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Showing 1 to 12 of 41 entries
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Current trends in robotic surgery for otolaryngology.

Current otorhinolaryngology reports

Byrd JK, Duvvuri U.
PMID: 24069577
Curr Otorhinolaryngol Rep. 2013 Sep 01;1(3):153-157. doi: 10.1007/s40136-013-0025-6.

As minimally invasive surgery has become common in head and neck surgery, the role of robotic surgery has expanded from thyroid surgery and transoral robotic surgery (TORS) of the oropharynx and supraglottic to other areas. Surgeons have advanced the...

Cisplatin-Based Chemotherapy Options for Recurrent and/or Metastatic Squamous Cell Cancer of the Head and Neck.

Clinical medicine insights. Therapeutics

Pendleton KP, Grandis JR.
PMID: 24273416
Clin Med Insights Ther. 2013;2013(5). doi: 10.4137/CMT.S10409.

Recurrent and/or metastatic head and neck squamous cell carcinoma (R/M HNSCC) is a devastating malignancy with a poor prognosis. Treatment is limited to chemotherapeutic approaches. Cisplatin is an established and effective treatment for R/M HNSCC, and many studies have...

Mechanism of action of selective inhibitors of IL-6 induced STAT3 pathway in head and neck cancer cell lines.

Journal of chemical biology

Sen M, Johnston PA, Pollock NI, DeGrave K, Joyce SC, Freilino ML, Hua Y, Camarco DP, Close DA, Huryn DM, Wipf P, Grandis JR.
PMID: 28684999
J Chem Biol. 2017 May 11;10(3):129-141. doi: 10.1007/s12154-017-0169-9. eCollection 2017 Jul.

Studies indicate that elevated interleukin-6 (IL-6) levels engage IL6Rα-gp130 receptor complexes to activate signal transducer and activator of transcription 3 (STAT3) that is hyperactivated in many cancers including head and neck squamous cell carcinoma (HNSCC). Our previous HCS campaign...

Investigating immune and non-immune cell interactions in head and neck tumors by single-cell RNA sequencing.

Nature communications

Kürten CHL, Kulkarni A, Cillo AR, Santos PM, Roble AK, Onkar S, Reeder C, Lang S, Chen X, Duvvuri U, Kim S, Liu A, Tabib T, Lafyatis R, Feng J, Gao SJ, Bruno TC, Vignali DAA, Lu X, Bao R, Vujanovic L, Ferris RL.
PMID: 34921143
Nat Commun. 2021 Dec 17;12(1):7338. doi: 10.1038/s41467-021-27619-4.

Head and neck squamous cell carcinoma (HNSCC) is characterized by complex relations between stromal, epithelial, and immune cells within the tumor microenvironment (TME). To enable the development of more efficacious therapies, we aim to study the heterogeneity, signatures of...

Investigating immune and non-immune cell interactions in head and neck tumors by single-cell RNA sequencing.

Nature communications

Kürten CHL, Kulkarni A, Cillo AR, Santos PM, Roble AK, Onkar S, Reeder C, Lang S, Chen X, Duvvuri U, Kim S, Liu A, Tabib T, Lafyatis R, Feng J, Gao SJ, Bruno TC, Vignali DAA, Lu X, Bao R, Vujanovic L, Ferris RL.
PMID: 34921143
Nat Commun. 2021 Dec 17;12(1):7338. doi: 10.1038/s41467-021-27619-4.

Head and neck squamous cell carcinoma (HNSCC) is characterized by complex relations between stromal, epithelial, and immune cells within the tumor microenvironment (TME). To enable the development of more efficacious therapies, we aim to study the heterogeneity, signatures of...

Investigating immune and non-immune cell interactions in head and neck tumors by single-cell RNA sequencing.

Nature communications

Kürten CHL, Kulkarni A, Cillo AR, Santos PM, Roble AK, Onkar S, Reeder C, Lang S, Chen X, Duvvuri U, Kim S, Liu A, Tabib T, Lafyatis R, Feng J, Gao SJ, Bruno TC, Vignali DAA, Lu X, Bao R, Vujanovic L, Ferris RL.
PMID: 34921143
Nat Commun. 2021 Dec 17;12(1):7338. doi: 10.1038/s41467-021-27619-4.

