 (2017): 245-252. doi: https://doi.org/10.1016/j.apradiso.2017.06.028
Waldmann CM, Lebedev A, Allison N, Sadeghi S. An automated synthesizer for electrochemical . Appl Radiat Isot. 2017 Sep;127:245-252. doi: 10.1016/j.apradiso.2017.06.028. Epub 2017 Jun 21. PMID: 28662441; PMCID: PMC5585111.
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FDG-PET/CT Imaging Predicts Histopathologic Treatment Responses after Neoadjuvant Therapy in Adult Primary Bone Sarcomas.

Sarcoma

Benz MR, Czernin J, Tap WD, Eckardt JJ, Seeger LL, Allen-Auerbach MS, Dry SM, Phelps ME, Weber WA, Eilber FC.
PMID: 20414348
Sarcoma. 2010;2010:143540. doi: 10.1155/2010/143540. Epub 2010 Apr 18.

Purpose. The aim of this study was to prospectively evaluate whether FDG-PET allows an accurate assessment of histopathologic response to neoadjuvant treatment in adult patients with primary bone sarcomas. Methods. Twelve consecutive patients with resectable, primary high grade bone...

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Benz MR, Czernin J, Tap WD, et al. FDG-PET/CT Imaging Predicts Histopathologic Treatment Responses after Neoadjuvant Therapy in Adult Primary Bone Sarcomas. Sarcoma. 2010;2010:143540doi: 10.1155/2010/143540.
Benz, M. R., Czernin, J., Tap, W. D., Eckardt, J. J., Seeger, L. L., Allen-Auerbach, M. S., Dry, S. M., Phelps, M. E., Weber, W. A., & Eilber, F. C. (2010). FDG-PET/CT Imaging Predicts Histopathologic Treatment Responses after Neoadjuvant Therapy in Adult Primary Bone Sarcomas. Sarcoma, 2010143540. https://doi.org/10.1155/2010/143540
Benz, Matthias R, et al. "FDG-PET/CT Imaging Predicts Histopathologic Treatment Responses after Neoadjuvant Therapy in Adult Primary Bone Sarcomas." Sarcoma vol. 2010 (2010): 143540. doi: https://doi.org/10.1155/2010/143540
Benz MR, Czernin J, Tap WD, Eckardt JJ, Seeger LL, Allen-Auerbach MS, Dry SM, Phelps ME, Weber WA, Eilber FC. FDG-PET/CT Imaging Predicts Histopathologic Treatment Responses after Neoadjuvant Therapy in Adult Primary Bone Sarcomas. Sarcoma. 2010;2010:143540. doi: 10.1155/2010/143540. Epub 2010 Apr 18. PMID: 20414348; PMCID: PMC2855986.
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Electrochemical Fluorination and Radiofluorination of Methyl(phenylthio)acetate Using Tetrabutylammonium Fluoride (TBAF).

Journal of the Electrochemical Society

Balandeh M, Waldmann C, Shirazi D, Gomez A, Rios A, Allison N, Khan A, Sadeghi S.
PMID: 28890550
J Electrochem Soc. 2017;164(9):G99-G103. doi: 10.1149/2.0941709jes. Epub 2017 Jul 14.

Electrochemical fluorination of methyl(phenylthio)acetate was achieved using tetrabutylammonium fluoride (TBAF). Electrochemical fluorination was performed under potentiostatic anodic oxidation using an undivided cell in acetonitrile containing TBAF and triflic acid. The influence of several parameters including: oxidation potential, time, temperature,...

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Balandeh M, Waldmann C, Shirazi D, et al. Electrochemical Fluorination and Radiofluorination of Methyl(phenylthio)acetate Using Tetrabutylammonium Fluoride (TBAF). J Electrochem Soc. 2017;164(9):G99-G103doi: 10.1149/2.0941709jes.
Balandeh, M., Waldmann, C., Shirazi, D., Gomez, A., Rios, A., Allison, N., Khan, A., & Sadeghi, S. (2017). Electrochemical Fluorination and Radiofluorination of Methyl(phenylthio)acetate Using Tetrabutylammonium Fluoride (TBAF). Journal of the Electrochemical Society, 164(9), G99-G103. https://doi.org/10.1149/2.0941709jes
Balandeh, Mehrdad, et al. "Electrochemical Fluorination and Radiofluorination of Methyl(phenylthio)acetate Using Tetrabutylammonium Fluoride (TBAF)." Journal of the Electrochemical Society vol. 164,9 (2017): G99-G103. doi: https://doi.org/10.1149/2.0941709jes
Balandeh M, Waldmann C, Shirazi D, Gomez A, Rios A, Allison N, Khan A, Sadeghi S. Electrochemical Fluorination and Radiofluorination of Methyl(phenylthio)acetate Using Tetrabutylammonium Fluoride (TBAF). J Electrochem Soc. 2017;164(9):G99-G103. doi: 10.1149/2.0941709jes. Epub 2017 Jul 14. PMID: 28890550; PMCID: PMC5589193.
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Combined treatment with dabrafenib and trametinib with immune-stimulating antibodies for BRAF mutant melanoma.

