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Tyrosyl-DNA Phosphodiesterase I a critical survival factor for neuronal development and homeostasis.

Journal of neurology & neuromedicine

van Waardenburg RC.
PMID: 27747316
J Neurol Neuromedicine. 2016;1(5):25-29. doi: 10.29245/2572.942x/2016/5.1048.

Tyrosyl-DNA phosphodiesterase I (TDP1), like most DNA repair associated proteins, is not essential for cell viability. However, dysfunctioning TDP1 or ATM (ataxia telangiectasia mutated) results in autosomal recessive neuropathology with similar phenotypes, including cerebellar atrophy. Dual inactivation of TDP1...

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van Waardenburg RC. Tyrosyl-DNA Phosphodiesterase I a critical survival factor for neuronal development and homeostasis. J Neurol Neuromedicine. 2016;1(5):25-29doi: 10.29245/2572.942x/2016/5.1048.
van Waardenburg, R. C. (2016). Tyrosyl-DNA Phosphodiesterase I a critical survival factor for neuronal development and homeostasis. Journal of neurology & neuromedicine, 1(5), 25-29. https://doi.org/10.29245/2572.942x/2016/5.1048
van Waardenburg, Robert C A M. "Tyrosyl-DNA Phosphodiesterase I a critical survival factor for neuronal development and homeostasis." Journal of neurology & neuromedicine vol. 1,5 (2016): 25-29. doi: https://doi.org/10.29245/2572.942x/2016/5.1048
van Waardenburg RC. Tyrosyl-DNA Phosphodiesterase I a critical survival factor for neuronal development and homeostasis. J Neurol Neuromedicine. 2016;1(5):25-29. doi: 10.29245/2572.942x/2016/5.1048. PMID: 27747316; PMCID: PMC5064944.
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Aging alters hepatic DNA hydroxymethylation, as measured by liquid chromatography/mass spectrometry.

Journal of cancer prevention

Tammen SA, Dolnikowski GG, Ausman LM, Liu Z, Kim KC, Friso S, Choi SW.
PMID: 25574465
J Cancer Prev. 2014 Dec;19(4):301-8. doi: 10.15430/jcp.2014.19.4.301.

BACKGROUND: Aging is one of the most important risk factors for cancer. It appears that aberrant epigenetic changes might be a common driver of aging and cancer. Among them are changes in DNA methylation and DNA hydroxymethylation. The 5'...

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Tammen SA, Dolnikowski GG, Ausman LM, et al. Aging alters hepatic DNA hydroxymethylation, as measured by liquid chromatography/mass spectrometry. J Cancer Prev. 2014;19(4):301-8doi: 10.15430/jcp.2014.19.4.301.
Tammen, S. A., Dolnikowski, G. G., Ausman, L. M., Liu, Z., Kim, K. C., Friso, S., & Choi, S. W. (2014). Aging alters hepatic DNA hydroxymethylation, as measured by liquid chromatography/mass spectrometry. Journal of cancer prevention, 19(4), 301-8. https://doi.org/10.15430/jcp.2014.19.4.301
Tammen, Stephanie A, et al. "Aging alters hepatic DNA hydroxymethylation, as measured by liquid chromatography/mass spectrometry." Journal of cancer prevention vol. 19,4 (2014): 301-8. doi: https://doi.org/10.15430/jcp.2014.19.4.301
Tammen SA, Dolnikowski GG, Ausman LM, Liu Z, Kim KC, Friso S, Choi SW. Aging alters hepatic DNA hydroxymethylation, as measured by liquid chromatography/mass spectrometry. J Cancer Prev. 2014 Dec;19(4):301-8. doi: 10.15430/jcp.2014.19.4.301. PMID: 25574465; PMCID: PMC4285961.
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Correction to Synthesis and Biological Evaluation of the First Dual Tyrosyl-DNA Phosphodiesterase I (Tdp1)-Topoisomerase I (Top1) Inhibitors.

Journal of medicinal chemistry

Nguyen TX, Morrell A, Conda-Sheridan M, Marchand C, Agama K, Bermingham A, Stephen AG, Chergui A, Naumova A, Fisher R, O'Keefe BR, Pommier Y, Cushman M.
PMID: 22891611
J Med Chem. 2012 Aug 23;55(16):7297. doi: 10.1021/jm301167v. Epub 2012 Aug 14.

No abstract available.

