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Interactions of pharmacologically active snake venom sPLA.

Biotechnology, biotechnological equipment

Doumanov J, Mladenova K, Aleksandrov R, Danovski G, Petrova S.
PMID: 26019578
Biotechnol Biotechnol Equip. 2014 Sep 03;28(5):918-922. doi: 10.1080/13102818.2014.965014. Epub 2014 Nov 11.

Secreted Phospholipases A

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Doumanov J, Mladenova K, Aleksandrov R, et al. Interactions of pharmacologically active snake venom sPLA. Biotechnol Biotechnol Equip. 2014;28(5):918-922doi: 10.1080/13102818.2014.965014.
Doumanov, J., Mladenova, K., Aleksandrov, R., Danovski, G., & Petrova, S. (2014). Interactions of pharmacologically active snake venom sPLA. Biotechnology, biotechnological equipment, 28(5), 918-922. https://doi.org/10.1080/13102818.2014.965014
Doumanov, Jordan, et al. "Interactions of pharmacologically active snake venom sPLA." Biotechnology, biotechnological equipment vol. 28,5 (2014): 918-922. doi: https://doi.org/10.1080/13102818.2014.965014
Doumanov J, Mladenova K, Aleksandrov R, Danovski G, Petrova S. Interactions of pharmacologically active snake venom sPLA. Biotechnol Biotechnol Equip. 2014 Sep 03;28(5):918-922. doi: 10.1080/13102818.2014.965014. Epub 2014 Nov 11. PMID: 26019578; PMCID: PMC4433929.
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Multi-drug strategies are necessary to inhibit the synergistic mechanism causing tissue damage and organ failure in post infectious sequelae.

Inflammopharmacology

Ginsburg I.
PMID: 17638092
Inflammopharmacology. 1999;7(3):207-17. doi: 10.1007/s10787-999-0004-1.

The paper discusses the principal evidence that supports the concept that cell and tissue injury in infectious and post-infectious and inflammatory sequelae might involve a deleterious synergistic interaction among microbial- and host-derived pro-inflammatory agonists. Experimental models had proposed that...

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Ginsburg I. Multi-drug strategies are necessary to inhibit the synergistic mechanism causing tissue damage and organ failure in post infectious sequelae. Inflammopharmacology. 1999;7(3):207-17doi: 10.1007/s10787-999-0004-1.
Ginsburg, I. (1999). Multi-drug strategies are necessary to inhibit the synergistic mechanism causing tissue damage and organ failure in post infectious sequelae. Inflammopharmacology, 7(3), 207-17. https://doi.org/10.1007/s10787-999-0004-1
Ginsburg, I. "Multi-drug strategies are necessary to inhibit the synergistic mechanism causing tissue damage and organ failure in post infectious sequelae." Inflammopharmacology vol. 7,3 (1999): 207-17. doi: https://doi.org/10.1007/s10787-999-0004-1
Ginsburg I. Multi-drug strategies are necessary to inhibit the synergistic mechanism causing tissue damage and organ failure in post infectious sequelae. Inflammopharmacology. 1999;7(3):207-17. doi: 10.1007/s10787-999-0004-1. PMID: 17638092.
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Phospholipase A(2) activates hemostasis.

Drug target insights

Stief TW.
PMID: 21901065
Drug Target Insights. 2007;2:83-96. Epub 2007 Mar 22.

BACKGROUND: Phospholipases A(2) (PLA(2)) are aggressive enzymes that can destroy phospholipids of cell membranes. The resulting cell fragments trigger the kallikrein-mediated contact phase of coagulation. The aim of the present study was to expose citrated whole blood to PLA(2)...

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Stief TW. Phospholipase A(2) activates hemostasis. Drug Target Insights. 2007;2:83-96
Stief, T. W. (2007). Phospholipase A(2) activates hemostasis. Drug target insights, 283-96.
Stief, Thomas W. "Phospholipase A(2) activates hemostasis." Drug target insights vol. 2 (2007): 83-96.
Stief TW. Phospholipase A(2) activates hemostasis. Drug Target Insights. 2007;2:83-96. Epub 2007 Mar 22. PMID: 21901065; PMCID: PMC3155239.
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Exploration of immunoglobulin transcriptomes from mice immunized with three-finger toxins and phospholipases A.

PeerJ

Laustsen AH, Engmark M, Clouser C, Timberlake S, Vigneault F, Gutiérrez JM, Lomonte B.
PMID: 28149694
PeerJ. 2017 Jan 24;5:e2924. doi: 10.7717/peerj.2924. eCollection 2017.

Snakebite envenomings represent a neglected public health issue in many parts of the rural tropical world. Animal-derived antivenoms have existed for more than a hundred years and are effective in neutralizing snake venom toxins when timely administered. However, the...