Oncoimmunology

Homet Moreno B, Mok S, Comin-Anduix B, Hu-Lieskovan S, Ribas A.
PMID: 27622011
Oncoimmunology. 2015 Aug 17;5(7):e1052212. doi: 10.1080/2162402X.2015.1052212. eCollection 2016 Jul.

The combination of targeted therapy with BRAF and MEK inhibitors has become the standard of care in patients with BRAF (V600E) mutant melanoma, but responses are not durable. In addition, the impressive clinical benefits with anti-PD-1 and anti-PD-L1 antibodies...

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Homet Moreno B, Mok S, Comin-Anduix B, et al. Combined treatment with dabrafenib and trametinib with immune-stimulating antibodies for BRAF mutant melanoma. Oncoimmunology. 2015;5(7):e1052212doi: 10.1080/2162402X.2015.1052212.
Homet Moreno, B., Mok, S., Comin-Anduix, B., Hu-Lieskovan, S., & Ribas, A. (2016). Combined treatment with dabrafenib and trametinib with immune-stimulating antibodies for BRAF mutant melanoma. Oncoimmunology, 5(7), e1052212. https://doi.org/10.1080/2162402X.2015.1052212
Homet Moreno, Blanca, et al. "Combined treatment with dabrafenib and trametinib with immune-stimulating antibodies for BRAF mutant melanoma." Oncoimmunology vol. 5,7 (2016): e1052212. doi: https://doi.org/10.1080/2162402X.2015.1052212
Homet Moreno B, Mok S, Comin-Anduix B, Hu-Lieskovan S, Ribas A. Combined treatment with dabrafenib and trametinib with immune-stimulating antibodies for BRAF mutant melanoma. Oncoimmunology. 2015 Aug 17;5(7):e1052212. doi: 10.1080/2162402X.2015.1052212. eCollection 2016 Jul. PMID: 27622011; PMCID: PMC5006894.
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Influence of dietary state and insulin on myocardial, skeletal muscle and brain [F]-fluorodeoxyglucose kinetics in mice.

EJNMMI research

Kreissl MC, Stout DB, Wong KP, Wu HM, Caglayan E, Ladno W, Zhang X, Prior JO, Reiners C, Huang SC, Schelbert HR.
PMID: 21841971
EJNMMI Res. 2011 Jul 06;1:8. doi: 10.1186/2191-219X-1-8.

BACKGROUND: We evaluated the effect of insulin stimulation and dietary changes on myocardial, skeletal muscle and brain [(18)F]-fluorodeoxyglucose (FDG) kinetics and uptake in vivo in intact mice.METHODS: Mice were anesthetized with isoflurane and imaged under different conditions: non-fasted (n...

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Kreissl MC, Stout DB, Wong KP, et al. Influence of dietary state and insulin on myocardial, skeletal muscle and brain [F]-fluorodeoxyglucose kinetics in mice. EJNMMI Res. 2011;1:8doi: 10.1186/2191-219X-1-8.
Kreissl, M. C., Stout, D. B., Wong, K. P., Wu, H. M., Caglayan, E., Ladno, W., Zhang, X., Prior, J. O., Reiners, C., Huang, S. C., & Schelbert, H. R. (2011). Influence of dietary state and insulin on myocardial, skeletal muscle and brain [F]-fluorodeoxyglucose kinetics in mice. EJNMMI research, 18. https://doi.org/10.1186/2191-219X-1-8
Kreissl, Michael C, et al. "Influence of dietary state and insulin on myocardial, skeletal muscle and brain [F]-fluorodeoxyglucose kinetics in mice." EJNMMI research vol. 1 (2011): 8. doi: https://doi.org/10.1186/2191-219X-1-8
Kreissl MC, Stout DB, Wong KP, Wu HM, Caglayan E, Ladno W, Zhang X, Prior JO, Reiners C, Huang SC, Schelbert HR. Influence of dietary state and insulin on myocardial, skeletal muscle and brain [F]-fluorodeoxyglucose kinetics in mice. EJNMMI Res. 2011 Jul 06;1:8. doi: 10.1186/2191-219X-1-8. PMID: 21841971; PMCID: PMC3155201.
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An Automated Mouse Tail Vascular Access System by Vision and Pressure Feedback.