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Nguyen TX, Morrell A, Conda-Sheridan M, et al. Correction to Synthesis and Biological Evaluation of the First Dual Tyrosyl-DNA Phosphodiesterase I (Tdp1)-Topoisomerase I (Top1) Inhibitors. J Med Chem. 2012;55(16):7297doi: 10.1021/jm301167v.
Nguyen, T. X., Morrell, A., Conda-Sheridan, M., Marchand, C., Agama, K., Bermingham, A., Stephen, A. G., Chergui, A., Naumova, A., Fisher, R., O'Keefe, B. R., Pommier, Y., & Cushman, M. (2012). Correction to Synthesis and Biological Evaluation of the First Dual Tyrosyl-DNA Phosphodiesterase I (Tdp1)-Topoisomerase I (Top1) Inhibitors. Journal of medicinal chemistry, 55(16), 7297. https://doi.org/10.1021/jm301167v
Nguyen, Trung Xuan, et al. "Correction to Synthesis and Biological Evaluation of the First Dual Tyrosyl-DNA Phosphodiesterase I (Tdp1)-Topoisomerase I (Top1) Inhibitors." Journal of medicinal chemistry vol. 55,16 (2012): 7297. doi: https://doi.org/10.1021/jm301167v
Nguyen TX, Morrell A, Conda-Sheridan M, Marchand C, Agama K, Bermingham A, Stephen AG, Chergui A, Naumova A, Fisher R, O'Keefe BR, Pommier Y, Cushman M. Correction to Synthesis and Biological Evaluation of the First Dual Tyrosyl-DNA Phosphodiesterase I (Tdp1)-Topoisomerase I (Top1) Inhibitors. J Med Chem. 2012 Aug 23;55(16):7297. doi: 10.1021/jm301167v. Epub 2012 Aug 14. PMID: 22891611; PMCID: PMC3434871.
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Two phosphodiesterases from ustilago maydis share structural and biochemical properties with non-fungal phosphodiesterases.

Frontiers in microbiology

Agarwal C, Schultz DJ, Perlin MH.
PMID: 21687762
Front Microbiol. 2010 Nov 29;1:127. doi: 10.3389/fmicb.2010.00127. eCollection 2010.

The dependence of Protein Kinase A (PKA) activity on cAMP levels is an important facet of the dimorphic switch between budding and filamentous growth as well as for pathogenicity in some fungi. To better understand these processes in the...

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Agarwal C, Schultz DJ, Perlin MH. Two phosphodiesterases from ustilago maydis share structural and biochemical properties with non-fungal phosphodiesterases. Front Microbiol. 2010;1:127doi: 10.3389/fmicb.2010.00127.
Agarwal, C., Schultz, D. J., & Perlin, M. H. (2010). Two phosphodiesterases from ustilago maydis share structural and biochemical properties with non-fungal phosphodiesterases. Frontiers in microbiology, 1127. https://doi.org/10.3389/fmicb.2010.00127
Agarwal, Charu, et al. "Two phosphodiesterases from ustilago maydis share structural and biochemical properties with non-fungal phosphodiesterases." Frontiers in microbiology vol. 1 (2010): 127. doi: https://doi.org/10.3389/fmicb.2010.00127
Agarwal C, Schultz DJ, Perlin MH. Two phosphodiesterases from ustilago maydis share structural and biochemical properties with non-fungal phosphodiesterases. Front Microbiol. 2010 Nov 29;1:127. doi: 10.3389/fmicb.2010.00127. eCollection 2010. PMID: 21687762; PMCID: PMC3109409.
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Targeting Tyrosyl-DNA phosphodiesterase I to enhance toxicity of phosphodiester linked DNA-adducts.

Cancer drug resistance (Alhambra, Calif.)

Brettrager EJ, van Waardenburg RCAM.
PMID: 31875206
Cancer Drug Resist. 2019;2:1153-1163. doi: 10.20517/cdr.2019.91. Epub 2019 Dec 19.

Our genomic DNA is under constant assault from endogenous and exogenous sources, which needs to be resolved to maintain cellular homeostasis. The eukaryotic DNA repair enzyme Tyrosyl-DNA phosphodiesterase I (Tdp1) catalyzes the hydrolysis of phosphodiester bonds that covalently link...