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Laustsen AH, Engmark M, Clouser C, et al. Exploration of immunoglobulin transcriptomes from mice immunized with three-finger toxins and phospholipases A. PeerJ. 2017;5:e2924doi: 10.7717/peerj.2924.
Laustsen, A. H., Engmark, M., Clouser, C., Timberlake, S., Vigneault, F., Gutiérrez, J. M., & Lomonte, B. (2017). Exploration of immunoglobulin transcriptomes from mice immunized with three-finger toxins and phospholipases A. PeerJ, 5e2924. https://doi.org/10.7717/peerj.2924
Laustsen, Andreas H, et al. "Exploration of immunoglobulin transcriptomes from mice immunized with three-finger toxins and phospholipases A." PeerJ vol. 5 (2017): e2924. doi: https://doi.org/10.7717/peerj.2924
Laustsen AH, Engmark M, Clouser C, Timberlake S, Vigneault F, Gutiérrez JM, Lomonte B. Exploration of immunoglobulin transcriptomes from mice immunized with three-finger toxins and phospholipases A. PeerJ. 2017 Jan 24;5:e2924. doi: 10.7717/peerj.2924. eCollection 2017. PMID: 28149694; PMCID: PMC5267563.
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Varespladib (LY315920) rescued mice from fatal neurotoxicity caused by venoms of five major Asiatic kraits (Bungarus spp.) in an experimental envenoming and rescue model.

Acta tropica

Tan CH, Lingam TMC, Tan KY.
PMID: 34929179
Acta Trop. 2021 Dec 18;227:106289. doi: 10.1016/j.actatropica.2021.106289. Epub 2021 Dec 18.

The venoms of Asiatic kraits (Bungarus spp.) contain various neurotoxic phospholipases A

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Tan CH, Lingam TMC, Tan KY. Varespladib (LY315920) rescued mice from fatal neurotoxicity caused by venoms of five major Asiatic kraits (Bungarus spp.) in an experimental envenoming and rescue model. Acta Trop. 2021;227:106289doi: 10.1016/j.actatropica.2021.106289.
Tan, C. H., Lingam, T. M. C., & Tan, K. Y. (2021). Varespladib (LY315920) rescued mice from fatal neurotoxicity caused by venoms of five major Asiatic kraits (Bungarus spp.) in an experimental envenoming and rescue model. Acta tropica, 227106289. https://doi.org/10.1016/j.actatropica.2021.106289
Tan, Choo Hock, et al. "Varespladib (LY315920) rescued mice from fatal neurotoxicity caused by venoms of five major Asiatic kraits (Bungarus spp.) in an experimental envenoming and rescue model." Acta tropica vol. 227 (2021): 106289. doi: https://doi.org/10.1016/j.actatropica.2021.106289
Tan CH, Lingam TMC, Tan KY. Varespladib (LY315920) rescued mice from fatal neurotoxicity caused by venoms of five major Asiatic kraits (Bungarus spp.) in an experimental envenoming and rescue model. Acta Trop. 2021 Dec 18;227:106289. doi: 10.1016/j.actatropica.2021.106289. Epub 2021 Dec 18. PMID: 34929179.
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Proteomic characterization of .

The journal of venomous animals and toxins including tropical diseases

Beraldo E, Coelho GR, Sciani JM, Pimenta DC.
PMID: 34394208
J Venom Anim Toxins Incl Trop Dis. 2021 Jul 30;27:e20200125. doi: 10.1590/1678-9199-JVATITD-2020-0125. eCollection 2021.

METHODS: We have performed a liquid-chromatography (C18-RP-HPLC) mass spectrometry (ESI-IT-TOF/MS) based approach in order to biochemically characterize RESULTS: A wide variety of three-finger toxins (cardiotoxins) and metallopeptidases were detected. Less abundant, but still representative, were cysteine-rich secretory proteins, L-amino-acid...

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Beraldo E, Coelho GR, Sciani JM, et al. Proteomic characterization of . J Venom Anim Toxins Incl Trop Dis. 2021;27:e20200125doi: 10.1590/1678-9199-JVATITD-2020-0125.
Beraldo, E., Coelho, G. R., Sciani, J. M., & Pimenta, D. C. (2021). Proteomic characterization of . The journal of venomous animals and toxins including tropical diseases, 27e20200125. https://doi.org/10.1590/1678-9199-JVATITD-2020-0125
Beraldo, Emídio, et al. "Proteomic characterization of ." The journal of venomous animals and toxins including tropical diseases vol. 27 (2021): e20200125. doi: https://doi.org/10.1590/1678-9199-JVATITD-2020-0125
Beraldo E, Coelho GR, Sciani JM, Pimenta DC. Proteomic characterization of . J Venom Anim Toxins Incl Trop Dis. 2021 Jul 30;27:e20200125. doi: 10.1590/1678-9199-JVATITD-2020-0125. eCollection 2021. PMID: 34394208; PMCID: PMC8331017.
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Varespladib (LY315920) rescued mice from fatal neurotoxicity caused by venoms of five major Asiatic kraits (Bungarus spp.) in an experimental envenoming and rescue model.

