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[(3)H]XAC (xanthine amine congener) is a radioligand for A(2)-adenosine receptors in rabbit striatum.

Neurochemistry international

Ji XD, Stiles GL, Jacobson KA.
PMID: 20504695
Neurochem Int. 1991;18(2):207-13. doi: 10.1016/0197-0186(91)90187-i.

The intrinsic affinity of 8-phenylxanthine analogs at striatal A(2)-adenosine receptors is highly species dependent. [(3)H]XAC (8-[2-aminoethyl[amino[carbonyl[methyl[oxyphenyl]]]]]-1,3-dipropylxanthine), although A(1)-selective in the rat brain, binds to A(2) receptors in rabbit striatal membranes with sufficiently high affinity to serve as a radioligand....

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Ji XD, Stiles GL, Jacobson KA. [(3)H]XAC (xanthine amine congener) is a radioligand for A(2)-adenosine receptors in rabbit striatum. Neurochem Int. 1991;18(2):207-13doi: 10.1016/0197-0186(91)90187-i.
Ji, X. D., Stiles, G. L., & Jacobson, K. A. (1991). [(3)H]XAC (xanthine amine congener) is a radioligand for A(2)-adenosine receptors in rabbit striatum. Neurochemistry international, 18(2), 207-13. https://doi.org/10.1016/0197-0186(91)90187-i
Ji, X D, et al. "[(3)H]XAC (xanthine amine congener) is a radioligand for A(2)-adenosine receptors in rabbit striatum." Neurochemistry international vol. 18,2 (1991): 207-13. doi: https://doi.org/10.1016/0197-0186(91)90187-i
Ji XD, Stiles GL, Jacobson KA. [(3)H]XAC (xanthine amine congener) is a radioligand for A(2)-adenosine receptors in rabbit striatum. Neurochem Int. 1991;18(2):207-13. doi: 10.1016/0197-0186(91)90187-i. PMID: 20504695; PMCID: PMC4827159.
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Activation of Phosphoinositide Breakdown and Elevation of Intracellular Calcium in a Rat RBL-2H3 Mast Cell Line by Adenosine Analogs: Involvement of A(3)-Adenosine Receptors?.

Drug development research

Shin Y, Daly JW, Jacobson KA.
PMID: 23087534
Drug Dev Res. 1996 Sep 01;39(1):36-46. doi: 10.1002/(sici)1098-2299(19960901)39:1<36::aid-ddr5>3.0.co;2-l.

A variety of adenosine analogs activate phosphoinositide breakdown in a rat RBL-2H3 mast cell line. It is presumed that an A(3)-adenosine receptor is involved, since the phosphoinositide response is insensitive to xanthines. However, the very potent A(3)- receptor agonist...

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Shin Y, Daly JW, Jacobson KA. Activation of Phosphoinositide Breakdown and Elevation of Intracellular Calcium in a Rat RBL-2H3 Mast Cell Line by Adenosine Analogs: Involvement of A(3)-Adenosine Receptors?. Drug Dev Res. 1996;39(1):36-46doi: 10.1002/(sici)1098-2299(19960901)39:1<36::aid-ddr5>3.0.co;2-l.
Shin, Y., Daly, J. W., & Jacobson, K. A. (1996). Activation of Phosphoinositide Breakdown and Elevation of Intracellular Calcium in a Rat RBL-2H3 Mast Cell Line by Adenosine Analogs: Involvement of A(3)-Adenosine Receptors?. Drug development research, 39(1), 36-46. https://doi.org/10.1002/(sici)1098-2299(19960901)39:1<36::aid-ddr5>3.0.co;2-l
Shin, Yangmee, et al. "Activation of Phosphoinositide Breakdown and Elevation of Intracellular Calcium in a Rat RBL-2H3 Mast Cell Line by Adenosine Analogs: Involvement of A(3)-Adenosine Receptors?." Drug development research vol. 39,1 (1996): 36-46. doi: https://doi.org/10.1002/(sici)1098-2299(19960901)39:1<36::aid-ddr5>3.0.co;2-l
Shin Y, Daly JW, Jacobson KA. Activation of Phosphoinositide Breakdown and Elevation of Intracellular Calcium in a Rat RBL-2H3 Mast Cell Line by Adenosine Analogs: Involvement of A(3)-Adenosine Receptors?. Drug Dev Res. 1996 Sep 01;39(1):36-46. doi: 10.1002/(sici)1098-2299(19960901)39:1<36::aid-ddr5>3.0.co;2-l. PMID: 23087534; PMCID: PMC3475513.
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Involvement of N-ethylmaleimide-sensitive G proteins in the modulation of evoked [(3)H]noradrenaline release from rabbit hippocampus synaptosomes.

Neurochemistry international

Wurster S, Nakov R, Allgaier C, Hertting G.
PMID: 20504615
Neurochem Int. 1990;17(2):149-55. doi: 10.1016/0197-0186(90)90137-i.

The effect of the sulfhydryl alkylating agent N-ethylmaleimide on the modulation of potassium-evoked [(3)H]noradrenaline release via inhibitory presynaptic receptors was studied using synaptosomes from rabbit hippocampus. Dose-response curves for the ?(2)-adrenoceptor agonist clonidine, the preferential ?-opioid receptor agonist ethylketocyclazocine...