IEEE/ASME transactions on mechatronics : a joint publication of the IEEE Industrial Electronics Society and the ASME Dynamic Systems and Control Division

Chang YC, Berry-Pusey B, Yasin R, Vu N, Maraglia B, Chatziioannou AX, Tsao TC.
PMID: 26478693
IEEE ASME Trans Mechatron. 2015 Aug;20(4):1616-1623. doi: 10.1109/TMECH.2014.2360886. Epub 2014 Oct 16.

This paper develops an automated vascular access system (A-VAS) with novel vision-based vein and needle detection methods and real-time pressure feedback for murine drug delivery. Mouse tail vein injection is a routine but critical step for preclinical imaging applications....

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Chang YC, Berry-Pusey B, Yasin R, et al. An Automated Mouse Tail Vascular Access System by Vision and Pressure Feedback. IEEE ASME Trans Mechatron. 2014;20(4):1616-1623doi: 10.1109/TMECH.2014.2360886.
Chang, Y. C., Berry-Pusey, B., Yasin, R., Vu, N., Maraglia, B., Chatziioannou, A. X., & Tsao, T. C. (2015). An Automated Mouse Tail Vascular Access System by Vision and Pressure Feedback. IEEE/ASME transactions on mechatronics : a joint publication of the IEEE Industrial Electronics Society and the ASME Dynamic Systems and Control Division, 20(4), 1616-1623. https://doi.org/10.1109/TMECH.2014.2360886
Chang, Yen-Chi, et al. "An Automated Mouse Tail Vascular Access System by Vision and Pressure Feedback." IEEE/ASME transactions on mechatronics : a joint publication of the IEEE Industrial Electronics Society and the ASME Dynamic Systems and Control Division vol. 20,4 (2015): 1616-1623. doi: https://doi.org/10.1109/TMECH.2014.2360886
Chang YC, Berry-Pusey B, Yasin R, Vu N, Maraglia B, Chatziioannou AX, Tsao TC. An Automated Mouse Tail Vascular Access System by Vision and Pressure Feedback. IEEE ASME Trans Mechatron. 2015 Aug;20(4):1616-1623. doi: 10.1109/TMECH.2014.2360886. Epub 2014 Oct 16. PMID: 26478693; PMCID: PMC4607285.
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Factors affecting tumor (18) F-FDG uptake in longitudinal mouse PET studies.

EJNMMI research

Sha W, Ye H, Iwamoto KS, Wong KP, Wilks MQ, Stout D, McBride W, Huang SC.
PMID: 23841937
EJNMMI Res. 2013 Jul 10;3:51. doi: 10.1186/2191-219X-3-51. eCollection 2013.

BACKGROUND: Many biological factors of 2-[(18) F]fluoro-2-deoxy-d-glucose ((18) F-FDG) in blood can affect (18) F-FDG uptake in tumors. In this study, longitudinal (18) F-FDG positron emission tomography (PET) studies were performed on tumor-bearing mice to investigate the effect of...

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Sha W, Ye H, Iwamoto KS, et al. Factors affecting tumor (18) F-FDG uptake in longitudinal mouse PET studies. EJNMMI Res. 2013;3:51doi: 10.1186/2191-219X-3-51.
Sha, W., Ye, H., Iwamoto, K. S., Wong, K. P., Wilks, M. Q., Stout, D., McBride, W., & Huang, S. C. (2013). Factors affecting tumor (18) F-FDG uptake in longitudinal mouse PET studies. EJNMMI research, 351. https://doi.org/10.1186/2191-219X-3-51
Sha, Wei, et al. "Factors affecting tumor (18) F-FDG uptake in longitudinal mouse PET studies." EJNMMI research vol. 3 (2013): 51. doi: https://doi.org/10.1186/2191-219X-3-51
Sha W, Ye H, Iwamoto KS, Wong KP, Wilks MQ, Stout D, McBride W, Huang SC. Factors affecting tumor (18) F-FDG uptake in longitudinal mouse PET studies. EJNMMI Res. 2013 Jul 10;3:51. doi: 10.1186/2191-219X-3-51. eCollection 2013. PMID: 23841937; PMCID: PMC3718724.
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Endothelial cyclooxygenase-1 paradoxically drives local vasoconstriction and atherogenesis despite underpinning prostacyclin generation.

Science advances

Mitchell JA, Shala F, Pires MEL, Loy RY, Ravendren A, Benson J, Urquhart P, Nicolaou A, Herschman HR, Kirkby NS.
PMID: 33741600
Sci Adv. 2021 Mar 19;7(12). doi: 10.1126/sciadv.abf6054. Print 2021 Mar.

Endothelial cyclooxygenase-1-derived prostanoids, including prostacyclin, have clear cardioprotective roles associated with their anti-thrombotic potential but have also been suggested to have paradoxical pathological activities within arteries. To date it has not been possible to test the importance of this...