Acta tropica

Tan CH, Lingam TMC, Tan KY.
PMID: 34929179
Acta Trop. 2021 Dec 18;227:106289. doi: 10.1016/j.actatropica.2021.106289. Epub 2021 Dec 18.

The venoms of Asiatic kraits (Bungarus spp.) contain various neurotoxic phospholipases A

Cite
Tan CH, Lingam TMC, Tan KY. Varespladib (LY315920) rescued mice from fatal neurotoxicity caused by venoms of five major Asiatic kraits (Bungarus spp.) in an experimental envenoming and rescue model. Acta Trop. 2021;227:106289doi: 10.1016/j.actatropica.2021.106289.
Tan, C. H., Lingam, T. M. C., & Tan, K. Y. (2021). Varespladib (LY315920) rescued mice from fatal neurotoxicity caused by venoms of five major Asiatic kraits (Bungarus spp.) in an experimental envenoming and rescue model. Acta tropica, 227106289. https://doi.org/10.1016/j.actatropica.2021.106289
Tan, Choo Hock, et al. "Varespladib (LY315920) rescued mice from fatal neurotoxicity caused by venoms of five major Asiatic kraits (Bungarus spp.) in an experimental envenoming and rescue model." Acta tropica vol. 227 (2021): 106289. doi: https://doi.org/10.1016/j.actatropica.2021.106289
Tan CH, Lingam TMC, Tan KY. Varespladib (LY315920) rescued mice from fatal neurotoxicity caused by venoms of five major Asiatic kraits (Bungarus spp.) in an experimental envenoming and rescue model. Acta Trop. 2021 Dec 18;227:106289. doi: 10.1016/j.actatropica.2021.106289. Epub 2021 Dec 18. PMID: 34929179.
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Hydrolysis of glycerophosphocholine epoxides by human group IIA, V, and X secretory phospholipases A.

Lipids

Kuksis A, Pruzanski W.
PMID: 34278577
Lipids. 2021 Sep;56(5):521-535. doi: 10.1002/lipd.12320. Epub 2021 Jul 18.

This study was prompted by recent reports that epoxyeicosatrienoic (EET) and epoxyeicosatetraenoic (EEQ) acids accelerate tumor growth and metastasis by stimulation of angiogenesis, while eicosapentaenoic (EPA) and epoxydocosapentaenoic (EDP) acids inhibit angiogenesis, tumor growth, and metastasis. Cytochrome P450 epoxygenases...

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Kuksis A, Pruzanski W. Hydrolysis of glycerophosphocholine epoxides by human group IIA, V, and X secretory phospholipases A. Lipids. 2021;56(5):521-535doi: 10.1002/lipd.12320.
Kuksis, A., & Pruzanski, W. (2021). Hydrolysis of glycerophosphocholine epoxides by human group IIA, V, and X secretory phospholipases A. Lipids, 56(5), 521-535. https://doi.org/10.1002/lipd.12320
Kuksis, Arnis, and Pruzanski, Waldemar. "Hydrolysis of glycerophosphocholine epoxides by human group IIA, V, and X secretory phospholipases A." Lipids vol. 56,5 (2021): 521-535. doi: https://doi.org/10.1002/lipd.12320
Kuksis A, Pruzanski W. Hydrolysis of glycerophosphocholine epoxides by human group IIA, V, and X secretory phospholipases A. Lipids. 2021 Sep;56(5):521-535. doi: 10.1002/lipd.12320. Epub 2021 Jul 18. PMID: 34278577.
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Inflammatory Effects of .

Toxins

Moreira V, Leiguez E, Janovits PM, Maia-Marques R, Fernandes CM, Teixeira C.
PMID: 34941706
Toxins (Basel). 2021 Dec 04;13(12). doi: 10.3390/toxins13120868.

Phospholipases A

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Moreira V, Leiguez E, Janovits PM, et al. Inflammatory Effects of . Toxins (Basel). 2021;13(12)doi: 10.3390/toxins13120868.
Moreira, V., Leiguez, E., Janovits, P. M., Maia-Marques, R., Fernandes, C. M., & Teixeira, C. (2021). Inflammatory Effects of . Toxins, 13(12), . https://doi.org/10.3390/toxins13120868
Moreira, Vanessa, et al. "Inflammatory Effects of ." Toxins vol. 13,12 (2021). doi: https://doi.org/10.3390/toxins13120868
Moreira V, Leiguez E, Janovits PM, Maia-Marques R, Fernandes CM, Teixeira C. Inflammatory Effects of . Toxins (Basel). 2021 Dec 04;13(12). doi: 10.3390/toxins13120868. PMID: 34941706; PMCID: PMC8709003.
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Inflammatory Effects of .