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Wurster S, Nakov R, Allgaier C, et al. Involvement of N-ethylmaleimide-sensitive G proteins in the modulation of evoked [(3)H]noradrenaline release from rabbit hippocampus synaptosomes. Neurochem Int. 1990;17(2):149-55doi: 10.1016/0197-0186(90)90137-i.
Wurster, S., Nakov, R., Allgaier, C., & Hertting, G. (1990). Involvement of N-ethylmaleimide-sensitive G proteins in the modulation of evoked [(3)H]noradrenaline release from rabbit hippocampus synaptosomes. Neurochemistry international, 17(2), 149-55. https://doi.org/10.1016/0197-0186(90)90137-i
Wurster, S, et al. "Involvement of N-ethylmaleimide-sensitive G proteins in the modulation of evoked [(3)H]noradrenaline release from rabbit hippocampus synaptosomes." Neurochemistry international vol. 17,2 (1990): 149-55. doi: https://doi.org/10.1016/0197-0186(90)90137-i
Wurster S, Nakov R, Allgaier C, Hertting G. Involvement of N-ethylmaleimide-sensitive G proteins in the modulation of evoked [(3)H]noradrenaline release from rabbit hippocampus synaptosomes. Neurochem Int. 1990;17(2):149-55. doi: 10.1016/0197-0186(90)90137-i. PMID: 20504615.
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8-(3-Isothiocyanatostyryl)caffeine Is a Selective, Irreversible Inhibitor of Striatal A(2)-Adenosine Receptors.

Drug development research

Ji XD, Gallo-Rodriguez C, Jacobson KA.
PMID: 22787287
Drug Dev Res. 1993 Aug 01;29(4):292-298. doi: 10.1002/ddr.430290407. Epub 2004 Oct 05.

8-(3-Isothiocyanatostyryl)caffeine (ISC) was synthesized and shown to inhibit selectively the binding of [(3)H]CGS 21680 (an A(2a)-selective agonist) at adenosine receptors in striatal membranes. The K(i) value at A(2a)-receptors was found to be 110 nM (rat), with selectivity ratios for...

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Ji XD, Gallo-Rodriguez C, Jacobson KA. 8-(3-Isothiocyanatostyryl)caffeine Is a Selective, Irreversible Inhibitor of Striatal A(2)-Adenosine Receptors. Drug Dev Res. 2004;29(4):292-298doi: 10.1002/ddr.430290407.
Ji, X. D., Gallo-Rodriguez, C., & Jacobson, K. A. (1993). 8-(3-Isothiocyanatostyryl)caffeine Is a Selective, Irreversible Inhibitor of Striatal A(2)-Adenosine Receptors. Drug development research, 29(4), 292-298. https://doi.org/10.1002/ddr.430290407
Ji, Xiao-Duo, et al. "8-(3-Isothiocyanatostyryl)caffeine Is a Selective, Irreversible Inhibitor of Striatal A(2)-Adenosine Receptors." Drug development research vol. 29,4 (1993): 292-298. doi: https://doi.org/10.1002/ddr.430290407
Ji XD, Gallo-Rodriguez C, Jacobson KA. 8-(3-Isothiocyanatostyryl)caffeine Is a Selective, Irreversible Inhibitor of Striatal A(2)-Adenosine Receptors. Drug Dev Res. 1993 Aug 01;29(4):292-298. doi: 10.1002/ddr.430290407. Epub 2004 Oct 05. PMID: 22787287; PMCID: PMC3392128.
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Desensitization of the adipocyte A(1) adenosine receptor during untreated experimental diabetes mellitus.

Endocrine

Barrington WW, Crum M, Forst C, Scheetz M, Weide LG.
PMID: 21153275
Endocrine. 1996 Jun;4(3):199-205. doi: 10.1007/BF02738685.

We examined the changes that occur in the adenosine receptor system during diabetes mellitus. Experimental diabetes mellitus was induced in male Lewis rats with streptozocin (65 mg/kg), and A(1) adenosine receptor binding was characterized with [(125)I]N (6)-2-(4-aminophenyl) ethyladenosine. In...

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Barrington WW, Crum M, Forst C, et al. Desensitization of the adipocyte A(1) adenosine receptor during untreated experimental diabetes mellitus. Endocrine. 1996;4(3):199-205doi: 10.1007/BF02738685.
Barrington, W. W., Crum, M., Forst, C., Scheetz, M., & Weide, L. G. (1996). Desensitization of the adipocyte A(1) adenosine receptor during untreated experimental diabetes mellitus. Endocrine, 4(3), 199-205. https://doi.org/10.1007/BF02738685
Barrington, W W, et al. "Desensitization of the adipocyte A(1) adenosine receptor during untreated experimental diabetes mellitus." Endocrine vol. 4,3 (1996): 199-205. doi: https://doi.org/10.1007/BF02738685
Barrington WW, Crum M, Forst C, Scheetz M, Weide LG. Desensitization of the adipocyte A(1) adenosine receptor during untreated experimental diabetes mellitus. Endocrine. 1996 Jun;4(3):199-205. doi: 10.1007/BF02738685. PMID: 21153275.
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