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The isolation, Characterization and Preclinical Studies of Metal Complex of Thespesia populnea for the Potential Peroxisome Proliferator-activated Receptors-γ Agonist Activity.

Pharmacognosy magazine

Phanse MA, Patil MJ, Abbulu K.
PMID: 26929578
Pharmacogn Mag. 2015 Oct;11:S434-8. doi: 10.4103/0973-1296.168984.

BACKGROUND: Diabetes mellitus is an international public health problem since ancient days. The condition is predominantly more severe in developing countries like India where, life is more sedentary due to the even changing lifestyles in this fast-paced global scenario....

Peroxisome proliferator-activated receptors (PPARα, PPARγ and PPARβ/δ) gene expression profile on ram spermatozoa and their relation to the sperm motility.

Veterinary research forum : an international quarterly journal

Kadivar A, Heidari Khoei H, Hassanpour H, Ghanaei H, Golestanfar A, Mehraban H, Davoodian N, Dehghani Tafti R.
PMID: 27226884
Vet Res Forum. 2016;7(1):27-34. Epub 2016 Mar 15.

Peroxisome proliferator-activated receptors (PPARs) are a member of nuclear receptors superfamily, which mainly regulate the expression of target genes involved in lipid and energy metabolism. These receptors are divided to three isotypes: PPARα, PPARγ and PPARβ/δ. Each isotype has...

Natalizumab Treatment Modulates Peroxisome Proliferator-Activated Receptors Expression in Women with Multiple Sclerosis.

PPAR research

Ferret-Sena V, Maia E Silva A, Sena A, Cavaleiro I, Vale J, Derudas B, Chinetti-Gbaguidi G, Staels B.
PMID: 28077943
PPAR Res. 2016;2016:5716415. doi: 10.1155/2016/5716415. Epub 2016 Dec 18.

Peroxisome Proliferator-Activated Receptors (PPAR) are transcription factors suggested to be involved in inflammatory lesions of autoimmune encephalomyelitis and multiple sclerosis (MS). Our objective was to assess whether Natalizumab (NTZ) therapy is associated with alterations of PPAR expression in MS...

Involvement of peroxisome proliferator-activated receptors in the estradiol production of ovine Sertoli cells.

Veterinary research forum : an international quarterly journal

Hassanpour H, Khalaji-Pirbalouty V, Adibi M, Nazari H.
PMID: 29085614
Vet Res Forum. 2017;8(3):251-257. Epub 2017 Sep 15.

Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors of transcription factors composed of three family members: PPARα, PPARβ/δ and PPARγ. This study was aimed to evaluate the role of PPARs in the estradiol production via follicle stimulating hormone (FSH) in...

Emerging links between type 2 diabetes and Alzheimer's disease.

World journal of diabetes

Sridhar GR, Lakshmi G, Nagamani G.
PMID: 26069723
World J Diabetes. 2015 Jun 10;6(5):744-51. doi: 10.4239/wjd.v6.i5.744.

Type 2 diabetes mellitus and Alzheimer's disease are both associated with increasing age, and each increases the risk of development of the other. Epidemiological, clinical, biochemical and imaging studies have shown that elevated glucose levels and diabetes are associated...

Discovery of Potent Dual PPARα Agonists/CB1 Ligands.

ACS medicinal chemistry letters

Pérez-Fernández R, Fresno N, Macías-González M, Elguero J, Decara J, Girón R, Rodríguez-Álvarez A, Martín MI, Rodríguez de Fonseca F, Goya P.
PMID: 24936232
ACS Med Chem Lett. 2011 Sep 16;2(11):793-7. doi: 10.1021/ml200091q. eCollection 2011 Nov 10.

This letter describes the synthesis and in vitro and in vivo evaluation of dual ligands targeting the cannabinoid and peroxisome proliferator-activated receptors (PPAR). These compounds were obtained from fusing the pharmacophores of fibrates and the diarylpyrazole rimonabant, a cannabinoid...