Toxins

Moreira V, Leiguez E, Janovits PM, Maia-Marques R, Fernandes CM, Teixeira C.
PMID: 34941706
Toxins (Basel). 2021 Dec 04;13(12). doi: 10.3390/toxins13120868.

Phospholipases A

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Moreira V, Leiguez E, Janovits PM, et al. Inflammatory Effects of . Toxins (Basel). 2021;13(12)doi: 10.3390/toxins13120868.
Moreira, V., Leiguez, E., Janovits, P. M., Maia-Marques, R., Fernandes, C. M., & Teixeira, C. (2021). Inflammatory Effects of . Toxins, 13(12), . https://doi.org/10.3390/toxins13120868
Moreira, Vanessa, et al. "Inflammatory Effects of ." Toxins vol. 13,12 (2021). doi: https://doi.org/10.3390/toxins13120868
Moreira V, Leiguez E, Janovits PM, Maia-Marques R, Fernandes CM, Teixeira C. Inflammatory Effects of . Toxins (Basel). 2021 Dec 04;13(12). doi: 10.3390/toxins13120868. PMID: 34941706.
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Green synthesis of silver nanoparticles using Indian male fern (.

Toxicology research

Singh P, Yasir M, Khare R, Shrivastava R.
PMID: 33178431
Toxicol Res (Camb). 2020 Oct 15;9(5):706-713. doi: 10.1093/toxres/tfaa070. eCollection 2020 Sep.

Snakebite is considered as one of the acute severe medical problems across the world. Snake venoms composed of various group of toxins, enzymes and non-toxic enzymes. Phospholipases A

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Singh P, Yasir M, Khare R, et al. Green synthesis of silver nanoparticles using Indian male fern (. Toxicol Res (Camb). 2020;9(5):706-713doi: 10.1093/toxres/tfaa070.
Singh, P., Yasir, M., Khare, R., & Shrivastava, R. (2020). Green synthesis of silver nanoparticles using Indian male fern (. Toxicology research, 9(5), 706-713. https://doi.org/10.1093/toxres/tfaa070
Singh, Pushpendra, et al. "Green synthesis of silver nanoparticles using Indian male fern (." Toxicology research vol. 9,5 (2020): 706-713. doi: https://doi.org/10.1093/toxres/tfaa070
Singh P, Yasir M, Khare R, Shrivastava R. Green synthesis of silver nanoparticles using Indian male fern (. Toxicol Res (Camb). 2020 Oct 15;9(5):706-713. doi: 10.1093/toxres/tfaa070. eCollection 2020 Sep. PMID: 33178431; PMCID: PMC7640931.
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Antimalarial activity of basic phospholipases A.

Toxicon: X

Vitorino KA, Alfonso JJ, Gómez AF, Santos APA, Antunes YR, Caldeira CADS, Gómez CV, Teles CBG, Soares AM, Calderon LA.
PMID: 32885164
Toxicon X. 2020 Aug 08;8:100056. doi: 10.1016/j.toxcx.2020.100056. eCollection 2020 Dec.

Malaria is a parasitic infectious disease and was responsible for 400.000 deaths in 2018.

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Vitorino KA, Alfonso JJ, Gómez AF, et al. Antimalarial activity of basic phospholipases A. Toxicon X. 2020;8:100056doi: 10.1016/j.toxcx.2020.100056.
Vitorino, K. A., Alfonso, J. J., Gómez, A. F., Santos, A. P. A., Antunes, Y. R., Caldeira, C. A. D. S., Gómez, C. V., Teles, C. B. G., Soares, A. M., & Calderon, L. A. (2020). Antimalarial activity of basic phospholipases A. Toxicon: X, 8100056. https://doi.org/10.1016/j.toxcx.2020.100056
Vitorino, Keila A, et al. "Antimalarial activity of basic phospholipases A." Toxicon: X vol. 8 (2020): 100056. doi: https://doi.org/10.1016/j.toxcx.2020.100056
Vitorino KA, Alfonso JJ, Gómez AF, Santos APA, Antunes YR, Caldeira CADS, Gómez CV, Teles CBG, Soares AM, Calderon LA. Antimalarial activity of basic phospholipases A. Toxicon X. 2020 Aug 08;8:100056. doi: 10.1016/j.toxcx.2020.100056. eCollection 2020 Dec. PMID: 32885164; PMCID: PMC7451622.
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Showing 1 to 12 of 56 entries