Head and neck squamous cell carcinoma (HNSCC) is characterized by complex relations between stromal, epithelial, and immune cells within the tumor microenvironment (TME). To enable the development of more efficacious therapies, we aim to study the heterogeneity, signatures of...

Metabolic support of tumour-infiltrating regulatory T cells by lactic acid.

Nature

Watson MJ, Vignali PDA, Mullett SJ, Overacre-Delgoffe AE, Peralta RM, Grebinoski S, Menk AV, Rittenhouse NL, DePeaux K, Whetstone RD, Vignali DAA, Hand TW, Poholek AC, Morrison BM, Rothstein JD, Wendell SG, Delgoffe GM.
PMID: 33589820
Nature. 2021 Mar;591(7851):645-651. doi: 10.1038/s41586-020-03045-2. Epub 2021 Feb 15.

Regulatory T (T

Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of function.

Nature communications

Kumar M, Molkentine D, Molkentine J, Bridges K, Xie T, Yang L, Hefner A, Gao M, Bahri R, Dhawan A, Frederick MJ, Seth S, Abdelhakiem M, Beadle BM, Johnson F, Wang J, Shen L, Heffernan T, Sheth A, Ferris RL, Myers JN, Pickering CR, Skinner HD.
PMID: 34732714
Nat Commun. 2021 Nov 03;12(1):6340. doi: 10.1038/s41467-021-26570-8.

Despite radiation forming the curative backbone of over 50% of malignancies, there are no genomically-driven radiosensitizers for clinical use. Herein we perform in vivo shRNA screening to identify targets generally associated with radiation response as well as those exhibiting...

Regulatory T Cell-Derived TRAIL Is Not Required for Peripheral Tolerance.

ImmunoHorizons

Dadey RE, Grebinoski S, Zhang Q, Brunazzi EA, Burton A, Workman CJ, Vignali DAA.
PMID: 33483333
Immunohorizons. 2021 Jan 22;5(1):48-58. doi: 10.4049/immunohorizons.2000098.

TRAIL (

Combination of a thioxodihydroquinazolinone with cisplatin eliminates ovarian cancer stem cell-like cells (CSC-LCs) and shows preclinical potential.

Oncotarget

Ma J, Salamoun J, Wipf P, Edwards R, Van Houten B, Qian W.
PMID: 29464053
Oncotarget. 2017 Dec 26;9(5):6042-6054. doi: 10.18632/oncotarget.23679. eCollection 2018 Jan 19.

Cancer stem cell-like cells (CSC-LCs) contribute to drug resistance and recurrence of ovarian cancer. Strategies that can eradicate CSC-LCs are expected to substantially improve the outcome of ovarian cancer treatment. We have previously identified a class of thioxodihydroquinazolinone small...

Critical analysis of the potential for targeting STAT3 in human malignancy.

OncoTargets and therapy

Peyser ND, Grandis JR.
PMID: 23935373
Onco Targets Ther. 2013 Jul 30;6:999-1010. doi: 10.2147/OTT.S47903. Print 2013.

The signal transducer and activator of transcription (STAT) family of proteins was originally discovered in the context of normal cell biology where they function to transduce intracellular and extracellular signals to the nucleus, ultimately leading to transcription of specific...

Expression of Tim-3 drives phenotypic and functional changes in Treg cells in secondary lymphoid organs and the tumor microenvironment.

Cell reports

Banerjee H, Nieves-Rosado H, Kulkarni A, Murter B, McGrath KV, Chandran UR, Chang A, Szymczak-Workman AL, Vujanovic L, Delgoffe GM, Ferris RL, Kane LP.
PMID: 34525351
Cell Rep. 2021 Sep 14;36(11):109699. doi: 10.1016/j.celrep.2021.109699.

Regulatory T cells (Treg cells) are critical mediators of self-tolerance, but they can also limit effective anti-tumor immunity. Although under homeostasis a small fraction of Treg cells in lymphoid organs express the putative checkpoint molecule Tim-3, this protein is...

Showing 1 to 12 of 41 entries