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Brettrager EJ, van Waardenburg RCAM. Targeting Tyrosyl-DNA phosphodiesterase I to enhance toxicity of phosphodiester linked DNA-adducts. Cancer Drug Resist. 2019;2:1153-1163doi: 10.20517/cdr.2019.91.
Brettrager, E. J., & van Waardenburg, R. C. A. M. (2019). Targeting Tyrosyl-DNA phosphodiesterase I to enhance toxicity of phosphodiester linked DNA-adducts. Cancer drug resistance (Alhambra, Calif.), 21153-1163. https://doi.org/10.20517/cdr.2019.91
Brettrager, Evan J, and van Waardenburg, Robert C A M. "Targeting Tyrosyl-DNA phosphodiesterase I to enhance toxicity of phosphodiester linked DNA-adducts." Cancer drug resistance (Alhambra, Calif.) vol. 2 (2019): 1153-1163. doi: https://doi.org/10.20517/cdr.2019.91
Brettrager EJ, van Waardenburg RCAM. Targeting Tyrosyl-DNA phosphodiesterase I to enhance toxicity of phosphodiester linked DNA-adducts. Cancer Drug Resist. 2019;2:1153-1163. doi: 10.20517/cdr.2019.91. Epub 2019 Dec 19. PMID: 31875206; PMCID: PMC6929713.
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Purification and Properties of a Unique Nucleotide Pyrophosphatase/Phosphodiesterase I That Accumulates in Soybean Leaves in Response to Fruit Removal.

Plant physiology

Salvucci ME, Crafts-Brandner SJ.
PMID: 12228543
Plant Physiol. 1995 Jul;108(3):1269-1276. doi: 10.1104/pp.108.3.1269.

Several unique proteins accumulate in soybean (Glycine max) leaves when the developing fruits are removed. In the present study, elevated levels of nucleotide pyrophosphatase and phosphodiesterase I activities were present in leaves of defruited soybean plants. The soluble enzyme...

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Salvucci ME, Crafts-Brandner SJ. Purification and Properties of a Unique Nucleotide Pyrophosphatase/Phosphodiesterase I That Accumulates in Soybean Leaves in Response to Fruit Removal. Plant Physiol. 1995;108(3):1269-1276doi: 10.1104/pp.108.3.1269.
Salvucci, M. E., & Crafts-Brandner, S. J. (1995). Purification and Properties of a Unique Nucleotide Pyrophosphatase/Phosphodiesterase I That Accumulates in Soybean Leaves in Response to Fruit Removal. Plant physiology, 108(3), 1269-1276. https://doi.org/10.1104/pp.108.3.1269
Salvucci, M. E., and Crafts-Brandner, S. J.. "Purification and Properties of a Unique Nucleotide Pyrophosphatase/Phosphodiesterase I That Accumulates in Soybean Leaves in Response to Fruit Removal." Plant physiology vol. 108,3 (1995): 1269-1276. doi: https://doi.org/10.1104/pp.108.3.1269
Salvucci ME, Crafts-Brandner SJ. Purification and Properties of a Unique Nucleotide Pyrophosphatase/Phosphodiesterase I That Accumulates in Soybean Leaves in Response to Fruit Removal. Plant Physiol. 1995 Jul;108(3):1269-1276. doi: 10.1104/pp.108.3.1269. PMID: 12228543; PMCID: PMC157482.
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Identification of Lys49-PLA2 from crude venom of Crotalus atrox as a human neutrophil-calcium modulating protein.

The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology

Sultan MT, Li HM, Lee YZ, Lim SS, Song DK.
PMID: 26937214
Korean J Physiol Pharmacol. 2016 Mar;20(2):177-83. doi: 10.4196/kjpp.2016.20.2.177. Epub 2016 Feb 23.

We fortuitously observed a human neutrophil intracellular free-calcium concentration ([Ca(2+)]i) increasing activity in the commercially available phosphodiesterase I (PDE I), which is actually dried crude venom of Crotalus atrox. As this activity was not observed with another commercially available...

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Sultan MT, Li HM, Lee YZ, et al. Identification of Lys49-PLA2 from crude venom of Crotalus atrox as a human neutrophil-calcium modulating protein. Korean J Physiol Pharmacol. 2016;20(2):177-83doi: 10.4196/kjpp.2016.20.2.177.
Sultan, M. T., Li, H. M., Lee, Y. Z., Lim, S. S., & Song, D. K. (2016). Identification of Lys49-PLA2 from crude venom of Crotalus atrox as a human neutrophil-calcium modulating protein. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, 20(2), 177-83. https://doi.org/10.4196/kjpp.2016.20.2.177
Sultan, Md Tipu, et al. "Identification of Lys49-PLA2 from crude venom of Crotalus atrox as a human neutrophil-calcium modulating protein." The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology vol. 20,2 (2016): 177-83. doi: https://doi.org/10.4196/kjpp.2016.20.2.177
Sultan MT, Li HM, Lee YZ, Lim SS, Song DK. Identification of Lys49-PLA2 from crude venom of Crotalus atrox as a human neutrophil-calcium modulating protein. Korean J Physiol Pharmacol. 2016 Mar;20(2):177-83. doi: 10.4196/kjpp.2016.20.2.177. Epub 2016 Feb 23. PMID: 26937214; PMCID: PMC4770108.
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Showing 1 to 7 of 7 entries