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Mitchell JA, Shala F, Pires MEL, et al. Endothelial cyclooxygenase-1 paradoxically drives local vasoconstriction and atherogenesis despite underpinning prostacyclin generation. Sci Adv. 2021;7(12)doi: 10.1126/sciadv.abf6054.
Mitchell, J. A., Shala, F., Pires, M. E. L., Loy, R. Y., Ravendren, A., Benson, J., Urquhart, P., Nicolaou, A., Herschman, H. R., & Kirkby, N. S. (2021). Endothelial cyclooxygenase-1 paradoxically drives local vasoconstriction and atherogenesis despite underpinning prostacyclin generation. Science advances, 7(12), . https://doi.org/10.1126/sciadv.abf6054
Mitchell, Jane A, et al. "Endothelial cyclooxygenase-1 paradoxically drives local vasoconstriction and atherogenesis despite underpinning prostacyclin generation." Science advances vol. 7,12 (2021). doi: https://doi.org/10.1126/sciadv.abf6054
Mitchell JA, Shala F, Pires MEL, Loy RY, Ravendren A, Benson J, Urquhart P, Nicolaou A, Herschman HR, Kirkby NS. Endothelial cyclooxygenase-1 paradoxically drives local vasoconstriction and atherogenesis despite underpinning prostacyclin generation. Sci Adv. 2021 Mar 19;7(12). doi: 10.1126/sciadv.abf6054. Print 2021 Mar. PMID: 33741600; PMCID: PMC7978428.
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Performing radiosynthesis in microvolumes to maximize molar activity of tracers for positron emission tomography.

Communications chemistry

Sergeev ME, Lazari M, Morgia F, Collins J, Javed MR, Sergeeva O, Jones J, Phelps ME, Lee JT, Keng PY, van Dam RM.
PMID: 34291178
Commun Chem. 2018;1(1). doi: 10.1038/s42004-018-0009-z. Epub 2018 Mar 22.

Positron emission tomography (PET) is a molecular diagnostic imaging technology to quantitatively visualize biological processes

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Sergeev ME, Lazari M, Morgia F, et al. Performing radiosynthesis in microvolumes to maximize molar activity of tracers for positron emission tomography. Commun Chem. 2018;1(1)doi: 10.1038/s42004-018-0009-z.
Sergeev, M. E., Lazari, M., Morgia, F., Collins, J., Javed, M. R., Sergeeva, O., Jones, J., Phelps, M. E., Lee, J. T., Keng, P. Y., & van Dam, R. M. (2018). Performing radiosynthesis in microvolumes to maximize molar activity of tracers for positron emission tomography. Communications chemistry, 1(1), . https://doi.org/10.1038/s42004-018-0009-z
Sergeev, Maxim E, et al. "Performing radiosynthesis in microvolumes to maximize molar activity of tracers for positron emission tomography." Communications chemistry vol. 1,1 (2018). doi: https://doi.org/10.1038/s42004-018-0009-z
Sergeev ME, Lazari M, Morgia F, Collins J, Javed MR, Sergeeva O, Jones J, Phelps ME, Lee JT, Keng PY, van Dam RM. Performing radiosynthesis in microvolumes to maximize molar activity of tracers for positron emission tomography. Commun Chem. 2018;1(1). doi: 10.1038/s42004-018-0009-z. Epub 2018 Mar 22. PMID: 34291178; PMCID: PMC8291036.
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Role of Kinetic Modeling in Biomedical Imaging.

Journal of medical sciences (Taipei, Taiwan)

Huang SC.
PMID: 20640185
J Med Sci. 2008;28(2):57-63. doi: 10.1901/jaba.2008.28-57.

Biomedical imaging can reveal clear 3-dimensional body morphology non-invasively with high spatial resolution. Its efficacy, in both clinical and pre-clinical settings, is enhanced with its capability to provide in vivo functional/biological information in tissue. The role of kinetic modeling...

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Huang SC. Role of Kinetic Modeling in Biomedical Imaging. J Med Sci. 2008;28(2):57-63doi: 10.1901/jaba.2008.28-57.
Huang, S. C. (2008). Role of Kinetic Modeling in Biomedical Imaging. Journal of medical sciences (Taipei, Taiwan), 28(2), 57-63. https://doi.org/10.1901/jaba.2008.28-57
Huang, Sung-Cheng. "Role of Kinetic Modeling in Biomedical Imaging." Journal of medical sciences (Taipei, Taiwan) vol. 28,2 (2008): 57-63. doi: https://doi.org/10.1901/jaba.2008.28-57
Huang SC. Role of Kinetic Modeling in Biomedical Imaging. J Med Sci. 2008;28(2):57-63. doi: 10.1901/jaba.2008.28-57. PMID: 20640185; PMCID: PMC2904993.
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Showing 1 to 12 of 14 entries