PPARα Is Required for PPARδ Action in Regulation of Body Weight and Hepatic Steatosis in Mice.

PPAR research

Garbacz WG, Huang JT, Higgins LG, Wahli W, Palmer CN.
PMID: 26604919
PPAR Res. 2015;2015:927057. doi: 10.1155/2015/927057. Epub 2015 Oct 29.

Peroxisome proliferator activated receptors alpha (PPARα) and delta (PPARδ) belong to the nuclear receptor superfamily. PPARα is a target of well established lipid-lowering drugs. PPARδ (also known as PPARβ/δ) has been investigated as a promising antidiabetic drug target; however,...

PPARs: Protectors or Opponents of Myocardial Function?.

PPAR research

Pol CJ, Lieu M, Drosatos K.
PMID: 26713088
PPAR Res. 2015;2015:835985. doi: 10.1155/2015/835985. Epub 2015 Dec 02.

Over 5 million people in the United States suffer from the complications of heart failure (HF), which is a rapidly expanding health complication. Disorders that contribute to HF include ischemic cardiac disease, cardiomyopathies, and hypertension. Peroxisome proliferator-activated receptors (PPARs)...

Impact of the Pro12Ala polymorphism of the PPARγ2 gene on diabetes and obesity in a highly consanguineous population.

Indian journal of endocrinology and metabolism

Bener A, Zirie M, Al-Hamaq A, Nawaz Z, Samson N, Mohammad R.
PMID: 25593831
Indian J Endocrinol Metab. 2015 Jan-Feb;19(1):77-83. doi: 10.4103/2230-8210.131766.

BACKGROUND: The peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor subfamily of transcription factors. It has been reported that they play important roles in obesity and the development of type 2 diabetes mellitus (T2DM).MATERIALS AND METHODS:...

Relationship between Platelet PPARs, cAMP Levels, and P-Selectin Expression: Antiplatelet Activity of Natural Products.

Evidence-based complementary and alternative medicine : eCAM

Fuentes E, Palomo I.
PMID: 24324520
Evid Based Complement Alternat Med. 2013;2013:861786. doi: 10.1155/2013/861786. Epub 2013 Nov 13.

Platelets are no longer considered simply as cells participating in thrombosis. In atherosclerosis, platelets are regulators of multiple processes, with the recruitment of inflammatory cells towards the lesion sites, inflammatory mediators release, and regulation of endothelial function. The antiplatelet...

Decrease of PPARδ in Type-1-Like Diabetic Rat for Higher Mortality after Spinal Cord Injury.

PPAR research

Tsai CC, Lee KS, Chen SH, Chen LJ, Liu KF, Cheng JT.
PMID: 24817882
PPAR Res. 2014;2014:456386. doi: 10.1155/2014/456386. Epub 2014 Apr 10.

Changes in the peroxisome proliferator-activated receptors- δ (PPAR δ ) expression in rats after spinal cord injury (SCI) have been previously reported. Diabetic animals show a higher mortality after SCI. However, the relationship between the progress of diabetes and...

Gene-Gene Interactions among Pparα/δ/γ Polymorphisms for Apolipoprotein (Apo) A-I/Apob Ratio in Chinese Han Population.

Iranian journal of public health

Hai B, Xie H, Guo Z, Dong C, Wu M, Chen Q, Zhou Z, Zhu Q, Liu M, Fan W, Zhou H.
PMID: 26110145
Iran J Public Health. 2014 Jun;43(6):749-59.

BACKGROUND: The peroxisome proliferator-activated receptors (PPARs) -α, -δ/β and -γ are the ligand-activated transcription factors involved in the regulation of fatty acid and lipoprotein metabolism, energy balance, cell proliferation and differentiation and atherosclerosis, etc. We investigated the associations of...

Showing 1 to 12 of 498 entries